Prakash Vempati

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Quantifying the proteolytic release of extracellular matrix-sequestered VEGF with a computational model
    Prakash Vempati
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e11860. 2010
  2. ncbi Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis
    Prakash Vempati
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    BMC Syst Biol 5:59. 2011
  3. ncbi Module-based multiscale simulation of angiogenesis in skeletal muscle
    Gang Liu
    Systems Biology Laboratory, Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Theor Biol Med Model 8:6. 2011
  4. ncbi Multiscale models of angiogenesis
    Amina A Qutub
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
    IEEE Eng Med Biol Mag 28:14-31. 2009
  5. ncbi A biochemical model of matrix metalloproteinase 9 activation and inhibition
    Prakash Vempati
    Department of Biomedical Engineering, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Biol Chem 282:37585-96. 2007

Detail Information

Publications5

  1. ncbi Quantifying the proteolytic release of extracellular matrix-sequestered VEGF with a computational model
    Prakash Vempati
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e11860. 2010
    ..To address these uncertainties, we develop a molecular-detailed quantitative model of VEGF proteolysis, used here in the context of an endothelial sprout...
  2. ncbi Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis
    Prakash Vempati
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    BMC Syst Biol 5:59. 2011
    ..However, computational models have predicted that HSPG binding alone does not affect VEGF localization or gradients at steady state...
  3. ncbi Module-based multiscale simulation of angiogenesis in skeletal muscle
    Gang Liu
    Systems Biology Laboratory, Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Theor Biol Med Model 8:6. 2011
    ..Integration of models at different scales is a challenging and currently unsolved problem...
  4. ncbi Multiscale models of angiogenesis
    Amina A Qutub
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
    IEEE Eng Med Biol Mag 28:14-31. 2009
    ..As bioengineers, we approach angiogenesis as a complex, interconnected system of events occurring in sequence and in parallel, on multiple levels, triggered by a main stimulus, e.g., hypoxia...
  5. ncbi A biochemical model of matrix metalloproteinase 9 activation and inhibition
    Prakash Vempati
    Department of Biomedical Engineering, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Biol Chem 282:37585-96. 2007
    ..In all, our analysis serves as a summary of existing kinetic data for MMP9 and a foundation for future models utilizing MMP9 or other MMPs under physiologically well defined microenvironments...