Robert A Wise

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint The value of forced expiratory volume in 1 second decline in the assessment of chronic obstructive pulmonary disease progression
    Robert A Wise
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med 119:4-11. 2006
  2. ncbi request reprint Changing smoking patterns and mortality from chronic obstructive pulmonary disease
    R A Wise
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21212, USA
    Prev Med 26:418-21. 1997
  3. ncbi request reprint Preventing chronic obstructive pulmonary disease: what is known and what needs to be done to make a difference to the patient?
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Med 120:S14-22. 2007
  4. ncbi request reprint Optimizing treatment of chronic obstructive pulmonary disease: an assessment of current therapies
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Med 120:S4-13. 2007
  5. doi request reprint Effect of urbanisation on asthma, allergy and airways inflammation in a developing country setting
    Colin L Robinson
    Division of Pulmonary and Critical Care, Johns Hopkins University, 1830 Monument Street, Fifth Floor, Baltimore, MD 21205, USA
    Thorax 66:1051-7. 2011
  6. doi request reprint Continuous oxygen use in nonhypoxemic emphysema patients identifies a high-risk subset of patients: retrospective analysis of the National Emphysema Treatment Trial
    Michael B Drummond
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Chest 134:497-506. 2008
  7. doi request reprint Spirometric predictors of lung function decline and mortality in early chronic obstructive pulmonary disease
    M Bradley Drummond
    Division of Pulmonary Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 185:1301-6. 2012
  8. doi request reprint The effect of HIV infection on longitudinal lung function decline among IDUs: a prospective cohort
    MICHAEL BRADLEY DRUMMOND
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    AIDS 27:1303-11. 2013
  9. pmc Prevalence and risk factors for unrecognized obstructive lung disease among urban drug users
    M Bradley Drummond
    Department of Medicine, School of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Int J Chron Obstruct Pulmon Dis 6:89-95. 2011
  10. doi request reprint Tiotropium Respimat inhaler and the risk of death in COPD
    Robert A Wise
    Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    N Engl J Med 369:1491-501. 2013

Detail Information

Publications80

  1. ncbi request reprint The value of forced expiratory volume in 1 second decline in the assessment of chronic obstructive pulmonary disease progression
    Robert A Wise
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med 119:4-11. 2006
    ..Consequently, FEV1 and its change over time are important outcomes in COPD and valuable measures for the assessment of disease progression...
  2. ncbi request reprint Changing smoking patterns and mortality from chronic obstructive pulmonary disease
    R A Wise
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21212, USA
    Prev Med 26:418-21. 1997
    ..Recent studies indicate that early identification of individuals with airflow obstruction and smoking intervention can halt the progression of COPD, but widespread screening and intervention programs have not yet been established...
  3. ncbi request reprint Preventing chronic obstructive pulmonary disease: what is known and what needs to be done to make a difference to the patient?
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Med 120:S14-22. 2007
    ....
  4. ncbi request reprint Optimizing treatment of chronic obstructive pulmonary disease: an assessment of current therapies
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Med 120:S4-13. 2007
    ..A treatment algorithm that combines both pharmacologic and nonpharmacologic interventions for the management of COPD is presented...
  5. doi request reprint Effect of urbanisation on asthma, allergy and airways inflammation in a developing country setting
    Colin L Robinson
    Division of Pulmonary and Critical Care, Johns Hopkins University, 1830 Monument Street, Fifth Floor, Baltimore, MD 21205, USA
    Thorax 66:1051-7. 2011
    ..However, few studies have studied the role of urbanisation in this phenomenon. It was hypothesised that children living in a peri-urban setting in Peru have higher rates of asthma and allergy than rural counterparts...
  6. doi request reprint Continuous oxygen use in nonhypoxemic emphysema patients identifies a high-risk subset of patients: retrospective analysis of the National Emphysema Treatment Trial
    Michael B Drummond
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Chest 134:497-506. 2008
    ..Little is known regarding the clinical characteristics and survival of nonhypoxemic emphysema patients using continuous oxygen. Analysis of data from the National Emphysema Treatment Trial (NETT) offers insight into this population...
