Bert Vogelstein

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Genetics. Please don't call it cloning!
    Bert Vogelstein
    Howard Hughes Medical Institute and Kimmel Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA
    Science 295:1237. 2002
  2. ncbi request reprint Cancer genes and the pathways they control
    Bert Vogelstein
    Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Med 10:789-99. 2004
  3. ncbi request reprint Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia
    Mohamed Bentires-Alj
    Cancer Biology Program, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Cancer Res 64:8816-20. 2004
  4. ncbi request reprint Colorectal cancer: mutations in a signalling pathway
    D Williams Parsons
    The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
    Nature 436:792. 2005
  5. pmc Patient-oriented gene set analysis for cancer mutation data
    Simina M Boca
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 N, Wolfe Street, Baltimore, MD 21205, USA
    Genome Biol 11:R112. 2010
  6. pmc Genome-wide linkage scan for colorectal cancer susceptibility genes supports linkage to chromosome 3q
    Simone Picelli
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    BMC Cancer 8:87. 2008
  7. ncbi request reprint Mutant PIK3CA promotes cell growth and invasion of human cancer cells
    Yardena Samuels
    The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Cancer Cell 7:561-73. 2005
  8. pmc Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation
    Kajsa Ericson
    The Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 107:2598-603. 2010
  9. ncbi request reprint Serial assessment of human tumor burdens in mice by the analysis of circulating DNA
    Carlo Rago
    The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute, Baltimore, Maryland, USA
    Cancer Res 67:9364-70. 2007
  10. pmc A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane
    Diana Mandelker
    The Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 106:16996-7001. 2009

Research Grants

  1. MOLECULAR GENETIC ANALYSIS OF COLORECTAL CANCER
    Bert Vogelstein; Fiscal Year: 2007

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Genetics. Please don't call it cloning!
    Bert Vogelstein
    Howard Hughes Medical Institute and Kimmel Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA
    Science 295:1237. 2002
  2. ncbi request reprint Cancer genes and the pathways they control
    Bert Vogelstein
    Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Med 10:789-99. 2004
    ..The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation...
  3. ncbi request reprint Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia
    Mohamed Bentires-Alj
    Cancer Biology Program, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Cancer Res 64:8816-20. 2004
    ..Our data demonstrate that mutations in PTPN11 occur at low frequency in several human cancers, especially neuroblastoma and AML, and suggest that Shp2 may be a novel target for antineoplastic therapy...
  4. ncbi request reprint Colorectal cancer: mutations in a signalling pathway
    D Williams Parsons
    The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
    Nature 436:792. 2005
    ..The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention...
  5. pmc Patient-oriented gene set analysis for cancer mutation data
    Simina M Boca
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 N, Wolfe Street, Baltimore, MD 21205, USA
    Genome Biol 11:R112. 2010
    ..In mutation analysis, these patient-oriented methods are more transparent, interpretable, and statistically powerful than traditional gene-oriented methods...
  6. pmc Genome-wide linkage scan for colorectal cancer susceptibility genes supports linkage to chromosome 3q
    Simone Picelli
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    BMC Cancer 8:87. 2008
    ..In an attempt to identify novel colorectal cancer predisposing genes, we have performed a genome-wide linkage analysis in 30 Swedish non-FAP/non-HNPCC families with a strong family history of colorectal cancer...
  7. ncbi request reprint Mutant PIK3CA promotes cell growth and invasion of human cancer cells
    Yardena Samuels
    The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Cancer Cell 7:561-73. 2005
    ..Treatment with the PI3K inhibitor LY294002 abrogated PIK3CA signaling and preferentially inhibited growth of PIK3CA mutant cells. These data have important implications for therapy of cancers harboring PIK3CA alterations...
  8. pmc Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation
    Kajsa Ericson
    The Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 107:2598-603. 2010
    ..These findings show that the PI3K signaling pathway is wired differently in human cancer cells than in other cell types or organisms, which has important implications for the design and testing of drugs that target this pathway...
  9. ncbi request reprint Serial assessment of human tumor burdens in mice by the analysis of circulating DNA
    Carlo Rago
    The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute, Baltimore, Maryland, USA
    Cancer Res 67:9364-70. 2007
    ..A marked, transient spike in circulating human tumor DNA occurred immediately after cytotoxic therapy or surgery. This simple assay may find broad utility in target validation studies and preclinical drug development programs...
