Research Topics
Species | Robert WiseSummaryAffiliation: Johns Hopkins University Country: USA Publications
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The Tiotropium Safety and Performance in Respimat® Trial (TIOSPIR®), a large scale, randomized, controlled, parallel-group trial-design and rationaleRobert A Wise
Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD, 21224, USA
Respir Res 14:40. 2013..Comparing across programs tiotropium Respimat® Soft Mist™ inhaler was at least as efficacious as tiotropium HandiHaler®, however, concerns have been raised about tiotropium's safety when given via Respimat®...
Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional studyNicholas D Giardino
Mental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
Respir Res 11:29. 2010..The purpose of this study is to determine whether there is an association between anxiety and functional measures, quality of life and dyspnea...- Cross sectional analysis of respiratory symptoms in an injection drug user cohort: the impact of obstructive lung disease and HIVM Bradley Drummond
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
BMC Pulm Med 10:27. 2010..We characterized the independent and joint effects of HIV and OLD on respiratory symptoms of a cohort of inner-city IDUs... - Randomized trial of the effect of drug presentation on asthma outcomes: the American Lung Association Asthma Clinical Research CentersRobert A Wise
Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Allergy Clin Immunol 124:436-44, 444e1-8. 2009..Although asthma symptoms often improve with placebo, it is not known whether the response to placebo or active treatment can be augmented by increasing expectation of benefit... 
Respiratory physiologic changes in pregnancyRobert A Wise
Department of Medicine Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Immunol Allergy Clin North Am 26:1-12. 2006..Patients who have many lung diseases tolerate pregnancy well, with the exception of those who have pulmonary hypertension or chronic respiratory insufficiency from parenchymal or neuromuscular disease...- Standardization of the single-breath diffusing capacity in a multicenter clinical trialRobert A Wise
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Chest 132:1191-7. 2007..The safety assessment of inhalable insulin required the standardization of measurement of single-breath DLCO in multicenter clinical trials to optimize test precision... - Field tests of exercise in COPD: the six-minute walk test and the shuttle walk testCynthia D Brown
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
COPD 4:217-23. 2007..This article reviews how these tests are performed and to what degree they are reliable, and how these tests are used in assessment of individuals with chronic obstructive pulmonary disease... - The value of forced expiratory volume in 1 second decline in the assessment of chronic obstructive pulmonary disease progressionRobert A Wise
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Med 119:4-11. 2006..Consequently, FEV1 and its change over time are important outcomes in COPD and valuable measures for the assessment of disease progression... - The role of NETT in emphysema researchRobert A Wise
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Proc Am Thorac Soc 5:385-92. 2008..In many ways, the story of NETT serves as a model for evaluation of new surgical approaches to chronic diseases... - Minimal clinically important differences in the six-minute walk test and the incremental shuttle walking testRobert A Wise
Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 4B 72, 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
COPD 2:125-9. 2005.... - Ethical issues confronted in pulmonary clinical trialsRobert A Wise
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Proc Am Thorac Soc 4:200-5; discussion 205. 2007.... - Continuous oxygen use in nonhypoxemic emphysema patients identifies a high-risk subset of patients: retrospective analysis of the National Emphysema Treatment TrialMichael B Drummond
Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Chest 134:497-506. 2008..Little is known regarding the clinical characteristics and survival of nonhypoxemic emphysema patients using continuous oxygen. Analysis of data from the National Emphysema Treatment Trial (NETT) offers insight into this population... - Physical activity, health status and risk of hospitalization in patients with severe chronic obstructive pulmonary diseaseRoberto P Benzo
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Respiration 80:10-8. 2010..Self-reported daily physical activity and health status have been reported as predictors of a hospitalization in COPD but are not routinely assessed... - Physiological and computed tomographic predictors of outcome from lung volume reduction surgeryGeorge R Washko
Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 181:494-500. 2010..We therefore sought to examine radiographic and physiologic predictors of surgical outcomes in a large, multicenter clinical investigation, the National Emphysema Treatment Trial... - Variability of spirometry in chronic obstructive pulmonary disease: results from two clinical trialsLaura B Herpel
The Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Am J Respir Crit Care Med 173:1106-13. 2006..This may be applied to determine criteria that can be used to assess a clinically meaningful change in spirometry... - Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program studyJohn M Brehm
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
J Allergy Clin Immunol 126:52-8.e5. 2010..Vitamin D status might play a role in preventing asthma exacerbations... - Sex differences in severe pulmonary emphysemaFernando J Martinez
University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, Michigan 48109 0360, USA
Am J Respir Crit Care Med 176:243-52. 2007..Limited data on sex differences in advanced COPD are available... - Predicting treatment outcomes and responder subsets in scleroderma-related interstitial lung diseaseMichael D Roth
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
Arthritis Rheum 63:2797-808. 2011..To identify baseline characteristics of patients with scleroderma-related interstitial lung disease (SSc-ILD) that could serve as predictors of the most favorable response to 12-month treatment with oral cyclophosphamide (CYC)... - Integrating health status and survival data: the palliative effect of lung volume reduction surgeryRoberto Benzo
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota 55902, USA
Am J Respir Crit Care Med 180:239-46. 2009..This practice tends to inflate the apparent benefits of interventions with a high risk of mortality. Assessing a composite QoL-death outcome is a potential solution to this problem... - In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthmaRobyn T Cohen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachussetts, USA
J Allergy Clin Immunol 126:491-7. 2010..Few studies have examined the effects of in utero smoke exposure (IUS) on lung function in children with asthma, and there are no published data on the impact of IUS on treatment outcomes in children with asthma... - Perfusion scintigraphy and patient selection for lung volume reduction surgeryDivay Chandra
Division of Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Am J Respir Crit Care Med 182:937-46. 2010..It is unclear if lung perfusion can predict response to lung volume reduction surgery (LVRS)... - Changes in arterial oxygenation and self-reported oxygen use after lung volume reduction surgeryMargaret L Snyder
Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington 98195 6522, USA
Am J Respir Crit Care Med 178:339-45. 2008..Lung volume reduction surgery (LVRS) is inconsistently reported to improve arterial oxygenation in patients with chronic obstructive pulmonary disease... - Exposure to neonatal cigarette smoke causes durable lung changes but does not potentiate cigarette smoke-induced chronic obstructive pulmonary disease in adult miceSharon McGrath-Morrow
Division of Pediatric Pulmonary, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2533, USA
Exp Lung Res 37:354-63. 2011..Additional studies may be warranted to determine the utility of these genes as biomarkers of respiratory outcomes... - Optimizing treatment of chronic obstructive pulmonary disease: an assessment of current therapiesRobert A Wise
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Am J Med 120:S4-13. 2007..A treatment algorithm that combines both pharmacologic and nonpharmacologic interventions for the management of COPD is presented... - Preventing chronic obstructive pulmonary disease: what is known and what needs to be done to make a difference to the patient?Robert A Wise
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Am J Med 120:S14-22. 2007.... - Adult asthma severity in individuals with a history of childhood asthmaSusan L Limb
Division of Allergy and Clinical Immunology, Bloomberg School of Public Health, Johns Hopkinds University, Baltimore, MD, USA
J Allergy Clin Immunol 115:61-6. 2005..Childhood asthma can have a range of outcomes in adulthood... - Eosinophil and T cell markers predict functional decline in COPD patientsJEANINE M D'ARMIENTO
Department of Medicine, Columbia University, New York, NY, USA
Respir Res 10:113. 2009..We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease... - Exercise testing in severe emphysema: association with quality of life and lung functionCynthia D Brown
Division of Pulmonary and Critical Care Medicine, University of Virginia, VA, USA
COPD 5:117-24. 2008..Moreover, the 6MWT may be a better test of functional capacity given its greater association with QOL measures whereas CPX is a better test of physiologic impairment... - Predictors of mortality in patients with emphysema and severe airflow obstructionFernando J Martinez
Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0360, and Section of Thoracic Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA
Am J Respir Crit Care Med 173:1326-34. 2006..Limited data exist describing risk factors for mortality in patients having predominantly emphysema... - Impaired lung homeostasis in neonatal mice exposed to cigarette smokeSharon McGrath-Morrow
Department of Pediatrics, Division of Pediatric Pulmonary, Johns Hopkins Hospital, Park 316 600 N Wolfe St, Baltimore, MD 21287 2533, USA
Am J Respir Cell Mol Biol 38:393-400. 2008..These findings may in part explain the increased incidence of respiratory symptoms in infants and children exposed to CS... - Methodologic issues in terminating enrollment of a subgroup of patients in a multicenter randomized trialShing M Lee
Department of Biostatistics, Columbia University, New York, NY, USA
Clin Trials 1:326-38. 2004..We also describe the repercussions of the publication and the misinterpretations of the results based on media coverage... - HIV and COPD: impact of risk behaviors and diseases on quality of lifeM Bradley Drummond
Department of Medicine, School of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, JHAAC 4B 70, Baltimore, MD 21224, USA
Qual Life Res 19:1295-302. 2010..Smoking worsens quality of life among HIV-infected individuals, but it remains unclear if this association is related simply to smoking or to chronic obstructive pulmonary disease (COPD), the end-organ disease caused by smoking... - Spirometer calibration checks: is 3.5% good enough?Meredith C McCormack
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21205, USA
Chest 131:1486-93. 2007..5% of the inserted volume but do not require evaluation of trends over time. We examined the current guidelines and candidate quality control rules to determine the best method for identifying spirometers with suboptimal performance... - Chronic intermittent hypoxia induces lung growth in adult miceChristian Reinke
Department of Medicine, Div of Pulmonary Medicine, Johns Hopkins University, Baltimore, MD, USA
Am J Physiol Lung Cell Mol Physiol 300:L266-73. 2011..We conclude that IH increases alveolar surface area by stimulating lung growth in adult mice... - Mortality in COPD: causes, risk factors, and preventionCristine E Berry
Johns Hopkins University School of Medicine, Baltimore, MD, USA
COPD 7:375-82. 2010..Smoking cessation improves survival in COPD patients, and in select patients with advanced disease, oxygen therapy, lung volume reduction surgery, or lung transplantation may also improve survival... - Maternal vitamin A supplementation and lung function in offspringWilliam Checkley
Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
N Engl J Med 362:1784-94. 2010.... - Accuracy of death certificates in COPD: analysis from the TORCH trialM Bradley Drummond
Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
COPD 7:179-85. 2010..COPD is under-reported on death certificates, and this under-reporting is more frequent when the primary cause of death is not pulmonary... - Intersession variability in single-breath diffusing capacity in diabetics without overt lung diseaseMichael B Drummond
Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Am J Respir Crit Care Med 178:225-32. 2008..However, little is known about the short-term intersession variability in DL(CO) in untrained subjects or how variability is affected by rigorous external quality control... - The effect of smoking intervention and an inhaled bronchodilator on airways reactivity in COPD: the Lung Health StudyRobert A Wise
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Chest 124:449-58. 2003..The greater the decline in FEV(1), the greater the increase in AR. Smoking cessation had a small additional benefit in AR beyond its favorable effects on FEV(1) changes... - Racial difference in lung function in African-American and White children: effect of anthropometric, socioeconomic, nutritional, and environmental factorsRaida I Harik-Khan
Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA
Am J Epidemiol 160:893-900. 2004..The authors conclude that in healthy children, the major explanatory variable for the racial difference in lung function is body habitus; socioeconomic, nutritional, and environmental confounders play a smaller role... - Paradoxical physical findings described by Kussmaul: pulsus paradoxus and Kussmaul's signKenneth C Bilchick
Johns Hopkins University School of Medicine, Department of Medicine, Baltimore, MD 21287, USA
Lancet 359:1940-2. 2002 - Irreversible lung function deficits in young adults with a history of childhood asthmaSusan L Limb
Division of Allergy and Clinical Immunology, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
J Allergy Clin Immunol 116:1213-9. 2005..Childhood spirometry, duration of asthma, methacholine sensitivity, and birth prematurity might identify such individuals at a young age... - Measurement variability in single-breath diffusing capacity of the lungNaresh M Punjabi
