Farhad Vesuna

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α
    F Vesuna
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21250, USA
    Oncogene 31:3223-34. 2012
  2. pmc The transcription factor encyclopedia
    Dimas Yusuf
    Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Genome Biol 13:R24. 2012
  3. pmc Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression
    Farhad Vesuna
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Traylor 338, Baltimore, MD 21205, USA
    Neoplasia 11:1318-28. 2009
  4. pmc Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells
    Mahendran Botlagunta
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e17563. 2011
  5. pmc Peptides derived from type IV collagen, CXC chemokines, and thrombospondin-1 domain-containing proteins inhibit neovascularization and suppress tumor growth in MDA-MB-231 breast cancer xenografts
    Jacob E Koskimaki
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Neoplasia 11:1285-91. 2009
  6. pmc Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer
    Farhad Vesuna
    Department of Radiology, Johns Hopkins University School of Medicine, 340 Traylor, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 367:235-41. 2008
  7. pmc Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer
    Maria D Cao
    The Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    NMR Biomed 25:1033-42. 2012
  8. pmc Contributing factors of temozolomide resistance in MCF-7 tumor xenograft models
    Yoshinori Kato
    Department of Radiology, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Biol Ther 6:891-7. 2007
  9. doi request reprint Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model
    Kristine Glunde
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 68:172-80. 2008
  10. pmc HOXA5 regulates hMLH1 expression in breast cancer cells
    Sai Duriseti
    Department of Radiology, Johns Hopkins University School of Medicine, 340 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Neoplasia 8:250-8. 2006

Collaborators

  • Venu Raman
  • Kristine Glunde
  • Yoshinori Kato
  • Petra van der Groep
  • Phuoc T Tran
  • Michelle A Rudek
  • Ming Zhao
  • Jacob E Koskimaki
  • Elena V Rosca
  • Maria D Cao
  • Paul J van Diest
  • Arvind P Pathak
  • Emmanouil D Karagiannis
  • Brian M Polster
  • Zaver Bhujwalla
  • Guus M Bol
  • Paul T Winnard
  • Yelena Mironchik
  • Dimas Yusuf
  • Mahendran Botlagunta
  • Sai Duriseti
  • Nishant Gandhi
  • Elsken van der Wall
  • Evan A Bordt
  • Khaled Aziz
  • Ashley Irving
  • Atul Kondaskar
  • Jing Zeng
  • Dorian Korz
  • Kathleen Gabrielson
  • Marise R Heerma van Voss
  • Leslie Cope
  • Min Xie
  • Ramachandra S Hosmane
  • Anne Levine
  • Saritha Tantravedi
  • Henriette O'Geen
  • Sekhar P Reddy
  • Rebecca L Cullum
  • Oliver Hankinson
  • Philip H Bradley
  • Angie Rizzino
  • Edwin Chen
  • Marrit Putker
  • Karin Dahlman-Wright
  • Peter John Noy
  • Lars Grontved
  • Carol F Webb
  • Susanne Mandrup
  • Christophe Heligon
  • Scott A Waldman
  • Julien J Karrich
  • Margaret R Hough
  • Xiao Yu Cindy Zhang
  • Shyam Biswal
  • Warren A Cheung
  • Christopher J Harvey
  • Bérénice A Benayoun
  • Raquel Marco-Ferreres
  • Leonardo L Beccari
  • Mary B Breslin
  • Mireille Vasseur-Cognet
  • Amy Ticoll
  • Mark W Woodcroft
  • Pamela A Hoodless
  • Jarrod Bailey
  • MICHAELA LIEDTKE
  • Tiziana De Cristofaro
  • Elodie Portales-Casamar
  • Frances M Sladek
  • Jake M Schnabl
  • Alison H Banham
  • Capucine Van Rechem
  • Philip J Brown
  • Daniel J Peet
  • Elizabeth M Simpson
  • Roland H Wenger
  • Michael Taggart
  • Reiner A Veitia
  • Gieri Camenisch
  • Jason P Debruyne
  • Jan J Brosens
  • Oscar H P Ramos
  • John B Hogenesch
  • Xin M Luo
  • Luis del Peso
  • Jason Park
  • Chunyan Zhao
  • Jonathan S Lim
  • Charles N de Leeuw