  7. doi request reprint Spirometric predictors of lung function decline and mortality in early chronic obstructive pulmonary disease
    M Bradley Drummond
    Division of Pulmonary Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 185:1301-6. 2012
    ..The course of lung function decline for smokers with early airflow obstruction remains undefined. It is also unclear which early spirometric characteristics identify individuals at risk for rapid decline and increased mortality...
  8. doi request reprint The effect of HIV infection on longitudinal lung function decline among IDUs: a prospective cohort
    MICHAEL BRADLEY DRUMMOND
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    AIDS 27:1303-11. 2013
    ..We sought to determine the independent association of HIV infection on lung function decline...
  9. pmc Prevalence and risk factors for unrecognized obstructive lung disease among urban drug users
    M Bradley Drummond
    Department of Medicine, School of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Int J Chron Obstruct Pulmon Dis 6:89-95. 2011
    ..Urban drug users are at higher risk for OLD due to race, behavioral, and socioeconomic characteristics, yet little data exist on prevalence and risk factors associated with unrecognized OLD in this population...
  10. doi request reprint Tiotropium Respimat inhaler and the risk of death in COPD
    Robert A Wise
    Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    N Engl J Med 369:1491-501. 2013
    ..Although tiotropium HandiHaler was associated with reduced mortality, as compared with placebo, more deaths were reported with tiotropium Respimat than with placebo...
  11. doi request reprint Association between obstructive lung disease and markers of HIV infection in a high-risk cohort
    M Bradley Drummond
    Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, JHAAC 4B 70, Baltimore, MD 21224, USA
    Thorax 67:309-14. 2012
    ..A study was undertaken to determine the independent associations of HIV infection, CD4 cell count and plasma HIV viral load with the presence of OLD in an urban cohort...
  12. pmc Variability of spirometry in chronic obstructive pulmonary disease: results from two clinical trials
    Laura B Herpel
    The Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 173:1106-13. 2006
    ..This may be applied to determine criteria that can be used to assess a clinically meaningful change in spirometry...
  13. pmc Intersession variability in single-breath diffusing capacity in diabetics without overt lung disease
    Michael B Drummond
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 178:225-32. 2008
    ..However, little is known about the short-term intersession variability in DL(CO) in untrained subjects or how variability is affected by rigorous external quality control...
  14. ncbi request reprint Racial difference in lung function in African-American and White children: effect of anthropometric, socioeconomic, nutritional, and environmental factors
    Raida I Harik-Khan
    Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA
    Am J Epidemiol 160:893-900. 2004
    ..The authors conclude that in healthy children, the major explanatory variable for the racial difference in lung function is body habitus; socioeconomic, nutritional, and environmental confounders play a smaller role...
  15. pmc Relationship between lung function impairment and health-related quality of life in COPD and interstitial lung disease
    Cristine E Berry
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Chest 142:704-11. 2012
    ..However, different pathophysiologic mechanisms may influence how these distinct diseases affect HRQL, resulting in differing HRQL by pulmonary diagnosis among patients with similar severity of ventilatory impairment...
  16. pmc Changes in arterial oxygenation and self-reported oxygen use after lung volume reduction surgery
    Margaret L Snyder
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington 98195 6522, USA
    Am J Respir Crit Care Med 178:339-45. 2008
    ..Lung volume reduction surgery (LVRS) is inconsistently reported to improve arterial oxygenation in patients with chronic obstructive pulmonary disease...
  17. doi request reprint Long-term intersession variability for single-breath diffusing capacity
    Matthew J Hegewald
    Division of Pulmonary and Critical Care Medicine, University of Utah School of Medicine and Intermountain Medical Center, Salt Lake City Murray, Utah, USA
    Respiration 84:377-84. 2012
    ..Characterizing long-term diffusing capacity (DL(CO)) variability is important in assessing quality control for DL(CO) equipment and patient management. Long-term DL(CO) variability has not been reported...
