Jeremy D Walston

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Frailty--the search for underlying causes
    Jeremy Walston
    Center on Aging and Health, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Sci Aging Knowledge Environ 2004:pe4. 2004
  2. pmc Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults
    Ravi Varadhan
    Raymond and Anna Lublin Professor of Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Rm 1A 62, Baltimore, MD 21224
    J Gerontol A Biol Sci Med Sci 69:165-73. 2014
  3. pmc Sarcopenia in older adults
    Jeremy D Walston
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Curr Opin Rheumatol 24:623-7. 2012
  4. ncbi request reprint Arg64 beta3-adrenoceptor variant and the components of energy expenditure
    Jeremy Walston
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Obes Res 11:509-11. 2003
  5. pmc Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults
    Jeremy D Walston
    Johns Hopkins Medical Institutions, Johns Hopkins University, John R Burton Pavilion, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Exp Gerontol 44:350-5. 2009
  6. ncbi request reprint The physical and biological characterization of a frail mouse model
    Jeremy Walston
    The Biology of Frailty Working Group, Johns Hopkins University, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 63:391-8. 2008
  7. ncbi request reprint IL-6 gene variation is associated with IL-6 and C-reactive protein levels but not cardiovascular outcomes in the Cardiovascular Health Study
    Jeremy D Walston
    Johns Hopkins Medical Institutions, Johns Hopkins University, John R Burton Pavilion, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Hum Genet 122:485-94. 2007
  8. ncbi request reprint Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults
    Jeremy Walston
    Department of Medicine, Johns Hopkins Medical Institutions, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Am Geriatr Soc 54:991-1001. 2006
  9. ncbi request reprint Serum antioxidants, inflammation, and total mortality in older women
    J Walston
    School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Epidemiol 163:18-26. 2006
  10. ncbi request reprint IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women
    J Walston
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Exp Gerontol 40:344-52. 2005

Detail Information

Publications60

  1. ncbi request reprint Frailty--the search for underlying causes
    Jeremy Walston
    Center on Aging and Health, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Sci Aging Knowledge Environ 2004:pe4. 2004
    ..Translational research programs that connect mechanisms related to aging, such as oxidative damage and telomere shortening, to clinical aging-related syndromes will be necessary to further this critical area of geriatric research...
  2. pmc Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults
    Ravi Varadhan
    Raymond and Anna Lublin Professor of Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Rm 1A 62, Baltimore, MD 21224
    J Gerontol A Biol Sci Med Sci 69:165-73. 2014
    ..This study was designed to identify biologically informed, aggregate measures of inflammation for optimal risk assessment and to inform further biological study of inflammatory pathways...
  3. pmc Sarcopenia in older adults
    Jeremy D Walston
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Curr Opin Rheumatol 24:623-7. 2012
    ..The purpose of this article is to review the current definitions of sarcopenia, its potential causes and clinical consequences, and the potential for intervention...
  4. ncbi request reprint Arg64 beta3-adrenoceptor variant and the components of energy expenditure
    Jeremy Walston
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Obes Res 11:509-11. 2003
    ..To determine Trp64Arg beta(3)-adrenoceptor genotype-specific differences in the components of energy expenditure...
  5. pmc Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults
    Jeremy D Walston
    Johns Hopkins Medical Institutions, Johns Hopkins University, John R Burton Pavilion, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Exp Gerontol 44:350-5. 2009
    ..79 (95%CI 0.62-1.02; p=0.07). These findings warrant further study of the potential role of PARP1 genotype in inflammatory and aging-related phenotypes...
  6. ncbi request reprint The physical and biological characterization of a frail mouse model
    Jeremy Walston
    The Biology of Frailty Working Group, Johns Hopkins University, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 63:391-8. 2008
    ..We hypothesized that with increasing age, IL-10(tm/tm) mice would develop physical and biological characteristics similar to those of human frailty as compared to C57BL/6J control mice...
  7. ncbi request reprint IL-6 gene variation is associated with IL-6 and C-reactive protein levels but not cardiovascular outcomes in the Cardiovascular Health Study
    Jeremy D Walston
    Johns Hopkins Medical Institutions, Johns Hopkins University, John R Burton Pavilion, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Hum Genet 122:485-94. 2007
    ....
