W H Westra

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Detection of human papillomavirus in clinical samples
    William H Westra
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Otolaryngol Clin North Am 45:765-77. 2012
  2. pmc The morphologic profile of HPV-related head and neck squamous carcinoma: implications for diagnosis, prognosis, and clinical management
    William H Westra
    Departments of Pathology, Oncology, and Otolaryngology, Head and Neck Surgery, The Johns Hopkins Medical Institutions, 401 N Broadway, Weinberg 2242, Baltimore, MD 21231, USA
    Head Neck Pathol 6:S48-54. 2012
  3. ncbi request reprint Diagnostic difficulties in the classification and grading of salivary gland tumors
    William H Westra
    Departments of Pathology, and Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Int J Radiat Oncol Biol Phys 69:S49-51. 2007
  4. pmc Early glandular neoplasia of the lung
    W H Westra
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Respir Res 1:163-9. 2000
  5. doi request reprint Inverse relationship between human papillomavirus-16 infection and disruptive p53 gene mutations in squamous cell carcinoma of the head and neck
    William H Westra
    Department of Pathology and Otolaryngology, Head and Neck Surgery Division of Head and Neck Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Clin Cancer Res 14:366-9. 2008
  6. ncbi request reprint Fluorescence visualization in oral neoplasia: shedding light on an old problem
    William H Westra
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 2410, USA
    Clin Cancer Res 12:6594-7. 2006
  7. ncbi request reprint The impact of second opinion surgical pathology on the practice of head and neck surgery: a decade experience at a large referral hospital
    William H Westra
    Department of Pathology, The Johns Hopkins Medical Institutions, The Weinberg Cancer Center, Room 2242, 410 N Broadway, Baltimore, MD 21231, USA
    Head Neck 24:684-93. 2002
  8. ncbi request reprint Bizarre epithelial atypia of the sinonasal tract after chemotherapy
    W H Westra
    Departments of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 2410, USA
    Am J Surg Pathol 25:652-6. 2001
  9. pmc The changing face of head and neck cancer in the 21st century: the impact of HPV on the epidemiology and pathology of oral cancer
    William H Westra
    Department of Pathology and Otolaryngology Head and Neck Surgery, The Johns Hopkins Medical Institutions, The Weinberg Bldg, Room 2242, 401 N, Broadway, Baltimore, MD 21231, USA
    Head Neck Pathol 3:78-81. 2009
  10. ncbi request reprint Increased loss of chromosome 9p21 but not p16 inactivation in primary non-small cell lung cancer from smokers
    M Sanchez-Cespedes
    Department of Otolaryngology, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Cancer Res 61:2092-6. 2001

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. doi request reprint Detection of human papillomavirus in clinical samples
    William H Westra
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Otolaryngol Clin North Am 45:765-77. 2012
    ..This review addresses the current state of HPV detection and focuses on the importance, appropriate time, and need for HPV testing...
  2. pmc The morphologic profile of HPV-related head and neck squamous carcinoma: implications for diagnosis, prognosis, and clinical management
    William H Westra
    Departments of Pathology, Oncology, and Otolaryngology, Head and Neck Surgery, The Johns Hopkins Medical Institutions, 401 N Broadway, Weinberg 2242, Baltimore, MD 21231, USA
    Head Neck Pathol 6:S48-54. 2012
    ....
  3. ncbi request reprint Diagnostic difficulties in the classification and grading of salivary gland tumors
    William H Westra
    Departments of Pathology, and Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Int J Radiat Oncol Biol Phys 69:S49-51. 2007
  4. pmc Early glandular neoplasia of the lung
    W H Westra
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Respir Res 1:163-9. 2000
    ..Indeed, the genetic characterization of AAH promises to further our understanding of lung cancer development and might facilitate the design of novel strategies for early detection of lung cancer...
  5. doi request reprint Inverse relationship between human papillomavirus-16 infection and disruptive p53 gene mutations in squamous cell carcinoma of the head and neck
    William H Westra
    Department of Pathology and Otolaryngology, Head and Neck Surgery Division of Head and Neck Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Clin Cancer Res 14:366-9. 2008
    ..The purpose of this study was to discern whether HNSCCs differ in the type of p53 mutations as a function of HPV16 status...
  6. ncbi request reprint Fluorescence visualization in oral neoplasia: shedding light on an old problem
    William H Westra
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 2410, USA
    Clin Cancer Res 12:6594-7. 2006
  7. ncbi request reprint The impact of second opinion surgical pathology on the practice of head and neck surgery: a decade experience at a large referral hospital
    William H Westra
    Department of Pathology, The Johns Hopkins Medical Institutions, The Weinberg Cancer Center, Room 2242, 410 N Broadway, Baltimore, MD 21231, USA
    Head Neck 24:684-93. 2002
    ..Identification of anatomic regions and specimen types that are prone to diagnostic error will be helpful in guiding policy decisions regarding mandatory second opinion surgical pathology...
