G Wand

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Catechol-O-methyltransferase polymorphism alters hypothalamic-pituitary-adrenal axis responses to naloxone: a preliminary report
    Lynn M Oswald
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biol Psychiatry 55:102-5. 2004
  2. ncbi The mu-opioid receptor polymorphism A118G predicts cortisol responses to naloxone and stress
    Rachel Y Chong
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 31:204-11. 2006
  3. ncbi The cAMP-protein kinase A signal transduction pathway modulates ethanol consumption and sedative effects of ethanol
    G Wand
    Departments of Medicine, Psychiatry, and Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 21:5297-303. 2001
  4. ncbi Confirmation that offspring from families with alcohol-dependent individuals have greater hypothalamic-pituitary-adrenal axis activation induced by naloxone compared with offspring without a family history of alcohol dependence
    G Wand
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 25:1134-9. 2001
  5. ncbi The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 26:106-14. 2002
  6. ncbi Restraint stress and ethanol consumption in two mouse strains
    Xiaoju Yang
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 32:840-52. 2008
  7. ncbi Comparison of HPA axis hormonal responses to naloxone vs psychologically-induced stress
    Lynn M Oswald
    Department of Medicine and Psychiatry, The Johns Hopkins University School of Medicine, Ross Research Building, Room 863, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Psychoneuroendocrinology 29:371-88. 2004
  8. ncbi Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence
    Badreddine Bencherif
    Department of Radiology and Radiological Sciences, The Johns Hopkins University School of Medicine, 601 N Caroline Street, Baltimore, MD 21287, USA
    Biol Psychiatry 55:255-62. 2004
  9. ncbi Whites have a more robust hypothalamic-pituitary-adrenal axis response to a psychological stressor than blacks
    Rachel Y Chong
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Psychoneuroendocrinology 33:246-54. 2008
  10. ncbi Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects
    Elise M Weerts
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 33:653-65. 2008

Collaborators

  • L Chandler
  • James Potash
  • Elise Weerts
  • Anil Kumar
  • Deborah Mangold
  • Lynn M Oswald
  • Magdalena Uhart
  • Rachel Y Chong
  • Cynthia A Munro
  • Mary E McCaul
  • Xiaoju Yang
  • Lynn Oswald
  • Brian K Lee
  • Ping-I Lin
  • Hiroto Kuwabara
  • Dean F Wong
  • James Brasic
  • Yun Zhou
  • Leena Choi
  • Mary McCaul
  • Badreddine Bencherif
  • Elizabeth Johnson
  • Kenner C Rice
  • Karen Bandeen-Roche
  • Shelun Wang
  • Thomas A Glass
  • Matthew J McAtee
  • Karen I Bolla
  • Brian S Schwartz
  • Gerald Nestadt
  • Rachel Chong
  • Mohab Alexander
  • Weiguo Ye
  • Peter Zandi
  • Amanda E Kalaydjian
  • Ping I Lin
  • Joanna R Mathena
  • Nese Ilgin
  • Robert F Dannals
  • Yu Kyeong Kim
  • Xioaju Yang
  • James J Frost

