Robert Wise

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc The Tiotropium Safety and Performance in Respimat Trial (TIOSPIR), a large scale, randomized, controlled, parallel-group trial-design and rationale
    Robert A Wise
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Respir Res 14:40. 2013
  2. pmc Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study
    Nicholas D Giardino
    Mental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Respir Res 11:29. 2010
  3. pmc Cross sectional analysis of respiratory symptoms in an injection drug user cohort: the impact of obstructive lung disease and HIV
    M Bradley Drummond
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    BMC Pulm Med 10:27. 2010
  4. pmc Randomized trial of the effect of drug presentation on asthma outcomes: the American Lung Association Asthma Clinical Research Centers
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 124:436-44, 444e1-8. 2009
  5. ncbi request reprint Respiratory physiologic changes in pregnancy
    Robert A Wise
    Department of Medicine Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Immunol Allergy Clin North Am 26:1-12. 2006
  6. ncbi request reprint Standardization of the single-breath diffusing capacity in a multicenter clinical trial
    Robert A Wise
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Chest 132:1191-7. 2007
  7. ncbi request reprint Field tests of exercise in COPD: the six-minute walk test and the shuttle walk test
    Cynthia D Brown
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    COPD 4:217-23. 2007
  8. ncbi request reprint The value of forced expiratory volume in 1 second decline in the assessment of chronic obstructive pulmonary disease progression
    Robert A Wise
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med 119:4-11. 2006
  9. pmc The role of NETT in emphysema research
    Robert A Wise
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Proc Am Thorac Soc 5:385-92. 2008
  10. ncbi request reprint Minimal clinically important differences in the six-minute walk test and the incremental shuttle walking test
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 4B 72, 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
    COPD 2:125-9. 2005

Research Grants

  1. MULTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASES
    Robert Wise; Fiscal Year: 2007
  2. SCLERODERMA LUNG STUDY
    Robert Wise; Fiscal Year: 2003
  3. The Placebo Effect in Asthma
    Robert Wise; Fiscal Year: 2005
  4. Clinical Trial of Acid Reflux Therapy in Asthma
    Robert Wise; Fiscal Year: 2007

Detail Information

Publications84

  1. pmc The Tiotropium Safety and Performance in Respimat Trial (TIOSPIR), a large scale, randomized, controlled, parallel-group trial-design and rationale
    Robert A Wise
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Respir Res 14:40. 2013
    ..Comparing across programs tiotropium Respimat Soft Mist inhaler was at least as efficacious as tiotropium HandiHaler, however, concerns have been raised about tiotropium's safety when given via Respimat...
  2. pmc Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study
    Nicholas D Giardino
    Mental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Respir Res 11:29. 2010
    ..The purpose of this study is to determine whether there is an association between anxiety and functional measures, quality of life and dyspnea...
  3. pmc Cross sectional analysis of respiratory symptoms in an injection drug user cohort: the impact of obstructive lung disease and HIV
    M Bradley Drummond
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    BMC Pulm Med 10:27. 2010
    ..We characterized the independent and joint effects of HIV and OLD on respiratory symptoms of a cohort of inner-city IDUs...
  4. pmc Randomized trial of the effect of drug presentation on asthma outcomes: the American Lung Association Asthma Clinical Research Centers
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 124:436-44, 444e1-8. 2009
    ..Although asthma symptoms often improve with placebo, it is not known whether the response to placebo or active treatment can be augmented by increasing expectation of benefit...
  5. ncbi request reprint Respiratory physiologic changes in pregnancy
    Robert A Wise
    Department of Medicine Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Immunol Allergy Clin North Am 26:1-12. 2006
    ..Patients who have many lung diseases tolerate pregnancy well, with the exception of those who have pulmonary hypertension or chronic respiratory insufficiency from parenchymal or neuromuscular disease...
  6. ncbi request reprint Standardization of the single-breath diffusing capacity in a multicenter clinical trial
    Robert A Wise
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Chest 132:1191-7. 2007
    ..The safety assessment of inhalable insulin required the standardization of measurement of single-breath DLCO in multicenter clinical trials to optimize test precision...