  8. ncbi request reprint Bizarre epithelial atypia of the sinonasal tract after chemotherapy
    W H Westra
    Departments of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 2410, USA
    Am J Surg Pathol 25:652-6. 2001
    ..These changes should not be interpreted as neoplastic in nature, a potential pitfall in the frozen section evaluation of a destructive nasal process in oncology patients...
  9. pmc The changing face of head and neck cancer in the 21st century: the impact of HPV on the epidemiology and pathology of oral cancer
    William H Westra
    Department of Pathology and Otolaryngology Head and Neck Surgery, The Johns Hopkins Medical Institutions, The Weinberg Bldg, Room 2242, 401 N, Broadway, Baltimore, MD 21231, USA
    Head Neck Pathol 3:78-81. 2009
    ..HPV-positive oropharyngeal cancer now dominates the head and neck oncology landscape, and its escalating incidence is impacting on diagnostic, preventive and therapeutic practices...
  10. ncbi request reprint Increased loss of chromosome 9p21 but not p16 inactivation in primary non-small cell lung cancer from smokers
    M Sanchez-Cespedes
    Department of Otolaryngology, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Cancer Res 61:2092-6. 2001
    ..The significant link between tobacco and loss of the p16 locus identifies additional genetic targets of smoking in the pathogenesis of lung cancer...
  11. ncbi request reprint Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers
    M Sanchez-Cespedes
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21206-2198, USA
    Cancer Res 61:1309-13. 2001
    ..These observations support the notion that lung cancers in nonsmokers arise through genetic alterations distinct from the common events observed in tumors from smokers...
  12. ncbi request reprint A putative oncogenic role for MPP11 in head and neck squamous cell cancer
    V A Resto
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    Cancer Res 60:5529-35. 2000
    ..Fluorescence in situ hybridization analysis done on the cell lines identified increased chromosome 7 copy number with a concomitant increase in MPP11 copy number. These results suggest an oncogenic role for MPP11 in HNSCC...
  13. ncbi request reprint Human telomerase reverse transcriptase (hTERT) gene expression in thyroid neoplasms
    M Saji
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Clin Cancer Res 5:1483-9. 1999
    ..These results suggest that hTERT expression may be more accurate than telomerase activity in distinguishing benign from malignant and may be measured in FNA samples from suspicious thyroid lesions...
  14. ncbi request reprint Allelic losses in OraTest-directed biopsies of patients with prior upper aerodigestive tract malignancy
    Z Guo
    Department of Otolaryngology, Division of Head and Neck Cancer Research, Johns Hopkins University, Baltimore, Maryland 21205-2196, USA
    Clin Cancer Res 7:1963-8. 2001
    ..In addition to detecting cancer, our study suggests that OraTest can detect clinically occult lesions in the progression pathway to oral cancer...
  15. ncbi request reprint Detection of head and neck squamous cell carcinoma among exfoliated oral mucosal cells by microsatellite analysis
    M F Spafford
    Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Clin Cancer Res 7:607-12. 2001
    ..This approach must now be refined and validated for the detection of clinically occult disease. Microsatellite analysis of oral samples may then become a valuable method for detecting and monitoring HNSCC...
  16. pmc Presence of HPV DNA in convalescent salivary rinses is an adverse prognostic marker in head and neck squamous cell carcinoma
    Alice Y Chuang
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, 601 North Caroline Street, 6th Floor, Baltimore, MD, USA
    Oral Oncol 44:915-9. 2008
    ..5 months. Patients with presence of HPV-16 DNA in surveillance salivary rinses are at significant risk for recurrence. Quantitative measurement of salivary HPV-16 DNA has promise for surveillance and early detection of recurrence...
  17. ncbi request reprint Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer
    Suhail K Mithani
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0910, USA
    Clin Cancer Res 13:4331-5. 2007
    ..To determine the timing of mitochondrial mutations in the progression of head and neck squamous cell carcinoma...
  18. ncbi request reprint Case-control study of human papillomavirus and oropharyngeal cancer
    Aimee R Kreimer
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    N Engl J Med 356:1944-56. 2007
    ..Substantial molecular evidence suggests a role for human papillomavirus (HPV) in the pathogenesis of oropharyngeal squamous-cell carcinoma, but epidemiologic data have been inconsistent...
  19. ncbi request reprint Epstein-Barr virus in head and neck cancer assessed by quantitative polymerase chain reaction
    David Goldenberg
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Laryngoscope 114:1027-31. 2004
    ..Using a sensitive method of detection, the authors sought to analyze the presence and quantity of EBV DNA in a large cohort of head and neck cancers...