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Chest 123:1082-9. 2003..The objectives of the present study were to examine whether the current reproducibility criteria were met in a general pulmonary function laboratory and to determine whether alternative criteria might be appropriate... - The Madison Avenue effect: how drug presentation style influences adherence and outcome in patients with asthmaEmmanuelle M Clerisme-Beaty
Johns Hopkins University, Baltimore, MD, USA
J Allergy Clin Immunol 127:406-11. 2011..Little is known about how drug presentation influences medication adherence... - Prevalence and risk factors for unrecognized obstructive lung disease among urban drug usersM Bradley Drummond
Department of Medicine, School of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Int J Chron Obstruct Pulmon Dis 6:89-95. 2011..Urban drug users are at higher risk for OLD due to race, behavioral, and socioeconomic characteristics, yet little data exist on prevalence and risk factors associated with unrecognized OLD in this population... - Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in miceMegan Podowski
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Clin Invest 122:229-40. 2012..More importantly, our findings provide a preclinical platform for the development of other TGF-β-targeted therapies for patients with COPD... - Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activityDeepti Malhotra
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Am J Respir Crit Care Med 180:1196-207. 2009..Because accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and ER stress-induced apoptosis, Nrf2 may potentially prevent ER stress-mediated apoptosis in COPD... - Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patientsDeepti Malhotra
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
J Clin Invest 121:4289-302. 2011..These effects of sulforaphane were glutathione dependent. We conclude that NRF2 is a novel drug target for reversing corticosteroid resistance in COPD and other corticosteroid-resistant inflammatory diseases... - Longitudinal change in the BODE index predicts mortality in severe emphysemaFernando J Martinez
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0360, USA
Am J Respir Crit Care Med 178:491-9. 2008..We hypothesized that decrease in a modified BODE (mBODE) would predict survival in National Emphysema Treatment Trial (NETT) patients... - Six-minute walk distance in chronic obstructive pulmonary disease: reproducibility and effect of walking course layout and lengthFrank Sciurba
Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Am J Respir Crit Care Med 167:1522-7. 2003..The training effect found in these patients with severe emphysema is less than in previous reports of patients with chronic obstructive pulmonary disease. Furthermore, the layout of the track may influence the 6-minute walk performance... - Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management programSunita Sharma
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Allergy Clin Immunol 122:921-928.e4. 2008..Among asthmatic subjects, bronchodilator response (BDR) to inhaled beta(2)-adrenergic agonists is variable, and the significance of a consistent response over time is unknown... - Airway obstruction is common but unsuspected in patients admitted to a general medicine serviceDavid Zaas
Longcope Medical Firm, Osler Medical Service, Johns Hopkins Department of Medicine, Baltimore, MD 21205, USA
Chest 125:106-11. 2004..CONCLUSIONS: Airway obstruction is common in hospitalized patients and is usually undiagnosed and untreated. Spirometry may be a useful component of the examination of hospitalized medical patients to identify OLD... - Serum vitamin levels and the risk of asthma in childrenRaida I Harik-Khan
Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
Am J Epidemiol 159:351-7. 2004..65 (p < 0.05), whereas it was 0.74 for alpha-carotene (p = 0.066). The authors concluded that low vitamin C and alpha-carotene intakes are associated with asthma risk in children... - Criteria to screen for chronic sinonasal diseaseAnne E Dixon
Department of Medicine, University of Vermont, Burlington, VT 05401, USA
Chest 136:1324-32. 2009..There are no simple, validated tools to screen for these diseases. The objective of this study was to assess instruments to assist in the diagnosis of chronic sinonasal disease... - Oxygen therapy in chronic obstructive pulmonary diseaseVictor Kim
Division of Pulmonary and Critical Care Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
Proc Am Thorac Soc 5:513-8. 2008..The goals of this article are to briefly describe the indications for chronic oxygen administration, the physiologic effects of treatment, and potential toxicities, as well as its effect on morbidity and mortality... - Natural history of mild-moderate pulmonary hypertension and the risk factors for severe pulmonary hypertension in sclerodermaBetty Chang
