RAPHAEL PAUL VISCIDI

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Genetic diversity of Neisseria gonorrhoeae housekeeping genes
    Raphael P Viscidi
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Clin Microbiol 41:197-204. 2003
  2. pmc Strategy for eliciting antigen-specific CD8+ T cell-mediated immune response against a cryptic CTL epitope of merkel cell polyomavirus large T antigen
    Bianca P Gomez
    Departments of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Cell Biosci 2:36. 2012
  3. pmc Population dynamics of Neisseria gonorrhoeae in Shanghai, China: a comparative study
    Loubna Tazi
    Division of Epidemiology and Disease Control, University of Texas, Health Science Center at Houston, School of Public Health, Brownsville Regional Campus, Brownsville, TX, USA
    BMC Infect Dis 10:13. 2010
  4. pmc Distinguishing importation from diversification of quinolone-resistant Neisseria gonorrhoeae by molecular evolutionary analysis
    Marcos Pérez-Losada
    Department of Integrative Biology, Brigham Young University, Provo, UT, USA
    BMC Evol Biol 7:84. 2007
  5. pmc Population genetic estimation of the loss of genetic diversity during horizontal transmission of HIV-1
    Charles T T Edwards
    Nuffield Department of Clinical Medicine, University of Oxford, The Peter Medawar Building for Pathogen Research, Oxford, OX1 3SY, UK
    BMC Evol Biol 6:28. 2006
  6. pmc Serological cross-reactivities between antibodies to simian virus 40, BK virus, and JC virus assessed by virus-like-particle-based enzyme immunoassays
    Raphael P Viscidi
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore Maryland, USA
    Clin Diagn Lab Immunol 10:278-85. 2003
  7. pmc Age-specific seroprevalence of Merkel cell polyomavirus, BK virus, and JC virus
    Raphael P Viscidi
    Department of Pediatrics, The Johns Hopkins Hospital, Blalock 1153, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Clin Vaccine Immunol 18:1737-43. 2011
  8. pmc JC virus antibody and viremia as predictors of progressive multifocal leukoencephalopathy in human immunodeficiency virus-1-infected individuals
    Raphael P Viscidi
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Infect Dis 53:711-5. 2011
  9. ncbi request reprint Cancer. A skin cancer virus?
    Raphael P Viscidi
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Science 319:1049-50. 2008
  10. ncbi request reprint Serological cross reactivity between polyomavirus capsids
    Raphael P Viscidi
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Adv Exp Med Biol 577:73-84. 2006

Research Grants

  1. Virus-Like Particle Vaccine for SARS-CoV
    Raphael Viscidi; Fiscal Year: 2009
  2. Virus-Like Particle Vaccine for SARS-CoV
    Raphael Viscidi; Fiscal Year: 2007
  3. Molecular Epidemiology of N. gonorrhoeae
    Raphael Viscidi; Fiscal Year: 2006
  4. ANTIBODIES TO HPV CAPSID PROTEINS AS IMMUNITY CORRELATES
    Raphael Viscidi; Fiscal Year: 2001
  5. Virus-Like Particle Vaccine for SARS-CoV
    RAPHAEL PAUL VISCIDI; Fiscal Year: 2010

Detail Information

Publications48

  1. pmc Genetic diversity of Neisseria gonorrhoeae housekeeping genes
    Raphael P Viscidi
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Clin Microbiol 41:197-204. 2003
    ..A potential MLST for N. gonorrhoeae, based on approximately 500- to 600-bp gene fragments of seven housekeeping gene loci, would include the pilA, abcZ, serC, glnA, gdh, gnd, and pip loci...
  2. pmc Strategy for eliciting antigen-specific CD8+ T cell-mediated immune response against a cryptic CTL epitope of merkel cell polyomavirus large T antigen
    Bianca P Gomez
    Departments of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Cell Biosci 2:36. 2012
    ..abstract:..