  20. doi request reprint Prognostic significance of human papillomavirus in oropharyngeal squamous cell carcinomas
    Ahmad R Sedaghat
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Laryngoscope 119:1542-9. 2009
    ..In this study, we correlate clinical outcomes with HPV status for patients with oropharyngeal carcinomas who were uniformly treated with a concurrent chemoradiation treatment protocol...
  21. doi request reprint Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status
    Shanaz Begum
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 32:1044-50. 2008
    ..HPV16 detection thus permits resolution of a less aggressive component within a high-grade subtype of head and neck carcinoma...
  22. ncbi request reprint Immunohistochemical staining for thyroid transcription factor-1: a helpful aid in discerning primary site of tumor origin in patients with brain metastases
    M Srodon
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Hum Pathol 33:642-5. 2002
    ..TTF-1 immunohistochemistry could focus the search for the primary tumor for patients presenting with brain metastasis as the initial manifestation...
  23. ncbi request reprint Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer
    Shuiying Hu
    Department of Medicine, Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int J Cancer 119:2322-9. 2006
    ..These results suggest that aberrant methylation and hence silencing of TIMP3, SLC5A8, DAPK and RARbeta2, in association with BRAF mutation, may be an important step in PTC tumorigenesis and progression...
  24. ncbi request reprint Mitochondrial C-tract alteration in premalignant lesions of the head and neck: a marker for progression and clonal proliferation
    Patrick K Ha
    Departments of Otolaryngology, Head and Neck Cancer Research Division, Johns Hopkins Medical Institution, Baltimore, Maryland 21205, USA
    Clin Cancer Res 8:2260-5. 2002
    ..Somatic microsatellites at six loci were also tested on a subset of patients with metachronous or synchronous lesions found to possess a mitochondrial C-tract alteration...
  25. doi request reprint Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial
    Carole Fakhry
    Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    J Natl Cancer Inst 100:261-9. 2008
    ....
  26. ncbi request reprint Mitochondrial DNA alterations in thyroid cancer
    Betty C Tong
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Surg Oncol 82:170-3. 2003
    ..The objective of the present study was to examine a series of thyroid cancers for genetic alterations in this region...
  27. ncbi request reprint BRAF mutations in anaplastic thyroid carcinoma: implications for tumor origin, diagnosis and treatment
    Shahnaz Begum
    Department of Pathology, Head and Neck Surgery Division of Head and Neck Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Mod Pathol 17:1359-63. 2004
    ..The high frequency of BRAF mutations in a tumor that is generally regarded as uniformly fatal justifies evaluation of the potential benefits of anti-BRAF therapy for patients with anaplastic thyroid carcinoma...
  28. ncbi request reprint Giant cell reparative granuloma of the sphenoid bone
    A Aralasmak
    Russell H Morgan Department of Radiology and Radiological Science, Division of Neuroradiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    AJNR Am J Neuroradiol 27:1675-7. 2006
    ..However, the imaging and, occasionally, even the histologic findings may not suggest the specific diagnosis of GCRG, which must be added into the differential diagnosis of rapidly enlarging cystic bone lesions of the sphenoid bone...
  29. pmc Human papillomavirus and head and neck squamous cell carcinoma: recent evidence and clinical implications
    P T Hennessey
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, 601 N Caroline Street, 6th Floor, Baltimore, MD 21287 0910, USA
    J Dent Res 88:300-6. 2009
    ....
  30. ncbi request reprint BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer
    Mingzhao Xing
    Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 90:6373-9. 2005
    ..Use of BRAF mutation in papillary thyroid cancer (PTC) has the potential to improve risk stratification of this cancer...
  31. ncbi request reprint Neck dissection followed by radiotherapy or chemoradiotherapy for small primary oropharynx carcinoma with cervical metastasis
    Ashok N Reddy
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Laryngoscope 115:1196-200. 2005
    ..Our rationale for this algorithm and our results are examined...
  32. ncbi request reprint Mutational activation of BRAF is not a major event in sporadic childhood papillary thyroid carcinoma
    Eli Rosenbaum
    Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mod Pathol 18:898-902. 2005
    ..The increasing frequency of BRAF mutations as a function of age could help account for the well documented but poorly understood observation that age is a relevant prognostic indicator for patients with papillary thyroid carcinoma...
  33. ncbi request reprint Increased plasma DNA integrity index in head and neck cancer patients
    Wei Wen Jiang
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins Medical Institutions, Baltimore, MA, USA
    Int J Cancer 119:2673-6. 2006
    ..Lack of normalization of plasma DNA integrity index after surgical resection implies the persistence of a population of cells with an altered pattern of DNA degradation despite removal of malignancy...
  34. pmc Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment
    Sara I Pai
    Departments of Otolarygology, Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Annu Rev Pathol 4:49-70. 2009
    ....
