Jian Wang

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Preclinical and clinical research on inflammation after intracerebral hemorrhage
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University, School of Medicine, 720 Rutland Avenue, Traylor Building 809, Baltimore, MD 21205, USA
    Prog Neurobiol 92:463-77. 2010
  2. ncbi Association between platelet activation and fibrinolysis in acute stroke patients
    Jian Wang
    Department of Neurology, The Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450003, PR China
    Neurosci Lett 384:305-9. 2005
  3. ncbi Inflammation after intracerebral hemorrhage
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Cereb Blood Flow Metab 27:894-908. 2007
  4. ncbi Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, School of Medicine, 720 Rutland Ave, Traylor Bldg 809, Baltimore, MD 21205, USA
    Brain 130:1643-52. 2007
  5. ncbi The development of an improved preclinical mouse model of intracerebral hemorrhage using double infusion of autologous whole blood
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Brain Res 1222:214-21. 2008
  6. ncbi Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage
    J Wang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Neuroscience 155:1133-41. 2008
  7. ncbi HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes
    Larissa A Shimoda
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, JHAAC 4A 52, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 291:L941-9. 2006
  8. ncbi Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes
    E Miles Whitman
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 294:L309-18. 2008
  9. ncbi Knockdown of stromal interaction molecule 1 attenuates store-operated Ca2+ entry and Ca2+ responses to acute hypoxia in pulmonary arterial smooth muscle
    Wenju Lu
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
    Am J Physiol Lung Cell Mol Physiol 297:L17-25. 2009
  10. ncbi Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia
    Wenju Lu
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
    Am J Physiol Lung Cell Mol Physiol 295:L104-13. 2008

Detail Information

Publications73

  1. ncbi Preclinical and clinical research on inflammation after intracerebral hemorrhage
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University, School of Medicine, 720 Rutland Avenue, Traylor Building 809, Baltimore, MD 21205, USA
    Prog Neurobiol 92:463-77. 2010
    ....
  2. ncbi Association between platelet activation and fibrinolysis in acute stroke patients
    Jian Wang
    Department of Neurology, The Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450003, PR China
    Neurosci Lett 384:305-9. 2005
    ..052, p < 0.0001). Our results indicate increased platelet activation and decreased fibrinolysis in patients with acute atherosclerotic ischemic stroke. Increased platelet activation may be correlated with decreased fibrinolysis...
  3. ncbi Inflammation after intracerebral hemorrhage
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Cereb Blood Flow Metab 27:894-908. 2007
    ..In the near future, additional strategies that target inflammation could offer exciting new promise in the therapeutic approach to ICH...
  4. ncbi Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, School of Medicine, 720 Rutland Ave, Traylor Bldg 809, Baltimore, MD 21205, USA
    Brain 130:1643-52. 2007
    ..These data reveal a previously unrecognized role of HO-1 in early brain injury after ICH. Thus, modulation of HO-1 signalling should be assessed further in clinical settings, especially for haemorrhagic states...
  5. ncbi The development of an improved preclinical mouse model of intracerebral hemorrhage using double infusion of autologous whole blood
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Brain Res 1222:214-21. 2008
    ....
  6. ncbi Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage
    J Wang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Neuroscience 155:1133-41. 2008
    ..The results provide additional evidence that HO2 plays a critical protective role against ICH-induced early brain injury...
  7. ncbi HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes
    Larissa A Shimoda
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, JHAAC 4A 52, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 291:L941-9. 2006
    ....
  8. ncbi Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes
    E Miles Whitman
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 294:L309-18. 2008
    ..These results suggest that the inhibition of K(v) channel expression and rise in [Ca(2+)](i) during chronic hypoxia may be the result of HIF-1-dependent induction of ET-1...
  9. ncbi Knockdown of stromal interaction molecule 1 attenuates store-operated Ca2+ entry and Ca2+ responses to acute hypoxia in pulmonary arterial smooth muscle
    Wenju Lu
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
    Am J Physiol Lung Cell Mol Physiol 297:L17-25. 2009
    ....
