Virginia Willour

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint A genome-wide association study of attempted suicide
    V L Willour
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Mol Psychiatry 17:433-44. 2012
  2. doi request reprint Family-based association of FKBP5 in bipolar disorder
    V L Willour
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Mol Psychiatry 14:261-8. 2009
  3. ncbi request reprint Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12
    Virginia L Willour
    Department of Psychiatry and Behaviorial Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Biol Psychiatry 61:725-7. 2007
  4. pmc Replication study supports evidence for linkage to 9p24 in obsessive-compulsive disorder
    Virginia L Willour
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Hum Genet 75:508-13. 2004
  5. ncbi request reprint Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21
    Virginia L Willour
    The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 121:21-7. 2003
  6. ncbi request reprint Clinical correlates and familial aggregation of age at onset in bipolar disorder
    Ping I Lin
    Dept of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, 624 N Broadway, 8th Floor, Baltimore, MD 21205, USA
    Am J Psychiatry 163:240-6. 2006
  7. pmc Monoamine oxidase A regulates antisocial personality in whites with no history of physical abuse
    Irving M Reti
    The School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Compr Psychiatry 52:188-94. 2011
  8. ncbi request reprint Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees
    Melvin G McInnis
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287 7463, USA
    Biol Psychiatry 54:1265-73. 2003
  9. ncbi request reprint SNP fine mapping of chromosome 8q24 in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 144:625-30. 2007
  10. ncbi request reprint Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X
    Peter P Zandi
    Department of Mental Hygiene, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21204, USA
    Am J Med Genet B Neuropsychiatr Genet 119:69-76. 2003

Research Grants

  1. Genetic Risk Factor Suicidal Behavior
    Virginia Willour; Fiscal Year: 2007
  2. Genetic Risk Factor Suicidal Behavior
    Virginia Willour; Fiscal Year: 2009
  3. Genetic Risk Factor Suicidal Behavior
    Virginia L Willour; Fiscal Year: 2010

