Research Topics
Genomes and Genes | Jeremy D WalstonSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Sarcopenia in older adultsJeremy D Walston
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Curr Opin Rheumatol 24:623-7. 2012..The purpose of this article is to review the current definitions of sarcopenia, its potential causes and clinical consequences, and the potential for intervention...
Exploring biologically relevant pathways in frailtyYen Yi Ho
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Bayview Circle, Baltimore, MD 21224, USA
J Gerontol A Biol Sci Med Sci 66:975-9. 2011..As with longevity research, genetic analyses may help to provide insights into biologically relevant pathways that contribute to frailty...- The physical and biological characterization of a frail mouse modelJeremy Walston
The Biology of Frailty Working Group, Johns Hopkins University, Baltimore, MD 21224, USA
J Gerontol A Biol Sci Med Sci 63:391-8. 2008..We hypothesized that with increasing age, IL-10(tm/tm) mice would develop physical and biological characteristics similar to those of human frailty as compared to C57BL/6J control mice... - IL-6 gene variation is associated with IL-6 and C-reactive protein levels but not cardiovascular outcomes in the Cardiovascular Health StudyJeremy D Walston
Johns Hopkins Medical Institutions, Johns Hopkins University, John R Burton Pavilion, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Hum Genet 122:485-94. 2007.... - Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adultsJeremy D Walston
Johns Hopkins Medical Institutions, Johns Hopkins University, John R Burton Pavilion, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Exp Gerontol 44:350-5. 2009..79 (95%CI 0.62-1.02; p=0.07). These findings warrant further study of the potential role of PARP1 genotype in inflammatory and aging-related phenotypes... - Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older AdultsJeremy Walston
Department of Medicine, Johns Hopkins Medical Institutions, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Am Geriatr Soc 54:991-1001. 2006..This meeting and subsequent article were not meant to be a comprehensive review of frailty research; instead, they were and are meant to provide a more-targeted research agenda-setting process... - Serum antioxidants, inflammation, and total mortality in older womenJ Walston
School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
Am J Epidemiol 163:18-26. 2006..54, 95% confidence interval: 1.03, 2.32). These findings suggest that specific antioxidant nutrients may play an important role in suppressing IL-6 levels in disabled older women... - Frailty--the search for underlying causesJeremy Walston
Center on Aging and Health, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Sci Aging Knowledge Environ 2004:pe4. 2004..Translational research programs that connect mechanisms related to aging, such as oxidative damage and telomere shortening, to clinical aging-related syndromes will be necessary to further this critical area of geriatric research... - Arg64 beta3-adrenoceptor variant and the components of energy expenditureJeremy Walston
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Obes Res 11:509-11. 2003..To determine Trp64Arg beta(3)-adrenoceptor genotype-specific differences in the components of energy expenditure... - Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health StudyJeremy Walston
Johns Hopkins Medical Institutions, Baltimore, MD, USA
Arch Intern Med 162:2333-41. 2002..The biological basis of frailty has been difficult to establish owing to the lack of a standard definition, its complexity, and its frequent coexistence with illness... - IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older womenJ Walston
Johns Hopkins Medical Institutions, Baltimore, MD, USA
Exp Gerontol 40:344-52. 2005..These results suggest that IL-6 gene variation may not be an important factor in the determination of elevated IL-6 levels and related phenotypes found in older women... - IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adultsSean X Leng
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
Age Ageing 40:475-81. 2011..Previous studies have shown significant association between elevated interleukin-6 (IL-6) levels and frailty. The objective of this study was to evaluate IL-6-independent association of serum neopterin levels with prevalent frailty... - Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14(+) monocytes in frail older adultsTao Qu
Johns Hopkins University School of Medicine, Biology of Frailty Program, Division of Geriatric Medicine and Gerontology, Department of Medicine, Baltimore, MD, USA
Mech Ageing Dev 130:161-6. 2009..These findings suggest upregulated expression of specific stress-responsive genes in monocyte-mediated inflammatory pathway in the syndrome of frailty with potential mechanistic and interventional implications... - Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort studyGeorge C Wang
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Am J Epidemiol 171:1144-52. 2010..79, 95% confidence interval: 1.22, 6.40). Better understanding of the long-term clinical consequences of CMV infection in immunocompetent humans is needed to guide public health efforts for this widely prevalent infection... - Inflammation and frailty in older womenSean X Leng
Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
J Am Geriatr Soc 55:864-71. 2007..To evaluate relationships between white blood cell (WBC) count and interleukin-6 (IL-6) and prevalent frailty... - From bedside to bench: research agenda for frailtyLinda P Fried
Center on Aging and Health and Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA corrected
Sci Aging Knowledge Environ 2005:pe24. 2005..This article summarizes the central theoretical observations on frailty and research needs and opportunities presented and discussed at this conference, and lays out an agenda for future research on frailty... - T-lymphocytes expressing CC chemokine receptor-5 are increased in frail older adultsUmberto De Fanis
Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Am Geriatr Soc 56:904-8. 2008..To evaluate the frequencies of T-lymphocytes expressing CC chemokine receptor-5 (CCR5(+) T-cells) and their relationship with frailty in older adults... - Serum levels of the immune activation marker neopterin change with age and gender and are modified by race, BMI, and percentage of body fatMonique E Spencer
Biology of Frailty Program, Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 65:858-65. 2010..In addition to age, we assessed gender, race, body mass index (BMI), and percentage of body fat (%fat) as potential covariates... - Relationship between cytomegalovirus (CMV) IgG serology, detectable CMV DNA in peripheral monocytes, and CMV pp65(495-503)-specific CD8+ T cells in older adultsSean X Leng
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Age (Dordr) 33:607-14. 2011.... - Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailtyTao Qu
Biology of Frailty Program, Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Cytokine 46:319-24. 2009..Therapeutic implications include potential development of CXCL-10-based interventional strategies for the prevention and treatment of frailty in older adults... - Thyroid autoantibodies are associated with a reduced prevalence of frailty in community-dwelling older womenGeorge C Wang
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
J Clin Endocrinol Metab 95:1161-8. 2010..These trends were not observed with antinuclear antibodies. Conclusion: Independent of thyroid function status, community-dwelling older women who are seropositive for TgAbs and TPOAbs are less likely to be frail than seronegative women... - Maximal heart rate prediction in adults that are overweight or obeseShawn C Franckowiak
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Strength Cond Res 25:1407-12. 2011..48 × age estimated MHR to be 178 ± 4 b·min⁻¹, which was greater than the actual value (175 ± 12, p = 0.005). Prediction equations showed close agreement to actual MHR, with 208 - 0.7 × age being the most accurate... - Heritability estimates of endophenotypes of long and health life: the Long Life Family StudyAmy M Matteini
Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Gerontol A Biol Sci Med Sci 65:1375-9. 2010..Identification of gene variants that contribute to exceptional survival may provide critical biologic information that informs optimal health across the life span... - Glutathione peroxidase enzyme activity in agingSara E Espinoza
Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 63:505-9. 2008..Age-related decline in activity of the antioxidant enzyme glutathione peroxidase (GPx) may contribute to increased free radicals. We hypothesized that GPx activity decreases with age in a population of older women with disability... - Decreased cell proliferation and altered cytokine production in frail older adultsSean X Leng
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Aging Clin Exp Res 16:249-52. 2004..In order to investigate specific immune system modulations that may contribute to frailty, eleven age- and sex-matched pairs of community-dwelling frail and non-frail older adults were identified... - Measurement of organ structure and function enhances understanding of the physiological basis of frailty: the Cardiovascular Health StudyJason L Sanders
Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Am Geriatr Soc 59:1581-8. 2011..To determine whether disease burden is associated with frailty independent of diagnosed chronic disease and whether physiological measurements provide greater understanding of the etiology of frailty... - Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus reportLuigi Ferrucci
Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
J Am Geriatr Soc 52:625-34. 2004.... - Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailtySean X Leng
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Aging Clin Exp Res 16:153-7. 2004..The trend toward an inverse correlation between IGF-I and IL-6 in the frail, but not the non-frail group, suggests potential interaction between endocrine and immune/cytokine dysregulation that requires further study in larger cohorts... - Baseline total and specific differential white blood cell counts and 5-year all-cause mortality in community-dwelling older womenSean X Leng
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Exp Gerontol 40:982-7. 2005..They provide a basis for further investigation into the role of leukocytes in age-related inflammation and its associated adverse outcomes in older adults... - Identification and characterization of a functional mitochondrial angiotensin systemPeter M Abadir
Division of Geriatric Medicine and Gerontology, Biology of Healthy Aging Program, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 108:14849-54. 2011.... - A genome-wide association analysis of serum iron concentrationsToshiko Tanaka
MedStar Research Institute, Baltimore, MD, USA
Blood 115:94-6. 2010..Our results confirm the association of TMPRSS6 variants with iron level and provide further evidence of association with other anemia-related phenotypes... - Measuring systemic inflammatory regulation in older adults: evidence and utilityKaren Bandeen-Roche
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205 2179, USA
Rejuvenation Res 12:403-10. 2009..We conclude that systemic inflammation is relevant to the process that leads to functional loss in older persons and can be validly measured through biologically informed summary of inflammatory markers... - Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI studyAlessandro Ble
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
J Gerontol A Biol Sci Med Sci 61:278-83. 2006..30; 95% confidence interval, 0.10-0.91). CONCLUSIONS: Our findings show an association between low circulating levels of one of the most important components of the human antioxidant system and the presence of frailty... - Frailty in older adults: insights and interventionsSara Espinoza
Department of Geriatric Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Cleve Clin J Med 72:1105-12. 2005..Frail older adults are among the most challenging for medical management. However, awareness of this syndrome and its risks can help us care for these patients more confidently and decrease their risk for adverse outcomes... 