  10. pmc A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane
    Diana Mandelker
    The Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 106:16996-7001. 2009
    ..These structural and biochemical data suggest a previously undescribed mechanism for mutational activation of a kinase that involves perturbation of its interaction with the cellular membrane...
  11. ncbi request reprint Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers
    Laura D Wood
    The Ludwig Center for Cancer Genetics and Therapeutics, The Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA
    Hum Mutat 27:1060-1. 2006
    ..Our results implicate these tyrosine kinase genes in the pathogenesis of other tumor types and suggest that they may be useful targets for diagnostic and therapeutic intervention in selected patients...
  12. pmc Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells
    Jihye Yun
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 325:1555-9. 2009
    ..Together, these data suggest that glucose deprivation can drive the acquisition of KRAS pathway mutations in human tumors...
  13. ncbi request reprint Mutational analysis of the tyrosine phosphatome in colorectal cancers
    Zhenghe Wang
    Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Science 304:1164-6. 2004
    ..These observations suggest that the mutated tyrosine phosphatases are tumor suppressor genes, regulating cellular pathways that may be amenable to therapeutic intervention...
  14. pmc PI3Kα inhibitors that inhibit metastasis
    Oleg Schmidt-Kittler
    The Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Oncotarget 1:339-48. 2010
    ..These data support the idea that PI3Kα plays an important role in the metastatic process and suggest a more informed strategy for selecting drugs worthy of further development for clinical application...
  15. pmc Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types
    Sian Jones
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, USA
    Hum Mutat 33:100-3. 2012
    ..These findings suggest that the aberrant chromatin remodeling consequent to ARID1A inactivation contributes to a variety of different types of neoplasms...
  16. pmc Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    Sian Jones
    Sol Goldman Pancreatic Cancer Research Center, Ludwig Center and Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 321:1801-6. 2008
    ..Dysregulation of these core pathways and processes through mutation can explain the major features of pancreatic tumorigenesis...
  17. pmc A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
    Surojit Sur
    The Howard Hughes Medical Institute and The Ludwig Center for Cancer Genetics and Therapeutics, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 106:3964-9. 2009
    ..This hypothesis was validated by demonstrating that stressed cancer cells without WT TP53 alleles were highly sensitive to PLK1 inhibitors, both in vivo and in vitro...
  18. pmc GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct
    Hanno Matthaei
    Departments of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    HPB (Oxford) 14:677-83. 2012
    ..Intraductal papillary neoplasms of the bile ducts (IPNBs) morphologically resemble pancreatic IPMNs. This study sought to assess the mutational status of GNAS at codon 201 in IPNBs...
  19. ncbi request reprint Pharmacologic and toxicologic evaluation of C. novyi-NT spores
    Luis A Diaz
    Howard Hughes Medical Institute, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Toxicol Sci 88:562-75. 2005
    ..However, there was no laboratory or histopathologic evidence of sepsis, and the toxicity could be effectively controlled by simple hydration...
  20. ncbi request reprint The genomic landscapes of human breast and colorectal cancers
    Laura D Wood
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 318:1108-13. 2007
    ..These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy...
  21. pmc Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas
    Yuchen Jiao
    1 The Ludwig Center, Johns Hopkins University, Baltimore, Maryland, USA 2 Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, Maryland, USA 3 Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA 4
    Nat Genet 45:1470-3. 2013
    ..In contrast, TP53 was the most frequently altered gene in a series of nine gallbladder carcinomas. These discoveries highlight the key role of dysregulated chromatin remodeling in intrahepatic cholangiocarcinomas. ..
  22. pmc Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
    Yuchen Jiao
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, The Johns Hopkins Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Oncotarget 3:709-22. 2012
    ....
  23. ncbi request reprint The consensus coding sequences of human breast and colorectal cancers
    Tobias Sjoblom
    Ludwig Center and Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Science 314:268-74. 2006
    ..These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention, and open fertile avenues for basic research in tumor biology...
  24. pmc A nanoparticle formulation that selectively transfects metastatic tumors in mice
    Jian Yang
    Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 110:14717-22. 2013
    ..At the same time, they illustrate that major increases in the effectiveness of such approaches are needed for utility in patients with metastatic cancer. ..
  25. ncbi request reprint The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT
    Chetan Bettegowda
    The Howard Hughes Medical Institute, The Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Biotechnol 24:1573-80. 2006
    ..Through this analysis, we found that C. novyi-NT spores contained mRNA and that the spore transcripts were distinct from those in vegetative forms of the bacterium...