  35. pmc Plasmablastic lymphoma involving the parotid gland
    Justin A Bishop
    Department of Pathology, The Johns Hopkins Medical Institutions, 600 N Wolfe St, Baltimore, MD 21287, USA
    Head Neck Pathol 4:148-51. 2010
    ....
  36. doi request reprint HPV-associated head and neck cancer: a virus-related cancer epidemic
    Shanthi Marur
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Lancet Oncol 11:781-9. 2010
    ....
  37. ncbi request reprint Genital HPVs in the aerodigestive tract: etiologic association with a subset of oropharyngeal/tonsillar cancers and with recurrent respiratory papillomatosis
    Keerti V Shah
    Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Dis Markers 23:235-45. 2007
  38. pmc Most basal-like breast carcinomas demonstrate the same Rb-/p16+ immunophenotype as the HPV-related poorly differentiated squamous cell carcinomas which they resemble morphologically
    Andrea Proctor Subhawong
    Department of Pathology, The Johns Hopkins Medical Institutions, MD 21231 2410, USA
    Am J Surg Pathol 33:163-75. 2009
    ..This subset may represent a more homogenous group than BLC as defined currently...
  39. ncbi request reprint Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis
    Julie Wu
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Dermatopathol 29:534-7. 2007
    ..Nevi also harbor the BRAF mutation. A description of mutation distribution in nevi could provide insight into the significance of this event in melanocytic tumorigenesis...
  40. doi request reprint Lymphoepithelial-like carcinoma of the oropharynx: a morphologic variant of HPV-related head and neck carcinoma
    Aatur D Singhi
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 34:800-5. 2010
    ..For lymphoepithelial carcinomas presenting as cervical lymph node metastases, testing for HPV and EBV is mandatory...
  41. ncbi request reprint Tissue distribution of human papillomavirus 16 DNA integration in patients with tonsillar carcinoma
    Shahnaz Begum
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 2410, USA
    Clin Cancer Res 11:5694-9. 2005
    ..This study was undertaken to discern the distribution and timing of HPV viral integration during tumorigenesis of the upper respiratory tract...
  42. ncbi request reprint Mutational analysis of BRAF in fine needle aspiration biopsies of the thyroid: a potential application for the preoperative assessment of thyroid nodules
    Yoram Cohen
    Department of Otolaryngology, and Head and Neck Surgery, Division of Head and Neck Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Cancer Res 10:2761-5. 2004
    ..Mutational analysis of FNAs could enhance selection of thyroid nodules for surgical removal...
  43. ncbi request reprint Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavity
    Patrick K Ha
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Clin Cancer Res 8:1203-9. 2002
    ....
  44. ncbi request reprint Anaplastic pseudothyroiditis
    Shehzad Basaria
    Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Bayview Medical Center, 4940 Eastern Avenue, A 5 E, Suite 503, Baltimore, MD 21224, USA
    Clin Endocrinol (Oxf) 56:553-5. 2002
    ..Histopathology showed destruction of the normal thyroid follicles by the invasion of the tumour. As this form of thyrotoxicosis resembles various thyroiditides, we hereby refer this condition as "anaplastic pseudothyroiditis"...
  45. ncbi request reprint Real-time gap ligase chain reaction: a rapid semiquantitative assay for detecting p53 mutation at low levels in surgical margins and lymph nodes from resected lung and head and neck tumors
    Susan V Harden
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA
    Clin Cancer Res 10:2379-85. 2004
    ..We have developed a real-time semiquantitative gap ligase chain reaction for detecting p53 point mutations at low level in a background of excess of wild-type DNA...
  46. ncbi request reprint A transcriptional progression model for head and neck cancer
    Patrick K Ha
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Clin Cancer Res 9:3058-64. 2003
    ..Significance analysis of microarrays, hierarchical clustering, and principal components analysis was used to identify genes with differential expression patterns...
  47. ncbi request reprint Intraoperative molecular margin analysis in head and neck cancer
    David Goldenberg
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Otolaryngol Head Neck Surg 130:39-44. 2004
    ..Tumor-specific molecular alterations in surgical margins have been shown to predict risk of local recurrence. However, assays used for these analyses are time-consuming and therefore cannot be used in the intraoperative setting...
  48. ncbi request reprint BRAF mutation in papillary thyroid carcinoma
    Yoram Cohen
    Division of Head and Neck Cancer Research, Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    J Natl Cancer Inst 95:625-7. 2003
    ..Our data suggest that activating BRAF mutations may be an important event in the development of papillary thyroid cancer...
  49. ncbi request reprint The N-methyl-D-aspartate receptor type 2A is frequently methylated in human colorectal carcinoma and suppresses cell growth
    M S Kim
    Department of Otolaryngology, Head and Neck Cancer Research Division, Johns Hopkins University, Baltimore, MD, USA
    Oncogene 27:2045-54. 2008
    ..Thus, NMDAR2A is commonly hypermethylated in primary human CRC and possesses tumor-suppressive activity...