  7. ncbi request reprint Field tests of exercise in COPD: the six-minute walk test and the shuttle walk test
    Cynthia D Brown
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    COPD 4:217-23. 2007
    ..This article reviews how these tests are performed and to what degree they are reliable, and how these tests are used in assessment of individuals with chronic obstructive pulmonary disease...
  8. ncbi request reprint The value of forced expiratory volume in 1 second decline in the assessment of chronic obstructive pulmonary disease progression
    Robert A Wise
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med 119:4-11. 2006
    ..Consequently, FEV1 and its change over time are important outcomes in COPD and valuable measures for the assessment of disease progression...
  9. pmc The role of NETT in emphysema research
    Robert A Wise
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Proc Am Thorac Soc 5:385-92. 2008
    ..In many ways, the story of NETT serves as a model for evaluation of new surgical approaches to chronic diseases...
  10. ncbi request reprint Minimal clinically important differences in the six-minute walk test and the incremental shuttle walking test
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 4B 72, 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
    COPD 2:125-9. 2005
    ....
  11. ncbi request reprint Ethical issues confronted in pulmonary clinical trials
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Proc Am Thorac Soc 4:200-5; discussion 205. 2007
    ....
  12. doi request reprint Continuous oxygen use in nonhypoxemic emphysema patients identifies a high-risk subset of patients: retrospective analysis of the National Emphysema Treatment Trial
    Michael B Drummond
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Chest 134:497-506. 2008
    ..Little is known regarding the clinical characteristics and survival of nonhypoxemic emphysema patients using continuous oxygen. Analysis of data from the National Emphysema Treatment Trial (NETT) offers insight into this population...
  13. pmc Physical activity, health status and risk of hospitalization in patients with severe chronic obstructive pulmonary disease
    Roberto P Benzo
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Respiration 80:10-8. 2010
    ..Self-reported daily physical activity and health status have been reported as predictors of a hospitalization in COPD but are not routinely assessed...
  14. pmc Physiological and computed tomographic predictors of outcome from lung volume reduction surgery
    George R Washko
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 181:494-500. 2010
    ..We therefore sought to examine radiographic and physiologic predictors of surgical outcomes in a large, multicenter clinical investigation, the National Emphysema Treatment Trial...
  15. pmc Variability of spirometry in chronic obstructive pulmonary disease: results from two clinical trials
    Laura B Herpel
    The Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 173:1106-13. 2006
    ..This may be applied to determine criteria that can be used to assess a clinically meaningful change in spirometry...
  16. pmc Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study
    John M Brehm
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    J Allergy Clin Immunol 126:52-8.e5. 2010
    ..Vitamin D status might play a role in preventing asthma exacerbations...
  17. pmc Sex differences in severe pulmonary emphysema
    Fernando J Martinez
    University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, Michigan 48109 0360, USA
    Am J Respir Crit Care Med 176:243-52. 2007
    ..Limited data on sex differences in advanced COPD are available...
  18. doi request reprint Predicting treatment outcomes and responder subsets in scleroderma-related interstitial lung disease
    Michael D Roth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
    Arthritis Rheum 63:2797-808. 2011
    ..To identify baseline characteristics of patients with scleroderma-related interstitial lung disease (SSc-ILD) that could serve as predictors of the most favorable response to 12-month treatment with oral cyclophosphamide (CYC)...
  19. pmc Integrating health status and survival data: the palliative effect of lung volume reduction surgery
    Roberto Benzo
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota 55902, USA
    Am J Respir Crit Care Med 180:239-46. 2009
    ..This practice tends to inflate the apparent benefits of interventions with a high risk of mortality. Assessing a composite QoL-death outcome is a potential solution to this problem...
  20. pmc In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthma
    Robyn T Cohen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachussetts, USA
    J Allergy Clin Immunol 126:491-7. 2010
    ..Few studies have examined the effects of in utero smoke exposure (IUS) on lung function in children with asthma, and there are no published data on the impact of IUS on treatment outcomes in children with asthma...
  21. pmc Perfusion scintigraphy and patient selection for lung volume reduction surgery
    Divay Chandra
    Division of Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 182:937-46. 2010
    ..It is unclear if lung perfusion can predict response to lung volume reduction surgery (LVRS)...