  26. pmc Comparative lesion sequencing provides insights into tumor evolution
    Sian Jones
    The Ludwig Center for Cancer Genetics and Therapeutics, Department of Biostatistics, Howard Hughes Medical Institute, and Sidney Kimmel Cancer Center at The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 105:4283-8. 2008
    ..These results have important implications for understanding human tumor pathogenesis, particularly those associated with metastasis...
  27. pmc Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design
    Sandra B Gabelli
    Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University, Baltimore, MD 21205, USA
    Biochim Biophys Acta 1804:533-40. 2010
    ..Structural biology is providing insights into the flexibility of the PI3Ks, and providing basis for understanding the effects of mutations, drug resistance and specificity...
  28. pmc Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers
    Thomas D Barber
    The Ludwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 105:3443-8. 2008
    ..These results suggest that defective sister chromatid cohesion as a result of somatic mutations may represent a major cause of chromosome instability in human cancers...
  29. pmc The genetic landscape of the childhood cancer medulloblastoma
    D Williams Parsons
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 331:435-9. 2011
    ....
  30. ncbi request reprint BEAMing up for detection and quantification of rare sequence variants
    Meng Li
    The Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, and Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Methods 3:95-7. 2006
    ..This allowed enumeration of mutant and wild-type sequences even when they were present at ratios less than 1:10,000 and was sensitive enough to directly quantify the error rate of DNA polymerases used for PCR...
  31. pmc Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    Shinichi Yachida
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nature 467:1114-7. 2010
    ..These data provide novel insights into the genetic features underlying pancreatic cancer progression and define a broad time window of opportunity for early detection to prevent deaths from metastatic disease...
  32. pmc An integrated genomic analysis of human glioblastoma multiforme
    D Williams Parsons
    Ludwig Center for Cancer Genetics and Therapeutics, and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 321:1807-12. 2008
    ..These studies demonstrate the value of unbiased genomic analyses in the characterization of human brain cancer and identify a potentially useful genetic alteration for the classification and targeted therapy of GBMs...
  33. pmc A multidimensional analysis of genes mutated in breast and colorectal cancers
    Jimmy Lin
    Ludwig Center for Cancer Genetics and Therapeutics, and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA
    Genome Res 17:1304-18. 2007
    ..These studies provide a multidimensional framework to guide further research and help identify cellular processes critical for malignant progression and therapeutic intervention...
  34. pmc Mutations in CIC and FUBP1 contribute to human oligodendroglioma
    Chetan Bettegowda
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA
    Science 333:1453-5. 2011
    ..These results suggest a critical role for these genes in the biology and pathology of oligodendrocytes...
  35. pmc Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma
    Mark Sausen
    Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Nat Genet 45:12-7. 2013
    ..These results highlight the dysregulation of chromatin remodeling in pediatric tumorigenesis and provide new approaches for the management of patients with neuroblastoma...
  36. pmc Circulating mutant DNA to assess tumor dynamics
    Frank Diehl
    The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Med 14:985-90. 2008
    ..We suggest that this personalized genetic approach could be generally applied to individuals with other types of cancer...
  37. pmc Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene
    Sian Jones
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Baltimore, MD 21231, USA
    Science 324:217. 2009
    ..These results illustrate that complete, unbiased sequencing of protein-coding genes can lead to the identification of a gene responsible for a hereditary disease...
  38. ncbi request reprint A bacterial protein enhances the release and efficacy of liposomal cancer drugs
    Ian Cheong
    Howard Hughes Medical Institute and the Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA
    Science 314:1308-11. 2006
    ..This protein could potentially be incorporated into diverse experimental approaches for the specific delivery of chemotherapeutic agents to tumors...
  39. pmc Exomic sequencing of four rare central nervous system tumor types
    Chetan Bettegowda
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Oncotarget 4:572-83. 2013
    ..Our study supports the hypothesis that pathologically similar tumors arising in different age groups and from different compartments may represent distinct disease processes with varied genetic composition...
  40. ncbi request reprint Mutational analysis of the tyrosine kinome in colorectal cancers
    Alberto Bardelli
    The Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Science 300:949. 2003
  41. pmc Sensitive digital quantification of DNA methylation in clinical samples
    Meng Li
    The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Nat Biotechnol 27:858-63. 2009
    ..In addition to diagnostic and prognostic applications, this digital quantification of rare methylation events should be applicable to preclinical assessment of new epigenetic biomarkers and quantitative analyses in epigenetic research...