  3. pmc Population dynamics of Neisseria gonorrhoeae in Shanghai, China: a comparative study
    Loubna Tazi
    Division of Epidemiology and Disease Control, University of Texas, Health Science Center at Houston, School of Public Health, Brownsville Regional Campus, Brownsville, TX, USA
    BMC Infect Dis 10:13. 2010
    ..We compare these findings with our previous study of the evolution of a fluoroquinolone sensitive gonococcal population from Baltimore, MD...
  4. pmc Distinguishing importation from diversification of quinolone-resistant Neisseria gonorrhoeae by molecular evolutionary analysis
    Marcos Pérez-Losada
    Department of Integrative Biology, Brigham Young University, Provo, UT, USA
    BMC Evol Biol 7:84. 2007
    ..We applied molecular evolutionary analyses to DNA sequences from 9 housekeeping genes and gyrA, parC and porB of 24 quinolone resistant N. gonorrhoeae (QRNG) and 24 quinolone sensitive isolates collected in Israel during 2000-2001...
  5. pmc Population genetic estimation of the loss of genetic diversity during horizontal transmission of HIV-1
    Charles T T Edwards
    Nuffield Department of Clinical Medicine, University of Oxford, The Peter Medawar Building for Pathogen Research, Oxford, OX1 3SY, UK
    BMC Evol Biol 6:28. 2006
    ..Despite this, the magnitude of this population bottleneck is unclear...
  6. pmc Serological cross-reactivities between antibodies to simian virus 40, BK virus, and JC virus assessed by virus-like-particle-based enzyme immunoassays
    Raphael P Viscidi
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore Maryland, USA
    Clin Diagn Lab Immunol 10:278-85. 2003
    ..With their greater versatility and their suitability for large-scale testing, the VLP-based EIAs for SV40, BKV, and JCV are likely to contribute to a better understanding of the biology of these viruses...
  7. pmc Age-specific seroprevalence of Merkel cell polyomavirus, BK virus, and JC virus
    Raphael P Viscidi
    Department of Pediatrics, The Johns Hopkins Hospital, Blalock 1153, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Clin Vaccine Immunol 18:1737-43. 2011
    ..In agreement with results from other studies, we found an association between MCPyV seropositivity and MCC, and higher levels of serum MCPyV capsid antibodies in MCC patients than in controls...
  8. pmc JC virus antibody and viremia as predictors of progressive multifocal leukoencephalopathy in human immunodeficiency virus-1-infected individuals
    Raphael P Viscidi
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Infect Dis 53:711-5. 2011
    ..JCV viremia was not predictive of PML, but some patients showed higher anti-JCV immunoglobulin G (IgG) responses 6 months prior to diagnosis...
  9. ncbi request reprint Cancer. A skin cancer virus?
    Raphael P Viscidi
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Science 319:1049-50. 2008
  10. ncbi request reprint Serological cross reactivity between polyomavirus capsids
    Raphael P Viscidi
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Adv Exp Med Biol 577:73-84. 2006
    ..SV40 and LPV VLP-based EIAs and competitive inhibition assays with heterologous VLPs provide tools for seroepidemiological studies of possible SV40 and LPV-like infections of humans...
  11. ncbi request reprint Vaccination of healthy volunteers with human papillomavirus type 16 L2E7E6 fusion protein induces serum antibody that neutralizes across papillomavirus species
    Ratish Gambhira
    Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Res 66:11120-4. 2006
    ..001). Vaccination of healthy volunteers thrice with 533-mug HPV16 L2E7E6 at monthly intervals induced L2-specific serum antibodies that neutralized across papillomavirus species. Responses in AGIN patients were infrequent...