  10. ncbi Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia
    Wenju Lu
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
    Am J Physiol Lung Cell Mol Physiol 295:L104-13. 2008
    ..These results provide further support for the importance of SOCE in HPV and suggest that HPV is greater in distal than proximal PA because greater numbers and activation of SOCC in distal PASMC generate bigger increases in [Ca(2+)](i)...
  11. ncbi Ca2+ responses of pulmonary arterial myocytes to acute hypoxia require release from ryanodine and inositol trisphosphate receptors in sarcoplasmic reticulum
    Jian Wang
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 303:L161-8. 2012
    ....
  12. ncbi Ca2+ signaling in hypoxic pulmonary vasoconstriction: effects of myosin light chain and Rho kinase antagonists
    Jian Wang
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 293:L674-85. 2007
    ....
  13. ncbi Iron toxicity in mice with collagenase-induced intracerebral hemorrhage
    He Wu
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Cereb Blood Flow Metab 31:1243-50. 2011
    ..Results of our study indicate that iron toxicity contributes to collagenase-induced hemorrhagic brain injury and that reducing iron accumulation can reduce neuronal death and modestly improve functional outcome after ICH in mice...
  14. ncbi Efficacy of the lipid-soluble iron chelator 2,2'-dipyridyl against hemorrhagic brain injury
    He Wu
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Neurobiol Dis 45:388-94. 2012
    ..Post-treatment reduced brain lesion volume and edema and improved neurologic function. These results indicate that the lipid-soluble ferrous iron chelator 2,2'-dipyridyl can reduce brain injury and improve functional outcome after ICH...
  15. ncbi Ca2+ channels and chronic hypoxia
    Larissa A Shimoda
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
    Microcirculation 13:657-70. 2006
    ..We will also highlight future directions of investigation that might improve our understanding of the response of pulmonary vascular cells to chronic hypoxia...
  16. ncbi Heme oxygenase 2 is neuroprotective against intracerebral hemorrhage
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Bldg 364 365, Baltimore, MD 21205, USA
    Neurobiol Dis 22:473-6. 2006
    ....
  17. ncbi Role of Nrf2 in protection against intracerebral hemorrhage injury in mice
    Jian Wang
    Anesthesiology Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Free Radic Biol Med 43:408-14. 2007
    ..In combination, these results suggest that Nrf2 reduces ICH-induced early brain injury, possibly by providing protection against leukocyte-mediated free radical oxidative damage...
  18. ncbi Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells
    Jian Wang
    Division of Pulmonary and Critical Care Medicine, Institute for Cell Engineering, Baltimore, MD, USA
    Circ Res 98:1528-37. 2006
    ....
  19. ncbi Bone morphogenetic protein 4 enhances canonical transient receptor potential expression, store-operated Ca2+ entry, and basal [Ca2+]i in rat distal pulmonary arterial smooth muscle cells
    Wenju Lu
    Guangzhou Institute of Respiratory Diseases, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, People s Republic of China
    Am J Physiol Cell Physiol 299:C1370-8. 2010
    ....
  20. ncbi Chronic hypoxia inhibits Kv channel gene expression in rat distal pulmonary artery
    Jian Wang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1049-58. 2005
    ....
  21. ncbi Inhibition of hypoxic pulmonary vasoconstriction by antagonists of store-operated Ca2+ and nonselective cation channels
    Letitia Weigand
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    Am J Physiol Lung Cell Mol Physiol 289:L5-L13. 2005
    ....
  22. ncbi Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain
    Tao Wu
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    J Neuroinflammation 8:22. 2011
    ..This study examines the expression and cellular localization of COX-1, COX-2, microsomal PGES-1 (mPGES-1), mPGES-2, and cytosolic PGES (cPGES) in mice that have undergone hemorrhagic brain injury...
