Research Topics
Genomes and Genes | M Wills-KarpSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Interleukin-13: central mediator of allergic asthmaM Wills-Karp
Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
Science 282:2258-61. 1998..Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses...- Immunologic basis of antigen-induced airway hyperresponsivenessM Wills-Karp
Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
Annu Rev Immunol 17:255-81. 1999.... - Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in miceX M Li
Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD 21224, USA
J Immunol 157:3216-9. 1996..These findings suggest that mucosal IFN-gamma gene transfer is effective in modulating pulmonary allergic responses and provides a basis for developing a novel therapeutic approach... 
Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus productionD Kuperman
Department of Environmental Health Sciences, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
J Exp Med 187:939-48. 1998..These results indicate that Stat6 signal transduction is critical in the development of allergen-induced AHR and that agents that specifically inhibit this pathway may provide a novel strategy for the treatment of allergic disorders...- Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in miceS H Gavett
Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
Am J Physiol 272:L253-61. 1997..These results demonstrate that IL-4 is necessary for in vivo development of antigen-induced AHR, goblet cell metaplasia, and pulmonary eosinophilia... - Elevated lung G protein levels and muscarinic receptor affinity in a mouse model of airway hyperreactivityS H Gavett
Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205
Am J Physiol 265:L493-500. 1993.... - Development of murine allergic asthma is dependent upon B7-2 costimulationA M Keane-Myers
Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
J Immunol 160:1036-43. 1998..We conclude that B7-2 provides the necessary costimulatory signal required for the development of in vivo allergic responses to inhaled allergen exposure... - Ambient urban Baltimore particulate-induced airway hyperresponsiveness and inflammation in miceD M Walters
The Johns Hopkins School of Hygiene and Public Health, Department of Environmental Health Sciences, Baltimore, Maryland, USA
Am J Respir Crit Care Med 164:1438-43. 2001..We conclude that ambient PM can induce asthma-like parameters in naive mice, suggesting that PM exposure may be an important factor in increases in asthma prevalence... - Attenuation of lung inflammation and fibrosis in interferon-gamma-deficient mice after intratracheal bleomycinE S Chen
Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
Am J Respir Cell Mol Biol 24:545-55. 2001..Together, these results suggest that IFN-gamma mediates, in part, bleomycin-induced pulmonary inflammation and fibrosis... - The environment and asthma in U.S. inner citiesP A Eggleston
School of Medicine, Department of Pediatrics, The Johns Hopkins University, Baltimore, MD 21287 3923, USA
Environ Health Perspect 107:439-50. 1999..However, to examine the relationship of morbidity in genetically predisposed individuals, it will be important to determine the most relevant method of making this assessment... - Identification of complement factor 5 as a susceptibility locus for experimental allergic asthmaC L Karp
Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MA, USA
Nat Immunol 1:221-6. 2000..The role of complement in modulating susceptibility to asthma highlights the importance of immunoregulatory events at the interface of innate and adaptive immunity in disease pathogenesis... - Measles: immunosuppression, interleukin-12, and complement receptorsC L Karp
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Immunol Rev 168:91-101. 1999..Exploitation of these pathways by other intracellular pathogens is likely... - Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin toleranceC L Karp
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Eur J Immunol 28:3128-36. 1998..Endotoxin tolerance-related suppression of IL-12 production provides a likely mechanism for the anergy seen during the immunological paralysis which follows septic shock... - Inhibition of IL-12 production by thalidomideD R Moller
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Immunol 159:5157-61. 1997..These results suggest that thalidomide may have therapeutic utility in a wide range of immunologic disorders that are characterized by inappropriate cellular immune responses... - The gene encoding interleukin-13: a susceptibility locus for asthma and related traitsM Wills-Karp
Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland 21205, USA
Respir Res 1:19-23. 2000.... - Bloodborne markers in humans during multiday exposure to ozoneW M Foster
Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Appl Physiol 81:794-800. 1996..Effects of O3 exposure on cellular and biochemical markers increased in magnitude after each exposure and did not parallel the apparent adaptability of bronchial sensitivity to O3... - Type I interferons and IL-12: convergence and cross-regulation among mediators of cellular immunityA A Byrnes
Department of Medicine, Johns Hopkins University, Baltimore, USA
Eur J Immunol 31:2026-34. 2001..The ability of IFN-alpha/beta to suppress IL-12 production while up-regulating IFN-gamma production suggests a possible mechanistic basis for the difficulties of employing these cytokines in diseases involving abnormalities of CMI... - Preferential activation of nuclear factor of activated T cells c correlates with mouse strain susceptibility to allergic responses and interleukin-4 gene expressionJ C Keen
Departments of Medicine and Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland, USA
Am J Respir Cell Mol Biol 24:58-65. 2001..In conclusion, our data link dysregulated activation of a specific transcription factor with susceptibility to allergic airway inflammation... - Serotonin induces constriction and relaxation of the guinea pig airwayR A Baumgartner
Department of Environmental Health Sciences, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland
J Pharmacol Exp Ther 255:165-73. 1990..In addition, part of the constrictor response of 5-HT is mediated through a cholinergic preganglionic pathway. Finally, inositol-monophosphate production induced by 5-HT correlates with the functional response... - A novel promoter polymorphism in the gene encoding complement component 5 receptor 1 on chromosome 19q13.3 is not associated with asthma and atopy in three independent populationsK C Barnes
Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21224, USA
Clin Exp Allergy 34:736-44. 2004..A susceptibility locus for murine allergen-induced airway hyper-responsiveness was identified in a region syntenic to human chromosome 19q13, where linkage to asthma has been demonstrated and where the gene encoding C5R1 is localized... - Leptin regulates proinflammatory immune responsesS Loffreda
Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
FASEB J 12:57-65. 1998..These results identify an important and novel function for leptin: up-regulation of inflammatory immune responses, which may provide a common pathogenetic mechanism that contributes to several of the major complications of obesity...