Raimond Winslow

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc A framework for the study of multiple realizations: the importance of levels of analysis
    Morten Overgaard
    CNRU, Department of Psychology and Communication, Aalborg University Aalborg, Denmark
    Front Physiol 2:79. 2011
  2. pmc Computational medicine: translating models to clinical care
    Raimond L Winslow
    The Institute for Computational Medicine, Center for Cardiovascular Bioinformatics and Modeling, and Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA
    Sci Transl Med 4:158rv11. 2012
  3. pmc Merging microarray data from separate breast cancer studies provides a robust prognostic test
    Lei Xu
    The Institute for Computational Medicine and Center for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Bioinformatics 9:125. 2008
  4. pmc Large-scale integration of cancer microarray data identifies a robust common cancer signature
    Lei Xu
    The Institute for Computational Medicine and Center for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Bioinformatics 8:275. 2007
  5. pmc Cardiac myocytes and local signaling in nano-domains
    Raimond L Winslow
    The Institute for Computational Medicine and Department of Biomedical Engineering, The Johns Hopkins University, School of Medicine and Whiting School of Engineering, Baltimore, MD 21218, USA
    Prog Biophys Mol Biol 107:48-59. 2011
  6. pmc Integrative modeling of the cardiac ventricular myocyte
    Raimond L Winslow
    Institute of Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
    Wiley Interdiscip Rev Syst Biol Med 3:392-413. 2011
  7. ncbi request reprint Multiscale modeling of calcium signaling in the cardiac dyad
    Raimond L Winslow
    Institute for Computational Medicine and Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, MD 21218, USA
    Ann N Y Acad Sci 1080:362-75. 2006
  8. pmc An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release
    Joseph L Greenstein
    Department of Biomedical Engineering, Center for Computational Medicine and Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biophys J 83:2918-45. 2002
  9. pmc CaMKII-induced shift in modal gating explains L-type Ca(2+) current facilitation: a modeling study
    Yasmin L Hashambhoy
    Institute for Computational Medicine, Center for Cardiovascular Bioinformatics and Modeling, and the Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, Maryland, USA
    Biophys J 96:1770-85. 2009
  10. pmc Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts
    Antonis A Armoundas
    The Johns Hopkins University, School of Medicine, Institute of Molecular Cardiobiology, 844 Ross Bldg, 720 Rutland Ave, Baltimore, Md 21205 219, USA
    Circ Res 93:46-53. 2003

Research Grants

  1. Anatomical Remodeling and Electrical Conduction in Heart
    Raimond Winslow; Fiscal Year: 2005
  2. Calcium Cycling and Regulation of the Cardiac AP
    Raimond Winslow; Fiscal Year: 2005
  3. Anatomical Remodeling and Electrical Conduction in Heart
    Raimond Winslow; Fiscal Year: 2004
  4. Anatomical Remodeling and Electrical Conduction in Heart
    Raimond Winslow; Fiscal Year: 2003
  5. EXPERIMENTAL STUDY OF ARRHYTHMIAS IN HEART FAILURE
    Raimond Winslow; Fiscal Year: 1999
  6. EXPERIMENTAL STUDY OF ARRHYTHMIAS IN HEART FAILURE
    Raimond Winslow; Fiscal Year: 2000
  7. Calcium Cycling and Regulation of the Cardiac AP
    Raimond Winslow; Fiscal Year: 2002
  8. The Systems Biology of Sudden Cardiac Death
    Raimond Winslow; Fiscal Year: 2007
  9. Short Course on Integrative Modeling of the Cardiac Myocyte
    Raimond Winslow; Fiscal Year: 2007
  10. The CardioVascular Research Grid
    Raimond Winslow; Fiscal Year: 2007