  12. ncbi request reprint Human papillomavirus capsid antibody response to natural infection and risk of subsequent HPV infection in HIV-positive and HIV-negative women
    Raphael P Viscidi
    Johns Hopkins Hospital, Blalock Room 1105, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Cancer Epidemiol Biomarkers Prev 14:283-8. 2005
    ..0-2.0). The lack of a protective immune effect from natural infection is most likely due to the low level of antibody elicited by natural HPV infection and/or the potential for reactivation of HPV, especially in HIV-positive women...
  13. pmc Development of a nucleocapsid-based human coronavirus immunoassay and estimates of individuals exposed to coronavirus in a U.S. metropolitan population
    Emily G Severance
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Blalock 1105, Baltimore, MD 21287 4933, USA
    Clin Vaccine Immunol 15:1805-10. 2008
    ..Demographic factors, such as race, smoking status, and socioeconomic status, may confer an increased risk of susceptibility to these viruses...
  14. pmc Coronavirus immunoreactivity in individuals with a recent onset of psychotic symptoms
    Emily G Severance
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Blalock 1105, Baltimore, MD 21287 4933, USA
    Schizophr Bull 37:101-7. 2011
    ..Future studies should explore links between the timing of coronavirus infections and subsequent development of schizophrenia and other disorders with psychotic symptoms...
  15. ncbi request reprint Seroreactivity to human papillomavirus (HPV) types 16, 18, or 31 and risk of subsequent HPV infection: results from a population-based study in Costa Rica
    Raphael P Viscidi
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Epidemiol Biomarkers Prev 13:324-7. 2004
    ..3; 95% CI 1.0-1.8). Thus, we did not observe immunity, although a protective effect from natural infection cannot be excluded because of the limits of available assays and study designs...
  16. ncbi request reprint Serum immunoglobulin A response to human papillomavirus type 16 virus-like particles in human immunodeficiency virus (HIV)-positive and high-risk HIV-negative women
    Raphael P Viscidi
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 188:1834-44. 2003
    ..9-5.4]), but there was no difference in the risk of incident HPV 16 or HPV 16-related infections. This may be evidence of partial type-specific or clade-specific immunity conferred by seropositivity to HPV 16 capsids...
  17. ncbi request reprint Interaction of L2 with beta-actin directs intracellular transport of papillomavirus and infection
    Rongcun Yang
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:12546-53. 2003
    ..Thus, binding of beta-actin by L2 residues 25-45 facilitates transport of HPV16 across the cytoplasm during infection, and blockade of this novel interaction may be useful for prophylaxis...
  18. ncbi request reprint Serum immunoglobulin G response to human papillomavirus type 16 virus-like particles in human immunodeficiency virus (HIV)-positive and risk-matched HIV-negative women
    Raphael P Viscidi
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 187:194-205. 2003
    ..Despite the higher prevalence of HPV infection in this group, most HIV-positive women are able to control HPV-16 replication at the cervix, and reactivation, if it occurs, is not very common...
  19. pmc Serological detection of human papillomavirus type 16 infection in human immunodeficiency virus (HIV)-positive and high-risk HIV-negative women
    Michael J Silverberg
    Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA
    Clin Vaccine Immunol 13:511-9. 2006
    ..Rises among HIV-positive women may more often result from reactivation of a latent HPV infection in the context of HIV-induced immunosuppression, while rises among HIV-negative women may more often result from reinfection with HPV...
  20. pmc Investigation of pre-diagnostic virological markers for progressive multifocal leukoencephalopathy in human immunodeficiency virus-infected patients
    Mary K Grabowski
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Med Virol 81:1140-50. 2009
    ..0, 95% CI: 1.2-394.5). The results suggest that persistent JCV viruria and increasing urinary concentration of JCV DNA may be predictive of PML for some patients...
  21. pmc Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer
    Rongcun Yang
    Department of Pathology, The Johns Hopkins School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Virol 79:6741-50. 2005
    ..Tumor progression is associated with genetic instability and L1 mutants. Selection for assembly-deficient L1 mutations suggests the evasion of MyD88-dependent immune control during cervical carcinogenesis...
