Gary Wand

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Hormonal responses to psychological stress and family history of alcoholism
    Magdalena Uhart
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 31:2255-63. 2006
  2. pmc The relationship between naloxone-induced cortisol and delta opioid receptor availability in mesolimbic structures is disrupted in alcohol-dependent subjects
    Gary S Wand
    Departments of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Addict Biol 18:181-92. 2013
  3. pmc The relationship between naloxone-induced cortisol and mu opioid receptor availability in mesolimbic structures is disrupted in alcohol dependent subjects
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Alcohol 46:511-7. 2012
  4. pmc The anxious amygdala: CREB signaling and predisposition to anxiety and alcoholism
    Gary Wand
    Department of Medicine and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Invest 115:2697-9. 2005
  5. ncbi request reprint Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamine
    Lynn M Oswald
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuropsychopharmacology 30:821-32. 2005
  6. pmc Naloxone-induced cortisol predicts mu opioid receptor binding potential in specific brain regions of healthy subjects
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States
    Psychoneuroendocrinology 36:1453-9. 2011
  7. ncbi request reprint Association of amphetamine-induced striatal dopamine release and cortisol responses to psychological stress
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 32:2310-20. 2007
  8. ncbi request reprint Sex differences in striatal dopamine release in healthy adults
    Cynthia A Munro
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biol Psychiatry 59:966-74. 2006
  9. doi request reprint Treatment of pituitary adenomas using radiosurgery and radiotherapy: a single center experience and review of literature
    Daniel Q Sun
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurosurg Rev 34:181-9. 2010
  10. ncbi request reprint Impulsivity and chronic stress are associated with amphetamine-induced striatal dopamine release
    Lynn M Oswald
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, MD 21205, USA
    Neuroimage 36:153-66. 2007

Research Grants

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Hormonal responses to psychological stress and family history of alcoholism
    Magdalena Uhart
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 31:2255-63. 2006
    ..Furthermore, the findings suggest that the association between the hypothalamic-pituitary-adrenal axis hormonal response and the subjective perception of stress might be deranged in offspring of alcoholics...
  2. pmc The relationship between naloxone-induced cortisol and delta opioid receptor availability in mesolimbic structures is disrupted in alcohol-dependent subjects
    Gary S Wand
    Departments of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Addict Biol 18:181-92. 2013
    ....
  3. pmc The relationship between naloxone-induced cortisol and mu opioid receptor availability in mesolimbic structures is disrupted in alcohol dependent subjects
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Alcohol 46:511-7. 2012
    ..However pathways governing the relationship between naloxone-induced cortisol and mu opioid receptor availability are disrupted during early abstinence in AD subjects...
  4. pmc The anxious amygdala: CREB signaling and predisposition to anxiety and alcoholism
    Gary Wand
    Department of Medicine and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Invest 115:2697-9. 2005
    ..These provocative data suggest that a CREB-dependent neuromechanism underlies high anxiety-like and excessive alcohol-drinking behavior...
  5. ncbi request reprint Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamine
    Lynn M Oswald
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuropsychopharmacology 30:821-32. 2005
    ..The results are consistent with those of preclinical studies, suggesting that individual differences in HPA axis function may influence vulnerability to alcohol and drug dependence in humans...
  6. pmc Naloxone-induced cortisol predicts mu opioid receptor binding potential in specific brain regions of healthy subjects
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States
    Psychoneuroendocrinology 36:1453-9. 2011
    ..The opioid receptor antagonist naloxone is not merely a non-specific pharmacologic activator of the HPA axis; it provides information about individual differences in opioid receptor availability...
  7. ncbi request reprint Association of amphetamine-induced striatal dopamine release and cortisol responses to psychological stress
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 32:2310-20. 2007
    ..The results are consistent with preclinical findings showing an interrelationship between glucocorticoids and mesolimbic DA dynamics, which may influence psychostimulant self-administration in humans...
  8. ncbi request reprint Sex differences in striatal dopamine release in healthy adults
    Cynthia A Munro
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biol Psychiatry 59:966-74. 2006
    ..Sex differences in addictive disorders have been described. Preclinical studies have implicated the striatal dopamine system in these differences, but human studies have yet to substantiate these findings...
  9. doi request reprint Treatment of pituitary adenomas using radiosurgery and radiotherapy: a single center experience and review of literature
    Daniel Q Sun
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurosurg Rev 34:181-9. 2010
    ....
  10. ncbi request reprint Impulsivity and chronic stress are associated with amphetamine-induced striatal dopamine release
    Lynn M Oswald
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, MD 21205, USA
    Neuroimage 36:153-66. 2007
    ..No associations were observed between impulsivity or stress and cortisol responses to AMPH. The findings are consistent with notions that blunted DA responses represent an endophenotype for substance use disorders...