  50. pmc Detection of Merkel cell virus and correlation with histologic presence of Merkel cell carcinoma in sentinel lymph nodes
    M Loyo
    Division of Head and Neck Cancer Research, Department of Otolaryngolgy Head and Neck Surgery, The Johns Hopkins School of Medicine, 1550 Orleans Street CRBII 5NC, Baltimore, MD 21321, USA
    Br J Cancer 106:1314-9. 2012
    ..The purpose of this study was to correlate Merkel cell virus (MCV) detection with histopathologic disease in sentinel lymph nodes (SLNs) of MCC...
  51. ncbi request reprint Intraoperative confirmation of parathyroid tissue during parathyroid exploration: a retrospective evaluation of the frozen section
    W H Westra
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21287 6417, USA
    Am J Surg Pathol 22:538-44. 1998
    ..In exceptional cases, however, the distinction between parathyroid and thyroid tissue may not be possible owing to a striking overlap seen at the clinical, gross, and microscopic levels...
  52. pmc Randomized prospective evaluation of frozen-section analysis for follicular neoplasms of the thyroid
    R Udelsman
    Departments of Surgery and Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Ann Surg 233:716-22. 2001
    ..To evaluate the clinical utility of frozen section in patients with follicular neoplasms of the thyroid in a randomized prospective trial...
  53. pmc AIS is an oncogene amplified in squamous cell carcinoma
    K Hibi
    Department of Otolaryngology Head and Neck Surgery, Division of Head and Neck Cancer Research, Johns Hopkins University School of Medicine, 818 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Proc Natl Acad Sci U S A 97:5462-7. 2000
    ..Overexpression of p40(AIS) in Rat 1a cells led to an increase in soft agar growth and tumor size in mice. Our results support the idea that AIS plays an oncogenic role in human cancer...
  54. ncbi request reprint Loss of chromosome arms 3p and 9p and inactivation of P16 (INK4a) in normal epithelium of patients with primary lung cancer
    O L Caballero
    Department of Otolaryngology-Head and Neck Surgery, Division of Head and Neck Cancer Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Genes Chromosomes Cancer 32:119-25. 2001
    ..Our results support the concept that the normal epithelial surface of large bronchi of patients with lung cancer has molecular changes suggestive of the outgrowth of numerous clonal foci...
  55. ncbi request reprint Detection of human papillomavirus-16 in fine-needle aspirates to determine tumor origin in patients with metastatic squamous cell carcinoma of the head and neck
    Shahnaz Begum
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 2410, USA
    Clin Cancer Res 13:1186-91. 2007
    ..HPV16 detection thus provides a strategy for localizing an important subset of HNSCCs, but this approach has not been applied to fine-needle aspiration specimens...
  56. doi request reprint Benign nodal nevi frequently harbor the activating V600E BRAF mutation
    Janis M Taube
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 33:568-71. 2009
    ..Indeed, these nodal nevi, like melanoma, frequently harbor activating mutations of the BRAF oncogene underscoring the potentially confounding impact of these inclusions on melanoma detection...
  57. pmc Oral human papillomavirus infection before and after treatment for human papillomavirus 16-positive and human papillomavirus 16-negative head and neck squamous cell carcinoma
    Yuri Agrawal
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    Clin Cancer Res 14:7143-50. 2008
    ..The prevalence of oral HPV infection before and after cancer therapy was investigated among patients with HPV16-positive and HPV16-negative HNSCC...
  58. ncbi request reprint Quantitative hypermethylation of NMDAR2B in human gastric cancer
    Jun Wei Liu
    Department of Otolaryngology, Division of Head and Neck Cancer Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Cancer 121:1994-2000. 2007
    ..Taken together, the above results suggest that NMDAR2B methylation is a common and important biologically relevant event in gastric cancer progression...
  59. ncbi request reprint Oncocytic neoplasms of the parotid gland: a 16-year institutional review
    Randolph B Capone
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Otolaryngol Head Neck Surg 126:657-62. 2002
    ..Mounting evidence has linked the presence of oncocytes to acquired mitochondrial dysfunction...
  60. pmc Identification of genes differentially expressed in benign versus malignant thyroid tumors
    Nijaguna B Prasad
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Clin Cancer Res 14:3327-37. 2008
    ..Therefore, other adjuncts, such as molecular-based diagnostic approaches are needed in the preoperative distinction of these lesions...
  61. ncbi request reprint Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing
    Yutaka Tokumaru
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Cancer Res 64:5982-7. 2004
    ..Pharmacological unmasking followed by microarray analysis is a powerful tool to identify key methylated tumor suppressor genes and relevant pathways...
