Maria J Wawer

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. ncbi Challenges in assessing associations between hormonal contraceptive use and the risks of HIV-1 acquisition and transmission
    Maria J Wawer
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Future Microbiol 7:315-8. 2012
  2. ncbi Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda
    Maria J Wawer
    Heilbrun Department of Population and Family Health, Columbia University Mailman School of Public Health, New York, New York 10032, USA
    J Infect Dis 191:1403-9. 2005
  3. ncbi Circumcision in HIV-infected men and its effect on HIV transmission to female partners in Rakai, Uganda: a randomised controlled trial
    Maria J Wawer
    Department of Population, Family and Reproductive Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 374:229-37. 2009
  4. ncbi Human papillomavirus incidence and clearance among HIV-positive and HIV-negative men in sub-Saharan Africa
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    AIDS 26:1555-65. 2012
  5. ncbi Determinants of incidence and clearance of high-risk human papillomavirus infections in rural Rakai, Uganda
    Mahboobeh Safaeian
    Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Cancer Epidemiol Biomarkers Prev 17:1300-7. 2008
  6. ncbi Male circumcision for the prevention of HSV-2 and HPV infections and syphilis
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    N Engl J Med 360:1298-309. 2009
  7. ncbi Male circumcision decreases acquisition and increases clearance of high-risk human papillomavirus in HIV-negative men: a randomized trial in Rakai, Uganda
    Ronald H Gray
    Department of Population, Family, and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 201:1455-62. 2010
  8. ncbi Effects of genital ulcer disease and herpes simplex virus type 2 on the efficacy of male circumcision for HIV prevention: Analyses from the Rakai trials
    Ronald H Gray
    Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Med 6:e1000187. 2009
  9. ncbi Clinical illness as a marker for initiation of HIV antiretroviral therapy in a rural setting, Rakai, Uganda
    Lisa A Spacek
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Int J STD AIDS 17:116-20. 2006
  10. ncbi Circumcision of HIV-infected men and transmission of human papillomavirus to female partners: analyses of data from a randomised trial in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Lancet Infect Dis 11:604-12. 2011

Collaborators

Detail Information

Publications70

  1. ncbi Challenges in assessing associations between hormonal contraceptive use and the risks of HIV-1 acquisition and transmission
    Maria J Wawer
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Future Microbiol 7:315-8. 2012
    ..Clinicians and clients need to balance potential HC risks with the known risks of unwanted pregnancies. Condom use remains essential for HIV prevention regardless of other contraceptive usage...
  2. ncbi Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda
    Maria J Wawer
    Heilbrun Department of Population and Family Health, Columbia University Mailman School of Public Health, New York, New York 10032, USA
    J Infect Dis 191:1403-9. 2005
    ..We estimated rates of human immunodeficiency virus (HIV)-1 transmission per coital act in HIV-discordant couples by stage of infection in the index partner...
  3. ncbi Circumcision in HIV-infected men and its effect on HIV transmission to female partners in Rakai, Uganda: a randomised controlled trial
    Maria J Wawer
    Department of Population, Family and Reproductive Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 374:229-37. 2009
    ..We assessed whether circumcision in HIV-infected men would reduce transmission of the virus to female sexual partners...
  4. ncbi Human papillomavirus incidence and clearance among HIV-positive and HIV-negative men in sub-Saharan Africa
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    AIDS 26:1555-65. 2012
    ..Penile and cervical cancer rates are highest in sub-Saharan Africa. However, little is known about the impact of HIV infection on HR-HPV acquisition and clearance among heterosexual men...
  5. ncbi Determinants of incidence and clearance of high-risk human papillomavirus infections in rural Rakai, Uganda
    Mahboobeh Safaeian
    Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Cancer Epidemiol Biomarkers Prev 17:1300-7. 2008
    ..We used self-administered vaginal swabs to assess the incidence and clearance of carcinogenic human papillomavirus (HPV) infections in rural Rakai, Uganda...