  11. doi request reprint Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype is associated with cortisol responsivity to naloxone challenge
    Mary Ann C Stephens
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 550 N Broadway, Ste 115, Baltimore, MD 21205, USA
    Psychopharmacology (Berl) 224:223-30. 2012
    ..Serotonin transporter (5-HTT) genotype has been studied as a marker of HPA axis dysregulation and for predicting risk of psychopathology, with mixed findings...
  12. ncbi request reprint Quantitative positron emission tomography studies of the serotonin transporter in humans previously treated with the appetite suppressants fenfluramine or dexfenfluramine
    Una D McCann
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Mol Imaging Biol 9:151-7. 2007
    ..This study used quantitative positron emission tomography (PET) with [(11)C] McN5652, a serotonin transporter (SERT) ligand to determine whether humans previously exposed to fenfluramines showed reductions in SERT binding parameters...
  13. ncbi request reprint Positron emission tomography imaging of the serotonin transporter in subjects with a history of alcoholism
    Zsolt Szabo
    Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Biol Psychiatry 55:766-71. 2004
    ..Our purpose was to investigate the serotonin transporter (SERT) in various brain regions of alcoholics using positron emission tomography and C-11 McN5652...
  14. ncbi request reprint Hormone responses to social stress in abstinent alcohol-dependent subjects and social drinkers with no history of alcohol dependence
    Cynthia A Munro
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 29:1133-8. 2005
    ..The aim of the present study was to compare ACTH, cortisol, and prolactin responses to a psychological stressor in abstinent alcohol-dependent subjects matched to healthy control subjects...
  15. ncbi request reprint Striatal dopamine release and family history of alcoholism
    Cynthia A Munro
    Department of Medicine, The John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 30:1143-51. 2006
    ....
  16. ncbi request reprint Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence
    Badreddine Bencherif
    Department of Radiology and Radiological Sciences, The Johns Hopkins University School of Medicine, 601 N Caroline Street, Baltimore, MD 21287, USA
    Biol Psychiatry 55:255-62. 2004
    ..The endogenous opioid system has been linked to alcohol dependence through animal and human studies. We investigated the relationship between alcohol craving and brain mu opioid receptors (mu-OR) in alcohol-dependent subjects...
  17. pmc Whites have a more robust hypothalamic-pituitary-adrenal axis response to a psychological stressor than blacks
    Rachel Y Chong
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Psychoneuroendocrinology 33:246-54. 2008
    ..We hypothesized that whites would differ from blacks in HPA axis response to a psychological stressor...
  18. ncbi request reprint Stress and the HPA Axis: Role of Glucocorticoids in Alcohol Dependence
    Mary Ann C Stephens
    Johns Hopkins University School of Medicine, Baltimore, Maryland
    Alcohol Res 34:468-83. 2012
    ..Finally, cortisol levels during abstinence may be useful clinical indicators of relapse vulnerability in alcohol-dependent people...
  19. pmc Outpatient treatment entry and health care utilization after a combined medical/substance abuse intervention for hospitalized medical patients
    THOMAS P O'TOOLE
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Gen Intern Med 17:334-40. 2002
    ..Drug-abusing patients utilize extensive amounts of health services resources, yet the acute medical hospitalization has typically not been used effectively to engage patients in substance abuse treatment...
  20. pmc Stress, alcohol and drug interaction: an update of human research
    Magdalena Uhart
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Addict Biol 14:43-64. 2009
    ..Ultimately, these efforts may improve our chances of designing treatment strategies that target addiction at the core of the disorder...
  21. ncbi request reprint Adrenal gland volume and dexamethasone-suppressed cortisol correlate with total daily salivary cortisol in African-American women
    Sherita Hill Golden
    Department of Medicine, Johns Hopkins University School of Medicine, Division of Endocrinology and Metabolism, 2024 East Monument Street, Suite 2 616, Baltimore, Maryland 21205, USA
    J Clin Endocrinol Metab 92:1358-63. 2007
    ..Alternative measures (salivary cortisol and adrenal gland volume) have not been systematically compared with 24-h urine free cortisol (UFC) in a healthy population...
  22. ncbi request reprint Higher levels and blunted diurnal variation of cortisol in frail older women
    Ravi Varadhan
    Division of Geriatric Medicine and Gerontology, School of Medicine, John Hopkins University, Baltimore, MD, USA
    J Gerontol A Biol Sci Med Sci 63:190-5. 2008
    ..We evaluated whether higher levels and blunted diurnal variation of salivary cortisol are cross-sectionally associated with frailty burden...