  18. doi request reprint Methacholine challenge test: diagnostic characteristics in asthmatic patients receiving controller medications
    Kaharu Sumino
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Allergy Clin Immunol 130:69-75.e6. 2012
    ....
  19. pmc Cross sectional analysis of respiratory symptoms in an injection drug user cohort: the impact of obstructive lung disease and HIV
    M Bradley Drummond
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    BMC Pulm Med 10:27. 2010
    ..We characterized the independent and joint effects of HIV and OLD on respiratory symptoms of a cohort of inner-city IDUs...
  20. doi request reprint Risk factors for montelukast treatment failure in step-down therapy for controlled asthma
    M Bradley Drummond
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Asthma 48:1051-7. 2011
    ..Because some patients fail montelukast step-down therapy, it would be helpful for clinicians to be able to predict the risk of treatment failure...
  21. ncbi request reprint Irreversible lung function deficits in young adults with a history of childhood asthma
    Susan L Limb
    Division of Allergy and Clinical Immunology, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 116:1213-9. 2005
    ..Asthma, traditionally characterized as reversible airway obstruction, might lead to structural changes and permanent impairment...
  22. doi request reprint Exercise testing in severe emphysema: association with quality of life and lung function
    Cynthia D Brown
    Division of Pulmonary and Critical Care Medicine, University of Virginia, VA, USA
    COPD 5:117-24. 2008
    ..Moreover, the 6MWT may be a better test of functional capacity given its greater association with QOL measures whereas CPX is a better test of physiologic impairment...
  23. ncbi request reprint Natural history of mild-moderate pulmonary hypertension and the risk factors for severe pulmonary hypertension in scleroderma
    Betty Chang
    Division of Pulmonary and Critical Care Medicine, University of New Mexico, Albuquerque, 87131, USA
    J Rheumatol 33:269-74. 2006
    ..To determine risk factors for developing pulmonary hypertension (PH) in patients with scleroderma (SSc, systemic sclerosis)...
  24. doi request reprint Racial differences in CT phenotypes in COPD
    Nadia N Hansel
    Johns Hopkins University, Baltimore, Maryland, USA
    COPD 10:20-7. 2013
    ..The objective is to determine racial differences in the extent of emphysema and airway remodeling in COPD...
  25. doi request reprint Effect of urbanisation on the relationship between total serum IgE and asthma
    William Checkley
    Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Eur Respir J 41:1074-81. 2013
    ..0 (95% CI 0.7-1.4) per log unit increase in total serum IgE, respectively. Total serum IgE was associated with atopic asthma but not with non-atopic asthma. Urbanisation did not appear to be an effect modifier of this relationship...
  26. pmc Asthma symptom utility index: reliability, validity, responsiveness, and the minimal important difference in adult asthmatic patients
    CHRISTIAN BIME
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 130:1078-84. 2012
    ..The psychometric properties of the ASUI are not well characterized, and a minimal important difference (MID) is not established...
  27. ncbi request reprint Scleroderma patients with combined pulmonary hypertension and interstitial lung disease
    Betty Chang
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Rheumatol 30:2398-405. 2003
    ..We studied the demographics, clinical features, and prognosis of individuals with both vascular and interstitial lung disease...
  28. pmc The Madison Avenue effect: how drug presentation style influences adherence and outcome in patients with asthma
    Emmanuelle M Clerisme-Beaty
    Johns Hopkins University, Baltimore, MD, USA
    J Allergy Clin Immunol 127:406-11. 2011
    ..Little is known about how drug presentation influences medication adherence...
  29. doi request reprint HIV and COPD: impact of risk behaviors and diseases on quality of life
    M Bradley Drummond
    Department of Medicine, School of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, JHAAC 4B 70, Baltimore, MD 21224, USA
    Qual Life Res 19:1295-302. 2010
    ..Smoking worsens quality of life among HIV-infected individuals, but it remains unclear if this association is related simply to smoking or to chronic obstructive pulmonary disease (COPD), the end-organ disease caused by smoking...
