DAVID NEIL WATKINS
Affiliation: Johns Hopkins University
- Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancerD Neil Watkins
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Nature 422:313-7. 2003..This requirement for Hh pathway activation identifies a common lethal malignancy that may respond to pharmacological blockade of the Hh signalling pathway...
- Hedgehog signaling: progenitor phenotype in small-cell lung cancerD Neil Watkins
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Room 572, Baltimore, MD 21231, USA
Cell Cycle 2:196-8. 2003..How Hh signaling works to promote the malignant phenotype promises to be as important biologically as the promise of Hh pathway inhibitors are clinically...
- Hedgehog signalling in foregut malignancyD N Watkins
School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
Biochem Pharmacol 68:1055-60. 2004..This demonstrates an ongoing requirement for Hh signalling in these highly lethal and aggressive tumors. A novel therapeutic strategy is proposed using pharmacologic targeting of Hh dependent tumors with high potency pathway antagonists...
- Roles for HIC1 in neural development and tumor suppressionDAVID NEIL WATKINS; Fiscal Year: 2010..These findings are of direct relevance to many cancers, since deregulation of pathways known to be important in embryonic development can help us understand the basis of human malignancy. ..