  8. ncbi request reprint Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults
    Jeremy Walston
    Department of Medicine, Johns Hopkins Medical Institutions, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Am Geriatr Soc 54:991-1001. 2006
    ..This meeting and subsequent article were not meant to be a comprehensive review of frailty research; instead, they were and are meant to provide a more-targeted research agenda-setting process...
  9. ncbi request reprint Serum antioxidants, inflammation, and total mortality in older women
    J Walston
    School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Epidemiol 163:18-26. 2006
    ..54, 95% confidence interval: 1.03, 2.32). These findings suggest that specific antioxidant nutrients may play an important role in suppressing IL-6 levels in disabled older women...
  10. ncbi request reprint IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women
    J Walston
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Exp Gerontol 40:344-52. 2005
    ..These results suggest that IL-6 gene variation may not be an important factor in the determination of elevated IL-6 levels and related phenotypes found in older women...
  11. pmc Exploring biologically relevant pathways in frailty
    Yen Yi Ho
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Bayview Circle, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 66:975-9. 2011
    ..As with longevity research, genetic analyses may help to provide insights into biologically relevant pathways that contribute to frailty...
  12. ncbi request reprint Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study
    Jeremy Walston
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Arch Intern Med 162:2333-41. 2002
    ..The biological basis of frailty has been difficult to establish owing to the lack of a standard definition, its complexity, and its frequent coexistence with illness...
  13. pmc Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14(+) monocytes in frail older adults
    Tao Qu
    Johns Hopkins University School of Medicine, Biology of Frailty Program, Division of Geriatric Medicine and Gerontology, Department of Medicine, Baltimore, MD, USA
    Mech Ageing Dev 130:161-6. 2009
    ..These findings suggest upregulated expression of specific stress-responsive genes in monocyte-mediated inflammatory pathway in the syndrome of frailty with potential mechanistic and interventional implications...
  14. pmc IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    Age Ageing 40:475-81. 2011
    ..Previous studies have shown significant association between elevated interleukin-6 (IL-6) levels and frailty. The objective of this study was to evaluate IL-6-independent association of serum neopterin levels with prevalent frailty...
  15. pmc Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort study
    George C Wang
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Epidemiol 171:1144-52. 2010
    ..79, 95% confidence interval: 1.22, 6.40). Better understanding of the long-term clinical consequences of CMV infection in immunocompetent humans is needed to guide public health efforts for this widely prevalent infection...
  16. ncbi request reprint Inflammation and frailty in older women
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    J Am Geriatr Soc 55:864-71. 2007
    ..To evaluate relationships between white blood cell (WBC) count and interleukin-6 (IL-6) and prevalent frailty...
  17. pmc Frailty and falls among adult patients undergoing chronic hemodialysis: a prospective cohort study
    Mara A McAdams-Demarco
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    BMC Nephrol 14:224. 2013
    ..We hypothesized that insights derived from studies of the elderly might apply to adults of all ages undergoing hemodialysis; we focused on frailty, a phenotype of physiological decline strongly associated with falls in the elderly...
  18. pmc Relationship between cytomegalovirus (CMV) IgG serology, detectable CMV DNA in peripheral monocytes, and CMV pp65(495-503)-specific CD8+ T cells in older adults
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Age (Dordr) 33:607-14. 2011
    ....
  19. ncbi request reprint From bedside to bench: research agenda for frailty
    Linda P Fried
    Center on Aging and Health and Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA corrected
    Sci Aging Knowledge Environ 2005:pe24. 2005
    ..This article summarizes the central theoretical observations on frailty and research needs and opportunities presented and discussed at this conference, and lays out an agenda for future research on frailty...
  20. pmc T-lymphocytes expressing CC chemokine receptor-5 are increased in frail older adults
    Umberto De Fanis
    Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Am Geriatr Soc 56:904-8. 2008
    ..To evaluate the frequencies of T-lymphocytes expressing CC chemokine receptor-5 (CCR5(+) T-cells) and their relationship with frailty in older adults...
  21. pmc Serum levels of the immune activation marker neopterin change with age and gender and are modified by race, BMI, and percentage of body fat
    Monique E Spencer
    Biology of Frailty Program, Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 65:858-65. 2010
    ..In addition to age, we assessed gender, race, body mass index (BMI), and percentage of body fat (%fat) as potential covariates...