Collaborators

Detail Information

Publications45

  1. pmc A framework for the study of multiple realizations: the importance of levels of analysis
    Morten Overgaard
    CNRU, Department of Psychology and Communication, Aalborg University Aalborg, Denmark
    Front Physiol 2:79. 2011
    ..We propose a (somewhat preliminary) system of levels of analysis, which can be applied to such studies...
  2. pmc Computational medicine: translating models to clinical care
    Raimond L Winslow
    The Institute for Computational Medicine, Center for Cardiovascular Bioinformatics and Modeling, and Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA
    Sci Transl Med 4:158rv11. 2012
    ..Advances in translating these computational methods to the clinic are described, as well as challenges in applying models for improving patient health...
  3. pmc Merging microarray data from separate breast cancer studies provides a robust prognostic test
    Lei Xu
    The Institute for Computational Medicine and Center for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Bioinformatics 9:125. 2008
    ..Integrating microarray data from multiple studies in order to increase sample size is therefore a promising approach to the development of more robust prognostic tests...
  4. pmc Large-scale integration of cancer microarray data identifies a robust common cancer signature
    Lei Xu
    The Institute for Computational Medicine and Center for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Bioinformatics 8:275. 2007
    ..DNA microarrays provide a means for measuring gene expression signatures which can then be used as components of genomic-based diagnostic tests to determine the presence of cancer...
  5. pmc Cardiac myocytes and local signaling in nano-domains
    Raimond L Winslow
    The Institute for Computational Medicine and Department of Biomedical Engineering, The Johns Hopkins University, School of Medicine and Whiting School of Engineering, Baltimore, MD 21218, USA
    Prog Biophys Mol Biol 107:48-59. 2011
    ....
  6. pmc Integrative modeling of the cardiac ventricular myocyte
    Raimond L Winslow
    Institute of Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
    Wiley Interdiscip Rev Syst Biol Med 3:392-413. 2011
    ..We describe key advances and limitations of the models as well as point to new directions for future modeling research. WIREs Syst Biol Med 2011 3 392-413 DOI: 10.1002/wsbm.122..
  7. ncbi request reprint Multiscale modeling of calcium signaling in the cardiac dyad
    Raimond L Winslow
    Institute for Computational Medicine and Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, MD 21218, USA
    Ann N Y Acad Sci 1080:362-75. 2006
    ..The simplified model may be solved many orders of magnitude faster than can either of the more detailed models, thus enabling incorporation into tissue-level simulations...
  8. pmc An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release
    Joseph L Greenstein
    Department of Biomedical Engineering, Center for Computational Medicine and Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biophys J 83:2918-45. 2002
    ..The local control myocyte model provides a means for studying the interrelationship between microscopic and macroscopic behaviors in a manner that would not be possible in experiments...
  9. pmc CaMKII-induced shift in modal gating explains L-type Ca(2+) current facilitation: a modeling study
    Yasmin L Hashambhoy
    Institute for Computational Medicine, Center for Cardiovascular Bioinformatics and Modeling, and the Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, Maryland, USA
    Biophys J 96:1770-85. 2009
    ..The model therefore serves as a powerful tool for interpreting I(CaL) experiments...
  10. pmc Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts
    Antonis A Armoundas
    The Johns Hopkins University, School of Medicine, Institute of Molecular Cardiobiology, 844 Ross Bldg, 720 Rutland Ave, Baltimore, Md 21205 219, USA
    Circ Res 93:46-53. 2003
    ....
  11. pmc A computational model of the human left-ventricular epicardial myocyte
    Vivek Iyer
    The Center for Cardiovascular Bioinformatics and Modeling and The Whitaker Biomedical Engineering Institute, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Maryland 21093, USA
    Biophys J 87:1507-25. 2004
    ..The model therefore serves as a useful tool for investigating mechanisms of arrhythmia and consequences of drug-channel interactions in the human left-ventricular myocyte...
  12. pmc Role of CaMKII in RyR leak, EC coupling and action potential duration: a computational model
    Yasmin L Hashambhoy
    Institute for Computational Medicine, Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University, Baltimore, MD, USA
    J Mol Cell Cardiol 49:617-24. 2010
    ..These results suggest that LCC phosphorylation sites may be a more effective target than RyR sites in modulating diastolic RyR flux...
  13. pmc A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyte
    Sonia Cortassa
    The Johns Hopkins University, Institute for Computational Medicine, and Institute of Molecular Cardiobiology, Baltimore, Maryland 21218, USA
    Biophys J 91:1564-89. 2006
    ....
  14. pmc Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodeling
    Zhong Gao
    The Institute for Computational Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Physiol Genomics 35:222-30. 2008
    ..As the transition to overt HF is characterized by few additional transcriptional changes, posttranscriptional modifications may be more critical in regulating myocardial structure and function during later stages of HF...
