Research Topics
| Gary WandSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Detail Information
Publications
Hormonal responses to psychological stress and family history of alcoholismMagdalena Uhart
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuropsychopharmacology 31:2255-63. 2006..Furthermore, the findings suggest that the association between the hypothalamic-pituitary-adrenal axis hormonal response and the subjective perception of stress might be deranged in offspring of alcoholics...
The relationship between naloxone-induced cortisol and delta opioid receptor availability in mesolimbic structures is disrupted in alcohol-dependent subjectsGary S Wand
Departments of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Addict Biol 18:181-92. 2013....
The relationship between naloxone-induced cortisol and mu opioid receptor availability in mesolimbic structures is disrupted in alcohol dependent subjectsGary S Wand
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Alcohol 46:511-7. 2012..However pathways governing the relationship between naloxone-induced cortisol and mu opioid receptor availability are disrupted during early abstinence in AD subjects...- Naloxone-induced cortisol predicts mu opioid receptor binding potential in specific brain regions of healthy subjectsGary S Wand
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States
Psychoneuroendocrinology 36:1453-9. 2011..The opioid receptor antagonist naloxone is not merely a non-specific pharmacologic activator of the HPA axis; it provides information about individual differences in opioid receptor availability... - Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamineLynn M Oswald
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neuropsychopharmacology 30:821-32. 2005..The results are consistent with those of preclinical studies, suggesting that individual differences in HPA axis function may influence vulnerability to alcohol and drug dependence in humans... - The anxious amygdala: CREB signaling and predisposition to anxiety and alcoholismGary Wand
Department of Medicine and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Clin Invest 115:2697-9. 2005..These provocative data suggest that a CREB-dependent neuromechanism underlies high anxiety-like and excessive alcohol-drinking behavior... - Association of amphetamine-induced striatal dopamine release and cortisol responses to psychological stressGary S Wand
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuropsychopharmacology 32:2310-20. 2007..The results are consistent with preclinical findings showing an interrelationship between glucocorticoids and mesolimbic DA dynamics, which may influence psychostimulant self-administration in humans... - Sex differences in striatal dopamine release in healthy adultsCynthia A Munro
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Biol Psychiatry 59:966-74. 2006..Our findings indicate that future studies should control for sex and may have implications for the interpretation of sex differences in other illnesses involving the striatum... - Impulsivity and chronic stress are associated with amphetamine-induced striatal dopamine releaseLynn M Oswald
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, MD 21205, USA
Neuroimage 36:153-66. 2007..No associations were observed between impulsivity or stress and cortisol responses to AMPH. The findings are consistent with notions that blunted DA responses represent an endophenotype for substance use disorders... - Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype is associated with cortisol responsivity to naloxone challengeMary Ann C Stephens
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 550 N Broadway, Ste 115, Baltimore, MD 21205, USA
Psychopharmacology (Berl) 224:223-30. 2012..Serotonin transporter (5-HTT) genotype has been studied as a marker of HPA axis dysregulation and for predicting risk of psychopathology, with mixed findings... - Positron emission tomography imaging of the serotonin transporter in subjects with a history of alcoholismZsolt Szabo
Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Biol Psychiatry 55:766-71. 2004..Differences in the radioligand distribution volumes are more significant before than after correction for nonspecific binding of the radioligand... - Quantitative positron emission tomography studies of the serotonin transporter in humans previously treated with the appetite suppressants fenfluramine or dexfenfluramineUna D McCann
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
Mol Imaging Biol 9:151-7. 2007..This study used quantitative positron emission tomography (PET) with [(11)C] McN5652, a serotonin transporter (SERT) ligand to determine whether humans previously exposed to fenfluramines showed reductions in SERT binding parameters... - Whites have a more robust hypothalamic-pituitary-adrenal axis response to a psychological stressor than blacksRachel Y Chong
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Psychoneuroendocrinology 33:246-54. 2008..We hypothesized that whites would differ from blacks in HPA axis response to a psychological stressor... - Striatal dopamine release and family history of alcoholismCynthia A Munro
Department of Medicine, The John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Alcohol Clin Exp Res 30:1143-51. 2006..CONCLUSIONS: Using amphetamine to provoke mesolimbic dopamine, we did not show significant differences in dopamine release, subjective responses, or stress hormone measures as a function of family history of alcoholism... - Hormone responses to social stress in abstinent alcohol-dependent subjects and social drinkers with no history of alcohol dependenceCynthia A Munro