  22. pmc Thyroid autoantibodies are associated with a reduced prevalence of frailty in community-dwelling older women
    George C Wang
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 95:1161-8. 2010
    ..These trends were not observed with antinuclear antibodies. Conclusion: Independent of thyroid function status, community-dwelling older women who are seropositive for TgAbs and TPOAbs are less likely to be frail than seronegative women...
  23. pmc Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailty
    Tao Qu
    Biology of Frailty Program, Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Cytokine 46:319-24. 2009
    ..Therapeutic implications include potential development of CXCL-10-based interventional strategies for the prevention and treatment of frailty in older adults...
  24. pmc Maximal heart rate prediction in adults that are overweight or obese
    Shawn C Franckowiak
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Strength Cond Res 25:1407-12. 2011
    ..48 × age estimated MHR to be 178 ± 4 b·min⁻¹, which was greater than the actual value (175 ± 12, p = 0.005). Prediction equations showed close agreement to actual MHR, with 208 - 0.7 × age being the most accurate...
  25. pmc Serum chitotriosidase, a putative marker of chronically activated macrophages, increases with normal aging
    Rohit Ramanathan
    Room 1A12 JHAAC, 5501 Hopkins Byview Circle, Baltimore, MD 21224
    J Gerontol A Biol Sci Med Sci 68:1303-9. 2013
    ....
  26. ncbi request reprint Decreased cell proliferation and altered cytokine production in frail older adults
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Aging Clin Exp Res 16:249-52. 2004
    ..In order to investigate specific immune system modulations that may contribute to frailty, eleven age- and sex-matched pairs of community-dwelling frail and non-frail older adults were identified...
  27. pmc Heritability estimates of endophenotypes of long and health life: the Long Life Family Study
    Amy M Matteini
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 65:1375-9. 2010
    ..Identification of gene variants that contribute to exceptional survival may provide critical biologic information that informs optimal health across the life span...
  28. ncbi request reprint Hepcidin-dependent and hepcidin-independent regulation of erythropoiesis in a mouse model of anemia of chronic inflammation
    Jacqueline M Langdon
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Am J Hematol 89:470-9. 2014
    ..Am. J. Hematol. 89:470-479, 2014. © 2014 Wiley Periodicals, Inc. ..
  29. pmc A genome-wide association analysis of serum iron concentrations
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD, USA
    Blood 115:94-6. 2010
    ..Our results confirm the association of TMPRSS6 variants with iron level and provide further evidence of association with other anemia-related phenotypes...
  30. ncbi request reprint Baseline total and specific differential white blood cell counts and 5-year all-cause mortality in community-dwelling older women
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Gerontol 40:982-7. 2005
    ..They provide a basis for further investigation into the role of leukocytes in age-related inflammation and its associated adverse outcomes in older adults...
  31. pmc Glutathione peroxidase enzyme activity in aging
    Sara E Espinoza
    Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 63:505-9. 2008
    ..Age-related decline in activity of the antioxidant enzyme glutathione peroxidase (GPx) may contribute to increased free radicals. We hypothesized that GPx activity decreases with age in a population of older women with disability...
  32. pmc Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age
    Gautam Sikka
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Exp Gerontol 48:128-35. 2013
    ..While emerging evidence suggests a role for IL-10 in vascular protection, a clear mechanism has not yet been elucidated...
  33. pmc Measurement of organ structure and function enhances understanding of the physiological basis of frailty: the Cardiovascular Health Study
    Jason L Sanders
    Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 59:1581-8. 2011
    ..To determine whether disease burden is associated with frailty independent of diagnosed chronic disease and whether physiological measurements provide greater understanding of the etiology of frailty...
  34. pmc Measuring systemic inflammatory regulation in older adults: evidence and utility
    Karen Bandeen-Roche
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205 2179, USA
    Rejuvenation Res 12:403-10. 2009
    ..We conclude that systemic inflammation is relevant to the process that leads to functional loss in older persons and can be validly measured through biologically informed summary of inflammatory markers...
  35. ncbi request reprint Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Am Geriatr Soc 52:625-34. 2004
    ....
  36. ncbi request reprint Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty
    Sean X Leng
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Aging Clin Exp Res 16:153-7. 2004
    ..In the present study, our aim is to evaluate the possible role of endocrine dysregulation and its relationship with serum IL-6 in the pathogenesis of this syndrome...
