Research Topics
| Elise WeertsSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
The adenosine receptor antagonist CGS15943 reinstates cocaine-seeking behavior and maintains self-administration in baboonsElise M Weerts
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychopharmacology (Berl) 168:155-63. 2003..Caffeine and the adenosine A(1) and A(2A) receptor antagonist CGS15943 produce many behavioral effects that are similar to those produced by classic stimulant drugs (e.g. cocaine and amphetamines)...- The value of nonhuman primates in drug abuse researchElise M Weerts
Division of Behavioral Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Exp Clin Psychopharmacol 15:309-27. 2007..This review focuses on important species differences between rodents and NHP and on the value of NHP in bridging the gap between rodents and humans to enhance the ability to generalize preclinical findings to human drug abuse... - Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjectsElise M Weerts
Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Neuropsychopharmacology 33:653-65. 2008..Further investigations on the relationship between individual differences in delta-OR blockade by naltrexone and clinical outcomes should be explored... 
Attenuation of cocaine-seeking by GABA B receptor agonists baclofen and CGP44532 but not the GABA reuptake inhibitor tiagabine in baboonsElise M Weerts
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Bayview Behavioral Biology Research Center, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 89:206-13. 2007..These data indicate that GABA(B) agonists may reduce relapse to cocaine taking...- Environmental cues, alcohol seeking, and consumption in baboons: effects of response requirement and duration of alcohol abstinenceElise M Weerts
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Alcohol Clin Exp Res 30:2026-36. 2006..Animal models using chained schedules of alcohol reinforcement may be useful for examining such complex interactions... - Comparison of the behavioral effects of bretazenil and flumazenil in triazolam-dependent and non-dependent baboonsElise M Weerts
Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, MD 21224, USA
Eur J Pharmacol 519:103-13. 2005..Thus, bretazenil can function as an antagonist under conditions of benzodiazepine physical dependence... - Effects of GABAergic modulators on food and cocaine self-administration in baboonsElise M Weerts
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Behavioral Biology Research Center, 5510 Nathan Shock Dr Suite 3000, Baltimore, MD 21224 6823, USA
Drug Alcohol Depend 80:369-76. 2005..Thus, the effects of alprazolam were specific for cocaine-maintained behavior, where as the effects of baclofen and CGP44532 were not... - Positron emission tomography imaging of mu- and delta-opioid receptor binding in alcohol-dependent and healthy control subjectsElise M Weerts
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Alcohol Clin Exp Res 35:2162-73. 2011.... - Spontaneous and precipitated withdrawal after chronic intragastric administration of gamma-hydroxybutyrate (GHB) in baboonsElise M Weerts
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychopharmacology (Berl) 179:678-87. 2005..gamma-Hydroxybuyrate (GHB) is a current drug of abuse that may produce physical dependence... - Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboonsAmy K Goodwin
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychopharmacology (Berl) 189:71-82. 2006..CONCLUSIONS: These data indicate that, like GHB, chronic GBL dosing produced physical dependence that likely involved the GABA-B receptor... - Dissociation of alcohol-seeking and consumption under a chained schedule of oral alcohol reinforcement in baboonsBarbara J Kaminski
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Alcohol Clin Exp Res 32:1014-22. 2008..Animal models using chained schedules of alcohol reinforcement may be useful for examining the complex interactions between cues and alcohol-seeking and -consumption... - The discrimination of baboon grunt calls and human vowel sounds by baboonsRobert D Hienz
Division of Behavioral Biology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine Bayview Campus, Baltimore, Maryland 21224 6823, USA
J Acoust Soc Am 116:1692-7. 2004..No distinct advantages in discrimination performances were observed when the baboons discriminated these synthetic grunt vocalizations... - Involvement of gamma-hydroxybutyrate (GHB) and GABA-B receptors in the acute behavioral effects of GHB in baboonsAmy K Goodwin