  42. pmc Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma
    Sian Jones
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 330:228-31. 2010
    ..In a total of 42 OCCCs, 7% had mutations in PPP2R1A and 57% had mutations in ARID1A. These results suggest that aberrant chromatin remodeling contributes to the pathogenesis of OCCC...
  43. pmc Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing
    Rebecca J Leary
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA
    Sci Transl Med 4:162ra154. 2012
    ..Given that chromosomal abnormalities are present in nearly all human cancers, this approach represents a useful method for the noninvasive detection of human tumors that is not dependent on the availability of tumor biopsies...
  44. pmc Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity
    YunFeng Cui
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 18:6519-30. 2012
    ..Chemotherapy for pancreatic cancer might be improved by adjusting it to individual genetic profiles. We attempt to identify genetic predictors of chemosensitivity to broad classes of anticancer drugs...
  45. pmc Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia
    Mitsuro Kanda
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 142:730-733.e9. 2012
    ..These findings could improve our understanding of the development and progression of these premalignant lesions...
  46. ncbi request reprint BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions
    Frank Diehl
    The Howard Hughes Medical Institute, and The Ludwig Center for Cancer Genetics and Therapeutics, The Johns Hopkins Kimmel Cancer Center, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Methods 3:551-9. 2006
  47. pmc The antisense transcriptomes of human cells
    Yiping He
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 322:1855-7. 2008
    ..Antisense transcripts thus appear to be a pervasive feature of human cells, which suggests that they are a fundamental component of gene regulation...
  48. ncbi request reprint The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
    Chuan Hsiang Huang
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 318:1744-8. 2007
    ..In addition to providing new insights about the structure of PI3Kalpha, these results suggest specific mechanisms for the effect of oncogenic mutations in p110alpha and p85alpha...
  49. ncbi request reprint Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells
    Kurtis E Bachman
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mol Cancer Ther 4:1026-30. 2005
    ..These compounds may prove useful for the treatment or prevention of gastrointestinal tumors arising after exposure to PhIP and related carcinogens...
  50. pmc Genetic mutations associated with cigarette smoking in pancreatic cancer
    Amanda Blackford
    Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 69:3681-8. 2009
    ..Pancreatic carcinomas from cigarette smokers harbor more mutations than do carcinomas from never smokers. The types and patterns of these mutations provide insight into the mechanisms by which cigarette smoking causes pancreatic cancer...
  51. ncbi request reprint Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene
    Kurtis E Bachman
    The Howard Hughes Medical Institute, The Sidney Kimmel Comprehensive Cancer Center, and Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
    Cancer Cell 3:89-95. 2003
    ..These results have important implications for understanding the biochemical events underlying the silencing of tumor suppressor genes and the resultant growth suppression...
  52. pmc Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations
    Hannah Carter
    Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Cancer Res 69:6660-7. 2009
    ..Based on a model that assumed the glioblastoma multiforme mutations are a mixture of drivers and passengers, we estimate that 8% of these mutations are drivers, causally contributing to tumorigenesis...
  53. ncbi request reprint Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R
    Akash Nanda
    The Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Cancer Res 64:8507-11. 2004
    ..These studies establish the overexpression of TEM7 protein in tumor endothelium and provide new opportunities for the delivery of therapeutic and imaging agents to the vessels of solid tumors...
  54. ncbi request reprint Inactivation of hCDC4 can cause chromosomal instability
    Harith Rajagopalan
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 428:77-81. 2004
    ..Our data suggest that chromosomal instability is caused by specific genetic alterations in a large fraction of human cancers and can occur before malignant conversion...
  55. doi request reprint Limited detection of IgH gene rearrangements in plasma of patients with primary central nervous system lymphoma
    Jian He
    Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    J Neurooncol 114:275-9. 2013
    ..Alternative strategies to develop circulating biomarkers for PCNSL patients need to be explored...
  56. pmc Whole-exome sequencing of pancreatic neoplasms with acinar differentiation
    Yuchen Jiao
    Department of Oncology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD, USA
    J Pathol 232:428-35. 2014
    ..Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  57. ncbi request reprint Three classes of genes mutated in colorectal cancers with chromosomal instability
    Zhenghe Wang
    Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute at Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 64:2998-3001. 2004
    ..This analysis buttresses the evidence that chromosomal instability has a genetic basis and provides clues to the mechanistic basis of instability in cancers...