  37. pmc Frailty as a novel predictor of mortality and hospitalization in individuals of all ages undergoing hemodialysis
    Mara A McAdams-Demarco
    Department of Surgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Am Geriatr Soc 61:896-901. 2013
    ..To quantify the prevalence of frailty in adults of all ages undergoing chronic hemodialysis, its relationship to comorbidity and disability, and its association with adverse outcomes of mortality and hospitalization...
  38. pmc Development and validation of a falls-grading scale
    Marcela Davalos-Bichara
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Geriatr Phys Ther 36:63-7. 2013
    ....
  39. pmc Identification and characterization of a functional mitochondrial angiotensin system
    Peter M Abadir
    Division of Geriatric Medicine and Gerontology, Biology of Healthy Aging Program, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 108:14849-54. 2011
    ....
  40. ncbi request reprint Frailty in older adults: insights and interventions
    Sara Espinoza
    Department of Geriatric Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cleve Clin J Med 72:1105-12. 2005
    ..Frail older adults are among the most challenging for medical management. However, awareness of this syndrome and its risks can help us care for these patients more confidently and decrease their risk for adverse outcomes...
  41. ncbi request reprint Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI study
    Alessandro Ble
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 61:278-83. 2006
    ....
  42. ncbi request reprint Odds of transfusion for older adults compared to younger adults undergoing surgery
    Charles H Brown
    From the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Transfusion Medicine, Brigham and Women s Hospital, Boston, Massachusetts and Division of Geriatric Medicine and Gerontology, Johns Hopkins Medical Institutions, Baltimore, Maryland and Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, Maryland
    Anesth Analg 118:1168-78. 2014
    ..Our objective in this study was to determine whether the odds of transfusion are higher in older patients than in younger patients in the perioperative period...
  43. pmc Interleukin-6 directly impairs the erythroid development of human TF-1 erythroleukemic cells
    Bryan J McCranor
    Division of Geriatric Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Blood Cells Mol Dis 52:126-33. 2014
    ..Our findings may indicate a novel pathway of action for IL-6 in the anemia of inflammation, and draw attention to the potential for new therapeutic targets that affect late erythroid development...
  44. doi request reprint Frailty and delayed graft function in kidney transplant recipients
    Jacqueline M Garonzik-Wang
    Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Arch Surg 147:190-3. 2012
    ..13-3.36; P = .02). The assessment of frailty may provide further insights into the pathophysiology of allograft dysfunction and may improve our ability to preoperatively risk-stratify kidney transplant recipients...
  45. pmc Late stage erythroid precursor production is impaired in mice with chronic inflammation
    Olivier D Prince
    Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Haematologica 97:1648-56. 2012
    ....
  46. pmc Decline in semicircular canal and otolith function with age
    Yuri Agrawal
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Otol Neurotol 33:832-9. 2012
    ..To characterize the physiologic nature of the vestibular dysfunction that occurs with the normative aging process...
  47. pmc Subcellular characteristics of functional intracellular renin-angiotensin systems
    Peter M Abadir
    Division of Geriatric Medicine and Gerontology, Biology of Healthy Aging Program, Johns Hopkins University School of Medicine, Baltimore, MD 21224, United States
    Peptides 38:437-45. 2012
    ....
  48. ncbi request reprint Frailty and the older man
    J Walston
    Department of Medicine, Johns Hopkins Geriatrics Center, Baltimore, Maryland, USA
    Med Clin North Am 83:1173-94. 1999
    ..There is also evidence that lower levels of activity and lower caloric intake in women as compared to men may also influence the phenotype of frailty and make women more vulnerable then men to the syndrome...
  49. pmc Angiotensin II Type-2 receptors modulate inflammation through signal transducer and activator of transcription proteins 3 phosphorylation and TNFα production
    Peter M Abadir
    Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Interferon Cytokine Res 31:471-4. 2011
    ..Restoration of AT(2)R expression and/or its activation constitute a potentially novel therapeutic target for the management of inflammatory processes...
  50. ncbi request reprint Tumor necrosis factor-alpha-238 and -308 polymorphisms do not associated with traits related to obesity and insulin resistance
    J Walston
    Division of Geriatric Medicine and Gerontology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Diabetes 48:2096-8. 1999
    ..Instead, homozygotes for this allele had a significantly lower BMI than their counterparts without the polymorphism. In addition, we found no relationship between the 238 polymorphism and BMI, fasting glucose, or log of fasting insulin...
