Elizabeth Wagner

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Chemokine localization in bronchial angiogenesis
    Maria Grazia Perino
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e66432. 2013
  2. pmc Effects of ischemia on lung macrophages
    Aigul Moldobaeva
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 6:e26716. 2011
  3. pmc Strain variation in response to lung ischemia: role of MMP-12
    Clarke G Tankersley
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA
    Respir Res 13:93. 2012
  4. ncbi request reprint Leukocyte transit through the airway circulation
    E Wagner
    Pulmonary Division, Johns Hopkins University, Baltimore, MD 21224 2780, USA
    Arch Physiol Biochem 111:345-6. 2003
  5. ncbi request reprint TNF-alpha induced bronchial vasoconstriction
    E M Wagner
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Am J Physiol Heart Circ Physiol 279:H946-51. 2000
  6. ncbi request reprint Pulmonary ischemia induces lung remodeling and angiogenesis
    Elizabeth M Wagner
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 100:587-93. 2006
  7. ncbi request reprint Changes in lung permeability after chronic pulmonary artery obstruction
    Elizabeth M Wagner
    Department of Medicine and Environmental Health Sciences, Johns Hopkins University, Baltimore, MD, USA
    J Appl Physiol (1985) 100:1224-9. 2006
  8. ncbi request reprint Effects of airway distension on leukocyte recruitment in the mouse tracheal microvasculature
    Elizabeth M Wagner
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Appl Physiol (1985) 102:1528-34. 2007
  9. ncbi request reprint Inflammation and ischemia-induced lung angiogenesis
    Elizabeth M Wagner
    Johns Hopkins Asthma and Allergy Center, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 294:L351-7. 2008
  10. pmc Lung and vascular function during chronic severe pulmonary ischemia
    Elizabeth M Wagner
    Johns Hopkins Asthma and Allergy Center, Div of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 110:538-44. 2011

Research Grants

  1. AIRWAY PARTICLE CLEARANCE--ROLE OF BRONCHIAL CIRCULATION
    Elizabeth Wagner; Fiscal Year: 2001
  2. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2010
  3. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2010
  4. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2009
  5. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2009
  6. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2006
  7. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2003
  8. AIRWAY PARTICLE CLEARANCE--ROLE OF BRONCHIAL CIRCULATION
    Elizabeth Wagner; Fiscal Year: 1999
  9. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2005
  10. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2004