  30. pmc Optimizing the 6-min walk test as a measure of exercise capacity in COPD
    Divay Chandra
    Emphysema Research Center, Division of Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Chest 142:1545-52. 2012
    ..It is uncertain whether the effort and expense of performing a second walk for the 6-min walk test improves test performance. Hence, we attempted to quantify the improvement in 6-min walk distance if an additional walk were to be performed...
  31. pmc The Peru Urban versus Rural Asthma (PURA) Study: methods and baseline quality control data from a cross-sectional investigation into the prevalence, severity, genetics, immunology and environmental factors affecting asthma in adolescence in Peru
    Colin L Robinson
    Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    BMJ Open 2:e000421. 2012
    ..The authors sought to characterise the epidemiology of asthma in Peru in two regions with disparate degrees of urbanisation. In this manuscript, the authors summarise the study design and implementation...
  32. doi request reprint Accuracy of death certificates in COPD: analysis from the TORCH trial
    M Bradley Drummond
    Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    COPD 7:179-85. 2010
    ..COPD is under-reported on death certificates, and this under-reporting is more frequent when the primary cause of death is not pulmonary...
  33. pmc Association of dietary soy genistein intake with lung function and asthma control: a post-hoc analysis of patients enrolled in a prospective multicentre clinical trial
    CHRISTIAN BIME
    Johns Hopkins University School of Medicine Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224 6801, USA
    Prim Care Respir J 21:398-404. 2012
    ..A positive association was previously reported between soy genistein intake and lung function but not with asthma exacerbations...
  34. pmc Forced expiratory capnography and chronic obstructive pulmonary disease (COPD)
    Robert H Brown
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Breath Res 7:017108. 2013
    ..Forced exhalation capnography would be of great clinical benefit if it can identify early disease changes and at-risk individuals...
  35. doi request reprint Interpretation of pulmonary function test: issues and controversies
    Cristine E Berry
    Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Clin Rev Allergy Immunol 37:173-80. 2009
    ....
  36. pmc Randomized trial of the effect of drug presentation on asthma outcomes: the American Lung Association Asthma Clinical Research Centers
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 124:436-44, 444e1-8. 2009
    ..Although asthma symptoms often improve with placebo, it is not known whether the response to placebo or active treatment can be augmented by increasing expectation of benefit...
  37. doi request reprint Chronic exposure to biomass fuel is associated with increased carotid artery intima-media thickness and a higher prevalence of atherosclerotic plaque
    Matthew S Painschab
    School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Heart 99:984-91. 2013
    ....
  38. pmc Changes in estimated right ventricular systolic pressure predict mortality and pulmonary hypertension in a cohort of scleroderma patients
    Ami A Shah
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Ann Rheum Dis 72:1136-40. 2013
    ..We evaluated whether change in right ventricular systolic pressure (RVSP) was a risk factor for mortality and development of pulmonary arterial hypertension (PAH) in a cohort of scleroderma patients...
  39. ncbi request reprint Ethical issues confronted in pulmonary clinical trials
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Proc Am Thorac Soc 4:200-5; discussion 205. 2007
    ....
  40. ncbi request reprint The effect of smoking intervention and an inhaled bronchodilator on airways reactivity in COPD: the Lung Health Study
    Robert A Wise
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Chest 124:449-58. 2003
    ..This report evaluates the effects of these interventions, demographic characteristics, smoking status, and FEV(1) changes on airway responsiveness (AR)...
  41. pmc Oxygen therapy in chronic obstructive pulmonary disease
    Victor Kim
    Division of Pulmonary and Critical Care Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Proc Am Thorac Soc 5:513-8. 2008
    ..The goals of this article are to briefly describe the indications for chronic oxygen administration, the physiologic effects of treatment, and potential toxicities, as well as its effect on morbidity and mortality...
  42. doi request reprint Measures of asthma control
    CHRISTIAN BIME
    Johns Hopkins University School of Medicine and Johns Hopkins University Bloomberg School of Public Health, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Curr Opin Pulm Med 18:48-56. 2012
    ..This review is a comprehensive description of the tools currently available for a methodical assessment of different aspects of asthma control in clinical practice and research...