  22. pmc Changes in arterial oxygenation and self-reported oxygen use after lung volume reduction surgery
    Margaret L Snyder
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington 98195 6522, USA
    Am J Respir Crit Care Med 178:339-45. 2008
    ..Lung volume reduction surgery (LVRS) is inconsistently reported to improve arterial oxygenation in patients with chronic obstructive pulmonary disease...
  23. doi request reprint Exposure to neonatal cigarette smoke causes durable lung changes but does not potentiate cigarette smoke-induced chronic obstructive pulmonary disease in adult mice
    Sharon McGrath-Morrow
    Division of Pediatric Pulmonary, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2533, USA
    Exp Lung Res 37:354-63. 2011
    ..Additional studies may be warranted to determine the utility of these genes as biomarkers of respiratory outcomes...
  24. ncbi request reprint Optimizing treatment of chronic obstructive pulmonary disease: an assessment of current therapies
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Med 120:S4-13. 2007
    ..A treatment algorithm that combines both pharmacologic and nonpharmacologic interventions for the management of COPD is presented...
  25. ncbi request reprint Preventing chronic obstructive pulmonary disease: what is known and what needs to be done to make a difference to the patient?
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Med 120:S14-22. 2007
    ....
  26. ncbi request reprint Adult asthma severity in individuals with a history of childhood asthma
    Susan L Limb
    Division of Allergy and Clinical Immunology, Bloomberg School of Public Health, Johns Hopkinds University, Baltimore, MD, USA
    J Allergy Clin Immunol 115:61-6. 2005
    ..Childhood asthma can have a range of outcomes in adulthood...
  27. pmc Eosinophil and T cell markers predict functional decline in COPD patients
    JEANINE M D'ARMIENTO
    Department of Medicine, Columbia University, New York, NY, USA
    Respir Res 10:113. 2009
    ..We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease...
  28. doi request reprint Exercise testing in severe emphysema: association with quality of life and lung function
    Cynthia D Brown
    Division of Pulmonary and Critical Care Medicine, University of Virginia, VA, USA
    COPD 5:117-24. 2008
    ..Moreover, the 6MWT may be a better test of functional capacity given its greater association with QOL measures whereas CPX is a better test of physiologic impairment...
  29. pmc Predictors of mortality in patients with emphysema and severe airflow obstruction
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0360, and Section of Thoracic Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Respir Crit Care Med 173:1326-34. 2006
    ..Limited data exist describing risk factors for mortality in patients having predominantly emphysema...
  30. pmc Impaired lung homeostasis in neonatal mice exposed to cigarette smoke
    Sharon McGrath-Morrow
    Department of Pediatrics, Division of Pediatric Pulmonary, Johns Hopkins Hospital, Park 316 600 N Wolfe St, Baltimore, MD 21287 2533, USA
    Am J Respir Cell Mol Biol 38:393-400. 2008
    ..These findings may in part explain the increased incidence of respiratory symptoms in infants and children exposed to CS...
  31. ncbi request reprint Methodologic issues in terminating enrollment of a subgroup of patients in a multicenter randomized trial
    Shing M Lee
    Department of Biostatistics, Columbia University, New York, NY, USA
    Clin Trials 1:326-38. 2004
    ..We also describe the repercussions of the publication and the misinterpretations of the results based on media coverage...
  32. doi request reprint HIV and COPD: impact of risk behaviors and diseases on quality of life
    M Bradley Drummond
    Department of Medicine, School of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, JHAAC 4B 70, Baltimore, MD 21224, USA
    Qual Life Res 19:1295-302. 2010
    ..Smoking worsens quality of life among HIV-infected individuals, but it remains unclear if this association is related simply to smoking or to chronic obstructive pulmonary disease (COPD), the end-organ disease caused by smoking...
  33. ncbi request reprint Spirometer calibration checks: is 3.5% good enough?
    Meredith C McCormack
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21205, USA
    Chest 131:1486-93. 2007
    ..5% of the inserted volume but do not require evaluation of trends over time. We examined the current guidelines and candidate quality control rules to determine the best method for identifying spirometers with suboptimal performance...
  34. pmc Chronic intermittent hypoxia induces lung growth in adult mice
    Christian Reinke
    Department of Medicine, Div of Pulmonary Medicine, Johns Hopkins University, Baltimore, MD, USA
    Am J Physiol Lung Cell Mol Physiol 300:L266-73. 2011
    ..We conclude that IH increases alveolar surface area by stimulating lung growth in adult mice...