Detail Information

Publications25

  1. ncbi request reprint A genome-wide association study of attempted suicide
    V L Willour
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Mol Psychiatry 17:433-44. 2012
    ..Larger GWAS sample sets will be required to confirm the signal on 2p25 and to identify additional genetic risk factors increasing susceptibility for attempted suicide...
  2. doi request reprint Family-based association of FKBP5 in bipolar disorder
    V L Willour
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Mol Psychiatry 14:261-8. 2009
    ..Ongoing whole-genome association studies in bipolar disorder and major depression should further clarify the role of FKBP5 and other HPA genes in these illnesses...
  3. ncbi request reprint Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12
    Virginia L Willour
    Department of Psychiatry and Behaviorial Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Biol Psychiatry 61:725-7. 2007
    ..We are interested in identifying susceptibility genes that predispose subjects to attempted suicide...
  4. pmc Replication study supports evidence for linkage to 9p24 in obsessive-compulsive disorder
    Virginia L Willour
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Hum Genet 75:508-13. 2004
    ..046 and .02, respectively) for association...
  5. ncbi request reprint Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21
    Virginia L Willour
    The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 121:21-7. 2003
    ..38, which exceeds standard criteria for suggestive linkage, and a corresponding parametric HLOD score of 2.98. The combined analysis did not provide further support for linkage to 4q32 and 4q35...
  6. ncbi request reprint Clinical correlates and familial aggregation of age at onset in bipolar disorder
    Ping I Lin
    Dept of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, 624 N Broadway, 8th Floor, Baltimore, MD 21205, USA
    Am J Psychiatry 163:240-6. 2006
    ....
  7. pmc Monoamine oxidase A regulates antisocial personality in whites with no history of physical abuse
    Irving M Reti
    The School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Compr Psychiatry 52:188-94. 2011
    ..The 30-base pair variable number tandem repeat in the MAOA promoter regulates MAOA levels, but its effects on ASP in humans are unclear...
  8. ncbi request reprint Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees
    Melvin G McInnis
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287 7463, USA
    Biol Psychiatry 54:1265-73. 2003
    ..The first 97 pedigrees showed evidence of linkage to chromosomes 1, 6, 7, 10, 16, and 22 (Nurnberger et al 1997). An additional 56 bipolar families have been genotyped, and the combined sample of 153 pedigrees studied...
  9. ncbi request reprint SNP fine mapping of chromosome 8q24 in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 144:625-30. 2007
    ..Several other interesting candidate genes are also located nearby. The congruence of findings across methods and samples suggests further investigation is warranted in these two targeted regions...
  10. ncbi request reprint Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X
    Peter P Zandi
    Department of Mental Hygiene, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21204, USA
    Am J Med Genet B Neuropsychiatr Genet 119:69-76. 2003
    ..Large samples such as that being collected by the NIMH Initiative will be necessary to examine the heterogeneity and identify these susceptibility genes...
  11. pmc Neurotransmission and bipolar disorder: a systematic family-based association study
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1270-7. 2008
    ....
  12. pmc Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categories
    Anthony Pinto
    Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI 02906, USA
    Psychiatry Res 160:83-93. 2008
    ..The results support investigation of this multidimensional model in OCD genetic linkage studies...
  13. pmc Association study of Wnt signaling pathway genes in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 65:785-93. 2008
    ..The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder...
  14. ncbi request reprint Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorder
    Bernadette Cullen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Depress Anxiety 25:218-24. 2008
    ..Clinical factors are predominant in predicting treatment status in family members with OCD. Although the mean duration from onset of symptoms to treatment was long, younger family members appear to receive treatment sooner...
  15. ncbi request reprint Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study
    Jack Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 N Wolfe St, Meyer 4 181, Baltimore, MD 21287 7228, USA
    Am J Psychiatry 164:493-9. 2007
    ..The objective of this study was to determine whether there are chromosomal regions specifically linked to compulsive hoarding behavior in families with obsessive-compulsive disorder...
  16. ncbi request reprint Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33
    Fernando S Goes
    Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:236-47. 2007
    ..This study attempts to characterize clinical correlates, familial aggregation, and genetic linkage in subjects with these features...
  17. pmc The OCD collaborative genetics study: methods and sample description
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7228, USA
    Am J Med Genet B Neuropsychiatr Genet 141:201-7. 2006
    ....
  18. ncbi request reprint Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 4 181, Baltimore, MD 21287 7228, USA
    Behav Res Ther 45:673-86. 2007
    ..The findings suggest that hoarding behavior may help differentiate a distinct clinical subgroup of people with OCD and may aggregate in some OCD families. Indecision may be a risk factor for hoarding in these families...
  19. ncbi request reprint Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study
    Gregor Hasler
    Laboratory of Clinical Science, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
    Biol Psychiatry 61:617-25. 2007
    ..While factor-analytic studies have found consistent, clinically meaningful OCD symptom dimensions, there have been only limited attempts to evaluate the familiality and potential genetic basis of such dimensions...
  20. ncbi request reprint Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder
    James B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, USA
    Am J Psychiatry 160:680-6. 2003
    ....
  21. pmc Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1047-55. 2008
    ..00000172). It remains significant after correcting for multiple testing using the False Discovery Rate method. Our results indicate an interaction between three circadian genes in susceptibility to bipolar disorder...
  22. ncbi request reprint CRELD1 mutations contribute to the occurrence of cardiac atrioventricular septal defects in Down syndrome
    Cheryl L Maslen
    Department of Medicine, Division of Endocrinology, Oregon Health and Science University, Portland 97239, USA
    Am J Med Genet A 140:2501-5. 2006
  23. pmc Family-based SNP association study on 8q24 in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 147:612-8. 2008
    ..These findings with ADCY8 and ST3GAL1 warrant further investigation in order to confirm the observed associations and their functional significance for BP susceptibility...
  24. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
    Ricardo Segurado
    Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 73:49-62. 2003
    ..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...
  25. pmc Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q
    Ping I Lin
    Department of Mental Health, The Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Hum Genet 77:545-55. 2005
    ..This inconsistency may be due to differences in the AAO characteristics of the samples examined. Future studies to fine map susceptibility genes for BP on chromosomes 21q22.13 and 18p11.2 should take AAO into account...

Research Grants4

  1. Genetic Risk Factor Suicidal Behavior
    Virginia Willour; Fiscal Year: 2007
    ....
  2. Genetic Risk Factor Suicidal Behavior
    Virginia Willour; Fiscal Year: 2009
    ....
  3. Genetic Risk Factor Suicidal Behavior
    Virginia L Willour; Fiscal Year: 2010
    ....