  62. ncbi request reprint Use of single nucleotide polymorphism arrays to identify a novel region of loss on chromosome 6q in squamous cell carcinomas of the oral cavity
    Betty C Tong
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins Medical School, 818 Ross Research Building, 720 Rutland Avenue, Baltimore, Maryland 21205 2196, USA
    Head Neck 26:345-52. 2004
    ..A subset of patients with oral cavity squamous cell carcinoma(SCC), often of young age yet lacking a history of carcinogen exposure, has been identified, with no clear etiology for tumor development...
  63. ncbi request reprint Human telomerase reverse transcriptase gene expression and the surgical management of suspicious thyroid tumors
    Christopher B Umbricht
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Cancer Res 10:5762-8. 2004
    ..Fine-needle aspirates (FNAs) of the thyroid with indeterminate cytology are an example of such cases...
  64. ncbi request reprint Molecular margin analysis predicts local recurrence after sublobar resection of lung cancer
    Brett G Masasyesva
    Department of Otolaryngology, Head and Neck Cancer Research Division, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Int J Cancer 113:1022-5. 2005
    ..This methodology may be adaptable to a real-time format for intraoperative use...
  65. ncbi request reprint Mitochondrial DNA quantity increases with histopathologic grade in premalignant and malignant head and neck lesions
    Michael M Kim
    Head and Neck Cancer Research Division, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0910, USA
    Clin Cancer Res 10:8512-5. 2004
    ..We performed quantitative polymerase chain reaction for genes specific to mitochondrial and nuclear genomes to investigate relative mitochondrial abundance in a spectrum of dysplastic head and neck lesions...
  66. ncbi request reprint Detection of human papillomavirus in cervical lymph nodes: a highly effective strategy for localizing site of tumor origin
    Shahnaz Begum
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Cancer Res 9:6469-75. 2003
    ..Detection of HPV-16 or a surrogate marker may be useful in localizing tumor origin in patients who present with metastatic HNSCC...
  67. ncbi request reprint Exon 15 BRAF mutations are uncommon in melanomas arising in nonsun-exposed sites
    Yoram Cohen
    Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 10:3444-7. 2004
    ..An activating point mutation of the BRAF oncogene has been identified in a high proportion of cutaneous nevi and cutaneous melanomas, but its frequency in melanomas arising from the mucosa of head and neck is unknown...
  68. doi request reprint Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience
    Aatur D Singhi
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 2410, USA
    Cancer 116:2166-73. 2010
    ..These HPV-related cancers have a clinicopathologic profile that diverges from HPV-negative HNSCCs. Accordingly, HPV testing may soon become integrated into standard pathologic assessment of HNSCCs...
  69. ncbi request reprint Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects
    Mohammad Obaidul Hoque
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Clin Oncol 23:6569-75. 2005
    ..We sought to develop a test for prostate cancer based on a quantitative methylation-specific polymerase chain reaction (QMSP) of multiple genes in urine sediment DNA...
  70. ncbi request reprint Decreased mitochondrial DNA content in posttreatment salivary rinses from head and neck cancer patients
    Wei Wen Jiang
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Division, Johns Hopkins Medical Institutions, Baltimore, MD 21287 0910, USA
    Clin Cancer Res 12:1564-9. 2006
    ..We also examined the relationship between changes in mtDNA content and postoperative radiation therapy, smoking exposure, alcohol intake, and other clinical characteristics...
  71. doi request reprint Selective versus comprehensive neck dissection after chemoradiation for advanced oropharyngeal squamous cell carcinoma
    Alexander T Hillel
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, and the Johns Hopkins Head and Neck Surgery, Baltimore, MD 21231, USA
    Otolaryngol Head Neck Surg 141:737-42. 2009
    ..To determine whether a comprehensive neck dissection (CND) or a selective neck dissection (SND) is indicated as planned post-primary chemoradiation treatment (CRT) for patients with advanced oropharyngeal squamous cell carcinoma (OPSCC)...
  72. doi request reprint Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma
    Andre Lopes Carvalho
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0910, USA
    Clin Cancer Res 14:97-107. 2008
    ..To evaluate aberrant promoter hypermethylation of candidate tumor suppressor genes as a means to detect epigenetic alterations specific to solid tumors, including head and neck squamous cell carcinoma (HNSCC)...
  73. ncbi request reprint Quantitative assessment of promoter methylation profiles in thyroid neoplasms
    M O Hoque
    Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins Medical Institutions, 720 Rutland Avenue, Ross 743, Baltimore, Maryland 21205, USA
    J Clin Endocrinol Metab 90:4011-8. 2005
    ....
  74. doi request reprint Accurate classification of non-small cell lung carcinoma using a novel microRNA-based approach
    Justin A Bishop
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Cancer Res 16:610-9. 2010
    ..For example, hsa-miR-205 is a miRNA that is highly expressed in lung squamous cell carcinomas (SqCC) but not in lung adenocarcinomas. The differential expression of miRNAs could be exploited to distinguish these tumor types...