  43. pmc The role of NETT in emphysema research
    Robert A Wise
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Proc Am Thorac Soc 5:385-92. 2008
    ..In many ways, the story of NETT serves as a model for evaluation of new surgical approaches to chronic diseases...
  44. doi request reprint Maternal vitamin A supplementation and lung function in offspring
    William Checkley
    Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    N Engl J Med 362:1784-94. 2010
    ....
  45. ncbi request reprint Serum vitamin levels and the risk of asthma in children
    Raida I Harik-Khan
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Am J Epidemiol 159:351-7. 2004
    ..65 (p < 0.05), whereas it was 0.74 for alpha-carotene (p = 0.066). The authors concluded that low vitamin C and alpha-carotene intakes are associated with asthma risk in children...
  46. ncbi request reprint Field tests of exercise in COPD: the six-minute walk test and the shuttle walk test
    Cynthia D Brown
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    COPD 4:217-23. 2007
    ..This article reviews how these tests are performed and to what degree they are reliable, and how these tests are used in assessment of individuals with chronic obstructive pulmonary disease...
  47. pmc Validation and psychometric properties of the Asthma Control Questionnaire among children
    Jessica M Nguyen
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
    J Allergy Clin Immunol 133:91-97.e6. 2014
    ..The Asthma Control Questionnaire (ACQ) is a patient-centered tool for evaluating asthma control. It has been validated in adults, but not well-validated among children...
  48. ncbi request reprint Efficacy and tolerability of a selective alpha(2C)-adrenergic receptor blocker in recovery from cold-induced vasospasm in scleroderma patients: a single-center, double-blind, placebo-controlled, randomized crossover study
    Robert A Wise
    Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
    Arthritis Rheum 50:3994-4001. 2004
    ..This study observed the effect of OPC-28326 on skin temperature and digital blood flow following an acute cold challenge in patients with Raynaud's phenomenon secondary to scleroderma...
  49. ncbi request reprint Measurement variability in single-breath diffusing capacity of the lung
    Naresh M Punjabi
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Chest 123:1082-9. 2003
    ..The objectives of the present study were to examine whether the current reproducibility criteria were met in a general pulmonary function laboratory and to determine whether alternative criteria might be appropriate...
  50. ncbi request reprint Adult asthma severity in individuals with a history of childhood asthma
    Susan L Limb
    Division of Allergy and Clinical Immunology, Bloomberg School of Public Health, Johns Hopkinds University, Baltimore, MD, USA
    J Allergy Clin Immunol 115:61-6. 2005
    ..Childhood asthma can have a range of outcomes in adulthood...
  51. ncbi request reprint Minimal clinically important differences in the six-minute walk test and the incremental shuttle walking test
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 4B 72, 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
    COPD 2:125-9. 2005
    ....
  52. ncbi request reprint Standardization of the single-breath diffusing capacity in a multicenter clinical trial
    Robert A Wise
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Chest 132:1191-7. 2007
    ..The safety assessment of inhalable insulin required the standardization of measurement of single-breath DLCO in multicenter clinical trials to optimize test precision...
  53. pmc The Tiotropium Safety and Performance in Respimat Trial (TIOSPIR), a large scale, randomized, controlled, parallel-group trial-design and rationale
    Robert A Wise
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Respir Res 14:40. 2013
    ..Comparing across programs tiotropium Respimat Soft Mist inhaler was at least as efficacious as tiotropium HandiHaler, however, concerns have been raised about tiotropium's safety when given via Respimat...
  54. doi request reprint A multi-centre, blinded, randomised, placebo-controlled, laboratory-based study of MQX-503, a novel topical gel formulation of nitroglycerine, in patients with Raynaud phenomenon
    Laura K Hummers
    Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ann Rheum Dis 72:1962-7. 2013
    ..MQX-503 is a novel nitroglycerine preparation designed to absorb quickly and allow local vasodilatation in the skin. We examined the efficacy and tolerability of this medication in Raynaud phenomenon (RP) in a laboratory-based study...