  35. doi request reprint Mortality in COPD: causes, risk factors, and prevention
    Cristine E Berry
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    COPD 7:375-82. 2010
    ..Smoking cessation improves survival in COPD patients, and in select patients with advanced disease, oxygen therapy, lung volume reduction surgery, or lung transplantation may also improve survival...
  36. doi request reprint Maternal vitamin A supplementation and lung function in offspring
    William Checkley
    Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    N Engl J Med 362:1784-94. 2010
    ....
  37. doi request reprint Accuracy of death certificates in COPD: analysis from the TORCH trial
    M Bradley Drummond
    Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    COPD 7:179-85. 2010
    ..COPD is under-reported on death certificates, and this under-reporting is more frequent when the primary cause of death is not pulmonary...
  38. pmc Intersession variability in single-breath diffusing capacity in diabetics without overt lung disease
    Michael B Drummond
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 178:225-32. 2008
    ..However, little is known about the short-term intersession variability in DL(CO) in untrained subjects or how variability is affected by rigorous external quality control...
  39. ncbi request reprint The effect of smoking intervention and an inhaled bronchodilator on airways reactivity in COPD: the Lung Health Study
    Robert A Wise
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Chest 124:449-58. 2003
    ..This report evaluates the effects of these interventions, demographic characteristics, smoking status, and FEV(1) changes on airway responsiveness (AR)...
  40. ncbi request reprint Racial difference in lung function in African-American and White children: effect of anthropometric, socioeconomic, nutritional, and environmental factors
    Raida I Harik-Khan
    Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA
    Am J Epidemiol 160:893-900. 2004
    ..The authors conclude that in healthy children, the major explanatory variable for the racial difference in lung function is body habitus; socioeconomic, nutritional, and environmental confounders play a smaller role...
  41. ncbi request reprint Paradoxical physical findings described by Kussmaul: pulsus paradoxus and Kussmaul's sign
    Kenneth C Bilchick
    Johns Hopkins University School of Medicine, Department of Medicine, Baltimore, MD 21287, USA
    Lancet 359:1940-2. 2002
  42. ncbi request reprint Irreversible lung function deficits in young adults with a history of childhood asthma
    Susan L Limb
    Division of Allergy and Clinical Immunology, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 116:1213-9. 2005
    ..Asthma, traditionally characterized as reversible airway obstruction, might lead to structural changes and permanent impairment...
  43. ncbi request reprint Measurement variability in single-breath diffusing capacity of the lung
    Naresh M Punjabi
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Chest 123:1082-9. 2003
    ..The objectives of the present study were to examine whether the current reproducibility criteria were met in a general pulmonary function laboratory and to determine whether alternative criteria might be appropriate...
  44. pmc The Madison Avenue effect: how drug presentation style influences adherence and outcome in patients with asthma
    Emmanuelle M Clerisme-Beaty
    Johns Hopkins University, Baltimore, MD, USA
    J Allergy Clin Immunol 127:406-11. 2011
    ..Little is known about how drug presentation influences medication adherence...
  45. pmc Prevalence and risk factors for unrecognized obstructive lung disease among urban drug users
    M Bradley Drummond
    Department of Medicine, School of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Int J Chron Obstruct Pulmon Dis 6:89-95. 2011
    ..Urban drug users are at higher risk for OLD due to race, behavioral, and socioeconomic characteristics, yet little data exist on prevalence and risk factors associated with unrecognized OLD in this population...
  46. pmc Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice
    Megan Podowski
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Invest 122:229-40. 2012
    ..More importantly, our findings provide a preclinical platform for the development of other TGF-β-targeted therapies for patients with COPD...
  47. pmc Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity
    Deepti Malhotra
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 180:1196-207. 2009
    ..Because accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and ER stress-induced apoptosis, Nrf2 may potentially prevent ER stress-mediated apoptosis in COPD...
  48. pmc Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients
    Deepti Malhotra
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    J Clin Invest 121:4289-302. 2011
    ..These effects of sulforaphane were glutathione dependent. We conclude that NRF2 is a novel drug target for reversing corticosteroid resistance in COPD and other corticosteroid-resistant inflammatory diseases...