  6. ncbi Male circumcision for the prevention of HSV-2 and HPV infections and syphilis
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    N Engl J Med 360:1298-309. 2009
    ..We assessed the efficacy of male circumcision for the prevention of herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) infections and syphilis in HIV-negative adolescent boys and men...
  7. ncbi Male circumcision decreases acquisition and increases clearance of high-risk human papillomavirus in HIV-negative men: a randomized trial in Rakai, Uganda
    Ronald H Gray
    Department of Population, Family, and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 201:1455-62. 2010
    ..HR-HPV clearance was determined in men with prior genotype-specific HR-HPV infections. Rate ratios (RRs) and 95% confidence intervals (CIs) of HR-HPV acquisition were estimated by Poisson multiple regression...
  8. ncbi Effects of genital ulcer disease and herpes simplex virus type 2 on the efficacy of male circumcision for HIV prevention: Analyses from the Rakai trials
    Ronald H Gray
    Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Med 6:e1000187. 2009
    ..We assessed the role of GUD and HSV-2 in the protection against HIV afforded by MC...
  9. ncbi Clinical illness as a marker for initiation of HIV antiretroviral therapy in a rural setting, Rakai, Uganda
    Lisa A Spacek
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Int J STD AIDS 17:116-20. 2006
    ..6%; P = 0.001).HIV-related illness and WHO stage predicted disease progression. The specificity of clinical illness to predict viral load >55,000 copies/mL was high and could be used to rule in HIV disease requiring ART...
  10. ncbi Circumcision of HIV-infected men and transmission of human papillomavirus to female partners: analyses of data from a randomised trial in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Lancet Infect Dis 11:604-12. 2011
    ..We assessed whether circumcision of HIV-infected men would reduce the transmission of high-risk HPV to their female partners...
  11. ncbi Increased risk of incident HIV during pregnancy in Rakai, Uganda: a prospective study
    Ronald H Gray
    Johns Hopkins University, Bloomberg School of Public Health, Baltimore, USA
    Lancet 366:1182-8. 2005
    ..HIV acquisition is significantly higher during pregnancy than in the postpartum period. We did a prospective study to estimate HIV incidence rates during pregnancy and lactation...
  12. ncbi Determinants of HIV-1 load in subjects with early and later HIV infections, in a general-population cohort of Rakai, Uganda
    Ronald H Gray
    Department of Population and Family Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    J Infect Dis 189:1209-15. 2004
    ..GUD was consistently associated with higher HIV loads in subjects with incident and those with prevalent HIV infection, suggesting that treatment of GUD might reduce HIV viremia...
  13. ncbi Effect of circumcision of HIV-negative men on transmission of human papillomavirus to HIV-negative women: a randomised trial in Rakai, Uganda
    Maria J Wawer
    Department of Population, Family, and Reproductive Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    Lancet 377:209-18. 2011
    ..We assessed the efficacy of male circumcision to reduce prevalence and incidence of high-risk HPV in female partners of circumcised men...
  14. ncbi Effect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda
    Chelsea B Polis
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    AIDS 24:1937-44. 2010
    ..To assess the association between hormonal contraceptive use and HIV progression...
  15. ncbi Geographic HIV type 1 subtype distribution in Rakai district, Uganda
    Aleisha N Collinson-Streng
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD 21205, USA
    AIDS Res Hum Retroviruses 25:1045-8. 2009
    ..001) and more subtype D in southern clusters compared with northern clusters (78% vs. 65%, p < 0.008). These data illustrate the geographic complexity of subtype variation, which has important implications for HIV-1 vaccine design...
  16. ncbi Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial
    Ronald H Gray
    Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21215, USA
    Lancet 369:657-66. 2007
    ..Ecological and observational studies suggest that male circumcision reduces the risk of HIV acquisition in men. Our aim was to investigate the effect of male circumcision on HIV incidence in men...