  23. ncbi Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury
    Jian Wang
    Department of Anesthesia, School of Medicine, Stanford University, Stanford, CA 94305-5117, USA
    Neuropharmacology 47:136-45. 2004
    ..Our data demonstrate protection of neurons by selective activation of epsilonPKC but enhanced astrocyte cell death with selective inhibition of betaIPKC. Thus PKC isozymes exhibit cell type-specific effects on ischemia-like injury...
  24. ncbi Acute hypoxia increases intracellular [Ca2+] in pulmonary arterial smooth muscle by enhancing capacitative Ca2+ entry
    Jian Wang
    Div. of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1059-69. 2005
    ..Our results suggest that acute hypoxia enhances CCE through SOCCs in distal PASMCs, leading to depolarization, secondary activation of VOCCs, and increased [Ca2+]i. SOCCs and CCE may play important roles in HPV...
  25. ncbi Chronic hypoxia elevates intracellular pH and activates Na+/H+ exchange in pulmonary arterial smooth muscle cells
    Eon J Rios
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Univ, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 289:L867-74. 2005
    ..Our findings indicate that exposure to CH caused increased pHi, NHE activity, and NHE1 expression, changes that may contribute to the development of pulmonary hypertension, in part, via pH-dependent induction of PASMC proliferation...
  26. ncbi Induced TRPC1 expression increases protein phosphatase 2A sensitizing intestinal epithelial cells to apoptosis through inhibition of NF-kappaB activation
    Bernard S Marasa
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Cell Physiol 294:C1277-87. 2008
    ..These results indicate that induced TRPC1 expression increases PP2A activity through Ca2+ influx and that increased PP2A sensitizes IECs to apoptosis as a result of NF-kappaB inactivation...
  27. ncbi Capacitative calcium entry and TRPC channel proteins are expressed in rat distal pulmonary arterial smooth muscle
    Jian Wang
    Div. of Pulmonary and Critical Care Medicine, The Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Cir, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 286:L848-58. 2004
    ..Our results suggest that CCE through TRPC-encoded Ca2+ channels could contribute to Ca2+ signaling in myocytes from distal intrapulmonary arteries...
  28. ncbi Divergent effects of caloric restriction on gene expression in normal and long-lived mice
    Michal M Masternak
    Department of Internal Medicine, Southern Illinois University, School of Medicine, Springfield 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 59:784-8. 2004
    ..Moreover, effects of dwarfism on the expression of the examined genes differed from the effects of CR, thus adding to the evidence that these long-lived mutants are not CR mimetics...
  29. ncbi The exon 1 Cys7Gly polymorphism within the betacellulin gene is associated with type 2 diabetes in African Americans
    Kristi Silver
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Diabetes 54:1179-84. 2005
    ..Further studies will be needed to understand the different roles that betacellulin polymorphisms play in susceptibility to type 2 diabetes in Caucasians and African Americans...
  30. ncbi Contribution of extracellular proteolysis and microglia to intracerebral hemorrhage
    Jian Wang
    Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY 11794-8451, USA
    Neurocrit Care 3:77-85. 2005
    ....
  31. ncbi Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhage
    Jian Wang
    Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY 11794-8651, USA
    Brain 128:1622-33. 2005
    ..Blockade of MMP activity during this critical period may have efficacy as a therapeutic strategy for the treatment of acute brain injury after ICH...
  32. ncbi Low-intensity voluntary running lowers blood pressure with simultaneous improvement in endothelium-dependent vasodilatation and insulin sensitivity in aged spontaneously hypertensive rats
    Meng Wei Sun
    Shanghai Research Institute of Sports Science, Shanghai, PR China
    Hypertens Res 31:543-52. 2008
    ....
  33. ncbi Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes
    Jian Wang
    Department of Medical Chemistry and Molecular Biology, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 102:11823-8. 2005
    ....