  23. ncbi request reprint Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects
    Elise M Weerts
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 33:653-65. 2008
    ..Further investigations on the relationship between individual differences in delta-OR blockade by naltrexone and clinical outcomes should be explored...
  24. ncbi request reprint Comparison of HPA axis hormonal responses to naloxone vs psychologically-induced stress
    Lynn M Oswald
    Department of Medicine and Psychiatry, The Johns Hopkins University School of Medicine, Ross Research Building, Room 863, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Psychoneuroendocrinology 29:371-88. 2004
    ..However, caution should be used in assuming that responses to naloxone directly parallel responses to physiological stress...
  25. ncbi request reprint Associations of salivary cortisol with cognitive function in the Baltimore memory study
    Brian K Lee
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 64:810-8. 2007
    ..Previous studies have concluded that an elevated level of cortisol is a risk factor for cognitive dysfunction and decline in aging but have been limited by sex exclusion, restricted cognitive batteries, and small sample sizes...
  26. doi request reprint On the shoulders of giants: Harvey Cushing's experience with acromegaly and gigantism at the Johns Hopkins Hospital, 1896-1912
    Courtney Pendleton
    Brain Tumor Stem Cell Laboratory, Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Pituitary 14:53-60. 2011
    ....
  27. ncbi request reprint The mu-opioid receptor polymorphism A118G predicts cortisol responses to naloxone and stress
    Rachel Y Chong
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 31:204-11. 2006
    ..We speculate that increased opioid avidity of the minor allele receptor contributes to the differential response to naloxone vs stress...
  28. ncbi request reprint Catechol-O-methyltransferase polymorphism alters hypothalamic-pituitary-adrenal axis responses to naloxone: a preliminary report
    Lynn M Oswald
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biol Psychiatry 55:102-5. 2004
    ..We hypothesized that subjects homozygous for the low-activity allele would have greater hypothalamic-pituitary-adrenal axis responses to opioid blockade than subjects with the high-activity allele...
  29. ncbi request reprint Gender differences in hypothalamic-pituitary-adrenal (HPA) axis reactivity
    Magdalena Uhart
    Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Room 863, Baltimore, MD 21205, USA
    Psychoneuroendocrinology 31:642-52. 2006
    ..Such differences are of interest as potential contributors to gender differences in health risks...
  30. doi request reprint Complications and death among elderly patients undergoing pituitary tumour surgery
    Rachel Grossman
    Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, Neuro Oncology Surgical Outcomes Research Laboratory, Baltimore, MD, USA
    Clin Endocrinol (Oxf) 73:361-8. 2010
    ..Preoperative determinants of surgical risk in elderly patients with pituitary tumour are not fully defined. The aim of this study was to quantify operative risk for these patients...
  31. pmc Single nucleotide polymorphism rs17849071 G/T in the PIK3CA gene is inversely associated with follicular thyroid cancer and PIK3CA amplification
    Jeffrey C Xing
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    PLoS ONE 7:e49192. 2012
    ..Thus, the present study uncovers an interesting phenomenon that rs17849071G/T is protective against FTC possibly through preventing PIK3CA amplifications...
  32. ncbi request reprint Hormone responses to citalopram in abstinent alcohol dependent subjects
    Deidre Gotjen
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 26:1625-31. 2002
    ....
  33. ncbi request reprint A mouse model of albright hereditary osteodystrophy generated by targeted disruption of exon 1 of the Gnas gene
    Emily L Germain-Lee
    Division of Pediatric Endocrinology, Department of Pediatrics, The Johns Hopkins University School of Medicine, Park Building, Suite 211, 600 North Wolfe Street, Baltimore, Maryland 21287 2520, USA
    Endocrinology 146:4697-709. 2005
    ..These findings confirm the tissue-specific paternal imprinting of GNAS and demonstrate that Galphas deficiency alone is sufficient to account for the hormone resistance of pseudohypoparathyroidism type 1a...
  34. pmc Dissociation of alcohol-seeking and consumption under a chained schedule of oral alcohol reinforcement in baboons
    Barbara J Kaminski
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Alcohol Clin Exp Res 32:1014-22. 2008
    ..Animal models using chained schedules of alcohol reinforcement may be useful for examining the complex interactions between cues and alcohol-seeking and -consumption...
  35. ncbi request reprint The cyclic AMP/protein kinase A signal transduction pathway modulates tolerance to sedative and hypothermic effects of ethanol
    Xioaju Yang
    Departments of Medicine and Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 27:1220-5. 2003
    ..The use of mice with heterozygous inactivation of the Gnas gene encoding Gsalpha allowed us to explore the relationship between tolerance to ethanol and cAMP/PKA signaling...