  49. pmc Longitudinal change in the BODE index predicts mortality in severe emphysema
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0360, USA
    Am J Respir Crit Care Med 178:491-9. 2008
    ..We hypothesized that decrease in a modified BODE (mBODE) would predict survival in National Emphysema Treatment Trial (NETT) patients...
  50. ncbi request reprint Six-minute walk distance in chronic obstructive pulmonary disease: reproducibility and effect of walking course layout and length
    Frank Sciurba
    Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 167:1522-7. 2003
    ..The training effect found in these patients with severe emphysema is less than in previous reports of patients with chronic obstructive pulmonary disease. Furthermore, the layout of the track may influence the 6-minute walk performance...
  51. pmc Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management program
    Sunita Sharma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 122:921-928.e4. 2008
    ..Among asthmatic subjects, bronchodilator response (BDR) to inhaled beta(2)-adrenergic agonists is variable, and the significance of a consistent response over time is unknown...
  52. ncbi request reprint Airway obstruction is common but unsuspected in patients admitted to a general medicine service
    David Zaas
    Longcope Medical Firm, Osler Medical Service, Johns Hopkins Department of Medicine, Baltimore, MD 21205, USA
    Chest 125:106-11. 2004
    ..The goal of this study was to measure the prevalence of airway obstruction in patients admitted to an urban teaching hospital and to determine the frequency of a diagnosis of OLD at admission or discharge...
  53. ncbi request reprint Serum vitamin levels and the risk of asthma in children
    Raida I Harik-Khan
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Am J Epidemiol 159:351-7. 2004
    ..65 (p < 0.05), whereas it was 0.74 for alpha-carotene (p = 0.066). The authors concluded that low vitamin C and alpha-carotene intakes are associated with asthma risk in children...
  54. pmc Criteria to screen for chronic sinonasal disease
    Anne E Dixon
    Department of Medicine, University of Vermont, Burlington, VT 05401, USA
    Chest 136:1324-32. 2009
    ..There are no simple, validated tools to screen for these diseases. The objective of this study was to assess instruments to assist in the diagnosis of chronic sinonasal disease...
  55. pmc Oxygen therapy in chronic obstructive pulmonary disease
    Victor Kim
    Division of Pulmonary and Critical Care Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Proc Am Thorac Soc 5:513-8. 2008
    ..The goals of this article are to briefly describe the indications for chronic oxygen administration, the physiologic effects of treatment, and potential toxicities, as well as its effect on morbidity and mortality...
  56. ncbi request reprint Natural history of mild-moderate pulmonary hypertension and the risk factors for severe pulmonary hypertension in scleroderma
    Betty Chang
    Division of Pulmonary and Critical Care Medicine, University of New Mexico, Albuquerque, 87131, USA
    J Rheumatol 33:269-74. 2006
    ..To determine risk factors for developing pulmonary hypertension (PH) in patients with scleroderma (SSc, systemic sclerosis)...
  57. ncbi request reprint Persistence of abnormal bronchoalveolar lavage findings after cyclophosphamide treatment in scleroderma patients with interstitial lung disease
    Shikha Mittoo
    Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Baltimore, MD 21224, USA
    Arthritis Rheum 56:4195-202. 2007
    ....
  58. pmc Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1690, USA
    Am J Respir Crit Care Med 176:1026-34. 2007
    ..Although treatment-related benefits in pulmonary function, skin scores, and patient-centered outcomes were demonstrated after 1 year of therapy, the duration of benefit beyond 1 year was unclear...
  59. ncbi request reprint Body mass index and the risk of COPD
    Raida I Harik-Khan
    Longitudinal Study Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Chest 121:370-6. 2002
    ..However, it is not clear whether low body weight is a risk factor for COPD or a consequence of established disease...
  60. ncbi request reprint Physician and patient perceptions in COPD: the COPD Resource Network Needs Assessment Survey
    R Graham Barr
    Division of General Medicine, Department of Medicine, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Med 118:1415. 2005
    ..National data are lacking on patient and physician perceptions of and patterns of care for COPD...