Collaborators

Detail Information

Publications31

  1. pmc Chemokine localization in bronchial angiogenesis
    Maria Grazia Perino
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e66432. 2013
    ..Our results suggest that early changes within the bronchial niche contribute to subsequent neovascularization during pulmonary ischemia...
  2. pmc Effects of ischemia on lung macrophages
    Aigul Moldobaeva
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 6:e26716. 2011
    ..Overall, an increase in the number of lung macrophages appears to be critical for neovascularization in the lung, since clodronate treatment decreased their number and attenuated functional angiogenesis...
  3. pmc Strain variation in response to lung ischemia: role of MMP-12
    Clarke G Tankersley
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA
    Respir Res 13:93. 2012
    ..Although previous work has demonstrated the CXC chemokines are essential growth factors in the process of angiogenesis in mice and rats, key matrix proteins have not been identified...
  4. ncbi request reprint Leukocyte transit through the airway circulation
    E Wagner
    Pulmonary Division, Johns Hopkins University, Baltimore, MD 21224 2780, USA
    Arch Physiol Biochem 111:345-6. 2003
  5. ncbi request reprint TNF-alpha induced bronchial vasoconstriction
    E M Wagner
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Am J Physiol Heart Circ Physiol 279:H946-51. 2000
    ..Although TNF-alpha exerts pro-inflammatory actions on most cells of the airways, vasoactive properties of this cytokine likely further contribute to the inflammatory status of the airways...
  6. ncbi request reprint Pulmonary ischemia induces lung remodeling and angiogenesis
    Elizabeth M Wagner
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 100:587-93. 2006
    ..Because sham surgeries had little effect on measured parameters, we conclude that both thoracic wound healing and pulmonary ischemia are required for systemic neovascularization...
  7. ncbi request reprint Changes in lung permeability after chronic pulmonary artery obstruction
    Elizabeth M Wagner
    Department of Medicine and Environmental Health Sciences, Johns Hopkins University, Baltimore, MD, USA
    J Appl Physiol (1985) 100:1224-9. 2006
    ..Thus the lung vasculature, remodeled as a consequence of chronic pulmonary artery obstruction, demonstrates increased water and protein permeability...
  8. ncbi request reprint Effects of airway distension on leukocyte recruitment in the mouse tracheal microvasculature
    Elizabeth M Wagner
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Appl Physiol (1985) 102:1528-34. 2007
    ..These findings demonstrate the essential nature of both P-selectin and ICAM-1 within airway postcapillary venular endothelium for leukocyte recruitment after airway distension...
  9. ncbi request reprint Inflammation and ischemia-induced lung angiogenesis
    Elizabeth M Wagner
    Johns Hopkins Asthma and Allergy Center, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 294:L351-7. 2008
    ..We conclude that inflammatory cells modulate the degree of angiogenesis in this lung model where lymphocytes appear to limit the degree of neovascularization, whereas monocytes/macrophages likely promote angiogenesis...
  10. pmc Lung and vascular function during chronic severe pulmonary ischemia
    Elizabeth M Wagner
    Johns Hopkins Asthma and Allergy Center, Div of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 110:538-44. 2011
    ..We conclude that despite the preservation of lung tissue, the proliferating bronchial neovasculature may contribute to a sustained decrement in pulmonary function...
  11. ncbi request reprint Effects of tamoxifen on ischemia-induced angiogenesis in the mouse lung
    Elizabeth M Wagner
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Angiogenesis 6:65-71. 2003
    ..Although tamoxifen appeared to slow the progression of blood vessel formation, it did not affect VEGF mRNA, therefore likely acting through an estrogen receptor-independent mechanism...
  12. ncbi request reprint Interdependence of bronchial circulation and clearance of 99mTc-DTPA from the airway surface
    E M Wagner
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Appl Physiol (1985) 90:1275-81. 2001
    ..This component was substantially decreased during no flow. The results demonstrate that both decreased and increased airway perfusion limit removal of soluble tracer applied to the conducting airways...
  13. pmc The role of the bronchial vasculature in soluble particle clearance
    E M Wagner
    Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21224, USA
    Environ Health Perspect 109:563-5. 2001
    ..These results emphasize the importance of normal perfusion of the airway vasculature for uptake of therapeutic agents delivered specifically to the conducting airways...
  14. ncbi request reprint Blood flow distribution within the airway wall
    Elizabeth M Wagner
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Appl Physiol (1985) 92:1964-9. 2002
    ..During challenge, there was greater MCh delivery to larger airways during increased flow and less delivery to smaller airways during control flow. The results demonstrate the effects of axial perfusion distribution on Raw...
  15. ncbi request reprint The role of CXCR2 in systemic neovascularization of the mouse lung
    Jesus Sanchez
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Appl Physiol (1985) 103:594-9. 2007
    ..We speculate that the CXCR(2)-deficient mice have compensatory mechanisms that mitigate their lack of gene expression and conclude that CXCR(2) contributes to chemokine-induced systemic angiogenesis after pulmonary artery obstruction...
  16. pmc Effects of distension on airway inflammation and venular P-selectin expression
    Aigul Moldobaeva
    Johns Hopkins Asthma and Allergy Center, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 295:L941-8. 2008