  15. pmc Protein geometry and placement in the cardiac dyad influence macroscopic properties of calcium-induced calcium release
    Antti J Tanskanen
    The Institute for Computational Medicine, Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Maryland, USA
    Biophys J 92:3379-96. 2007
    ..Results suggest the hypothesis that the relative placement and shape of the RyR2 proteins helps to "funnel" Ca2+ ions to RyR2 binding sites, thus increasing excitation-contraction coupling gain...
  16. pmc Improved reproducibility of reverse-phase protein microarrays using array microenvironment normalization
    Troy Anderson
    Institute for Computational Medicine, Center for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD 21218, USA
    Proteomics 9:5562-6. 2009
    ..The improved reproducibility and statistical power should facilitate clinical implementation of the platform...
  17. ncbi request reprint MASCOT HTML and XML parser: an implementation of a novel object model for protein identification data
    Chunguang G Yang
    Center for Cardiovascular Bioinformatics and Modeling, The Institute for Computational Medicine and The Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, MD 21218 2686, USA
    Proteomics 6:5688-93. 2006
    ..The source code is freely available at http://www.ccbm.jhu.edu and the program uses only free and open-source Java libraries...
  18. pmc Computational method for identifying and quantifying shape features of human left ventricular remodeling
    Siamak Ardekani
    Institute for Computational Medicine, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA
    Ann Biomed Eng 37:1043-54. 2009
    ..This approach may be useful in identifying differences in the remodeling process between ICM and NICM populations and possibly in differentiating the populations...
  19. ncbi request reprint Discovering robust protein biomarkers for disease from relative expression reversals in 2-D DIGE data
    Troy J Anderson
    Center for Cardiovascular Bioinformatics and Modeling and The Institute of Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA
    Proteomics 7:1197-207. 2007
    ..We propose that by accounting for sources of within- and between-gel variation, RER classifiers applied to 2-D DIGE data provide a useful approach for identifying biomarkers that discriminate among protein samples of interest...
  20. pmc The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations
    Antti J Tanskanen
    Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Maryland 21218, USA
    Biophys J 88:85-95. 2005
    ..These results suggest a novel stochastic mechanism, whereby phosphorylation-induced changes in LCC gating properties contribute to EAD generation...
  21. ncbi request reprint Evidence of structural remodeling in the dyssynchronous failing heart
    Patrick A Helm
    Centers for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD, USA
    Circ Res 98:125-32. 2006
    ..Measured changes in both fiber gradient and sheet structure will affect both the heterogeneity of passive myocardial properties as well as electrical activation of the ventricles...
  22. pmc Transcriptomic profiling of the canine tachycardia-induced heart failure model: global comparison to human and murine heart failure
    Zhong Gao
    Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, MD 21218, USA
    J Mol Cell Cardiol 40:76-86. 2006
    ..This study provides insights into the molecular pathways leading to end-stage tachycardia-induced HF, and into global transcriptomic differences between the animal HF models and human HF...
  23. pmc Using models of the myocyte for functional interpretation of cardiac proteomic data
    Raimond L Winslow
    Center for Cardiovascular Bioinformatics and Modelling, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, MD, USA
    J Physiol 563:73-81. 2005
    ....
  24. ncbi request reprint Gene expression profiles in end-stage human idiopathic dilated cardiomyopathy: altered expression of apoptotic and cytoskeletal genes
    Christina K Yung
    Department of Biomedical Engineering, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, MD 21218, USA
    Genomics 83:281-97. 2004
    ..These regulated genes take part in diverse cellular processes, including transcription, apoptosis, sarcomeric and cytoskeletal function, remodeling of the extracellular matrix, membrane transport, and metabolism...
  25. pmc Genome informatics: current status and future prospects
    Raimond L Winslow
    The Whitaker Biomedical Engineering Institute and Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA
    Circ Res 92:953-61. 2003
    ..In each instance, we provide links to relevant sources of information on the World Wide Web and critical appraisals of the promises and the challenges of an expanding and diverse information landscape...
  26. pmc Simple decision rules for classifying human cancers from gene expression profiles
    Aik Choon Tan
    Center for Cardiovascular Bioinformatics and Modeling, Whitaker Biomedical Engineering Institute, Baltimore, MD 21218, USA
    Bioinformatics 21:3896-904. 2005
    ..This method generates simple and accurate decision rules that only involve a small number of gene-to-gene expression comparisons, thereby facilitating follow-up studies...
  27. ncbi request reprint Robust prostate cancer marker genes emerge from direct integration of inter-study microarray data
    Lei Xu
    The Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, MD 21218, USA
    Bioinformatics 21:3905-11. 2005
    ..With the rapid accumulation of microarray data, it is of great interest to integrate inter-study microarray data to increase sample size, which could lead to the discovery of more reliable markers...