  34. ncbi [Effects of Naoluo Xintong Recipe on expression of HSP70 and bFGF in focal ischemia-reperfusion rats]
    Jian Wang
    Anhui College of Traditional Chinese Medicine, Hefei, Anhui Province 230038, China
    Zhong Xi Yi Jie He Xue Bao 2:271-3. 2004
    ..To investigate the possible beneficial effects of administration of Naoluo Xintong Recipe (NLXT) on the expression of HSP70 and bFGF in rats subjected to ischemia-reperfusion with qi deficiency and blood stasis syndrome...
  35. ncbi Tuftsin fragment 1-3 is beneficial when delivered after the induction of intracerebral hemorrhage
    Jian Wang
    Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY 11794-8651, USA
    Stroke 36:613-8. 2005
    ..CONCLUSIONS: Activated microglia/macrophages are important contributors to brain injury after ICH. MIF could be a valuable neuroprotective agent for the treatment of ICH, if treatment is initiated soon after the onset of hemorrhage...
  36. ncbi The effects of betamethasone (BM) on endothelial nitric oxide synthase (eNOS) expression in adult baboon femoral arterial endothelial cells
    Keiko Aida
    Center of Women's Health, New York University, New York, USA
    J Steroid Biochem Mol Biol 91:219-24. 2004
    ..We conclude that betamethasone can downregulate eNOS in cultured baboon endothelial cells via the glucocorticoid receptor pathway...
  37. ncbi Protective role of tuftsin fragment 1-3 in an animal model of intracerebral hemorrhage
    Jian Wang
    Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY 11794-8651, USA
    Ann Neurol 54:655-64. 2003
    ..Our results suggest that endogenous tPA assists in the clearance of intracerebral hemorrhage, presumably by affecting microglial activation, and MIF could be a valuable neuroprotective agent for the treatment of ICH...
  38. ncbi Gene expression of nitric oxide synthase by human umbilical vein endothelial cells: the effect of fetal plasma from pregnancy with umbilical placental vascular disease
    Xin Wang
    Department of Obstetrics and Gynaecology, University of Sydney at Westmead Hospital, New South Wales, Australia
    BJOG 110:53-8. 2003
    ..Our findings raise the possibility that the release of factors causing an up-regulation of iNOS and ecNOS in the endothelium in the fetal placenta may occur as part of an inflammatory response of the vascular endothelium to injury...
  39. ncbi A method for purifying enteric glia from rat myenteric plexus
    Pamela J Middlemiss
    Department of Medicine, McMaster University, 1200 Main Street West, HSC 4N71, Hamilton, Ontario, Canada L8N 3Z5
    In Vitro Cell Dev Biol Anim 38:188-90. 2002
    ..This method permits the culturing of large numbers of highly purified enteric glia without the use of expensive growth factors and complement-mediated cytolysis...
  40. ncbi Partial left ventricular unloading reverses contractile dysfunction and helps recover gene expressions in failing rat hearts
    Jian Wang
    Department of Cardiovasular Surgery, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Interact Cardiovasc Thorac Surg 7:27-31. 2008
    ..Partial left ventricular unloading regressed myocardial hypertrophy, reversed contractile dysfunction and normalized the mRNA (BNP, SERCA2a, beta(1) and beta(2)-AR) expressions of failing rat hearts...
  41. ncbi Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development
    James A McCormick
    Departments of Medicine and Molecular and Cellular Pharmacology, University of California, San Francisco, CA 94143, USA
    Mol Biol Cell 15:4278-88. 2004
    ..These data establish a role for SGK3 in normal postnatal hair follicle development, possibly involving effects on beta-catenin/Lef-1-mediated gene transcription...
  42. ncbi Lineage-specific responses to reduced embryonic Pax3 expression levels
    Hong Ming Zhou
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Dev Biol 315:369-82. 2008
    ..Thus, we have established that there are different minimum threshold requirements for Pax3 within different Pax3-expressing lineages...