Division of Pulmonary and Critical Care Medicine, University of New Mexico, Albuquerque, 87131, USA
J Rheumatol 33:269-74. 2006..To determine risk factors for developing pulmonary hypertension (PH) in patients with scleroderma (SSc, systemic sclerosis)... - Persistence of abnormal bronchoalveolar lavage findings after cyclophosphamide treatment in scleroderma patients with interstitial lung diseaseShikha Mittoo
Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Baltimore, MD 21224, USA
Arthritis Rheum 56:4195-202. 2007.... - Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung diseaseDonald P Tashkin
Department of Medicine, David Geffen School of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1690, USA
Am J Respir Crit Care Med 176:1026-34. 2007..Although treatment-related benefits in pulmonary function, skin scores, and patient-centered outcomes were demonstrated after 1 year of therapy, the duration of benefit beyond 1 year was unclear... - Body mass index and the risk of COPDRaida I Harik-Khan
Longitudinal Study Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Chest 121:370-6. 2002..However, it is not clear whether low body weight is a risk factor for COPD or a consequence of established disease... - Physician and patient perceptions in COPD: the COPD Resource Network Needs Assessment SurveyR Graham Barr
Division of General Medicine, Department of Medicine, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY, USA
Am J Med 118:1415. 2005..National data are lacking on patient and physician perceptions of and patterns of care for COPD... - Scleroderma patients with combined pulmonary hypertension and interstitial lung diseaseBetty Chang
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
J Rheumatol 30:2398-405. 2003..We studied the demographics, clinical features, and prognosis of individuals with both vascular and interstitial lung disease... - Drug distribution for a large crossover trial of the safety of inactivated influenza vaccine in asthmaticsJanet T Holbrook
Center for Clinical Trials, Bloomberg School of Hygiene and Public Health, The Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
Control Clin Trials 23:87-92. 2002..Utilizing individual syringe kits, using the same identification for patient, kit, and drug assignment, and dispensing drug from a central facility helped to successfully meet these challenges... - Efficacy and tolerability of a selective alpha(2C)-adrenergic receptor blocker in recovery from cold-induced vasospasm in scleroderma patients: a single-center, double-blind, placebo-controlled, randomized crossover studyRobert A Wise
Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
Arthritis Rheum 50:3994-4001. 2004.... - Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitalsRachel Ash-Bernal
Division of General Internal Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Medicine (Baltimore) 83:265-73. 2004..We hope that a heightened awareness of methemoglobinemia will result in improved recognition and treatment. Primary prevention efforts have the potential to reduce the morbidity and mortality associated with this condition... - Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patientsIrina G Luzina
Research Service, Veterans Affairs Maryland Health Care System, Baltimore VA Medical Center, Room 3C-125, 10 North Greene Street, Baltimore, MD 21201, USA
Arthritis Rheum 48:2262-74. 2003.... - Gene expression in bronchoalveolar lavage cells from scleroderma patientsIrina G Luzina
Research Service, Veterans Affairs Maryland Health Care System and Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Am J Respir Cell Mol Biol 26:549-57. 2002.... - Age and risk of pulmonary arterial hypertension in sclerodermaLionel Schachna
Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Chest 124:2098-104. 2003..CONCLUSIONS: We identified increasing age at scleroderma onset as a risk factor for PAH. Vigilance among these high-risk patients may provide an opportunity to intervene prior to development of irreversible pulmonary vascular disease... - Oxygen therapy in COPD: what do we know?M Bradley Drummond
Am J Respir Crit Care Med 176:321-2. 2007 - Randomized comparison of strategies for reducing treatment in mild persistent asthmaStephen P Peters
Wake Forest University, Winston Salem, NC, USA
N Engl J Med 356:2027-39. 2007.... - Effect of obesity on clinical presentation and response to treatment in asthmaAnne E Dixon
University of Vermont, Burlington, VT 05401, USA
J Asthma 43:553-8. 2006..Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people... - Allergic rhinitis and sinusitis in asthma: differential effects on symptoms and pulmonary functionAnne E Dixon
Pulmonary and Critical Care Medicine, University of Vermont, Burlington, 05401, USA
Chest 130:429-35. 2006..The purpose of this study was to determine the impact of self-reported allergic rhinitis and sinusitis on lower airway disease in a large cohort of participants with well-characterized asthma... - Single-breath diffusing capacity of the lung for carbon monoxide: a predictor of PaO2, maximum work rate, and walking distance in patients with emphysemaZab Mohsenifar