Johns Hopkins Bayview, Behavioral Biology Research Center, 5510 Nathan Shock Dr, Suite 3000, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 180:342-51. 2005..CONCLUSIONS: These data indicate that while GABA-B receptors play a significant role in mediating the behavioral effects of GHB in baboon, the role of GHB receptors is less clear... - Self-injection of flunitrazepam alone and in the context of methadone maintenance in baboonsNancy A Ator
Behavioral Biology Research Center, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 5510 Nathan Shock Dr, Suite 3000, Baltimore, MD 21224, USA
Drug Alcohol Depend 78:113-23. 2005..Lower doses maintained higher self-injection during and shortly after methadone maintenance. Further research should explore the duration of higher self-injection rates following methadone maintenance... - Cocaine's effects on the perception of socially significant vocalizations in baboonsRobert D Hienz
Division of Behavioral Biology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine Bayview Campus, 5510 Nathan Shock Drive, Suite 3000, Baltimore, MD 21224 6823, USA
Pharmacol Biochem Behav 81:440-50. 2005.... - Hormone responses to social stress in abstinent alcohol-dependent subjects and social drinkers with no history of alcohol dependenceCynthia A Munro
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Alcohol Clin Exp Res 29:1133-8. 2005..The aim of the present study was to compare ACTH, cortisol, and prolactin responses to a psychological stressor in abstinent alcohol-dependent subjects matched to healthy control subjects... - Metabolism of gamma-hydroxybutyrate to d-2-hydroxyglutarate in mammals: further evidence for d-2-hydroxyglutarate transhydrogenaseEduard A Struys
Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
Metabolism 55:353-8. 2006..Our results indicate that d-2-HG is a prominent GHB metabolite and provide further evidence for the existence of d-2-hydroxyglutarate transhydrogenase in different mammalian species...
Research Grants
- Behavioral Pharmacology and GHB Physical DependenceElise Weerts; Fiscal Year: 2007..Physical dependence in the context of self-injection of GHB, GBL and 1,4-BD will also be evalauted. These studies will provide critical information on the behavioral pharmacology and dependence-producing effects of GHB. ..
- Preclinical Assessment of Medications for Alcohol AbuseElise Weerts; Fiscal Year: 2009..abstract_text> ..
- Behavioral Pharmacology and GHB Physical DependenceElise M Weerts; Fiscal Year: 2010..Physical dependence in the context of self-injection of GHB, GBL and 1,4-BD will also be evaluated. These studies will provide critical information on the behavioral pharmacology and dependence-producing effects of GHB. ..
- Preclinical Assessment of Medications for Alcohol AbuseElise M Weerts; Fiscal Year: 2010..abstract_text> ..
- Preclinical Assessment of Medications for Alcohol AbuseElise Weerts; Fiscal Year: 2007....
- Behavioral Pharmacology and GHB Physical DependenceElise Weerts; Fiscal Year: 2007..Physical dependence in the context of self-injection of GHB, GBL and 1,4-BD will also be evaluated. These studies will provide critical information on the behavioral pharmacology and dependence-producing effects of GHB. ..
- Cue-Reactivity and Alcohol Self-DosingElise Weerts; Fiscal Year: 2003..This research will additionally provide important information on the behavioral processes underlying conditioned responses to drug-related cues in animals which may be relevant to cue-reactivity and drug-taking in humans. ..
- Dependence Potential of GHB, GBL and 1,4-BDElise Weerts; Fiscal Year: 2003..The results of these studies will provide critical information on the behavioral pharmacology and physical dependence potential of GHB and its precursors. ..
- Studies on the role of GABA in Cocaine AddictionElise Weerts; Fiscal Year: 2005..The results of these studies will increase our understanding of the role of GABA in the behavioral effects of cocaine and may lead to the development of better medications for the treatment of cocaine addiction. ..
- Alcohol Sensitivity and PET Derived Measures of Opioid ActivityElise M Weerts; Fiscal Year: 2010..The results of the proposed research will increase our understanding of to the relationship between individual variability in the opioid system and subjective sensitivity to alcohol. ..