Elise Weerts

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Spontaneous and precipitated withdrawal after chronic intragastric administration of gamma-hydroxybutyrate (GHB) in baboons
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 179:678-87. 2005
  2. ncbi request reprint The adenosine receptor antagonist CGS15943 reinstates cocaine-seeking behavior and maintains self-administration in baboons
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 168:155-63. 2003
  3. ncbi request reprint The value of nonhuman primates in drug abuse research
    Elise M Weerts
    Division of Behavioral Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Exp Clin Psychopharmacol 15:309-27. 2007
  4. ncbi request reprint Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects
    Elise M Weerts
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 33:653-65. 2008
  5. pmc Attenuation of cocaine-seeking by GABA B receptor agonists baclofen and CGP44532 but not the GABA reuptake inhibitor tiagabine in baboons
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Bayview Behavioral Biology Research Center, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 89:206-13. 2007
  6. ncbi request reprint Environmental cues, alcohol seeking, and consumption in baboons: effects of response requirement and duration of alcohol abstinence
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Alcohol Clin Exp Res 30:2026-36. 2006
  7. ncbi request reprint Comparison of the behavioral effects of bretazenil and flumazenil in triazolam-dependent and non-dependent baboons
    Elise M Weerts
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, MD 21224, USA
    Eur J Pharmacol 519:103-13. 2005
  8. ncbi request reprint Effects of GABAergic modulators on food and cocaine self-administration in baboons
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Behavioral Biology Research Center, 5510 Nathan Shock Dr Suite 3000, Baltimore, MD 21224 6823, USA
    Drug Alcohol Depend 80:369-76. 2005
  9. pmc Positron emission tomography imaging of mu- and delta-opioid receptor binding in alcohol-dependent and healthy control subjects
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Alcohol Clin Exp Res 35:2162-73. 2011
  10. ncbi request reprint Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboons
    Amy K Goodwin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 189:71-82. 2006

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Spontaneous and precipitated withdrawal after chronic intragastric administration of gamma-hydroxybutyrate (GHB) in baboons
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 179:678-87. 2005
    ..gamma-Hydroxybuyrate (GHB) is a current drug of abuse that may produce physical dependence...
  2. ncbi request reprint The adenosine receptor antagonist CGS15943 reinstates cocaine-seeking behavior and maintains self-administration in baboons
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 168:155-63. 2003
    ..Caffeine and the adenosine A(1) and A(2A) receptor antagonist CGS15943 produce many behavioral effects that are similar to those produced by classic stimulant drugs (e.g. cocaine and amphetamines)...
  3. ncbi request reprint The value of nonhuman primates in drug abuse research
    Elise M Weerts
    Division of Behavioral Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Exp Clin Psychopharmacol 15:309-27. 2007
    ..This review focuses on important species differences between rodents and NHP and on the value of NHP in bridging the gap between rodents and humans to enhance the ability to generalize preclinical findings to human drug abuse...
  4. ncbi request reprint Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects
    Elise M Weerts
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 33:653-65. 2008
    ..Further investigations on the relationship between individual differences in delta-OR blockade by naltrexone and clinical outcomes should be explored...
  5. pmc Attenuation of cocaine-seeking by GABA B receptor agonists baclofen and CGP44532 but not the GABA reuptake inhibitor tiagabine in baboons
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Bayview Behavioral Biology Research Center, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 89:206-13. 2007
    ..These data indicate that GABA(B) agonists may reduce relapse to cocaine taking...
  6. ncbi request reprint Environmental cues, alcohol seeking, and consumption in baboons: effects of response requirement and duration of alcohol abstinence
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Alcohol Clin Exp Res 30:2026-36. 2006
    ..Animal models using chained schedules of alcohol reinforcement may be useful for examining such complex interactions...
  7. ncbi request reprint Comparison of the behavioral effects of bretazenil and flumazenil in triazolam-dependent and non-dependent baboons
    Elise M Weerts
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, MD 21224, USA
    Eur J Pharmacol 519:103-13. 2005
    ..Thus, bretazenil can function as an antagonist under conditions of benzodiazepine physical dependence...
  8. ncbi request reprint Effects of GABAergic modulators on food and cocaine self-administration in baboons
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Behavioral Biology Research Center, 5510 Nathan Shock Dr Suite 3000, Baltimore, MD 21224 6823, USA
    Drug Alcohol Depend 80:369-76. 2005
    ..Thus, the effects of alprazolam were specific for cocaine-maintained behavior, where as the effects of baclofen and CGP44532 were not...
  9. pmc Positron emission tomography imaging of mu- and delta-opioid receptor binding in alcohol-dependent and healthy control subjects
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Alcohol Clin Exp Res 35:2162-73. 2011
    ....
  10. ncbi request reprint Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboons
    Amy K Goodwin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 189:71-82. 2006
    ..Abuse of gamma-hydroxybutyrate (GHB) and its precursors is a public health concern. Gamma-butyrolactone (GBL) is found in commercially available products and, when ingested, is metabolized to GHB...
  11. pmc Dissociation of alcohol-seeking and consumption under a chained schedule of oral alcohol reinforcement in baboons
    Barbara J Kaminski
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Alcohol Clin Exp Res 32:1014-22. 2008
    ..Animal models using chained schedules of alcohol reinforcement may be useful for examining the complex interactions between cues and alcohol-seeking and -consumption...
  12. ncbi request reprint The discrimination of baboon grunt calls and human vowel sounds by baboons
    Robert D Hienz
    Division of Behavioral Biology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine Bayview Campus, Baltimore, Maryland 21224 6823, USA
    J Acoust Soc Am 116:1692-7. 2004
    ..No distinct advantages in discrimination performances were observed when the baboons discriminated these synthetic grunt vocalizations...
  13. ncbi request reprint Involvement of gamma-hydroxybutyrate (GHB) and GABA-B receptors in the acute behavioral effects of GHB in baboons
    Amy K Goodwin
    Johns Hopkins Bayview, Behavioral Biology Research Center, 5510 Nathan Shock Dr, Suite 3000, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 180:342-51. 2005
    ..Gamma-hydroxybutyrate (GHB) is used for the treatment of narcolepsy, but it is also a drug of abuse. The behavioral pharmacology of GHB is not well defined...
  14. ncbi request reprint Self-injection of flunitrazepam alone and in the context of methadone maintenance in baboons
    Nancy A Ator
    Behavioral Biology Research Center, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 5510 Nathan Shock Dr, Suite 3000, Baltimore, MD 21224, USA
    Drug Alcohol Depend 78:113-23. 2005
    ..Lower doses maintained higher self-injection during and shortly after methadone maintenance. Further research should explore the duration of higher self-injection rates following methadone maintenance...
  15. ncbi request reprint Cocaine's effects on the perception of socially significant vocalizations in baboons
    Robert D Hienz
    Division of Behavioral Biology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine Bayview Campus, 5510 Nathan Shock Drive, Suite 3000, Baltimore, MD 21224 6823, USA
    Pharmacol Biochem Behav 81:440-50. 2005
    ....
  16. ncbi request reprint Hormone responses to social stress in abstinent alcohol-dependent subjects and social drinkers with no history of alcohol dependence
    Cynthia A Munro
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 29:1133-8. 2005
    ..The aim of the present study was to compare ACTH, cortisol, and prolactin responses to a psychological stressor in abstinent alcohol-dependent subjects matched to healthy control subjects...
  17. ncbi request reprint Metabolism of gamma-hydroxybutyrate to d-2-hydroxyglutarate in mammals: further evidence for d-2-hydroxyglutarate transhydrogenase
    Eduard A Struys
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Metabolism 55:353-8. 2006
    ..Our results indicate that d-2-HG is a prominent GHB metabolite and provide further evidence for the existence of d-2-hydroxyglutarate transhydrogenase in different mammalian species...

