M Wills-Karp

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
  2. ncbi Immunologic basis of antigen-induced airway hyperresponsiveness
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Annu Rev Immunol 17:255-81. 1999
  3. ncbi Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in mice
    X M Li
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD 21224, USA
    J Immunol 157:3216-9. 1996
  4. pmc Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production
    D Kuperman
    Department of Environmental Health Sciences, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    J Exp Med 187:939-48. 1998
  5. ncbi Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice
    S H Gavett
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Am J Physiol 272:L253-61. 1997
  6. ncbi Elevated lung G protein levels and muscarinic receptor affinity in a mouse model of airway hyperreactivity
    S H Gavett
    Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205
    Am J Physiol 265:L493-500. 1993
  7. ncbi Development of murine allergic asthma is dependent upon B7-2 costimulation
    A M Keane-Myers
    Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Immunol 160:1036-43. 1998
  8. ncbi Ambient urban Baltimore particulate-induced airway hyperresponsiveness and inflammation in mice
    D M Walters
    The Johns Hopkins School of Hygiene and Public Health, Department of Environmental Health Sciences, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 164:1438-43. 2001
  9. ncbi Attenuation of lung inflammation and fibrosis in interferon-gamma-deficient mice after intratracheal bleomycin
    E S Chen
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 24:545-55. 2001
  10. pmc The environment and asthma in U.S. inner cities
    P A Eggleston
    School of Medicine, Department of Pediatrics, The Johns Hopkins University, Baltimore, MD 21287 3923, USA
    Environ Health Perspect 107:439-50. 1999

Collaborators

Detail Information

Publications21

  1. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
    ..Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses...
  2. ncbi Immunologic basis of antigen-induced airway hyperresponsiveness
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Annu Rev Immunol 17:255-81. 1999
    ....
  3. ncbi Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in mice
    X M Li
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD 21224, USA
    J Immunol 157:3216-9. 1996
    ..These findings suggest that mucosal IFN-gamma gene transfer is effective in modulating pulmonary allergic responses and provides a basis for developing a novel therapeutic approach...
  4. pmc Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production
    D Kuperman
    Department of Environmental Health Sciences, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    J Exp Med 187:939-48. 1998
    ..These results indicate that Stat6 signal transduction is critical in the development of allergen-induced AHR and that agents that specifically inhibit this pathway may provide a novel strategy for the treatment of allergic disorders...
  5. ncbi Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice
    S H Gavett
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Am J Physiol 272:L253-61. 1997
    ..These results demonstrate that IL-4 is necessary for in vivo development of antigen-induced AHR, goblet cell metaplasia, and pulmonary eosinophilia...
  6. ncbi Elevated lung G protein levels and muscarinic receptor affinity in a mouse model of airway hyperreactivity
    S H Gavett
    Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205
    Am J Physiol 265:L493-500. 1993
    ....
  7. ncbi Development of murine allergic asthma is dependent upon B7-2 costimulation
    A M Keane-Myers
    Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Immunol 160:1036-43. 1998
    ..We conclude that B7-2 provides the necessary costimulatory signal required for the development of in vivo allergic responses to inhaled allergen exposure...
  8. ncbi Ambient urban Baltimore particulate-induced airway hyperresponsiveness and inflammation in mice
    D M Walters
    The Johns Hopkins School of Hygiene and Public Health, Department of Environmental Health Sciences, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 164:1438-43. 2001
    ..We conclude that ambient PM can induce asthma-like parameters in naive mice, suggesting that PM exposure may be an important factor in increases in asthma prevalence...
  9. ncbi Attenuation of lung inflammation and fibrosis in interferon-gamma-deficient mice after intratracheal bleomycin
    E S Chen
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 24:545-55. 2001
    ..Together, these results suggest that IFN-gamma mediates, in part, bleomycin-induced pulmonary inflammation and fibrosis...
  10. pmc The environment and asthma in U.S. inner cities
    P A Eggleston
    School of Medicine, Department of Pediatrics, The Johns Hopkins University, Baltimore, MD 21287 3923, USA
    Environ Health Perspect 107:439-50. 1999
    ..However, to examine the relationship of morbidity in genetically predisposed individuals, it will be important to determine the most relevant method of making this assessment...
  11. ncbi Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma
    C L Karp
    Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MA, USA
    Nat Immunol 1:221-6. 2000
    ..The role of complement in modulating susceptibility to asthma highlights the importance of immunoregulatory events at the interface of innate and adaptive immunity in disease pathogenesis...
  12. ncbi Measles: immunosuppression, interleukin-12, and complement receptors
    C L Karp
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Immunol Rev 168:91-101. 1999
    ..Exploitation of these pathways by other intracellular pathogens is likely...
  13. ncbi Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance
    C L Karp
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Eur J Immunol 28:3128-36. 1998
    ..Endotoxin tolerance-related suppression of IL-12 production provides a likely mechanism for the anergy seen during the immunological paralysis which follows septic shock...
  14. ncbi Inhibition of IL-12 production by thalidomide
    D R Moller
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 159:5157-61. 1997
    ..These results suggest that thalidomide may have therapeutic utility in a wide range of immunologic disorders that are characterized by inappropriate cellular immune responses...
  15. pmc The gene encoding interleukin-13: a susceptibility locus for asthma and related traits
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Respir Res 1:19-23. 2000
    ....
  16. ncbi Bloodborne markers in humans during multiday exposure to ozone
    W M Foster
    Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol 81:794-800. 1996
    ..Effects of O3 exposure on cellular and biochemical markers increased in magnitude after each exposure and did not parallel the apparent adaptability of bronchial sensitivity to O3...
  17. ncbi Type I interferons and IL-12: convergence and cross-regulation among mediators of cellular immunity
    A A Byrnes
    Department of Medicine, Johns Hopkins University, Baltimore, USA
    Eur J Immunol 31:2026-34. 2001
    ..The ability of IFN-alpha/beta to suppress IL-12 production while up-regulating IFN-gamma production suggests a possible mechanistic basis for the difficulties of employing these cytokines in diseases involving abnormalities of CMI...
  18. ncbi Preferential activation of nuclear factor of activated T cells c correlates with mouse strain susceptibility to allergic responses and interleukin-4 gene expression
    J C Keen
    Departments of Medicine and Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 24:58-65. 2001
    ..In conclusion, our data link dysregulated activation of a specific transcription factor with susceptibility to allergic airway inflammation...
  19. ncbi Serotonin induces constriction and relaxation of the guinea pig airway
    R A Baumgartner
    Department of Environmental Health Sciences, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland
    J Pharmacol Exp Ther 255:165-73. 1990
    ..In addition, part of the constrictor response of 5-HT is mediated through a cholinergic preganglionic pathway. Finally, inositol-monophosphate production induced by 5-HT correlates with the functional response...
  20. ncbi A novel promoter polymorphism in the gene encoding complement component 5 receptor 1 on chromosome 19q13.3 is not associated with asthma and atopy in three independent populations
    K C Barnes
    Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21224, USA
    Clin Exp Allergy 34:736-44. 2004
    ..A susceptibility locus for murine allergen-induced airway hyper-responsiveness was identified in a region syntenic to human chromosome 19q13, where linkage to asthma has been demonstrated and where the gene encoding C5R1 is localized...
  21. ncbi Leptin regulates proinflammatory immune responses
    S Loffreda
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    FASEB J 12:57-65. 1998
    ..These results identify an important and novel function for leptin: up-regulation of inflammatory immune responses, which may provide a common pathogenetic mechanism that contributes to several of the major complications of obesity...