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Alcohol Clin Exp Res 29:1133-8. 2005..The aim of the present study was to compare ACTH, cortisol, and prolactin responses to a psychological stressor in abstinent alcohol-dependent subjects matched to healthy control subjects... - Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependenceBadreddine Bencherif
Department of Radiology and Radiological Sciences, The Johns Hopkins University School of Medicine, 601 N Caroline Street, Baltimore, MD 21287, USA
Biol Psychiatry 55:255-62. 2004..The endogenous opioid system has been linked to alcohol dependence through animal and human studies. We investigated the relationship between alcohol craving and brain mu opioid receptors (mu-OR) in alcohol-dependent subjects... - Outpatient treatment entry and health care utilization after a combined medical/substance abuse intervention for hospitalized medical patientsTHOMAS P O'TOOLE
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
J Gen Intern Med 17:334-40. 2002..Drug-abusing patients utilize extensive amounts of health services resources, yet the acute medical hospitalization has typically not been used effectively to engage patients in substance abuse treatment... - Adrenal gland volume and dexamethasone-suppressed cortisol correlate with total daily salivary cortisol in African-American womenSherita Hill Golden
Department of Medicine, Johns Hopkins University School of Medicine, Division of Endocrinology and Metabolism, 2024 East Monument Street, Suite 2 616, Baltimore, Maryland 21205, USA
J Clin Endocrinol Metab 92:1358-63. 2007..Alternative measures (salivary cortisol and adrenal gland volume) have not been systematically compared with 24-h urine free cortisol (UFC) in a healthy population... - Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjectsElise M Weerts
Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Neuropsychopharmacology 33:653-65. 2008..Further investigations on the relationship between individual differences in delta-OR blockade by naltrexone and clinical outcomes should be explored... - Higher levels and blunted diurnal variation of cortisol in frail older womenRavi Varadhan
Division of Geriatric Medicine and Gerontology, School of Medicine, John Hopkins University, Baltimore, MD, USA
J Gerontol A Biol Sci Med Sci 63:190-5. 2008..We evaluated whether higher levels and blunted diurnal variation of salivary cortisol are cross-sectionally associated with frailty burden... - Stress, alcohol and drug interaction: an update of human researchMagdalena Uhart
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Addict Biol 14:43-64. 2009..Ultimately, these efforts may improve our chances of designing treatment strategies that target addiction at the core of the disorder... - Comparison of HPA axis hormonal responses to naloxone vs psychologically-induced stressLynn M Oswald
Department of Medicine and Psychiatry, The Johns Hopkins University School of Medicine, Ross Research Building, Room 863, 720 Rutland Avenue, Baltimore, MD 21205, USA
Psychoneuroendocrinology 29:371-88. 2004..However, caution should be used in assuming that responses to naloxone directly parallel responses to physiological stress... - Associations of salivary cortisol with cognitive function in the Baltimore memory studyBrian K Lee
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Arch Gen Psychiatry 64:810-8. 2007..Previous studies have concluded that an elevated level of cortisol is a risk factor for cognitive dysfunction and decline in aging but have been limited by sex exclusion, restricted cognitive batteries, and small sample sizes... - Treatment of pituitary adenomas using radiosurgery and radiotherapy: a single center experience and review of literatureDaniel Q Sun
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Neurosurg Rev 34:181-9. 2010.... - Catechol-O-methyltransferase polymorphism alters hypothalamic-pituitary-adrenal axis responses to naloxone: a preliminary reportLynn M Oswald
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Biol Psychiatry 55:102-5. 2004..We hypothesized that subjects homozygous for the low-activity allele would have greater hypothalamic-pituitary-adrenal axis responses to opioid blockade than subjects with the high-activity allele... - Gender differences in hypothalamic-pituitary-adrenal (HPA) axis reactivityMagdalena Uhart
Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Room 863, Baltimore, MD 21205, USA
Psychoneuroendocrinology 31:642-52. 2006..Such differences are of interest as potential contributors to gender differences in health risks... - The mu-opioid receptor polymorphism A118G predicts cortisol responses to naloxone and stressRachel Y Chong
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuropsychopharmacology 31:204-11. 2006..We speculate that increased opioid avidity of the minor allele receptor contributes to the differential response to naloxone vs stress... - Stress and the HPA Axis: Role of Glucocorticoids in Alcohol DependenceMary Ann C Stephens
Johns Hopkins University School of Medicine, Baltimore, Maryland
Alcohol Res 34:468-83. 2012..Finally, cortisol levels during abstinence may be useful clinical indicators of relapse vulnerability in alcohol-dependent people... - Hormone responses to citalopram in abstinent alcohol dependent subjectsDeidre Gotjen
Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Alcohol Clin Exp Res 26:1625-31. 2002..CONCLUSION: By probing the functional capacity of the serotonin system with citalopram, we did not detect physiologically relevant hormone differences between abstinent alcohol dependent men and controls... - Dissociation of alcohol-seeking and consumption under a chained schedule of oral alcohol reinforcement in baboonsBarbara J Kaminski