Research Grants21

  1. Behavioral Pharmacology and GHB Physical Dependence
    Elise Weerts; Fiscal Year: 2007
    ..Physical dependence in the context of self-injection of GHB, GBL and 1,4-BD will also be evalauted. These studies will provide critical information on the behavioral pharmacology and dependence-producing effects of GHB. ..
  2. Preclinical Assessment of Medications for Alcohol Abuse
    Elise Weerts; Fiscal Year: 2009
    ..abstract_text> ..
  3. Behavioral Pharmacology and GHB Physical Dependence
    Elise M Weerts; Fiscal Year: 2010
    ..Physical dependence in the context of self-injection of GHB, GBL and 1,4-BD will also be evaluated. These studies will provide critical information on the behavioral pharmacology and dependence-producing effects of GHB. ..
  4. Preclinical Assessment of Medications for Alcohol Abuse
    Elise M Weerts; Fiscal Year: 2010
    ..abstract_text> ..
  5. Preclinical Assessment of Medications for Alcohol Abuse
    Elise Weerts; Fiscal Year: 2007
    ....
  6. Behavioral Pharmacology and GHB Physical Dependence
    Elise Weerts; Fiscal Year: 2007
    ..Physical dependence in the context of self-injection of GHB, GBL and 1,4-BD will also be evaluated. These studies will provide critical information on the behavioral pharmacology and dependence-producing effects of GHB. ..
  7. Cue-Reactivity and Alcohol Self-Dosing
    Elise Weerts; Fiscal Year: 2003
    ..This research will additionally provide important information on the behavioral processes underlying conditioned responses to drug-related cues in animals which may be relevant to cue-reactivity and drug-taking in humans. ..
  8. Dependence Potential of GHB, GBL and 1,4-BD
    Elise Weerts; Fiscal Year: 2003
    ..The results of these studies will provide critical information on the behavioral pharmacology and physical dependence potential of GHB and its precursors. ..
  9. Studies on the role of GABA in Cocaine Addiction
    Elise Weerts; Fiscal Year: 2005
    ..The results of these studies will increase our understanding of the role of GABA in the behavioral effects of cocaine and may lead to the development of better medications for the treatment of cocaine addiction. ..
  10. Alcohol Sensitivity and PET Derived Measures of Opioid Activity
    Elise M Weerts; Fiscal Year: 2010
    ..The results of the proposed research will increase our understanding of to the relationship between individual variability in the opioid system and subjective sensitivity to alcohol. ..