  17. ncbi Male circumcision and anatomic sites of penile high-risk human papillomavirus in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    Int J Cancer 129:2970-5. 2011
    ..3% vs. 23.8%, respectively, p = 0.02) and circumcised men (21.5% vs. 15.5%, respectively, p = 0.24). MC reduced HR-HPV prevalence on both the coronal sulcus and shaft...
  18. ncbi Male circumcision and herpes simplex virus type 2 infection in female partners: a randomized trial in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    J Infect Dis 205:486-90. 2012
    ..17 cases per 100 person-years in the control arm (IRR, 0.85 [95% CI, .44-1.67]; P = .62). Contrary to findings in males, male circumcision did not affect HSV-2 acquisition among female partners...
  19. ncbi Stochastic simulation of the impact of antiretroviral therapy and HIV vaccines on HIV transmission; Rakai, Uganda
    Ronald H Gray
    Department of Population and Family Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA
    AIDS 17:1941-51. 2003
    ..ART in combination with a low efficacy vaccine could control the epidemic, if behavioral disinhibition is prevented...
  20. ncbi Effect of hormonal contraceptive use before HIV seroconversion on viral load setpoint among women in Rakai, Uganda
    Chelsea B Polis
    Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21202, USA
    J Acquir Immune Defic Syndr 56:125-30. 2011
    ..High viral load (VL) setpoint is a marker for rapid HIV progression. Few studies have examined whether use of hormonal contraception (HC) prior to HIV seroconversion affects VL setpoint...
  21. ncbi The effects of male circumcision on female partners' genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda
    Ronald H Gray
    Department of Population, Family, and Reproductive Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Obstet Gynecol 200:42.e1-7. 2009
    ..The objective of the study was to assess effects of male circumcision on female genital symptoms and vaginal infections...
  22. ncbi The effectiveness of male circumcision for HIV prevention and effects on risk behaviors in a posttrial follow-up study
    Ron Gray
    John Hopkins University, Baltimore, Maryland, USA
    AIDS 26:609-15. 2012
    ..The efficacy of male circumcision for HIV prevention over 2 years has been demonstrated in three randomized trials, but the longer-term effectiveness of male circumcision is unknown...
  23. ncbi Trends and correlates of hormonal contraceptive use among HIV-infected women in Rakai, Uganda, 1994-2006
    Chelsea B Polis
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Contraception 83:549-55. 2011
    ..Little is known about what factors correlate with hormonal contraceptive (HC) use in HIV-infected women in sub-Saharan Africa...
  24. ncbi Limitations of rapid HIV-1 tests during screening for trials in Uganda: diagnostic test accuracy study
    Ronald H Gray
    Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    BMJ 335:188. 2007
    ..To evaluate the limitations of rapid tests for HIV-1...
  25. ncbi Changes in the distribution of HIV type 1 subtypes D and A in Rakai District, Uganda between 1994 and 2002
    Samantha A Conroy
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, USA
    AIDS Res Hum Retroviruses 26:1087-91. 2010
    ..Over this 8-year period, the overall viral population in this region evolved toward the less virulent HIV-1A strain, most likely as a consequence of the faster disease progression and lower transmissibility of HIV-1D...
  26. ncbi Incident HIV and herpes simplex virus type 2 infection among men in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    AIDS 23:1589-94. 2009
    ..Herpes simplex virus type 2 (HSV-2) infection is associated with an increased risk for acquiring HIV, but little is known about the temporal sequence of these infections...
  27. ncbi Foreskin inflammation is associated with HIV and herpes simplex virus type-2 infections in Rakai, Uganda
    Kristine E Johnson
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, USA
    AIDS 23:1807-15. 2009
    ..We assessed foreskin inflammation associated with HIV and herpes simplex virus type 2 (HSV-2) in circumcised men...
  28. ncbi The rates of HIV superinfection and primary HIV incidence in a general population in Rakai, Uganda
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD 21205, USA
    J Infect Dis 206:267-74. 2012
    ..Human immunodeficiency virus (HIV) superinfection has been documented in high-risk individuals; however, the rate of superinfection among HIV-infected individuals within a general population remains unknown...