  58. pmc Low-grade serous carcinomas of the ovary contain very few point mutations
    Sian Jones
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    J Pathol 226:413-20. 2012
    ..Our mutational analysis demonstrates that point mutations are much less common in low-grade serous tumours of the ovary than in other adult tumours, a finding with interesting scientific and clinical implications...
  59. pmc Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
    Jian Wu
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 108:21188-93. 2011
    ..These results highlight the essential role of ubiquitin ligases in these neoplasms and have important implications for the diagnosis and treatment of patients with cystic tumors...
  60. pmc SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells
    Manu Kohli
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 101:16897-902. 2004
    ..These results establish that SMAC/Diablo is essential for the apoptosis induced by NSAIDs in colon cancer cells...
  61. pmc Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers
    Rebecca J Leary
    The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 105:16224-9. 2008
    ..These analyses provide an integrated view of copy number and sequencing alterations on a genome-wide scale and identify genes and pathways that could prove useful for cancer diagnosis and therapy...
  62. pmc SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
    Amanda Blackford
    Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 15:4674-9. 2009
    ..Recently, the majority of protein coding genes were sequenced in a collection of pancreatic cancers, providing an unprecedented opportunity to identify genetic markers of prognosis for patients with adenocarcinoma of the pancreas...
  63. pmc Altered telomeres in tumors with ATRX and DAXX mutations
    Christopher M Heaphy
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Science 333:425. 2011
    ..ATRX mutations also correlate with abnormal telomeres in tumors of the central nervous system. These data suggest that an alternative telomere maintenance function may operate in human tumors with alterations in the ATRX or DAXX genes...
  64. pmc Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development
    Jian Wu
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Sci Transl Med 3:92ra66. 2011
    ..In addition to defining a new pathway for pancreatic neoplasia, these data suggest that GNAS mutations can inform the diagnosis and management of patients with cystic pancreatic lesions...
  65. pmc Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients
    Frank Diehl
    The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center, Baltimore, Maryland, USA
    Gastroenterology 135:489-98. 2008
    ..A secondary purpose was to compare the results of plasma and stool DNA testing using the same technology...
  66. ncbi request reprint High frequency of mutations of the PIK3CA gene in human cancers
    Yardena Samuels
    Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Science 304:554. 2004
  67. pmc Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors
    Akash Nanda
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:3351-6. 2006
    ..Therefore, they have significant implications for the mechanisms underlying tumor invasiveness and for models that evaluate this process...
  68. ncbi request reprint Tumour suppression: disruption of HAUSP gene stabilizes p53
    Jordan M Cummins
    Howard Hughes Medical Institute, The Sidney Kimmel Comprehensive Cancer Center, and Program in Cellular and Molecular Medicine, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
    Nature 428:1 p following 486. 2004
  69. pmc Heteroplasmic mitochondrial DNA mutations in normal and tumour cells
    Yiping He
    The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA
    Nature 464:610-4. 2010
    ..In particular, they demonstrate that individual humans are characterized by a complex mixture of related mitochondrial genotypes rather than a single genotype...
  70. pmc Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses
    Manu Kohli
    The Howard Hughes Medical Institute, The Sidney Kimmel Comprehensive Cancer Center, and The Cellular and Molecular Medicine Program, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Nucleic Acids Res 32:e3. 2004
    ..This technology should be broadly applicable to in vitro studies that require the manipulation of the human genome...
  71. pmc Bacteriolytic therapy can generate a potent immune response against experimental tumors
    Nishant Agrawal
    Howard Hughes Medical Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 101:15172-7. 2004
    ..Similar effects were observed in rabbits with intrahepatic tumors. It was particularly notable that the induced immune response, when combined with the bacteriolytic effects of C. novyi-NT, could eradicate large established tumors...
  72. ncbi request reprint Multicolor in vitro translation
    Giovanni Traverso
    Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center, and Graduate Program in Human Genetics, Johns Hopkins School of Medicine, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Biotechnol 21:1093-7. 2003
    ..This technology can be applied in various situations, including the simplified detection of rare truncating mutations in clinical samples from cancer patients...