  36. pmc Apolipoprotein e genotype, cortisol, and cognitive function in community-dwelling older adults
    Brian K Lee
    Division of Occupational and Environmental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Psychiatry 165:1456-64. 2008
    ..Background: Elevated cortisol indicates stress and may be a risk factor for cognitive decline in aging. Genetic factors may influence individual vulnerability to the adverse effects of stress on cognitive function in aging...
  37. pmc Restraint stress and ethanol consumption in two mouse strains
    Xiaoju Yang
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 32:840-52. 2008
    ..This study examined the interaction between restraint stress and ethanol drinking in mice that consume low and high amounts of ethanol...
  38. ncbi request reprint The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 26:106-14. 2002
    ..It is plausible that persons expressing the mu-opioid receptor variant have altered HPA axis dynamics and altered responses to other physiological processes regulated through activation of the mu-opioid receptor...
  39. ncbi request reprint Relationship between cortisol responses to stress and personality
    Lynn M Oswald
    Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 31:1583-91. 2006
    ..These findings suggest that personality traits that have been traditionally associated with greater psychopathology were also associated with blunted HPA axis responses to stress...
  40. pmc Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice
    Richard S Lee
    Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
    Endocrinology 151:4332-43. 2010
    ..In the CORT-treated mice, we also observed changes in blood DNAm in Fkbp5. Our results suggest DNAm plays a role in mediating effects of glucocorticoid exposure on Fkbp5 function, with potential consequences for behavior...
  41. ncbi request reprint The role of peroxisomal ABC transporters in the mouse adrenal gland: the loss of Abcd2 (ALDR), Not Abcd1 (ALD), causes oxidative damage
    Jyh Feng Lu
    Johns Hopkins School of Medicine, Kennedy Krieger Institute, Baltimore, MD, USA
    Lab Invest 87:261-72. 2007
    ....
  42. pmc Improving the diversity climate in academic medicine: faculty perceptions as a catalyst for institutional change
    Eboni G Price
    Division of General Internal Medicine and Geriatrics, Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Acad Med 84:95-105. 2009
    ..To assess perceptions of underrepresented minority (URM) and majority faculty physicians regarding an institution's diversity climate, and to identify potential improvement strategies...
  43. ncbi request reprint Cortisol and adrenocorticotropic hormone responses to naloxone in subjects with high and low neuroticism
    Deborah L Mangold
    University of Texas at San Antonio, San Antonio, Texas 78249, USA
    Biol Psychiatry 60:850-5. 2006
    ..Studies link neuroticism with alterations in the Hypothalamic-Pituitary-Adrenal (HPA) stress response. We interrogated HPA axis dynamics as a function of neuroticism, employing the opioid receptor antagonist, naloxone...

Research Grants33

  1. HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND ALCOHOLISM
    Gary Wand; Fiscal Year: 2004
    ..Finally, 5 and 10-year follow-up studies will determine if high cortisol production or high dopamine release is independent risk factors for alcoholism. ..
  2. Genes, Stress and Psychopathology
    Gary Wand; Fiscal Year: 2007
    ..Results from these studies will inform the mental health field as well as the broader disciplines of neuroscience and metabolism. ..
  3. HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND ALCOHOLISM
    Gary Wand; Fiscal Year: 2007
    ..1969), and obsessive-compulsive disorder (Bogetto et al., 1999). ..
  4. ALCOHOLISM AND ENDOGENOUS OPIOID ACTIVITY
    Gary Wand; Fiscal Year: 2007
    ..Name Organization Role on Project Gary Wand, M. D. Mary McCaul, Ph. D. Mark Peyrot, Ph D...
  5. Genes, Stress and Psychopathology
    Gary S Wand; Fiscal Year: 2010
    ..Results from these studies will inform the mental health field as well as the broader disciplines of neuroscience and metabolism. ..
  6. HYPOTHALAMIC/PITUITARY/ADRENAL AXIS AND ALCOHOLISM
    Gary Wand; Fiscal Year: 1999
    ..The resultant knowledge will aid in the diagnosis, evaluation, management and prognosis of alcoholism. ..
  7. MOLEC/BIOCHEM ANALYSIS OF ADENYLYL CYCLASE IN ALCOHOLISM
    Gary Wand; Fiscal Year: 1993
    ..To this end, we will compare the dynamics of the Pituitary-Adrenal axis in family history positive and family history negative non-alcoholics...
  8. HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND ALCOHOLISM
    Gary S Wand; Fiscal Year: 2010
    ..1969), and obsessive-compulsive disorder (Bogetto et al., 1999). ..