    ..We conclude that P-selectin expression on systemic venular endothelial cells contributes to a proinflammatory phenotype after mechanical stretch and can be selectively modulated by voltage-gated calcium channel inhibition...
  17. pmc Increased hyaluronan fragmentation during pulmonary ischemia
    Lindsey Eldridge
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 301:L782-8. 2011
    ..We conclude that ischemic injury results in matrix fragmentation, which leads to stimulation of neovascularization...
  18. ncbi request reprint Leukocyte recruitment in the airways: an intravital microscopic study of rat tracheal microcirculation
    Lina H K Lim
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Physiol Lung Cell Mol Physiol 282:L959-67. 2002
    ..These results demonstrate leukocyte recruitment in the airway microvasculature and provide an important new method to study airway inflammation in real time...
  19. doi request reprint Inhibition of CXCR2 attenuates bronchial angiogenesis in the ischemic rat lung
    Adlah Sukkar
    Johns Hopkins Asthma and Allergy Center, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 104:1470-5. 2008
    ..01). Our results confirm the time course of bronchial angiogenesis in the rat and suggest the importance of CXC chemokines in promoting systemic neovascularization in the lung...
  20. ncbi request reprint Angiotensin-converting enzyme activity in ovine bronchial vasculature
    Aigul Moldobaeva
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    J Appl Physiol 95:2278-84. 2003
    ..60% after; P = 0.05). These results demonstrate high ACE expression of the bronchial microvasculature and suggest an important regulatory role for ACE in the metabolism of kinin peptides known to contribute to airway pathology...
  21. ncbi request reprint Effects of pulmonary ischemia on lung morphology
    Michael J Fields
    Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 293:L254-8. 2007
    ..The LPAL model thus affords a unique opportunity to study lung functional responses to tissue ischemia and subsequent recovery...
  22. ncbi request reprint Heterogeneity of bronchial endothelial cell permeability
    Aigul Moldobaeva
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Am J Physiol Lung Cell Mol Physiol 283:L520-7. 2002
    ..These results demonstrate bronchial endothelial cell heterogeneity and establish methods to determine intracellular mechanisms contributing to airway disease in relevant cell systems...
  23. ncbi request reprint Vascular remodeling in the circulations of the lung
    Wayne Mitzner
    Department of Environmental Health Sciences, Johns Hopkins Medical Institutions, 615 North Wolfe St, Baltimore, MD 21205, USA
    J Appl Physiol (1985) 97:1999-2004. 2004
    ....
  24. ncbi request reprint Difference in proangiogenic potential of systemic and pulmonary endothelium: role of CXCR2
    Aigul Moldobaeva
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1117-23. 2005
    ..Thus the combined effects of increased cathepsin S activity, providing increased motility and enhanced CXCR2 expression after hypoxia, both contribute to the proangiogenic phenotype of systemic arterial endothelial cells...
  25. ncbi request reprint Airway distension promotes leukocyte recruitment in rat tracheal circulation
    Lina H K Lim
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 168:1068-74. 2003
    ..Pretreatment with endothelin receptor and selectin inhibitors blocked the effects of distension on leukocyte recruitment, suggesting their involvement in the proinflammatory response...
  26. ncbi request reprint Changes in lung permeability and lung mechanics accompany homeostatic instability in senescent mice
    Clarke G Tankersley
    Division of Physiology, Bloomberg School of Public Health, The Johns Hopkins Univ, 615 N Wolfe St, Baltimore, MD 21205, USA
    J Appl Physiol 95:1681-7. 2003
    ..Furthermore, this senescent-dependent increase in lung permeability may be a contributing factor for increased PM susceptibility in the elderly and patients with lung disease...
  27. ncbi request reprint Identification of genes promoting angiogenesis in mouse lung by transcriptional profiling
    Sorachai Srisuma
    Department of Physiology, Faculty of Medicine Sirraj Hospital, Mahidol University, Bangkok, Thailand
    Am J Respir Cell Mol Biol 29:172-9. 2003
    ..These altered profiles of expression in the early stage of lung ischemia show potential roles and interactions of the most important genes involved in promoting new blood vessel formation...
  28. ncbi request reprint Methods to track leukocyte and erythrocyte transit through the bronchial vasculature in sheep
    Sandra J Gallagher
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    J Immunol Methods 271:89-97. 2002
    ..These methods offer an approach for examining leukocyte kinetics in situ in the airways of a relevant animal model...
  29. ncbi request reprint PEEP-induced changes in epithelial permeability in inbred mouse strains
    John M Bishai
    Johns Hopkins Asthma and Allergy Center, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Respir Physiol Neurobiol 156:340-4. 2007
    ..001). Thus, when lung volume is increased, the susceptible C57Bl/6J strain shows a greater change in epithelial barrier than the resistant C3H/HeJ strain. These results may reflect fundamental differences in lung architecture...
  30. ncbi request reprint Role of IL-6 in systemic angiogenesis of the lung
    Jessica Y McClintock
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Appl Physiol (1985) 99:861-6. 2005
    ..3% cardiac output) was not altered. These results demonstrate that IL-6 plays an important modulatory role in lung angiogenesis, but the changes are not dependent on trapped neutrophils...
  31. pmc MIP-2 causes differential activation of RhoA in mouse aortic versus pulmonary artery endothelial cells
    Aigul Moldobaeva
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Microvasc Res 75:53-8. 2008
    ..This result provides one explanation for the difference in chemotaxis observed in these two endothelial subtypes that express similar levels of CXCR(2)...