  43. ncbi Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart
    Paige Snider
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA
    Circ Res 102:752-60. 2008
    ..Thus, peri(lacZ) knockouts provide a new model of viable latent valve disease...
  44. ncbi Arterial wall-determined risk factors to vascular diseases: a nonhuman primate model
    Xing Li Wang
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Cell Biochem Biophys 40:371-88. 2004
    ..The use of baboons from large pedigreed families in these studies will enable the identification of genes that interact with these environmental factors in determining individual risk of atherosclerosis...
  45. ncbi Herbal compound 861 regulates mRNA expression of collagen synthesis- and degradation-related genes in human hepatic stellate cells
    Lin Wang
    Beijing Genomic Institute, Beijing 101300, China
    World J Gastroenterol 14:1790-4. 2008
    ..To identify the role of herbal compound 861 (Cpd 861) in the regulation of mRNA expression of collagen synthesis- and degradation-related genes in human hepatic stellate cells (HSCs)...
  46. ncbi Transforming growth factor-beta-regulated miR-24 promotes skeletal muscle differentiation
    Qiang Sun
    State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, PR China
    Nucleic Acids Res 36:2690-9. 2008
    ....
  47. ncbi Genomic organization, transcript variants and comparative analysis of the human nucleoporin 155 (NUP155) gene
    Xiuqing Zhang
    Human Genome Center, Institute of Genetics, Chinese Academy of Sciences, Datun Road, Beijing 100101, China
    Gene 288:9-18. 2002
    ..Different gene orders in the human and Fugu genomic regions harboring the Nup155 orthologs advocate cautious interpretation of synteny in comparative genomic analysis even within the vertebrate lineage...
  48. ncbi Effects of anthocyanins and other phenolic compounds on the production of tumor necrosis factor alpha in LPS/IFN-gamma-activated RAW 264.7 macrophages
    Jian Wang
    Food Research Program, Pacific Agri-Food Research Centre, Agriculture and Agri-Food Canada, Summerland, British Columbia, Canada V0H 1Z0
    J Agric Food Chem 50:4183-9. 2002
    ..This is the first study to report the effects of anthocyanins and berry extracts on TNF-alpha production...
  49. ncbi [Study on the diagnostic significance of detecting the expression of AChR-gamma mRNA in rhabdomyosarcoma tissues]
    Bin Chang
    Department of Pathology, School of Medicine, Shihezi University, Shihezi 832002, China
    Zhonghua Bing Li Xue Za Zhi 32:413-6. 2003
    ..Cases of non-rhabdomyosarcomous small round cell tumors were all negative for AChR-gamma. CONCLUSION: AChR-gamma mRNA expression detected by molecular genetic methods is useful in diagnosis and differential diagnosis of rhabdomyosarcoma...
  50. ncbi Aldosterone stimulates angiotensin-converting enzyme expression and activity in rat neonatal cardiac myocytes
    Jian Wang
    Cardiovascular Research, Lilly Research Laboratory, Indianapolis, Indiana 46285, USA
    J Card Fail 8:167-74. 2002
    ....
  51. ncbi Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice
    Taku Okazaki
    Department of Medical Chemistry and Molecular Biology, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto, 606 8501, Japan
    Nat Med 9:1477-83. 2003
    ..These findings suggest that antibodies to cTnI induce heart dysfunction and dilatation by chronic stimulation of Ca2+ influx in cardiomyocytes...
  52. ncbi Enteric glia promote regeneration of transected dorsal root axons into spinal cord of adult rats
    Shucui Jiang
    Department of Medicine, McMaster University Health Sciences Centre 4N71, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Exp Neurol 181:79-83. 2003
    ..Thus, EG implantation may be beneficial in promoting axonal growth after central nervous system injury...