  75. pmc Long-term survival outcomes by smoking status in surgical and nonsurgical patients with non-small cell lung cancer: comparing never smokers and current smokers
    Robert A Meguid
    Division of Thoracic Surgery, Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Chest 138:500-9. 2010
    ..Survival outcomes of never smokers with non-small cell lung cancer (NSCLC) who undergo surgery are poorly characterized. This investigation compared surgical outcomes of never and current smokers with NSCLC...
  76. pmc Mitochondrial DNA mutation in normal margins and tumors of recurrent head and neck squamous cell carcinoma patients
    Santanu Dasgupta
    Department of Otolaryngology, Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 6221, Baltimore, MD 21287, USA
    Cancer Prev Res (Phila) 3:1205-11. 2010
    ..Analysis of mtDNA mutation could be an invaluable tool for molecular assessment of histologically negative margins and as well for monitoring HNSCC patients with locoregional recurrences...
  77. pmc Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck
    Shaoyu Zhou
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 104:7540-5. 2007
    ..Cancer-specific mitochondrial mutations may contribute to development of a malignant phenotype by direct genotoxic effects from increased reactive oxygen species production as well as induction of aerobic glycolysis and growth promotion...
  78. ncbi request reprint The role of second opinion pathology in the management of lesions of the head and neck
    Joseph D Kronz
    Department of Pathology, Mercy Medical Center, Nampa, Idaho, USA
    Curr Opin Otolaryngol Head Neck Surg 13:81-4. 2005
    ....
  79. ncbi request reprint Absence of V599E BRAF mutations in desmoplastic melanomas
    Jon M Davison
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer 103:788-92. 2005
    ..An activating point mutation of the BRAF oncogene has been identified in a high proportion of conventional cutaneous melanomas, but its frequency in the desmoplastic subtype is not known...
  80. ncbi request reprint DeltaNp63alpha up-regulates the Hsp70 gene in human cancer
    Guojun Wu
    Department of Otolaryngology Head and Neck Surgery, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Cancer Res 65:758-66. 2005
    ..Our study provides strong evidence for the physiologic association between DeltaNp63alpha and hsp70 in human cancer, thus further supporting the oncogenic potential of DeltaNp63alpha...
  81. ncbi request reprint The role of fine needle aspiration in the evaluation of parotid masses
    H H Alphs
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Curr Opin Otolaryngol Head Neck Surg 14:62-6. 2006
    ....
  82. ncbi request reprint Increased mitochondrial DNA content in saliva associated with head and neck cancer
    Wei Wen Jiang
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Division, Baltimore, MD 21287 0910, USA
    Clin Cancer Res 11:2486-91. 2005
    ..mtDNA content alteration is associated with HNSC independently of age and smoking exposure, can be detected in saliva, and may be due to elevation in mtDNA content in primary HNSC...
  83. ncbi request reprint The surgical pathology of salivary gland neoplasms
    W H Westra
    Departments of Pathology and Otolaryngology Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21287 6417, USA
    Otolaryngol Clin North Am 32:919-43. 1999
    ..This review emphasizes those morphologic patterns and cellular features that are most helpful in accurately classifying the primary epithelial neoplasms most commonly encountered in the major and minor salivary glands...
  84. ncbi request reprint Langerhans cell histiocytosis of the thyroid: a report of two cases and review of the literature
    R J Behrens
    National Cancer Institute, Bethesda, Maryland, USA
    Thyroid 11:697-705. 2001
    ..The first patient also received radiotherapy to his thyroid bed and scalp. We summarize the prior reported cases of LCH involving the thyroid and review the current treatment modalities used for LCH...
  85. ncbi request reprint Imaging findings of a hibernoma of the neck
    A C B S da Motta
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    AJNR Am J Neuroradiol 27:1658-9. 2006
    ..Computed tomography (CT) shows a well defined hypodense mass with septations. Magnetic resonance imaging (MRI) shows intermediate T1 and bright T2 signal of the mass and also demonstrates the characteristic marked contrast enhancement...
  86. ncbi request reprint Independent clonal origins of distinct tumor foci in multifocal papillary thyroid carcinoma
    Trisha M Shattuck
    Center for Molecular Medicine and Division of Endocrinology and Metabolism, University of Connecticut School of Medicine, Farmington, CT 06030 3101, USA
    N Engl J Med 352:2406-12. 2005
    ..Papillary thyroid carcinoma is frequently multifocal. We investigated whether noncontiguous tumor foci arise from intraglandular metastases from a single primary tumor or originate as unrelated clones derived from independent precursors...
  87. ncbi request reprint Toward early oral cancer detection using gene expression profiling of saliva: a thoroughfare or dead end?