Research Grants14

  1. AIRWAY PARTICLE CLEARANCE--ROLE OF BRONCHIAL CIRCULATION
    Elizabeth Wagner; Fiscal Year: 2001
    ..Furthermore, the results will contribute to an understanding of the factors that both limit and enhance uptake and distribution of aerosols. ..
  2. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2010
    ..In an animal model of chronic pulmonary thromboembolic disease, this project will determine the inflammatory cytokines and cells responsible for new vessel growth, and pharmacological and interventional inhibitors. ..
  3. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2010
    ..In an animal model of chronic pulmonary thromboembolic disease, this project will determine essential growth factors, pharmacological and interventional inhibitors, and physiology of bronchial angiogenesis. ..
  4. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2009
    ..In an animal model of chronic pulmonary thromboembolic disease, this project will determine the inflammatory cytokines and cells responsible for new vessel growth, and pharmacological and interventional inhibitors. ..
  5. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2009
    ..In an animal model of chronic pulmonary thromboembolic disease, this project will determine essential growth factors, pharmacological and interventional inhibitors, and physiology of bronchial angiogenesis. ..
  6. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2006
    ..The results of these studies will provide important new information defining the molecular, structural, and functional events of lung angiogenesis. ..
  7. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2003
    ..The results of these studies will provide important new information defining the molecular, structural, and functional events of lung angiogenesis. ..
  8. AIRWAY PARTICLE CLEARANCE--ROLE OF BRONCHIAL CIRCULATION
    Elizabeth Wagner; Fiscal Year: 1999
    ..Furthermore, the results will contribute to an understanding of the factors that both limit and enhance uptake and distribution of aerosols. ..
  9. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2005
    ..The results of these studies will provide important new information defining the molecular, structural, and functional events of lung angiogenesis. ..
  10. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2004
    ..The results of these studies will provide important new information defining the molecular, structural, and functional events of lung angiogenesis. ..
  11. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2007
    ..The results of these studies will provide important new information defining the molecular, structural, and functional events of lung angiogenesis. ..
  12. AIRWAY PARTICLE CLEARANCE--ROLE OF BRONCHIAL CIRCULATION
    Elizabeth Wagner; Fiscal Year: 2000
    ..Furthermore, the results will contribute to an understanding of the factors that both limit and enhance uptake and distribution of aerosols. ..
  13. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2011
    ..In an animal model of chronic pulmonary thromboembolic disease, this project will determine essential growth factors, pharmacological and interventional inhibitors, and physiology of bronchial angiogenesis. ..