  22. ncbi request reprint Simian virus 40 (SV40) and human cancer: a review of the serological data
    Keerti V Shah
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Rev Med Virol 14:231-9. 2004
    ..Serological data thus do not support the possibility that SV40 is circulating in human communities or that it is associated with human cancer...
  23. ncbi request reprint Human papillomavirus seroprevalence among young male and female drug users
    Sabrina S Plitt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Sex Transm Dis 34:676-80. 2007
    ..To determine seroprevalence and correlates of exposure to HPV 16, 18, and 53 among 15- to 30-year-old drug users in Baltimore, MD...
  24. pmc Plasma antibodies against Chlamydia trachomatis, human papillomavirus, and human herpesvirus type 8 in relation to prostate cancer: a prospective study
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6132 A, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 16:1573-80. 2007
    ..70; 95% CI, 0.52-0.95). As this study is the first, to our knowledge, to observe such an inverse association, similar additional studies are warranted...
  25. ncbi request reprint B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88
    Rongcun Yang
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 174:7912-9. 2005
    ..Thus HPV16 L1 VLP directly activate B cells to induce CD4(+) T cell independent humoral immune responses via TLR4- and MyD88-dependent signaling...
  26. ncbi request reprint Human papillomavirus type-16 virus-like particles activate complementary defense responses in key dendritic cell subpopulations
    Rongcun Yang
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 173:2624-31. 2004
    ..Thus, before adaptive immunity, HPV16 VLPs signal complementary defense responses in key DC subpopulations, indicating specialized DC lineages with predetermined polarization...
  27. pmc Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88
    Rongcun Yang
    Department of Pathology, Johns Hopkins School of Medicine, Ross 512B, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Virol 78:11152-60. 2004
    ..Finally, Th1-biased immune responses to HPV16 VLPs are dramatically impaired in MyD88 and IFN-alpha/beta receptor-deficient mice. This implicates TLR recognition as central to immune recognition of HPV16 L1 VLPs...
  28. doi request reprint Serological pattern consistent with infection with type I Toxoplasma gondii in mothers and risk of psychosis among adult offspring
    Jianchun Xiao
    The Stanley Division of Developmental Neurovirology, Johns Hopkins School of Medicine, 600 N Wolfe Street, 1105 Blalock, Baltimore, MD 21287 4933, USA
    Microbes Infect 11:1011-8. 2009
    ..These findings suggest an influence of the parasite genotype on increased risk of psychosis and provide further support for a substantive role of Toxoplasma in the etiology of psychosis...
  29. ncbi request reprint BK virus-specific antibodies and BKV DNA in renal transplant recipients with BKV nephritis
    Sundaram Hariharan
    The Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI, USA
    Am J Transplant 5:2719-24. 2005
    ..Recovery from BKVN and elimination of BKV is associated with the development of BKV-specific IgG antibodies and this provides insight into the role of humoral immunity to BKV in the pathogenesis of BKVN...
  30. pmc Seroprevalences of herpes simplex virus type 2, five oncogenic human papillomaviruses, and Chlamydia trachomatis in Katowice, Poland
    Staffan Görander
    Department of Virology, Institute of Biomedicine, Sahlgrenska Academy, Goteborg University, S 413 46 Goteborg, Sweden
    Clin Vaccine Immunol 15:675-80. 2008
    ..The relatively high prevalence of HPV-51 may have implications for future vaccine programs, as the newly introduced HPV vaccines are based on the potentially oncogenic HPV types 16 and 18...
  31. ncbi request reprint Serologic evidence for exposure to simian virus 40 in North American zoo workers
    Eric A Engels
    National Cancer Institute, Rockville, Maryland 20892, USA
    J Infect Dis 190:2065-9. 2004
    ..3%, respectively; P=.04). SV40 seroreactivity therefore may reflect zoonotic exposure...