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Alcohol Clin Exp Res 32:1014-22. 2008..Animal models using chained schedules of alcohol reinforcement may be useful for examining the complex interactions between cues and alcohol-seeking and -consumption... - A mouse model of albright hereditary osteodystrophy generated by targeted disruption of exon 1 of the Gnas geneEmily L Germain-Lee
Division of Pediatric Endocrinology, Department of Pediatrics, The Johns Hopkins University School of Medicine, Park Building, Suite 211, 600 North Wolfe Street, Baltimore, Maryland 21287 2520, USA
Endocrinology 146:4697-709. 2005..These findings confirm the tissue-specific paternal imprinting of GNAS and demonstrate that Galphas deficiency alone is sufficient to account for the hormone resistance of pseudohypoparathyroidism type 1a... - The cyclic AMP/protein kinase A signal transduction pathway modulates tolerance to sedative and hypothermic effects of ethanolXioaju Yang
Departments of Medicine and Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Alcohol Clin Exp Res 27:1220-5. 2003..The mechanism through which cAMP/PKA signaling modulates the development of tolerance remains to be elucidated but may involve changes in phospho-CREB expression... - Relationship between cortisol responses to stress and personalityLynn M Oswald
Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuropsychopharmacology 31:1583-91. 2006..These findings suggest that personality traits that have been traditionally associated with greater psychopathology were also associated with blunted HPA axis responses to stress... - The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockadeGary S Wand
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuropsychopharmacology 26:106-14. 2002..It is plausible that persons expressing the mu-opioid receptor variant have altered HPA axis dynamics and altered responses to other physiological processes regulated through activation of the mu-opioid receptor... - Apolipoprotein e genotype, cortisol, and cognitive function in community-dwelling older adultsBrian K Lee
Division of Occupational and Environmental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Am J Psychiatry 165:1456-64. 2008..Background: Elevated cortisol indicates stress and may be a risk factor for cognitive decline in aging. Genetic factors may influence individual vulnerability to the adverse effects of stress on cognitive function in aging... - Restraint stress and ethanol consumption in two mouse strainsXiaoju Yang
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Alcohol Clin Exp Res 32:840-52. 2008..This study examined the interaction between restraint stress and ethanol drinking in mice that consume low and high amounts of ethanol... - Improving the diversity climate in academic medicine: faculty perceptions as a catalyst for institutional changeEboni G Price
Division of General Internal Medicine and Geriatrics, Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
Acad Med 84:95-105. 2009..To assess perceptions of underrepresented minority (URM) and majority faculty physicians regarding an institution's diversity climate, and to identify potential improvement strategies... - The role of peroxisomal ABC transporters in the mouse adrenal gland: the loss of Abcd2 (ALDR), Not Abcd1 (ALD), causes oxidative damageJyh Feng Lu
Johns Hopkins School of Medicine, Kennedy Krieger Institute, Baltimore, MD, USA
Lab Invest 87:261-72. 2007.... - Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in miceRichard S Lee
Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
Endocrinology 151:4332-43. 2010..In the CORT-treated mice, we also observed changes in blood DNAm in Fkbp5. Our results suggest DNAm plays a role in mediating effects of glucocorticoid exposure on Fkbp5 function, with potential consequences for behavior... - Cortisol and adrenocorticotropic hormone responses to naloxone in subjects with high and low neuroticismDeborah L Mangold
University of Texas at San Antonio, San Antonio, Texas 78249, USA
Biol Psychiatry 60:850-5. 2006..Studies link neuroticism with alterations in the Hypothalamic-Pituitary-Adrenal (HPA) stress response. We interrogated HPA axis dynamics as a function of neuroticism, employing the opioid receptor antagonist, naloxone...
Research Grants
- HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND ALCOHOLISMGary Wand; Fiscal Year: 2004..Finally, 5 and 10-year follow-up studies will determine if high cortisol production or high dopamine release is independent risk factors for alcoholism. ..
- Genes, Stress and PsychopathologyGary Wand; Fiscal Year: 2007..Results from these studies will inform the mental health field as well as the broader disciplines of neuroscience and metabolism. ..
- HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND ALCOHOLISMGary Wand; Fiscal Year: 2007..1969), and obsessive-compulsive disorder (Bogetto et al., 1999). ..
- ALCOHOLISM AND ENDOGENOUS OPIOID ACTIVITYGary Wand; Fiscal Year: 2007..Name Organization Role on Project Gary Wand, M. D. Mary McCaul, Ph. D. Mark Peyrot, Ph D...
- Genes, Stress and PsychopathologyGary S Wand; Fiscal Year: 2010..Results from these studies will inform the mental health field as well as the broader disciplines of neuroscience and metabolism. ..
- HYPOTHALAMIC/PITUITARY/ADRENAL AXIS AND ALCOHOLISMGary Wand; Fiscal Year: 1999..The resultant knowledge will aid in the diagnosis, evaluation, management and prognosis of alcoholism. ..
- MOLEC/BIOCHEM ANALYSIS OF ADENYLYL CYCLASE IN ALCOHOLISMGary Wand; Fiscal Year: 1993..To this end, we will compare the dynamics of the Pituitary-Adrenal axis in family history positive and family history negative non-alcoholics...
- HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND ALCOHOLISMGary S Wand; Fiscal Year: 2010..1969), and obsessive-compulsive disorder (Bogetto et al., 1999). ..