  29. ncbi The contribution of HIV-discordant relationships to new HIV infections in Rakai, Uganda
    Ron Gray
    Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA
    AIDS 25:863-5. 2011
    ..3% and 17.6% in married persons with unknown partner status, and 29.3% and 42.7% in the unmarried. Voluntary counseling and testing targeting discordant couples is unlikely to have a substantial impact in this setting...
  30. ncbi Decreased kidney function in a community-based cohort of HIV-Infected and HIV-negative individuals in Rakai, Uganda
    Gregory M Lucas
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 55:491-4. 2010
    ..However little is known about natural history HIV-related kidney disease or about background rates of reduced GFR in HIV-negative individuals in this region...
  31. ncbi The effects of placental malaria on mother-to-child HIV transmission in Rakai, Uganda
    Heena Brahmbhatt
    Department of Population and Family Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA
    AIDS 17:2539-41. 2003
    ..After multivariate adjustment for HIV viral load, the risk of MTCT associated with placental malaria was 2.89 and with HIV viral load the risk was 2.85. Interventions to prevent malaria during pregnancy could potentially reduce MTCT...
  32. ncbi Effects of HIV-1 and herpes simplex virus type 2 infection on lymphocyte and dendritic cell density in adult foreskins from Rakai, Uganda
    Kristine E Johnson
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Infect Dis 203:602-9. 2011
    ..To assess the cellular basis for these associations, we estimated immunologic cellular densities in foreskin tissue...
  33. ncbi Identification of HIV superinfection in seroconcordant couples in Rakai, Uganda, by use of next-generation deep sequencing
    Andrew D Redd
    Johns Hopkins University School of Medicine, Rangos Building, Room 530, 855 N Wolfe St, Baltimore, MD 21205, USA
    J Clin Microbiol 49:2859-67. 2011
    ..Our results indicate that NGS can be used for detection of HIV superinfection within large cohorts, which could assist in determining the incidence and the epidemiologic, virologic, and immunological correlates of this phenomenon...
  34. ncbi The natural history of bacterial vaginosis diagnosed by gram stain among women in Rakai, Uganda
    Marie E Thoma
    Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Sex Transm Dis 38:1040-5. 2011
    ..We report 2-year weekly vaginal flora changes based on Gram stain using lasagna plots...
  35. ncbi Utility of a point-of-care malaria rapid diagnostic test for excluding malaria as the cause of fever among HIV-positive adults in rural Rakai, Uganda
    Lisa A Mills
    Johns Hopkins School of Medicine, Division of Infectious Diseases, Baltimore, Maryland, USA
    Am J Trop Med Hyg 82:145-7. 2010
    ..7) and 99.1% (95% CI: 96.8-99.9), respectively. The rapid diagnostic test accurately ruled malaria "in or out" at the point-of-care, facilitating appropriate clinical management and averting unnecessary anti-malarial therapy...
  36. ncbi Experiences of sexual coercion among adolescent women: qualitative findings from Rakai district, Uganda
    Jennifer Wagman
    Johns Hopkins University, USA
    J Interpers Violence 24:2073-95. 2009
    ..This information may help violence prevention programs develop a range of strategies for addressing sexual coercion among adolescents...
  37. ncbi Effect of injectable contraceptive use on response to antiretroviral therapy among women in Rakai, Uganda
    Chelsea B Polis
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA Electronic address
    Contraception 86:725-30. 2012
    ..There is limited evidence on the effect of injectable contraception on response to antiretroviral therapy (ART)...
  38. ncbi Disclosure of HIV status on informed consent forms presents an ethical dilemma for protection of human subjects
    Ronald H Gray
    Department of Population and Family Health Sciences, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 41:246-8. 2006
    ....
  39. ncbi Comparison of a high-resolution melting assay to next-generation sequencing for analysis of HIV diversity
    Matthew M Cousins
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Microbiol 50:3054-9. 2012
    ..The HRM diversity assay is faster and less expensive than NGS, facilitating rapid analysis of large studies of HIV diversity and evolution...