  55. pmc Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD
    Nadia N Hansel
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Hum Genet 132:79-90. 2013
    ..Genes within these regions were expressed in relevant lung cells and their expression related to airflow limitation suggesting they may represent novel candidate genes for COPD susceptibility...
  56. pmc Effects of distance from a heavily transited avenue on asthma and atopy in a periurban shantytown in Lima, Peru
    Lauren M Baumann
    Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD 21205, USA
    J Allergy Clin Immunol 127:875-82. 2011
    ....
  57. doi request reprint Elevated HDL cholesterol levels are associated with osteoporosis in lung transplant candidates with chronic obstructive pulmonary disease
    Robert M Reed
    Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, USA
    Respir Med 104:1943-50. 2010
    ..Increased high density lipoprotein cholesterol (HDLc) has been observed in COPD and linked with osteoporosis in the general population. This association has not been previously examined in COPD...
  58. doi request reprint Mortality in COPD: causes, risk factors, and prevention
    Cristine E Berry
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    COPD 7:375-82. 2010
    ..Smoking cessation improves survival in COPD patients, and in select patients with advanced disease, oxygen therapy, lung volume reduction surgery, or lung transplantation may also improve survival...
  59. pmc Chronic intermittent hypoxia induces lung growth in adult mice
    Christian Reinke
    Department of Medicine, Div of Pulmonary Medicine, Johns Hopkins University, Baltimore, MD, USA
    Am J Physiol Lung Cell Mol Physiol 300:L266-73. 2011
    ..We conclude that IH increases alveolar surface area by stimulating lung growth in adult mice...
  60. pmc The minimal important difference in the 6-minute walk test for patients with pulmonary arterial hypertension
    Stephen C Mathai
    Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, 1830 E Monument Street, Room 516, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 186:428-33. 2012
    ....
  61. ncbi request reprint Body mass index and the risk of COPD
    Raida I Harik-Khan
    Longitudinal Study Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Chest 121:370-6. 2002
    ..However, it is not clear whether low body weight is a risk factor for COPD or a consequence of established disease...
  62. ncbi request reprint Spirometer calibration checks: is 3.5% good enough?
    Meredith C McCormack
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21205, USA
    Chest 131:1486-93. 2007
    ..5% of the inserted volume but do not require evaluation of trends over time. We examined the current guidelines and candidate quality control rules to determine the best method for identifying spirometers with suboptimal performance...
  63. ncbi request reprint Six-minute walk distance in chronic obstructive pulmonary disease: reproducibility and effect of walking course layout and length
    Frank Sciurba
    Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 167:1522-7. 2003
    ..The training effect found in these patients with severe emphysema is less than in previous reports of patients with chronic obstructive pulmonary disease. Furthermore, the layout of the track may influence the 6-minute walk performance...
  64. ncbi request reprint Age and risk of pulmonary arterial hypertension in scleroderma
    Lionel Schachna
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Chest 124:2098-104. 2003
    ..To investigate whether age at disease onset is a risk factor for pulmonary arterial hypertension (PAH) in scleroderma...
  65. ncbi request reprint Changes in smoking status affect women more than men: results of the Lung Health Study
    John E Connett
    Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    Am J Epidemiol 157:973-9. 2003
    ..001). Therefore, among persons at risk for chronic obstructive pulmonary disease, smoking cessation has an even clearer advantage for women than it does for men...
  66. doi request reprint A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
    ..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy...
  67. ncbi request reprint The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial
    Nicholas R Anthonisen
    University of Manitoba, Winnipeg, Manitoba, Canada
    Ann Intern Med 142:233-9. 2005
    ..Randomized clinical trials have not yet demonstrated the mortality benefit of smoking cessation...
  68. ncbi request reprint Physician and patient perceptions in COPD: the COPD Resource Network Needs Assessment Survey
    R Graham Barr
    Division of General Medicine, Department of Medicine, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Med 118:1415. 2005
    ..National data are lacking on patient and physician perceptions of and patterns of care for COPD...