  61. ncbi request reprint Scleroderma patients with combined pulmonary hypertension and interstitial lung disease
    Betty Chang
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Rheumatol 30:2398-405. 2003
    ..We studied the demographics, clinical features, and prognosis of individuals with both vascular and interstitial lung disease...
  62. ncbi request reprint Drug distribution for a large crossover trial of the safety of inactivated influenza vaccine in asthmatics
    Janet T Holbrook
    Center for Clinical Trials, Bloomberg School of Hygiene and Public Health, The Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Control Clin Trials 23:87-92. 2002
    ..Utilizing individual syringe kits, using the same identification for patient, kit, and drug assignment, and dispensing drug from a central facility helped to successfully meet these challenges...
  63. ncbi request reprint Efficacy and tolerability of a selective alpha(2C)-adrenergic receptor blocker in recovery from cold-induced vasospasm in scleroderma patients: a single-center, double-blind, placebo-controlled, randomized crossover study
    Robert A Wise
    Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
    Arthritis Rheum 50:3994-4001. 2004
    ..This study observed the effect of OPC-28326 on skin temperature and digital blood flow following an acute cold challenge in patients with Raynaud's phenomenon secondary to scleroderma...
  64. ncbi request reprint Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals
    Rachel Ash-Bernal
    Division of General Internal Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Medicine (Baltimore) 83:265-73. 2004
    ..We hope that a heightened awareness of methemoglobinemia will result in improved recognition and treatment. Primary prevention efforts have the potential to reduce the morbidity and mortality associated with this condition...
  65. ncbi request reprint Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients
    Irina G Luzina
    Research Service, Veterans Affairs Maryland Health Care System, Baltimore VA Medical Center, Room 3C 125, 10 North Greene Street, Baltimore, MD 21201, USA
    Arthritis Rheum 48:2262-74. 2003
    ..In the present study, we sought to determine whether activated CD8+ T cells contribute to pulmonary fibrosis in scleroderma patients through the production and activation of profibrotic mediators...
  66. ncbi request reprint Gene expression in bronchoalveolar lavage cells from scleroderma patients
    Irina G Luzina
    Research Service, Veterans Affairs Maryland Health Care System and Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Respir Cell Mol Biol 26:549-57. 2002
    ....
  67. ncbi request reprint Age and risk of pulmonary arterial hypertension in scleroderma
    Lionel Schachna
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Chest 124:2098-104. 2003
    ..To investigate whether age at disease onset is a risk factor for pulmonary arterial hypertension (PAH) in scleroderma...
  68. ncbi request reprint Oxygen therapy in COPD: what do we know?
    M Bradley Drummond
    Am J Respir Crit Care Med 176:321-2. 2007
  69. ncbi request reprint Randomized comparison of strategies for reducing treatment in mild persistent asthma
    Stephen P Peters
    Wake Forest University, Winston Salem, NC, USA
    N Engl J Med 356:2027-39. 2007
    ....
  70. ncbi request reprint Effect of obesity on clinical presentation and response to treatment in asthma
    Anne E Dixon
    University of Vermont, Burlington, VT 05401, USA
    J Asthma 43:553-8. 2006
    ..Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people...
  71. ncbi request reprint Allergic rhinitis and sinusitis in asthma: differential effects on symptoms and pulmonary function
    Anne E Dixon
    Pulmonary and Critical Care Medicine, University of Vermont, Burlington, 05401, USA
    Chest 130:429-35. 2006
    ..The purpose of this study was to determine the impact of self-reported allergic rhinitis and sinusitis on lower airway disease in a large cohort of participants with well-characterized asthma...
  72. ncbi request reprint Single-breath diffusing capacity of the lung for carbon monoxide: a predictor of PaO2, maximum work rate, and walking distance in patients with emphysema
    Zab Mohsenifar
    Cedars Sinai Medical Center, Division of Pulmonary Critical Care Medicine, Los Angeles, CA 90049, USA
    Chest 123:1394-400. 2003
    ....
  73. ncbi request reprint Changes in smoking status affect women more than men: results of the Lung Health Study
    John E Connett
    Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    Am J Epidemiol 157:973-9. 2003
    ..001). Therefore, among persons at risk for chronic obstructive pulmonary disease, smoking cessation has an even clearer advantage for women than it does for men...