Detail Information

Publications19

  1. ncbi Catechol-O-methyltransferase polymorphism alters hypothalamic-pituitary-adrenal axis responses to naloxone: a preliminary report
    Lynn M Oswald
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biol Psychiatry 55:102-5. 2004
    ..We hypothesized that subjects homozygous for the low-activity allele would have greater hypothalamic-pituitary-adrenal axis responses to opioid blockade than subjects with the high-activity allele...
  2. ncbi The mu-opioid receptor polymorphism A118G predicts cortisol responses to naloxone and stress
    Rachel Y Chong
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 31:204-11. 2006
    ..We speculate that increased opioid avidity of the minor allele receptor contributes to the differential response to naloxone vs stress...
  3. ncbi The cAMP-protein kinase A signal transduction pathway modulates ethanol consumption and sedative effects of ethanol
    G Wand
    Departments of Medicine, Psychiatry, and Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 21:5297-303. 2001
    ..Thus, the cAMP-PKA signal transduction pathway is critical in modulating sensitivity to the sedative effects of ethanol as well as influencing alcohol consumption...
  4. ncbi Confirmation that offspring from families with alcohol-dependent individuals have greater hypothalamic-pituitary-adrenal axis activation induced by naloxone compared with offspring without a family history of alcohol dependence
    G Wand
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 25:1134-9. 2001
    ....
  5. ncbi The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 26:106-14. 2002
    ..It is plausible that persons expressing the mu-opioid receptor variant have altered HPA axis dynamics and altered responses to other physiological processes regulated through activation of the mu-opioid receptor...
  6. ncbi Restraint stress and ethanol consumption in two mouse strains
    Xiaoju Yang
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 32:840-52. 2008
    ..This study examined the interaction between restraint stress and ethanol drinking in mice that consume low and high amounts of ethanol...
  7. ncbi Comparison of HPA axis hormonal responses to naloxone vs psychologically-induced stress
    Lynn M Oswald
    Department of Medicine and Psychiatry, The Johns Hopkins University School of Medicine, Ross Research Building, Room 863, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Psychoneuroendocrinology 29:371-88. 2004
    ..However, caution should be used in assuming that responses to naloxone directly parallel responses to physiological stress...
  8. ncbi Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence
    Badreddine Bencherif
    Department of Radiology and Radiological Sciences, The Johns Hopkins University School of Medicine, 601 N Caroline Street, Baltimore, MD 21287, USA
    Biol Psychiatry 55:255-62. 2004
    ..The endogenous opioid system has been linked to alcohol dependence through animal and human studies. We investigated the relationship between alcohol craving and brain mu opioid receptors (mu-OR) in alcohol-dependent subjects...
  9. ncbi Whites have a more robust hypothalamic-pituitary-adrenal axis response to a psychological stressor than blacks
    Rachel Y Chong
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Psychoneuroendocrinology 33:246-54. 2008
    ..We hypothesized that whites would differ from blacks in HPA axis response to a psychological stressor...
  10. ncbi Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects
    Elise M Weerts
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 33:653-65. 2008
    ..Further investigations on the relationship between individual differences in delta-OR blockade by naltrexone and clinical outcomes should be explored...
  11. ncbi Cortisol and adrenocorticotropic hormone responses to naloxone in subjects with high and low neuroticism
    Deborah L Mangold
    University of Texas at San Antonio, San Antonio, Texas 78249, USA
    Biol Psychiatry 60:850-5. 2006
    ..Studies link neuroticism with alterations in the Hypothalamic-Pituitary-Adrenal (HPA) stress response. We interrogated HPA axis dynamics as a function of neuroticism, employing the opioid receptor antagonist, naloxone...
  12. ncbi Striatal dopamine release and family history of alcoholism
    Cynthia A Munro
    Department of Medicine, The John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 30:1143-51. 2006
    ..CONCLUSIONS: Using amphetamine to provoke mesolimbic dopamine, we did not show significant differences in dopamine release, subjective responses, or stress hormone measures as a function of family history of alcoholism...
  13. ncbi Gender differences in hypothalamic-pituitary-adrenal (HPA) axis reactivity
    Magdalena Uhart
    Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Room 863, Baltimore, MD 21205, USA
    Psychoneuroendocrinology 31:642-52. 2006
    ..Such differences are of interest as potential contributors to gender differences in health risks...
  14. ncbi Hormonal responses to psychological stress and family history of alcoholism
    Magdalena Uhart
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 31:2255-63. 2006
    ..Furthermore, the findings suggest that the association between the hypothalamic-pituitary-adrenal axis hormonal response and the subjective perception of stress might be deranged in offspring of alcoholics...
  15. ncbi Relationship between cortisol responses to stress and personality
    Lynn M Oswald
    Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 31:1583-91. 2006
    ..These findings suggest that personality traits that have been traditionally associated with greater psychopathology were also associated with blunted HPA axis responses to stress...
  16. ncbi Hormone responses to social stress in abstinent alcohol-dependent subjects and social drinkers with no history of alcohol dependence
    Cynthia A Munro
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 29:1133-8. 2005
    ..The aim of the present study was to compare ACTH, cortisol, and prolactin responses to a psychological stressor in abstinent alcohol-dependent subjects matched to healthy control subjects...
  17. ncbi Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamine
    Lynn M Oswald
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuropsychopharmacology 30:821-32. 2005
    ..The results are consistent with those of preclinical studies, suggesting that individual differences in HPA axis function may influence vulnerability to alcohol and drug dependence in humans...
  18. ncbi Recent advances in cyclic-adenosine monophosphate/protein kinase A signaling in ethanol-induced synaptic and behavioral alterations
    L Judson Chandler
    Alcohol Research Center and Department of Physiology Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Alcohol Clin Exp Res 28:1129-36. 2004
    ..Morrisett; (4) and The cAMP/PKA signal transduction pathway modulates ethanol consumption and sedative effects of ethanol, by Gary S. Wand...
  19. ncbi Apolipoprotein e genotype, cortisol, and cognitive function in community-dwelling older adults
    Brian K Lee
    Division of Occupational and Environmental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Psychiatry 165:1456-64. 2008
    ..Background: Elevated cortisol indicates stress and may be a risk factor for cognitive decline in aging. Genetic factors may influence individual vulnerability to the adverse effects of stress on cognitive function in aging...