  40. ncbi Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, Uganda
    Mahboobeh Safaeian
    Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 20852, USA
    Sex Transm Dis 34:429-36. 2007
    ..The objective of this study was to compare human papillomavirus (HPV) DNA testing between self-administered vaginal swabs and physician-administered cervical swabs in women from rural Rakai District, Uganda...
  41. ncbi HIV status and union dissolution in sub-Saharan Africa: the case of Rakai, Uganda
    Laura Porter
    Department of Population and Family Health Sciences, Johns Hopkins University, USA
    Demography 41:465-82. 2004
    ..These results highlight women's vulnerability to the social impact of HIV infection and the importance of dyadic studies of the disruption of unions...
  42. ncbi Reassessing the hypothesis on STI control for HIV prevention
    Ronald H Gray
    Johns Hopkins University, Baltimore, MD 21205, USA
    Lancet 371:2064-5. 2008
  43. ncbi Age differences in sexual partners and risk of HIV-1 infection in rural Uganda
    Robert J Kelly
    Department of Population and Family Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Acquir Immune Defic Syndr 32:446-51. 2003
    ..CONCLUSION: The age difference between young women and their male partners is a significant HIV risk factor, suggesting that high HIV prevalence in younger women is caused, in part, by transmission from older male partners...
  44. ncbi Combination implementation for HIV prevention: moving from clinical trial evidence to population-level effects
    Larry W Chang
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA Rakai Health Sciences Program, Entebbe, Uganda Social and Behavioral Interventions Program, Department of International Health, Baltimore, MD, USA Electronic address
    Lancet Infect Dis 13:65-76. 2013
    ..Only through careful consideration of how to implement and operationalise HIV prevention interventions will the HIV community be able to move from clinical trial evidence to population-level effects...
  45. ncbi Effect of daily aciclovir on HIV disease progression in individuals in Rakai, Uganda, co-infected with HIV-1 and herpes simplex virus type 2: a randomised, double-blind placebo-controlled trial
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Lancet Infect Dis 12:441-8. 2012
    ..We investigated the effect of daily suppressive aciclovir on HIV-1 disease progression in Rakai, Uganda...
  46. ncbi Randomised trials of HIV prevention
    Ronald H Gray
    Department of Population and Family Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Lancet 370:200-1. 2007
  47. ncbi Higher risk behaviour and rates of sexually transmitted diseases in Mwanza compared to Uganda may help explain HIV prevention trial outcomes
    Kate K Orroth
    London School of Hygiene and Tropical Medicine, London, UK
    AIDS 17:2653-60. 2003
    ....
  48. ncbi HIV dynamics and behaviour change as determinants of the impact of sexually transmitted disease treatment on HIV transmission in the context of the Rakai trial
    Eline L Korenromp
    Erasmus University Rotterdam, Department of Public Health, The Netherlands
    AIDS 16:2209-18. 2002
    ..To assess how the impact of sexually transmitted disease (STD) treatment on HIV incidence varies between stages of the HIV epidemic...
  49. ncbi Hormonal contraceptive use and HIV-1 infection in a population-based cohort in Rakai, Uganda
    Mohammed Kiddugavu
    Rakai Project, Uganda Virus Research Institute, Entebbe, Uganda
    AIDS 17:233-40. 2003
    ..12 (95% CI, 0.48-2.56) with oral contraceptive use and 0.84 (95%CI, 0.41-1.72) with injectable methods. CONCLUSION: Use of hormonal contraception is not associated with HIV acquisition after adjustment for behavioral confounding...
  50. ncbi Human immunodeficiency virus acquisition associated with genital ulcer disease and herpes simplex virus type 2 infection: a nested case-control study in Rakai, Uganda
    David Serwadda
    Institute of Public Health, Makerere University, Kampala, Uganda
    J Infect Dis 188:1492-7. 2003
    ..HIV load is increased in HSV-2-positive subjects who seroconverted, suggesting a role for treatment of HSV-2 infection in HSV-2-seropositive, dually infected individuals...