  74. ncbi request reprint The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial
    Nicholas R Anthonisen
    University of Manitoba, Winnipeg, Manitoba, Canada
    Ann Intern Med 142:233-9. 2005
    ..Randomized clinical trials have not yet demonstrated the mortality benefit of smoking cessation...
  75. doi request reprint A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
    ..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy...
  76. doi request reprint Sleep quality in asthma: results of a large prospective clinical trial
    John G Mastronarde
    The Ohio State University, Columbus, Ohio 43201, USA
    J Asthma 45:183-9. 2008
    ..Previous studies have suggested that asthmatics have an increased incidence of sleep disturbances. However, these studies have been limited by reliance on population surveys or small numbers of participants...
  77. ncbi request reprint Survey on quality of training in pulmonary physiology during fellowship
    Steve H Salzman
    Chest 131:1270-1. 2007
  78. ncbi request reprint Feasibility of retinoids for the treatment of emphysema study
    Michael D Roth
    Division of Pulmonary and Critical Care, University of California, Los Angeles, CA 90095 1690, USA
    Chest 130:1334-45. 2006
    ..Retinoids promote alveolar septation in the developing lung and stimulate alveolar repair in some animal models of emphysema...
  79. ncbi request reprint Pharmacokinetics and metabolism of all-trans- and 13-cis-retinoic acid in pulmonary emphysema patients
    Josephia R Muindi
    Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA, USA
    J Clin Pharmacol 48:96-107. 2008
    ..25). The authors conclude that intermittent therapy with high-dose ATRA produced the greatest ATRA exposure, but alternative approaches for limiting self-induced ATRA catabolism should be sought...
  80. ncbi request reprint Loss of bone density with inhaled triamcinolone in Lung Health Study II
    Paul D Scanlon
    Mayo Clinic, Rochester, MN, USA
    Am J Respir Crit Care Med 170:1302-9. 2004
    ..In summary, the use of inhaled triamcinolone acetonide was associated with loss of BMD at the femoral neck and lumbar spine after 3 years of treatment...
  81. pmc Scleroderma lung study (SLS): differences in the presentation and course of patients with limited versus diffuse systemic sclerosis
    Philip J Clements
    Divisions of Rheumatology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Ann Rheum Dis 66:1641-7. 2007
    ..This report examines the differences at baseline and over 12 months between patients with limited versus diffuse cutaneous SSc who participated in the Scleroderma Lung Study...
  82. pmc Ascertainment of cause-specific mortality in COPD: operations of the TORCH Clinical Endpoint Committee
    Lorcan P McGarvey
    The Queen s University of Belfast, Grosvenor Road, Belfast BT12 6BJ, UK
    Thorax 62:411-5. 2007
    ..The primary outcome is all-cause mortality. Cause-specific mortality and deaths related to COPD are additional outcome measures, but systematic methods for ascertainment of these outcomes have not previously been described...
  83. ncbi request reprint Clinical research in chronic obstructive pulmonary disease: needs and opportunities
    Thomas L Croxton
    Division of Lung Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA
    Am J Respir Crit Care Med 167:1142-9. 2003
    ....
  84. ncbi request reprint Lack of long-term adverse adrenal effects from inhaled triamcinolone: Lung Health Study II
    Michael S Eichenhorn
    Henry Ford Hospital, Detroit, MI, USA
    Chest 124:57-62. 2003
    ..One of the potential adverse effects of their use is the development of adrenal suppression. Our study aimed to determine the effects of ICS on adrenal function over 3 years of use in patients with COPD...

Research Grants9

  1. MULTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASES
    Robert Wise; Fiscal Year: 2007
    ..64% of graduates are currently in full-time academic positions, indicative of the program's success. ..
  2. SCLERODERMA LUNG STUDY
    Robert Wise; Fiscal Year: 2003
    ..abstract_text> ..
  3. The Placebo Effect in Asthma
    Robert Wise; Fiscal Year: 2005
    ..Understanding the placebo response can lead to improvements in research and treatment of asthma. ..
  4. Clinical Trial of Acid Reflux Therapy in Asthma
    Robert Wise; Fiscal Year: 2007
    ..Pre-specified subgroup analyses will be conducted to determine if there are clinical or demographic characteristics that predict benefit from treatment of GERD in asthma. ..