  73. pmc Detection of tumor DNA at the margins of colorectal cancer liver metastasis
    Matthias Holdhoff
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, USA
    Clin Cancer Res 17:3551-7. 2011
    ..Defining an adequate resection margin of colorectal cancer liver metastases is essential for optimizing surgical technique. We have attempted to evaluate the resection margin through a combination of histopathologic and genetic analyses...
  74. pmc Digital karyotyping
    Tian Li Wang
    The Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 99:16156-61. 2002
    ..Foreign DNA sequences not present in the normal human genome could also be readily identified. Digital karyotyping provides a broadly applicable means for systematic detection of DNA copy number changes on a genomic scale...
  75. pmc Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
    Nishant Agrawal
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Science 333:1154-7. 2011
    ..Nearly 40% of the 28 mutations identified in NOTCH1 were predicted to truncate the gene product, suggesting that NOTCH1 may function as a tumor suppressor gene rather than an oncogene in this tumor type...
  76. ncbi request reprint Hyper-recombination and genetic instability in BLM-deficient epithelial cells
    Giovanni Traverso
    Howard Hughes Medical Institute and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Res 63:8578-81. 2003
    ..However, the enhanced homologous recombination was associated with losses of heterozygosity. These observations define a type of genetic instability that has significant implications for the evolution of cancer...
  77. pmc Detection and quantification of mutations in the plasma of patients with colorectal tumors
    Frank Diehl
    Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 102:16368-73. 2005
    ..01% to 1.7% of the total APC molecules. These results have implications for the mechanisms through which tumor DNA is released into the circulation and for diagnostic tests based on this phenomenon...
  78. pmc Structural comparisons of class I phosphoinositide 3-kinases
    L Mario Amzel
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Rev Cancer 8:665-9. 2008
    ..Comparison of the PI3K structures also identified structural features that could potentially be exploited for the design of isoform-specific inhibitors...
  79. ncbi request reprint X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells
    Jordan M Cummins
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Res 64:3006-8. 2004
    ..These results demonstrate that XIAP is a nonredundant modulator of TRAIL-mediated apoptosis and provide a rationale for XIAP as a therapeutic target...
  80. pmc DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors
    Yuchen Jiao
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 331:1199-203. 2011
    ..We also found mutations in genes in the mTOR (mammalian target of rapamycin) pathway in 14% of the tumors, a finding that could potentially be used to stratify patients for treatment with mTOR inhibitors...
  81. pmc Design and analysis issues in genome-wide somatic mutation studies of cancer
    Giovanni Parmigiani
    Ludwig Center for Cancer Genetics and Therapeutics, and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Genomics 93:17-21. 2009
    ....
  82. ncbi request reprint DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
    Ina Rhee
    The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 416:552-6. 2002
    ..Here we demonstrate that two enzymes cooperatively maintain DNA methylation and gene silencing in human cancer cells, and provide compelling evidence that such methylation is essential for optimal neoplastic proliferation...
  83. ncbi request reprint Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
    Harith Rajagopalan
    Sidney Kimmel Comprehensive Cancer Centre, Howard Hughes Medical Institution and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Nature 418:934. 2002
    ....
  84. ncbi request reprint Contribution of bone marrow-derived endothelial cells to human tumor vasculature
    Brock A Peters
    The Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Med 11:261-2. 2005
    ..These results illustrate substantial differences between human tumors and many mouse models with respect to angiogenesis and have important implications for the translation of experimental antiangiogenic therapies to the clinic...
  85. ncbi request reprint TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI)
    Akash Nanda
    Program in Human Genetics and Molecular Biology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Cancer Res 64:817-20. 2004
    ..These results suggest that the TEM8/C5 interaction may play an important biological role in tumor angiogenesis...
  86. ncbi request reprint Detection of APC mutations in fecal DNA from patients with colorectal tumors
    Giovanni Traverso
    Graduate Program in Human Genetics, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins School of Medicine, Baltimore, USA
    N Engl J Med 346:311-20. 2002
    ..The purpose of our study was to determine the feasibility of detecting APC mutations in fecal DNA with the use of newly developed methods...
  87. pmc Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria
    Chetan Bettegowda
    Howard Hughes Medical Institute and Sidney Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 100:15083-8. 2003
    ..C. novyi-NT spores added little toxicity to the radiotherapeutic regimens, and the combination resulted in long-term remissions in a significant fraction of animals...