Detail Information

Publications13

  1. pmc Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α
    F Vesuna
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21250, USA
    Oncogene 31:3223-34. 2012
    ..In summary, the regulation of ER by Twist could be an underlying mechanism for the loss of ER activity observed in breast tumors, and may contribute to the generation of hormone-resistant, ER-negative breast cancer...
  2. pmc The transcription factor encyclopedia
    Dimas Yusuf
    Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Genome Biol 13:R24. 2012
    ..TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written and vetted by experts in the field. TFe is available at http://www.cisreg.ca/tfe...
  3. pmc Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression
    Farhad Vesuna
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Traylor 338, Baltimore, MD 21205, USA
    Neoplasia 11:1318-28. 2009
    ..Taken together, our data demonstrate the direct involvement of Twist in generating a breast cancer stem cell phenotype through down-regulation of CD24 expression and independent of an epithelial-mesenchymal transition...
  4. pmc Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells
    Mahendran Botlagunta
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e17563. 2011
    ....
  5. pmc Peptides derived from type IV collagen, CXC chemokines, and thrombospondin-1 domain-containing proteins inhibit neovascularization and suppress tumor growth in MDA-MB-231 breast cancer xenografts
    Jacob E Koskimaki
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Neoplasia 11:1285-91. 2009
    ..We have demonstrated significant suppression of tumor growth in vivo and subsequent reductions in microvascular density, indicating the potential of these peptides as therapeutic agents for breast cancer...
  6. pmc Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer
    Farhad Vesuna
    Department of Radiology, Johns Hopkins University School of Medicine, 340 Traylor, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 367:235-41. 2008
    ..Finally, the functional relevance of this regulation was verified by quantitative real-time PCR and immunohistochemistry on a cohort of breast cancer samples...
  7. pmc Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer
    Maria D Cao
    The Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    NMR Biomed 25:1033-42. 2012
    ..Our study identified GDPD5 as a GPC-PDE that probably participates in the regulation of choline phospholipid metabolism in breast cancer, which possibly occurs in cooperation with CHKA and PLD1...
  8. pmc Contributing factors of temozolomide resistance in MCF-7 tumor xenograft models
    Yoshinori Kato
    Department of Radiology, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Biol Ther 6:891-7. 2007
    ..The absence of these molecular responses to TMZ treatment in MCF-7 tumors in vivo supports the possibility that the onset of cancer drug resistance is associated with reduced PS, which can decrease delivery of the drug to cancer cells...
  9. doi request reprint Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model
    Kristine Glunde
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 68:172-80. 2008
    ..These data suggest that HIF-1 activation of HREs within the putative chk-alpha promoter region can increase Chk-alpha expression within hypoxic environments, consequently increasing cellular PC and tCho levels within these environments...
  10. pmc HOXA5 regulates hMLH1 expression in breast cancer cells
    Sai Duriseti
    Department of Radiology, Johns Hopkins University School of Medicine, 340 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Neoplasia 8:250-8. 2006
    ..Furthermore, we demonstrate that, in the presence of HOXA5, there is an increase in in vivo repair activity in MCF-7 cells. Taken together, our results indicate that HOXA5 is a transcriptional regulator of hMLH1 in breast cancer cells...
  11. ncbi request reprint Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer
    Yelena Mironchik
    Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 65:10801-9. 2005
    ....
  12. pmc Histamine: a potential therapeutic agent for breast cancer treatment?
    Farhad Vesuna
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore Maryland, USA
    Cancer Biol Ther 5:1472-3. 2006
  13. pmc Targeting DDX3 with a small molecule inhibitor for lung cancer therapy
    Guus M Bol
    Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    EMBO Mol Med 7:648-69. 2015
    ..Overall, inhibition of DDX3 by RK-33 promotes tumor regression, thus providing a compelling argument to develop DDX3 inhibitors for lung cancer therapy. ..