  53. ncbi Guanosine promotes myelination and functional recovery in chronic spinal injury
    Shucui Jiang
    Department of Medicine, McMaster University Health Sciences Centre, Hamilton, ON, Canada
    Neuroreport 14:2463-7. 2003
    ..These data indicate that guanosine-induced remyelination resulted, at least in part, from activation of endogenous oligodendrocyte lineage cells. These findings may have significant implications for chronic demyelinating diseases...
  54. ncbi Cloning and expression of earthworm fibrinolytic enzyme PM(246) in Pichia pastoris
    Yan Hu
    College of Life Sciences, Wuhan University, Wuhan 430072, People's Republic of China
    Protein Expr Purif 43:18-25. 2005
    ..The main physiochemical features of the EFE PM(246), including temperature stability, pH resistance, and sensitivity to some protein inhibitors, were also characterized...
  55. ncbi [Diagnostic significance and clinical application of specific chimeric genes in soft tissue sarcomas by RT-PCR using paraffin-embedded tissues: a study of 103 specimens]
    Feng Li
    Department of Anatomic and Surgical Pathology, Shihezi University School of Medicine, Shihezi 832002, China
    Zhonghua Yi Xue Za Zhi 84:1518-21. 2004
    ..To investigate the expression of the chimeric genes resulting from the specific chromosomal translocations in soft tissue sarcomas (STS) and its diagnostic significance for STS...
  56. ncbi Decreased intestinal glucose transport in the sgk3-knockout mouse
    Ciprian Sandu
    Department of Physiology I, University of Tubingen, Gmelinstr 5, 72076 Tuebingen, Germany
    Pflugers Arch 451:437-44. 2005
    ..The hypoglycemia might lead to enhanced food intake to compensate for impaired intestinal absorption...
  57. ncbi Real-time quantitative fluorescent reverse transcriptase-PCR for detection of severe acute respiratory syndrome-associated coronavirus RNA
    Weijun Chen
    Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China
    Mol Diagn 8:231-5. 2004
    ..The aim of our study was to construct a sensitive and specific real-time quantitative fluorescent (QF) reverse transcriptase (RT)-PCR method for the detection of SARS-CoV RNA...
  58. ncbi Comparative transcriptome analysis of Yersinia pestis in response to hyperosmotic and high-salinity stress
    Yanping Han
    Laboratory of Analytical Microbiology, National Center for Biomedical Analysis, Army Center for Microbial Detection and Research, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences (AMMS, Beijing 100071, China
    Res Microbiol 156:403-15. 2005
    ..pestis still executed common mechanisms to accommodate both types of stress...
  59. ncbi Regulation of endothelial nitric oxide synthase by small RNA
    Ming-Xiang Zhang
    Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:16967-72. 2005
    ..In summary, we demonstrated that intron-based microRNAs in eNOS can induce significant gene specific transcriptional suppression, which could be an effective negative feedback regulator for gene expression...
  60. ncbi Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice
    Taku Okazaki
    Department of Medical Chemistry and Molecular Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Exp Med 202:1643-8. 2005
    ..These observations suggest cross talk between two immunoinhibitory receptors, FcgammaRIIB and PD-1, on the regulation of autoimmune diseases...
  61. ncbi Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cel
    Ying H Shen
    Section of Adult Cardiac Surgery, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    J Biol Chem 281:7727-36. 2006
    ..Our findings suggest that resistin-mediated inhibition of insulin signaling and eNOS activation may contribute to cardiovascular diseases...
  62. ncbi Overexpression of copper/zinc superoxide dismutase decreases ischemia-like astrocyte injury
    Jian Wang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Free Radic Biol Med 38:1112-8. 2005
    ....
  63. ncbi Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice
    Seng Lai Tan
    Lilly Research Laboratories, Eli Lilly, Indianapolis, IN 46285, USA
    J Immunol 176:2872-9. 2006
    ..These results underscore the importance of PKC theta in the regulation of multiple T cell functions necessary for the development of autoimmune disease...