  51. ncbi Performance of a commercial, type-specific enzyme-linked immunosorbent assay for detection of herpes simplex virus type 2-specific antibodies in Ugandans
    Oliver Laeyendecker
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Clin Microbiol 42:1794-6. 2004
    ..A higher index cutoff value was required for optimal sensitivity and specificity, and overall performance of the assay was not affected by HIV status...
  52. ncbi The incidence of HIV-1 associated with injections and transfusions in a prospective cohort, Rakai, Uganda
    Noah Kiwanuka
    The Rakai Project, Uganda Virus Research Institute, Entebbe
    AIDS 18:342-4. 2004
    ..92 (CI 1.22-12.58) associated with transfusions. Sexual behaviours were significantly associated with HIV risk. Medical injections did not increase HIV acquisition in this rural Ugandan population...
  53. ncbi Voluntary HIV counseling and testing acceptance, sexual risk behavior and HIV incidence in Rakai, Uganda
    Joseph K B Matovu
    Rakai Health Sciences Program, Uganda Virus Research Institute, Entebbe, Uganda
    AIDS 19:503-11. 2005
    ..4/100 PY) of VCT. CONCLUSION: In this rural cohort where VCT services are free and accessible, there is self-selection of individuals accepting VCT, and no impact of VCT on subsequent risk behaviors or HIV incidence...
  54. ncbi Maternal self-medication and provision of nevirapine to newborns by women in Rakai, Uganda
    Joseph Kagaayi
    Rakai Health Sciences Program, Uganda Virus Research Institute, Entebbe, Uganda
    J Acquir Immune Defic Syndr 39:121-4. 2005
    ..5%, 95% confidence interval [CI]: 0.3%-16.6%). Mothers can administer nevirapine to themselves and their newborns and can achieve low rates of perinatal HIV infection...
  55. ncbi The incidence and prevalence of orphanhood associated with parental HIV infection: a population-based study in Rakai, Uganda
    Fredrick E Makumbi
    Rakai Health Sciences Program, Uganda Virus Research Institute, Entebbe, Uganda
    AIDS 19:1669-76. 2005
    ..7%). CONCLUSIONS: Parental HIV infection markedly increased the incidence of orphanhood, especially among younger children and the children of younger mothers...
  56. ncbi Higher HIV-1 incidence and genetic complexity along main roads in Rakai District, Uganda
    Miguel A Arroyo
    US Military HIV Research Program (USMHRP, Division of Retrovirology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    J Acquir Immune Defic Syndr 43:440-5. 2006
    ..4 to 47.7). CONCLUSIONS: HIV-1 incidence and genetic complexity are associated with geographic strata and population mobility in Rakai District and are important variables to be considered in planning and recruitment for vaccine trials...
  57. ncbi Repeat voluntary HIV counseling and testing (VCT), sexual risk behavior and HIV incidence in Rakai, Uganda
    Joseph K B Matovu
    Rakai Health Sciences Program Uganda Virus Research Institute, Entebbe, Uganda
    AIDS Behav 11:71-8. 2007
    ..6/100 py in first time acceptors and 1.6/100 py in non-acceptors. These data suggest a need for intensive risk-reduction counseling interventions targeting HIV-negative repeat VCT acceptors as a special risk group...
  58. ncbi The safety of adult male circumcision in HIV-infected and uninfected men in Rakai, Uganda
    Godfrey Kigozi
    Rakai Health Sciences Program, Entebbe, Uganda
    PLoS Med 5:e116. 2008
    ....
  59. ncbi Empirical observations underestimate the proportion of HIV infections attributable to sexually transmitted diseases in Mwanza and Rakai STD treatment trials: simulation results
    Ronald H Gray
    Sex Transm Dis 34:61; author reply 62. 2007
  60. ncbi Reduced fertility among HIV-infected women associated with viral load in Rakai district, Uganda
    Ruby H N Nguyen
    Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC 27709, USA
    Int J STD AIDS 17:842-6. 2006
    ..OR of live birth which was 12% of the previous viral load category. Our data suggest that there may be considerable differences in the ability to produce a live birth among HIV-positive women with high viral loads...
