Genomes and Genes
Affiliation: Johns Hopkins University
- Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-αF Vesuna
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21250, USA
Oncogene 31:3223-34. 2012..In summary, the regulation of ER by Twist could be an underlying mechanism for the loss of ER activity observed in breast tumors, and may contribute to the generation of hormone-resistant, ER-negative breast cancer...
- The transcription factor encyclopediaDimas Yusuf
Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
Genome Biol 13:R24. 2012..TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written and vetted by experts in the field. TFe is available at http://www.cisreg.ca/tfe...
- Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expressionFarhad Vesuna
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Traylor 338, Baltimore, MD 21205, USA
Neoplasia 11:1318-28. 2009..Taken together, our data demonstrate the direct involvement of Twist in generating a breast cancer stem cell phenotype through down-regulation of CD24 expression and independent of an epithelial-mesenchymal transition...
- Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cellsMahendran Botlagunta
Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 6:e17563. 2011....
- Peptides derived from type IV collagen, CXC chemokines, and thrombospondin-1 domain-containing proteins inhibit neovascularization and suppress tumor growth in MDA-MB-231 breast cancer xenograftsJacob E Koskimaki
Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Neoplasia 11:1285-91. 2009..We have demonstrated significant suppression of tumor growth in vivo and subsequent reductions in microvascular density, indicating the potential of these peptides as therapeutic agents for breast cancer...
- Twist is a transcriptional repressor of E-cadherin gene expression in breast cancerFarhad Vesuna
Department of Radiology, Johns Hopkins University School of Medicine, 340 Traylor, 720 Rutland Avenue, Baltimore, MD 21205, USA
Biochem Biophys Res Commun 367:235-41. 2008..Finally, the functional relevance of this regulation was verified by quantitative real-time PCR and immunohistochemistry on a cohort of breast cancer samples...
- Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer modelKristine Glunde
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cancer Res 68:172-80. 2008..These data suggest that HIF-1 activation of HREs within the putative chk-alpha promoter region can increase Chk-alpha expression within hypoxic environments, consequently increasing cellular PC and tCho levels within these environments...
- Contributing factors of temozolomide resistance in MCF-7 tumor xenograft modelsYoshinori Kato
Department of Radiology, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cancer Biol Ther 6:891-7. 2007..The absence of these molecular responses to TMZ treatment in MCF-7 tumors in vivo supports the possibility that the onset of cancer drug resistance is associated with reduced PS, which can decrease delivery of the drug to cancer cells...
- Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancerMaria D Cao
The Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
NMR Biomed 25:1033-42. 2012..Our study identified GDPD5 as a GPC-PDE that probably participates in the regulation of choline phospholipid metabolism in breast cancer, which possibly occurs in cooperation with CHKA and PLD1...
- HOXA5 regulates hMLH1 expression in breast cancer cellsSai Duriseti
Department of Radiology, Johns Hopkins University School of Medicine, 340 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
Neoplasia 8:250-8. 2006..Furthermore, we demonstrate that, in the presence of HOXA5, there is an increase in in vivo repair activity in MCF-7 cells. Taken together, our results indicate that HOXA5 is a transcriptional regulator of hMLH1 in breast cancer cells...
- Histamine: a potential therapeutic agent for breast cancer treatment?Farhad Vesuna
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore Maryland, USA
Cancer Biol Ther 5:1472-3. 2006
- Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancerYelena Mironchik
Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
Cancer Res 65:10801-9. 2005....