  64. ncbi Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1
    Tiziana Piepoli
    Department of Experimental Research and Diagnostics, Istituto Nazionale Neurologico C. Besta, Milan 20133, Italy
    Neuro Oncol 8:96-108. 2006
    ..0001). Thus, our data confirm that LGI1 is involved in cell-matrix interactions but suggest that its expression is not relevant in glial cells, implying that its role as a tumor suppressor in gliomas should be reconsidered...
  65. ncbi Renal function of gene-targeted mice lacking both SGK1 and SGK3
    Florian Grahammer
    Department of Physiology, University of Tuebingen, Tuebingen, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R945-50. 2006
    ..Additional lack of the isoform kinase does not substantially compound the phenotype for either property...
  66. ncbi Effect of nuclear actin on endothelial nitric oxide synthase expression
    Hesheng Ou
    Texas Heart Institute, St Luke s Episcopal Hospital, Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    Arterioscler Thromb Vasc Biol 25:2509-14. 2005
    ..In the present study, we investigated nuclear protein that binds the 27nt repeat and mediates eNOS expression...
  67. ncbi Effect of change in posture and exercise on repolarization in patients with long QT syndrome with HERG channel mutations
    Bruce D Walker
    Division of Cardiology and the Blackburn Genetics Laboratory, Roberts Research Institute, University of Western Ontario, London
    Can J Cardiol 21:33-8. 2005
    ..CONCLUSIONS: Abnormal repolarization in LQT2 is accentuated by a change in posture and exercise. Beta-blockers normalize the QTc prolongation elicited by such manoeuvres...
  68. ncbi Cloning, characterization and primary function study of a novel gene, Cymg1, related to family 2 cystatins
    Yang Xiang
    Human Reproductive and Stem Cell Engineering Institute, Central South University, Changsha 410078, China
    Acta Biochim Biophys Sin (Shanghai) 37:11-8. 2005
    ..All these indicate that Cymg1 might play an important role in mouse spermatogenesis and sexual maturation...
  69. ncbi Combination of 4-HPR and oral contraceptive in monkey model of chemoprevention of ovarian cancer
    Molly Brewer
    Department of Ob Gyn, University of Arizona, College of Medicine, Tucson, AZ 8572, USA
    Front Biosci 12:2260-8. 2007
    ..However, the combination of 4-HPR with OCP had a larger effect on expression of retinoid receptors. Apoptosis was detected in the 4-HPR group (equivalent dose: 200 mg/day)...
  70. ncbi Features of chronic allograft rejection on rat small intestine transplantation
    Hao Ma
    Department of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China
    Pediatr Transplant 11:165-72. 2007
    ..These data suggested that in the early stage (POD 60), there were more active and intense inflammatory events; later (POD 90) allografts manifested less inflammation and more arterial obliteration and fibrosis...
  71. ncbi Sequential observations show upregulation of TGF-beta1 at the early phase of chronic small bowel rejection in rats
    Haiyun Zhang
    Medical College, Nanjing University, Nanjing 210093, China
    Dig Dis Sci 52:3224-30. 2007
    ..Dynamic expressions of TGF-beta1 and Type I receptor mRNA shown by sequential protocol biopsies support the view that TGF-beta1 signaling is involved in the pathogenesis of chronic small bowel rejection, especially at the early phase...
  72. ncbi Does normothermic normokalemic simultaneous antegrade/retrograde perfusion improve myocardial oxygenation and energy metabolism for hypertrophied hearts?
    Jian Wang
    Institute for Biodiagnostics, National Research Council, Winnipeg, Manitoba, Canada
    Ann Thorac Surg 83:1751-8. 2007
    ..The present study was to determine whether NNSP improved myocardial oxygenation and energy metabolism of hypertrophied hearts relative to normothermic normokalemic antegrade perfusion (NNAP)...
  73. ncbi Haplotype-specific effects on endothelial NO synthase promoter efficiency: modifiable by cigarette smoking
    Jian Wang
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Arterioscler Thromb Vasc Biol 22:e1-4. 2002
    ....