  32. ncbi request reprint Case-control study of simian virus 40 and non-Hodgkin lymphoma in the United States
    Eric A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, 6120 Executive Blvd, EPS 8010, Rockville, MD 20892, USA
    J Natl Cancer Inst 96:1368-74. 2004
    ..S. non-Hodgkin lymphoma (NHL) patients. SV40 accidentally contaminated U.S. poliovirus vaccines that were widely administered from 1955 through 1962. However, epidemiologic data linking SV40 with NHL are lacking...
  33. ncbi request reprint A population-based study of vaginal human papillomavirus infection in hysterectomized women
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7234, USA
    J Infect Dis 190:458-67. 2004
    ..e., A3/A4/A15) may have a predilection for vaginal epithelium...
  34. ncbi request reprint Lack of serological evidence for an association between simian virus 40 and lymphoma
    Silvia de Sanjose
    Institut Catala d Oncologia, Barcelona, Spain
    Int J Cancer 104:522-4. 2003
    ..VLPs of the human BK virus substantially inhibited the SV40 reactivity of human sera. There was no serological evidence of widespread SV40 infection and no association of SV40 seropositivity with human lymphomas in Spain...
  35. ncbi request reprint Prediagnostic circulating antibodies to JC and BK human polyomaviruses and risk of non-Hodgkin lymphoma
    Dana E Rollison
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cancer Epidemiol Biomarkers Prev 15:543-50. 2006
    ....
  36. ncbi request reprint Antibody responses to simian virus 40 T antigen: a case-control study of non-Hodgkin lymphoma
    Eric A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, 6120 Executive Boulevard, EPS 8010, Rockville, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:521-4. 2005
    ..We found no association between the presence of T antibody and NHL, arguing against SV40 as a cause of NHL. Infrequent and low-level T antibody responses among humans could represent cross-reactivity to BK virus T antigen...
  37. ncbi request reprint Antibodies to JC and BK viruses among persons with non-Hodgkin lymphoma
    Eric A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20892, USA
    Int J Cancer 117:1013-9. 2005
    ..Additional research is needed to determine whether JCV replication is decreased in individuals with NHL and whether these findings are consistent with an etiologic role for JCV in NHL...
  38. ncbi request reprint Markers of past infection with simian virus 40 (SV40) and risk of incident non-Hodgkin lymphoma in a Maryland cohort
    Dana E Rollison
    Division of Cancer Prevention and Control, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
    Cancer Epidemiol Biomarkers Prev 14:1448-52. 2005
    ..8% of cases and 1.6% of controls (OR, 1.51; 95% CI, 0.41-5.52). Our findings suggest that past infection with SV40 is not associated with an increased risk of developing NHL...
  39. ncbi request reprint Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada
    Javier Pintos
    Division of Cancer Epidemiology, McGill University, Montreal, Canada
    Oral Oncol 44:242-50. 2008
    ..16 (95%CI: 0.8-13.0), respectively. These results provide evidence supporting a strong causal association between HPV infection and tonsil-related cancers. The evidence for an etiologic link is less clear for non-tonsillar oral cancers...
  40. pmc Comparing phylogenetic codivergence between polyomaviruses and their hosts
    Marcos Pérez-Losada
    Department of Integrative Biology, Brigham Young University, Provo, UT 84602 5181, USA
    J Virol 80:5663-9. 2006
    ....
  41. ncbi request reprint Seroprevalence of human papillomavirus types 16 and 18 in the general population in Taiwan: implication for optimal age of human papillomavirus vaccination
    Chih Jung Chen
    Divisions of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5, Fu Shin Street, Kweishan 333, Taoyuan, Taiwan
    J Clin Virol 38:126-30. 2007
    ..The optimal age for administration of recently approved prophylactic human papillomavirus (HPV) vaccines remains undetermined...