Frailty and delayed graft function in kidney transplant recipientsJacqueline M Garonzik-Wang
Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Arch Surg 147:190-3. 2012..13-3.36; P = .02). The assessment of frailty may provide further insights into the pathophysiology of allograft dysfunction and may improve our ability to preoperatively risk-stratify kidney transplant recipients...- Decline in semicircular canal and otolith function with ageYuri Agrawal
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Otol Neurotol 33:832-9. 2012..To characterize the physiologic nature of the vestibular dysfunction that occurs with the normative aging process... - Subcellular characteristics of functional intracellular renin-angiotensin systemsPeter M Abadir
Division of Geriatric Medicine and Gerontology, Biology of Healthy Aging Program, Johns Hopkins University School of Medicine, Baltimore, MD 21224, United States
Peptides 38:437-45. 2012.... - Frailty and the older manJ Walston
Department of Medicine, Johns Hopkins Geriatrics Center, Baltimore, Maryland, USA
Med Clin North Am 83:1173-94. 1999..There is also evidence that lower levels of activity and lower caloric intake in women as compared to men may also influence the phenotype of frailty and make women more vulnerable then men to the syndrome... - Angiotensin II Type-2 receptors modulate inflammation through signal transducer and activator of transcription proteins 3 phosphorylation and TNFα productionPeter M Abadir
Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
J Interferon Cytokine Res 31:471-4. 2011..Restoration of AT(2)R expression and/or its activation constitute a potentially novel therapeutic target for the management of inflammatory processes... - Tumor necrosis factor-alpha-238 and -308 polymorphisms do not associated with traits related to obesity and insulin resistanceJ Walston
Division of Geriatric Medicine and Gerontology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Diabetes 48:2096-8. 1999..Instead, homozygotes for this allele had a significantly lower BMI than their counterparts without the polymorphism. In addition, we found no relationship between the 238 polymorphism and BMI, fasting glucose, or log of fasting insulin... - TRP64ARG beta 3-adrenergic receptor and obesity in Mexican AmericansK Silver
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Hum Genet 101:306-11. 1997..Since its effects are modest, study design (e.g., subject selection, genetic background, and statistical analyses) may influence which traits are associated with this variant and whether or not the effect is detectable in heterozygotes... - Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptorJ Walston
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Clin Endocrinol Metab 85:4019-22. 2000.... - Molecular scanning of the beta-3-adrenergic receptor gene in Pima Indians and CaucasiansK Silver
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21201, USA
Diabetes Metab Res Rev 15:175-80. 1999..Potentially another yet to be identified polymorphism in the beta3AR gene in linkage disequilibrium with the Trp64Arg polymorphism could explain the findings in the association and functional studies... - Frailty in older adults: evidence for a phenotypeL P Fried
Center on Aging and Health, The John Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
J Gerontol A Biol Sci Med Sci 56:M146-56. 2001..A standardized definition has not yet been established... - Frailty and risk of venous thromboembolism in older adultsAaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 South Second St, Minneapolis, MN 55454 1015, USA
J Gerontol A Biol Sci Med Sci 62:79-82. 2007..Recent evidence links frailty to activation of coagulation and inflammatory pathways. We aimed to determine whether frailty in community-dwelling older adults is a risk factor for venous thromboembolism (VTE)... - Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health StudyJoshua I Barzilay
Kaiser Permanente of Georgia, 200 Crescent Center Parkway, Tucker, GA 30084, USA
Arch Intern Med 167:635-41. 2007..Our research group has previously shown that the geriatric syndrome of frailty is associated with features of the metabolic syndrome (MetS) on cross-sectional analysis... - Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive proteinAlexander P Reiner
University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
Am J Hum Genet 82:1193-201. 2008.... - Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammationAlexander P Reiner
Department of Epidemiology, Box 357236, University of Washington, Seattle, Washington 98195, USA
Arterioscler Thromb Vasc Biol 28:1407-12. 2008..Circulating levels of acute phase reactant proteins such as plasma C-reactive protein (CRP) are likely influenced by multiple genes regulating the innate immune response... - ELISA and multiplex technologies for cytokine measurement in inflammation and aging researchSean X Leng
UConn Center on Aging, University of Connecticut Health Center, 263 Farmington, Farmington, CT 06030 5215, USA
J Gerontol A Biol Sci Med Sci 63:879-84. 2008.... - DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study IAnne R Cappola
Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Gerontol A Biol Sci Med Sci 61:957-62. 2006..Low DHEAS levels are associated with mortality in older men, but the relationship between DHEAS levels and mortality in women is not clearly defined...
Research Grants
- Development of a Mouse Model for FrailtyJeremy Walston; Fiscal Year: 2007..We expect to find that the frail mouse has higher levels of inflammatory markers, muscle weakness, and altered gene expression as it gets older, similar to what is found in frail, older humans. ..
- NFkb Related Genetic Influences on Inflammation and Poor Health in Older AdultsJeremy Walston; Fiscal Year: 2009..Clinically meaningful genotypes will highlight potential biologic pathways for interventions into a range of poor health outcomes in older adults. ..
- NFkb Related Genetic Influences on Inflammation and Poor Health in Older AdultsJeremy Walston; Fiscal Year: 2009..Clinically meaningful genotypes will highlight potential biologic pathways for interventions into a range of poor health outcomes in older adults. ..