  28. pmc Ex vivo 3D diffusion tensor imaging and quantification of cardiac laminar structure
    Patrick A Helm
    Center for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD 21218, USA
    Magn Reson Med 54:850-9. 2005
    ....
  29. ncbi request reprint Large deformation diffeomorphic metric mapping of vector fields
    Yan Cao
    Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA
    IEEE Trans Med Imaging 24:1216-30. 2005
    ..This is illustrated by numerical experiments on DT-MRI heart images...
  30. pmc Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte
    Joseph L Greenstein
    The Center for Cardiovascular Bioinformatics and Modeling and The Whitaker Biomedical Engineering Institute, The Johns Hopkins University Whiting School of Engineering and School of Medicine, Baltimore, Maryland, USA
    Biophys J 90:77-91. 2006
    ..We also demonstrate mechanisms by which alterations in the early repolarization phase of the action potential, resulting from reduction of the transient outward potassium current, alters properties of EC coupling...
  31. pmc Computational cardiac anatomy using MRI
    Mirza Faisal Beg
    Center for Imaging Science, The Whitaker Biomedical Engineering Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 52:1167-74. 2004
    ..Once heart anatomies have been registered, properties of tissue geometry and cardiac fiber orientation in corresponding regions of different hearts may be quantified...
  32. pmc A mitochondrial oscillator dependent on reactive oxygen species
    Sonia Cortassa
    The Johns Hopkins University, Institute of Molecular Cardiobiology and Center for Cardiovascular Bioinformatics and Modeling, Baltimore, Maryland 21205 2195, USA
    Biophys J 87:2060-73. 2004
    ....
  33. pmc Control and regulation of mitochondrial energetics in an integrated model of cardiomyocyte function
    Sonia Cortassa
    Division of Cardiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Biophys J 96:2466-78. 2009
    ..g., by a pharmacological agent) may bring about changes in processes without obvious direct mechanistic links between them...
  34. pmc Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytes
    Lufang Zhou
    Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Biophys J 97:1843-52. 2009
    ....
  35. pmc Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval
    Reza Mazhari
    Department of Medicine, Institute of Molecular Cardiobiology, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Clin Invest 109:1083-90. 2002
    ..Provided that fairly homogeneous ectopic ventricular expression of regulatory subunits can be achieved, this approach may be useful in enhancing repolarization and in treating long QT syndrome...
  36. pmc An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics
    Sonia Cortassa
    The Johns Hopkins University, Institute of Molecular Cardiobiology, Baltimore, Maryland 21205 2195, USA
    Biophys J 84:2734-55. 2003
    ..The steady-state and time-dependent behavior of the model support the hypothesis that mitochondrial matrix Ca(2+) plays an important role in matching energy supply with demand in cardiac myocytes...
  37. ncbi request reprint Measuring and mapping cardiac fiber and laminar architecture using diffusion tensor MR imaging
    Patrick Helm
    The Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Maryland 21218, USA
    Ann N Y Acad Sci 1047:296-307. 2005
    ....
  38. pmc Integrative systems models of cardiac excitation-contraction coupling
    Joseph L Greenstein
    Center for Cardiovascular Bioinformatics and Modeling, Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, MD, USA
    Circ Res 108:70-84. 2011
    ..Here, we review experimentally based multiscale computational models of excitation-contraction coupling and the insights that have been gained through their application...
  39. pmc Modeling the actions of beta-adrenergic signaling on excitation--contraction coupling processes
    Joseph L Greenstein
    Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine, and Whiting School of Engineering, Baltimore, MD 21218, USA
    Ann N Y Acad Sci 1015:16-27. 2004
    ....
  40. pmc Identification of novel serological biomarkers for inflammatory bowel disease using Escherichia coli proteome chip
    Chien Sheng Chen
    Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Proteomics 8:1765-76. 2009
    ..04). Taken together, we identified novel sets of serological biomarkers for diagnosis of CD versus healthy control and CD versus UC...
  41. ncbi request reprint Candidate gene discovery in cardiovascular disease
    Raimond L Winslow
    Circ Res 96:605-6. 2005
  42. ncbi request reprint The ongoing journey to understand heart function through integrative modeling
    Raimond L Winslow
    Circ Res 95:1135-6. 2004
  43. pmc From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scales
    Gernot Plank
    Institute of Biophysics, Medical University Graz, 8010 Graz, Austria
    Philos Trans A Math Phys Eng Sci 366:3381-409. 2008
    ....
  44. ncbi request reprint Imaging-based integrative models of the heart: closing the loop between experiment and simulation
    Raimond L Winslow
    The Whitaker Biomedical Engineering Institute Center for Computational Medicine and Biology, Johns Hopkins University, Baltimore MD 21218, USA
    Novartis Found Symp 247:129-41; discussion 141-3, 144-50, 244-52. 2002
    ..We believe this ability to electrically map and model individual hearts will lead to enhanced understanding of the relationship between anatomical structure, and electrical conduction in the cardiac ventricles...