  88. ncbi request reprint The role of companion diagnostics in the development and use of mutation-targeted cancer therapies
    Nickolas Papadopoulos
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, The Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans Street, CRB1, Baltimore, MD 21231, USA
    Nat Biotechnol 24:985-95. 2006
    ..These tests can simplify the drug discovery process, make clinical trials more efficient and informative, and be used to individualize the therapy of cancer patients...
  89. pmc Development of personalized tumor biomarkers using massively parallel sequencing
    Rebecca J Leary
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Sci Transl Med 2:20ra14. 2010
    ..This approach provides an exquisitely sensitive and broadly applicable approach for the development of personalized biomarkers to enhance the clinical management of cancer patients...
  90. pmc The colorectal microRNAome
    Jordan M Cummins
    The Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute, Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 103:3687-92. 2006
    ..These studies suggest that the human genome contains many more miRNAs than currently identified and provide an approach for the large-scale experimental cloning of novel human miRNAs in human tissues...
  91. ncbi request reprint Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents
    Long H Dang
    Howard Hughes Medical Institute and Sidney Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Cancer Biol Ther 3:326-37. 2004
    ..novyi-NT spores could germinate. A single intravenous injection of C. novyi-NT plus selected anti-microtubule agents was able to cause regressions of several human tumor xenografts in nude mice in the absence of excessive toxicity...
  92. pmc Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation
    Timothy A Chan
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 99:8265-70. 2002
    ..These findings pose several challenges to current models of APC/beta-catenin function...
  93. ncbi request reprint HAUSP is required for p53 destabilization
    Jordan M Cummins
    The Howard Hughes Medical Institute, The Sidney Kimmel Comprehensive Cancer Center, Program in Cellular and Molecular Medicine, The Johns Hopkins University Medical Institutions, Baltimore, Maryland, USA
    Cell Cycle 3:689-92. 2004
    ..These results demonstrate that MDM2, rather than p53, is the substrate for HAUSP under physiologic conditions and document a fascinating and unexpected twist to the regulation of the p53/MDM2 axis...
  94. ncbi request reprint Phosphorylation of beta-catenin at S33, S37, or T41 can occur in the absence of phosphorylation at T45 in colon cancer cells
    Zhenghe Wang
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 63:5234-5. 2003
    ....
  95. pmc DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities
    Leigh Zawel
    The Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 99:2848-53. 2002
    ..However, DEC1 may function in concert with other signaling components to mediate certain biologic effects of TGF-beta...
  96. ncbi request reprint Allele separation facilitates interpretation of potential splicing alterations and genomic rearrangements
    Hidewaki Nakagawa
    Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 62:4579-82. 2002
    ..These results allowed pathogenicity to be unambiguously assigned to the mutations and increased the sensitivity of genomic testing...
  97. ncbi request reprint Dynamics of genetic instability in sporadic and familial colorectal cancer
    Natalia L Komarova
    Institute for Advanced Study, Princeton, New Jersey, USA
    Cancer Biol Ther 1:685-92. 2002
    ..For a wide range of parameter values, we find support for the radical hypothesis that genetic instability initiates colonic tumorigenesis. We compare sporadic and hereditary forms of colorectal cancer...
  98. ncbi request reprint Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics
    Kristina Lagerstedt Robinson
    Department of Clinical Genetics, Karolinska University Hospital, S 17176 Stockholm, Sweden
    J Natl Cancer Inst 99:291-9. 2007
    ..The syndrome is explained by germline mutations in DNA mismatch repair (MMR) genes, and there is a need for diagnostic tools to preselect patients for genetic testing to diagnose those with HNPCC...
  99. ncbi request reprint Facultative or obligate anaerobic bacteria have the potential for multimodality therapy of solid tumours
    Ming Q Wei
    Department of Medicine, University of Queensland, Prince Charles Hospital, Brisbane, Qld 4032, Australia
    Eur J Cancer 43:490-6. 2007
    ....
  100. ncbi request reprint Wanted: cancer boss
    Donald McDonald
    Nature 440:978-9. 2006
  101. pmc Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket
    Mark Frazzetto
    Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia
    Biochem J 414:383-90. 2008
    ....

Research Grants2

  1. MOLECULAR GENETIC ANALYSIS OF COLORECTAL CANCER
    Bert Vogelstein; Fiscal Year: 2007
    ..It is likely to have substantial implications for the diagnosis and treatment of cancer patients. ..