    William H Westra
    Clin Cancer Res 10:8130-1. 2004
  88. ncbi request reprint Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study
    Steven A Ahrendt
    Department of Surgery, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Thorac Cardiovasc Surg 123:466-73; discussion 473-4. 2002
    ....
  89. doi request reprint Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon
    David Goldenberg
    The Department of Otolaryngology Head and Neck Surgery, Pennsylvania State Hershey Medical Center, Hershey, Pennsylvania, USA
    Head Neck 30:898-903. 2008
    ..A subset of oropharyngeal cancers contain human papillomavirus (HPV) DNA. The clinical and virologic associations of cystic nodal metastasis in head and neck cancer (HNSCC) were investigated...
  90. ncbi request reprint Utilization of fine-needle aspiration in patients undergoing thyroidectomy at two academic centers across the Atlantic
    Herbert Chen
    Department of Surgery, H4 750 Clinical Science Center, University of Wisconsin Medical School, 600 Highland Avenue, Madison, Wisconsin 53792, USA
    World J Surg 27:208-11. 2003
    ..Therefore in the hands of experienced thyroid surgeons, FNA can be utilized selectively based on the clinical presentation...
  91. ncbi request reprint Progression of microsatellite instability from premalignant lesions to tumors of the head and neck
    Patrick K Ha
    Head and Neck Cancer Research Division, Department of Otolaryngology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Int J Cancer 102:615-7. 2002
    ..Our findings indicate that MSI becomes increasingly more common as early dysplastic lesions progress to fully malignant HNSCC and confirm this as a supplemental detection method in microsatellite analysis...
  92. ncbi request reprint Solitary fibrous tumor of the thyroid: cytopathologic findings and differential diagnosis
    Anil V Parwani
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21287 6940, USA
    Diagn Cytopathol 28:213-6. 2003
    ..After the FNA diagnosis of "thyroid neoplasm" was made, the patient underwent a near-total thyroidectomy, which revealed a SFT. Differential diagnosis of spindle cell lesions in thyroid is also presented...
  93. ncbi request reprint Clinical and histopathologic features of recurrent vestibular schwannoma (acoustic neuroma) after stereotactic radiosurgery
    Daniel J Lee
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Otol Neurotol 24:650-60; discussion 660. 2003
    ..In addition, the underlying histopathologic changes to the tumor bed are not fully characterized. We seek to understand the clinical and histologic features of recurrent vestibular schwannoma after stereotactic radiation therapy...
  94. pmc Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung
    Julien D F Licchesi
    Cancer Biology Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Carcinogenesis 29:895-904. 2008
    ....
  95. pmc Increased thyroidal fat and goitrous hypothyroidism induced by interferon-gamma
    Hiroaki Kimura
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Int J Exp Pathol 86:97-106. 2005
    ....
  96. ncbi request reprint Management considerations for differentiated thyroid carcinoma presenting as a metastasis to the skull base
    Wojciech K Mydlarz
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Laryngoscope 117:1146-52. 2007
    ..To characterize the salient features of skull base metastasis from differentiated thyroid carcinoma, discuss the diagnostic and treatment strategies, and propose rational management guidelines for such tumors...
  97. ncbi request reprint Amyloidosis: role of fine-needle aspiration
    Shehzad Basaria
    Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Thyroid 13:313-4. 2003
  98. pmc Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression
    Brett G Masayesva
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:8715-20. 2004
    ..Loss and gain of chromosomal material in solid cancers can alter gene expression over large chromosomal regions, including multiple genes unrelated to malignant progression...
  99. ncbi request reprint Using gene expression profiling to differentiate benign versus malignant thyroid tumors
    Chiara Mazzanti
    Surgery Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 64:2898-903. 2004
    ..Our results support the premise that a molecular classification system for thyroid tumors is possible, and this in turn may provide a more accurate diagnostic tool for the clinician managing patients with suspicious thyroid lesions...
  100. ncbi request reprint Multifocal papillary thyroid carcinoma arising in a lingual thyroid: a case report
    Bradley Goldstein
    Head and Neck Cancer Research Division, Baltimore, MD 21205 2196, USA
    Arch Otolaryngol Head Neck Surg 128:1198-200. 2002
    ..We also discuss the management, diagnosis, and historical background of a malignant neoplasm arising in a lingual thyroid...
  101. ncbi request reprint The prevalence and significance of clinically unsuspected neoplasms in cervical lymph nodes
    M Ali Ansari-Lari
    Department of Pathology, The Weinberg Building, The Johns Hopkins Medical Institutions, Room 2242, 410 N Broadway, Baltimore, Maryland 21231, USA
    Head Neck 25:841-7. 2003
    ..We suspect that cervical lymph nodes removed from patients with known cancers of the head and neck might occasionally harbor clinically unsuspected neoplasms...