Research Grants18

  1. Anatomical Remodeling and Electrical Conduction in Heart
    Raimond Winslow; Fiscal Year: 2005
    ..Fifth, we will relate measured changes in fiber structure to measured changes of electrical propagation in each heart using both experimental approaches as well as computational models. ..
  2. Calcium Cycling and Regulation of the Cardiac AP
    Raimond Winslow; Fiscal Year: 2005
    ..The general goal of the proposed research is to test this hypothesis by means of experiments coupled with computational modeling. ..
  3. Anatomical Remodeling and Electrical Conduction in Heart
    Raimond Winslow; Fiscal Year: 2004
    ..Fifth, we will relate measured changes in fiber structure to measured changes of electrical propagation in each heart using both experimental approaches as well as computational models. ..
  4. Anatomical Remodeling and Electrical Conduction in Heart
    Raimond Winslow; Fiscal Year: 2003
    ..Fifth, we will relate measured changes in fiber structure to measured changes of electrical propagation in each heart using both experimental approaches as well as computational models. ..
  5. EXPERIMENTAL STUDY OF ARRHYTHMIAS IN HEART FAILURE
    Raimond Winslow; Fiscal Year: 1999
    ..The arrhythmogenic potential of the cellular mechanisms investigated in Aim 3 will be tested using the three-dimensional ventricular models. ..
  6. EXPERIMENTAL STUDY OF ARRHYTHMIAS IN HEART FAILURE
    Raimond Winslow; Fiscal Year: 2000
    ..The arrhythmogenic potential of the cellular mechanisms investigated in Aim 3 will be tested using the three-dimensional ventricular models. ..
  7. Calcium Cycling and Regulation of the Cardiac AP
    Raimond Winslow; Fiscal Year: 2002
    ..The general goal of the proposed research is to test this hypothesis by means of experiments coupled with computational modeling. ..
  8. The Systems Biology of Sudden Cardiac Death
    Raimond Winslow; Fiscal Year: 2007
    ..This project will test these hypotheses and the results will have major importance for our understanding of the mechanisms and treatment of arrhythmias. ..
  9. Short Course on Integrative Modeling of the Cardiac Myocyte
    Raimond Winslow; Fiscal Year: 2007
    ....
  10. The CardioVascular Research Grid
    Raimond Winslow; Fiscal Year: 2007
    ..End of Abstract). ..
  11. Anatomical Remodeling and Electrical Conduction in Heart
    Raimond Winslow; Fiscal Year: 2002
    ..Fifth, we will relate measured changes in fiber structure to measured changes of electrical propagation in each heart using both experimental approaches as well as computational models. ..
  12. Calcium Cycling and Regulation of the Cardiac AP
    Raimond Winslow; Fiscal Year: 2003
    ..The general goal of the proposed research is to test this hypothesis by means of experiments coupled with computational modeling. ..
  13. Calcium Cycling and Regulation of the Cardiac AP
    Raimond Winslow; Fiscal Year: 2004
    ..The general goal of the proposed research is to test this hypothesis by means of experiments coupled with computational modeling. ..