  42. pmc Immunoglobulin G, A, and M responses to BK virus in renal transplantation
    Parmjeet S Randhawa
    Department of Pathology, Division of Transplant Pathology, University of Pittsburgh, E 737 UPMC Montefiore Hospital, 3459 Fifth Ave, PA 15213, USA
    Clin Vaccine Immunol 13:1057-63. 2006
    ..In conclusion, measurement of anti-BKV antibody titer and class response can be used to detect the onset of viral replication. ELISAs can be quite specific despite considerable sequence homology between BK virus and JC virus...
  43. pmc Population genetics of microbial pathogens estimated from multilocus sequence typing (MLST) data
    Marcos Pérez-Losada
    Department of Integrative Biology, Brigham Young University, Provo, UT 84602, USA
    Infect Genet Evol 6:97-112. 2006
    ..Significant evidence of molecular adaptation was detected in 28 loci from 13 pathogens. Three of these loci showed concordant patterns of adaptive selection in two to four different species...
  44. pmc Temporal trends in gonococcal population genetics in a high prevalence urban community
    Marcos Pérez-Losada
    Department of Integrative Biology, Brigham Young University, Provo, UT, United States
    Infect Genet Evol 7:271-8. 2007
    ..The real time application of population genetic analysis can provide sentinel data on gonococcal prevalence, antibiotic resistance patterns and changing epidemiology of gonococcal infections...
  45. ncbi request reprint Population genetics of Neisseria gonorrhoeae in a high-prevalence community using a hypervariable outer membrane porB and 13 slowly evolving housekeeping genes
    Marcos Pérez-Losada
    Department of Integrative Biology, Brigham Young University, USA
    Mol Biol Evol 22:1887-902. 2005
    ..Thirteen amino acid physicochemical properties seem to drive protein evolution of the PI porins in N. gonorrhoeae...
  46. pmc Sexually transmissible infections and prostate cancer risk
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 17:2374-81. 2008
    ..Sexually transmissible infections (STI) have been variably associated with increased risks of prostate cancer, largely in case-control studies...
  47. ncbi request reprint No excess risk for colorectal cancer among subjects seropositive for the JC polyomavirus
    Annika Lundstig
    Department of Medical Microbiology, Lund University, University Hospital, Malmo, Sweden
    Int J Cancer 121:1098-102. 2007
    ..1 (95% CI: 0.8-1.5). Determining seropositivity using alternative cutoffs also found no evidence of excess risk. In summary, this prospective study found no association between JCV or BKV infections and excess risk for colorectal cancer...
  48. ncbi request reprint Phylogenomics and molecular evolution of polyomaviruses
    Keith A Crandall
    Brigham Young University, Provo, Utah, USA
    Adv Exp Med Biol 577:46-59. 2006
    ..The phylogenetic analysis suggested a close relationship among the BK viruses, JC viruses, and SV40 with a more distant association with mouse polyomavirus, monkey polymavirus (LPV) and then avian polyomavirus (BFDV)...

Research Grants14

  1. Virus-Like Particle Vaccine for SARS-CoV
    Raphael Viscidi; Fiscal Year: 2009
    ..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..
  2. Virus-Like Particle Vaccine for SARS-CoV
    Raphael Viscidi; Fiscal Year: 2007
    ..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..
  3. Molecular Epidemiology of N. gonorrhoeae
    Raphael Viscidi; Fiscal Year: 2006
    ..gonorrhea in the core. The third aim is to determine whether gender, age, or disseminated versus local infection influences the population genetic structure of N. gonorrhea. ..
  4. ANTIBODIES TO HPV CAPSID PROTEINS AS IMMUNITY CORRELATES
    Raphael Viscidi; Fiscal Year: 2001
    ..of incident HPV infection and/or disease? (6) In HIV seropositive women, is the extent of immunodeficiency, as measured by CD4+ cell counts, inversely correlated with the degree of protection provided by pre-existing anti-VLP antibodies? ..
  5. Virus-Like Particle Vaccine for SARS-CoV
    RAPHAEL PAUL VISCIDI; Fiscal Year: 2010
    ..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..