  51. ncbi request reprint TRP64ARG beta 3-adrenergic receptor and obesity in Mexican Americans
    K Silver
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hum Genet 101:306-11. 1997
    ..Since its effects are modest, study design (e.g., subject selection, genetic background, and statistical analyses) may influence which traits are associated with this variant and whether or not the effect is detectable in heterozygotes...
  52. ncbi request reprint Molecular scanning of the beta-3-adrenergic receptor gene in Pima Indians and Caucasians
    K Silver
    Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21201, USA
    Diabetes Metab Res Rev 15:175-80. 1999
    ..Potentially another yet to be identified polymorphism in the beta3AR gene in linkage disequilibrium with the Trp64Arg polymorphism could explain the findings in the association and functional studies...
  53. ncbi request reprint Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor
    J Walston
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 85:4019-22. 2000
    ....
  54. ncbi request reprint Frailty in older adults: evidence for a phenotype
    L P Fried
    Center on Aging and Health, The John Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Gerontol A Biol Sci Med Sci 56:M146-56. 2001
    ..A standardized definition has not yet been established...
  55. ncbi request reprint Frailty and risk of venous thromboembolism in older adults
    Aaron R Folsom
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 South Second St, Minneapolis, MN 55454 1015, USA
    J Gerontol A Biol Sci Med Sci 62:79-82. 2007
    ..Recent evidence links frailty to activation of coagulation and inflammatory pathways. We aimed to determine whether frailty in community-dwelling older adults is a risk factor for venous thromboembolism (VTE)...
  56. ncbi request reprint Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health Study
    Joshua I Barzilay
    Kaiser Permanente of Georgia, 200 Crescent Center Parkway, Tucker, GA 30084, USA
    Arch Intern Med 167:635-41. 2007
    ..Our research group has previously shown that the geriatric syndrome of frailty is associated with features of the metabolic syndrome (MetS) on cross-sectional analysis...
  57. pmc Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein
    Alexander P Reiner
    University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
    Am J Hum Genet 82:1193-201. 2008
    ....
  58. pmc Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammation
    Alexander P Reiner
    Department of Epidemiology, Box 357236, University of Washington, Seattle, Washington 98195, USA
    Arterioscler Thromb Vasc Biol 28:1407-12. 2008
    ..Circulating levels of acute phase reactant proteins such as plasma C-reactive protein (CRP) are likely influenced by multiple genes regulating the innate immune response...
  59. pmc DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study I
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Gerontol A Biol Sci Med Sci 61:957-62. 2006
    ..Low DHEAS levels are associated with mortality in older men, but the relationship between DHEAS levels and mortality in women is not clearly defined...
  60. pmc ELISA and multiplex technologies for cytokine measurement in inflammation and aging research
    Sean X Leng
    UConn Center on Aging, University of Connecticut Health Center, 263 Farmington, Farmington, CT 06030 5215, USA
    J Gerontol A Biol Sci Med Sci 63:879-84. 2008
    ....

Research Grants8

  1. Development of a Mouse Model for Frailty
    Jeremy Walston; Fiscal Year: 2007
    ..We expect to find that the frail mouse has higher levels of inflammatory markers, muscle weakness, and altered gene expression as it gets older, similar to what is found in frail, older humans. ..
  2. NFkb Related Genetic Influences on Inflammation and Poor Health in Older Adults
    Jeremy Walston; Fiscal Year: 2009
    ..Clinically meaningful genotypes will highlight potential biologic pathways for interventions into a range of poor health outcomes in older adults. ..
  3. NFkb Related Genetic Influences Inflammation Poor Health
    Jeremy Walston; Fiscal Year: 2006
    ..Clinically meaningful genotypes will highlight potential biologic pathways for interventions into a range of poor health outcomes in older adults. ..
  4. NFkb Related Genetic Influences on Inflammation and Poor Health in Older Adults
    Jeremy Walston; Fiscal Year: 2007
    ..Clinically meaningful genotypes will highlight potential biologic pathways for interventions into a range of poor health outcomes in older adults. ..
  5. NFkb Related Genetic Influences on Inflammation and Poor Health in Older Adults
    Jeremy Walston; Fiscal Year: 2009
    ..Clinically meaningful genotypes will highlight potential biologic pathways for interventions into a range of poor health outcomes in older adults. ..