  61. ncbi Sexually transmitted infection management, safer sex promotion and voluntary HIV counselling and testing in the male circumcision trial, Rakai, Uganda
    Joseph Kb Matovu
    Rakai Health Sciences Programme, Uganda Virus Research Institute, Rakai, Uganda
    Reprod Health Matters 15:68-74. 2007
  62. ncbi The effect of male circumcision on sexual satisfaction and function, results from a randomized trial of male circumcision for human immunodeficiency virus prevention, Rakai, Uganda
    Godfrey Kigozi
    Rakai Health Sciences Program, Entebbe, Uganda
    BJU Int 101:65-70. 2008
    ..To investigate the relationship between adult male circumcision and sexual satisfaction and function in men, as observational studies on the effect of adult male circumcision on sexual satisfaction show conflicting results...
  63. ncbi Personal and community benefits and harms of research: views from Rakai, Uganda
    Carrie Thiessen
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, Maryland, USA
    AIDS 21:2493-501. 2007
    ..To assess what individuals in low-income countries perceive as benefits and harms of population-based HIV/STD research...
  64. ncbi Treatment of Trichomonas in pregnancy and adverse outcomes of pregnancy: a subanalysis of a randomized trial in Rakai, Uganda
    Godfrey G Kigozi
    Rakai Project, Uganda Virus Research Institute, Entebbe and Kampala, Uganda
    Am J Obstet Gynecol 189:1398-400. 2003
    ..This is consistent with a National Institute for Child Health and Human Development trial that found an excess of preterm births in children of women with Trichomonas vaginalis infection who were treated with metronidazole...
  65. ncbi Knowledge about vaccines and willingness to participate in preventive HIV vaccine trials: a population-based study, Rakai, Uganda
    Noah Kiwanuka
    Rakai Project, Uganda Virus Research Institute, Entebbe
    J Acquir Immune Defic Syndr 36:721-5. 2004
    ..However, there still is need for education on the potential role of preventive HIV vaccines in the control of the epidemic and the importance of vaccination for men, especially in the context of an HIV vaccine...
  66. ncbi Effectiveness of syphilis treatment using azithromycin and/or benzathine penicillin in Rakai, Uganda
    Mohammed G Kiddugavu
    Rakai Health Science Program, Uganda Virus Research Institute, Entebbe, Uganda
    Sex Transm Dis 32:1-6. 2005
    ..In low-titer infections, the 3 drug combinations were equally effective. HIV status did not affect cure rates...
  67. ncbi What proportion of episodes of gonorrhoea and chlamydia becomes symptomatic?
    Eline L Korenromp
    Department of Public Health, Erasmus University Rotterdam, The Netherlands
    Int J STD AIDS 13:91-101. 2002
    ..In populations with low treatment rates like Uganda, these probabilities can be very low. Here, health education should have priority in STD management programmes...
  68. ncbi WHO HIV clinical staging or CD4 cell counts for antiretroviral therapy eligibility assessment? An evaluation in rural Rakai district, Uganda
    Joseph Kagaayi
    Rakai Health Sciences Programme, Rakai, Uganda
    AIDS 21:1208-10. 2007
    ..Clinical criteria missed half the patients with CD4 cell counts of 200 cells/microl or less, highlighting the importance of CD4 cell measurements for the scale-up of ART provision in resource-limited settings...
  69. ncbi Might male circumcision be more protective against HIV in the highly exposed? An immunological hypothesis
    Maria J Wawer
    AIDS 19:2181-2. 2005
  70. ncbi Research benefits for hypothetical HIV vaccine trials: The views of Ugandans in the Rakai District
    Christine Grady
    Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    IRB 30:1-7. 2008