  69. doi request reprint Sleep quality in asthma: results of a large prospective clinical trial
    John G Mastronarde
    The Ohio State University, Columbus, Ohio 43201, USA
    J Asthma 45:183-9. 2008
    ..Previous studies have suggested that asthmatics have an increased incidence of sleep disturbances. However, these studies have been limited by reliance on population surveys or small numbers of participants...
  70. ncbi request reprint Single-breath diffusing capacity of the lung for carbon monoxide: a predictor of PaO2, maximum work rate, and walking distance in patients with emphysema
    Zab Mohsenifar
    Cedars Sinai Medical Center, Division of Pulmonary Critical Care Medicine, Los Angeles, CA 90049, USA
    Chest 123:1394-400. 2003
    ....
  71. ncbi request reprint Effect of obesity on clinical presentation and response to treatment in asthma
    Anne E Dixon
    University of Vermont, Burlington, VT 05401, USA
    J Asthma 43:553-8. 2006
    ..Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people...
  72. ncbi request reprint Feasibility of retinoids for the treatment of emphysema study
    Michael D Roth
    Division of Pulmonary and Critical Care, University of California, Los Angeles, CA 90095 1690, USA
    Chest 130:1334-45. 2006
    ..Retinoids promote alveolar septation in the developing lung and stimulate alveolar repair in some animal models of emphysema...
  73. pmc Ascertainment of cause-specific mortality in COPD: operations of the TORCH Clinical Endpoint Committee
    Lorcan P McGarvey
    The Queen s University of Belfast, Grosvenor Road, Belfast BT12 6BJ, UK
    Thorax 62:411-5. 2007
    ..The primary outcome is all-cause mortality. Cause-specific mortality and deaths related to COPD are additional outcome measures, but systematic methods for ascertainment of these outcomes have not previously been described...
  74. ncbi request reprint Randomized comparison of strategies for reducing treatment in mild persistent asthma
    Stephen P Peters
    Wake Forest University, Winston Salem, NC, USA
    N Engl J Med 356:2027-39. 2007
    ....
  75. ncbi request reprint Allergic rhinitis and sinusitis in asthma: differential effects on symptoms and pulmonary function
    Anne E Dixon
    Pulmonary and Critical Care Medicine, University of Vermont, Burlington, 05401, USA
    Chest 130:429-35. 2006
    ..The purpose of this study was to determine the impact of self-reported allergic rhinitis and sinusitis on lower airway disease in a large cohort of participants with well-characterized asthma...
  76. pmc Scleroderma lung study (SLS): differences in the presentation and course of patients with limited versus diffuse systemic sclerosis
    Philip J Clements
    Divisions of Rheumatology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Ann Rheum Dis 66:1641-7. 2007
    ..This report examines the differences at baseline and over 12 months between patients with limited versus diffuse cutaneous SSc who participated in the Scleroderma Lung Study...
  77. ncbi request reprint Clinical research in chronic obstructive pulmonary disease: needs and opportunities
    Thomas L Croxton
    Division of Lung Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA
    Am J Respir Crit Care Med 167:1142-9. 2003
    ....
  78. ncbi request reprint Loss of bone density with inhaled triamcinolone in Lung Health Study II
    Paul D Scanlon
    Mayo Clinic, Rochester, MN, USA
    Am J Respir Crit Care Med 170:1302-9. 2004
    ..In summary, the use of inhaled triamcinolone acetonide was associated with loss of BMD at the femoral neck and lumbar spine after 3 years of treatment...
  79. ncbi request reprint Lack of long-term adverse adrenal effects from inhaled triamcinolone: Lung Health Study II
    Michael S Eichenhorn
    Henry Ford Hospital, Detroit, MI, USA
    Chest 124:57-62. 2003
    ..One of the potential adverse effects of their use is the development of adrenal suppression. Our study aimed to determine the effects of ICS on adrenal function over 3 years of use in patients with COPD...
  80. ncbi request reprint Oxygen therapy in COPD: what do we know?
    M Bradley Drummond
    Am J Respir Crit Care Med 176:321-2. 2007