Cedars Sinai Medical Center, Division of Pulmonary Critical Care Medicine, Los Angeles, CA 90049, USA
Chest 123:1394-400. 2003.... - Changes in smoking status affect women more than men: results of the Lung Health StudyJohn E Connett
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA
Am J Epidemiol 157:973-9. 2003..001). Therefore, among persons at risk for chronic obstructive pulmonary disease, smoking cessation has an even clearer advantage for women than it does for men... - The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trialNicholas R Anthonisen
University of Manitoba, Winnipeg, Manitoba, Canada
Ann Intern Med 142:233-9. 2005..LIMITATIONS: Results apply only to individuals with airway obstruction. CONCLUSION: Smoking cessation intervention programs can have a substantial effect on subsequent mortality, even when successful in a minority of participants... - A 4-year trial of tiotropium in chronic obstructive pulmonary diseaseDonald P Tashkin
David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
N Engl J Med 359:1543-54. 2008..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy... - Sleep quality in asthma: results of a large prospective clinical trialJohn G Mastronarde
The Ohio State University, Columbus, Ohio 43201, USA
J Asthma 45:183-9. 2008..Previous studies have suggested that asthmatics have an increased incidence of sleep disturbances. However, these studies have been limited by reliance on population surveys or small numbers of participants... - Survey on quality of training in pulmonary physiology during fellowshipSteve H Salzman
Chest 131:1270-1. 2007 - Feasibility of retinoids for the treatment of emphysema studyMichael D Roth
Division of Pulmonary and Critical Care, University of California, Los Angeles, CA 90095 1690, USA
Chest 130:1334-45. 2006..Retinoids promote alveolar septation in the developing lung and stimulate alveolar repair in some animal models of emphysema... - Pharmacokinetics and metabolism of all-trans- and 13-cis-retinoic acid in pulmonary emphysema patientsJosephia R Muindi
Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA, USA
J Clin Pharmacol 48:96-107. 2008..25). The authors conclude that intermittent therapy with high-dose ATRA produced the greatest ATRA exposure, but alternative approaches for limiting self-induced ATRA catabolism should be sought... - Loss of bone density with inhaled triamcinolone in Lung Health Study IIPaul D Scanlon
Mayo Clinic, Rochester, MN, USA
Am J Respir Crit Care Med 170:1302-9. 2004..In summary, the use of inhaled triamcinolone acetonide was associated with loss of BMD at the femoral neck and lumbar spine after 3 years of treatment... - Scleroderma lung study (SLS): differences in the presentation and course of patients with limited versus diffuse systemic sclerosisPhilip J Clements
Divisions of Rheumatology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Ann Rheum Dis 66:1641-7. 2007..This report examines the differences at baseline and over 12 months between patients with limited versus diffuse cutaneous SSc who participated in the Scleroderma Lung Study... - Ascertainment of cause-specific mortality in COPD: operations of the TORCH Clinical Endpoint CommitteeLorcan P McGarvey
The Queen s University of Belfast, Grosvenor Road, Belfast BT12 6BJ, UK
Thorax 62:411-5. 2007..The primary outcome is all-cause mortality. Cause-specific mortality and deaths related to COPD are additional outcome measures, but systematic methods for ascertainment of these outcomes have not previously been described... - Clinical research in chronic obstructive pulmonary disease: needs and opportunitiesThomas L Croxton
Division of Lung Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA
Am J Respir Crit Care Med 167:1142-9. 2003.... - Lack of long-term adverse adrenal effects from inhaled triamcinolone: Lung Health Study IIMichael S Eichenhorn
Henry Ford Hospital, Detroit, MI, USA
Chest 124:57-62. 2003..CONCLUSION: Use of inhaled triamcinolone, 1,200 microg/d, over 3 years does not suppress baseline adrenal function or diminish adrenal responsiveness to cosyntropin stimulation...
Research Grants
- MULTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASESRobert Wise; Fiscal Year: 2007..64% of graduates are currently in full-time academic positions, indicative of the program's success. ..
- SCLERODERMA LUNG STUDYRobert Wise; Fiscal Year: 2003..abstract_text> ..
- The Placebo Effect in AsthmaRobert Wise; Fiscal Year: 2005..Understanding the placebo response can lead to improvements in research and treatment of asthma. ..
- Clinical Trial of Acid Reflux Therapy in AsthmaRobert Wise; Fiscal Year: 2007..Pre-specified subgroup analyses will be conducted to determine if there are clinical or demographic characteristics that predict benefit from treatment of GERD in asthma. ..