Affiliation: Johns Hopkins University
- Quantifying the proteolytic release of extracellular matrix-sequestered VEGF with a computational modelPrakash Vempati
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 5:e11860. 2010..To address these uncertainties, we develop a molecular-detailed quantitative model of VEGF proteolysis, used here in the context of an endothelial sprout...
- Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysisPrakash Vempati
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
BMC Syst Biol 5:59. 2011..However, computational models have predicted that HSPG binding alone does not affect VEGF localization or gradients at steady state...
- Module-based multiscale simulation of angiogenesis in skeletal muscleGang Liu
Systems Biology Laboratory, Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Theor Biol Med Model 8:6. 2011..Integration of models at different scales is a challenging and currently unsolved problem...
- Multiscale models of angiogenesisAmina A Qutub
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
IEEE Eng Med Biol Mag 28:14-31. 2009..As bioengineers, we approach angiogenesis as a complex, interconnected system of events occurring in sequence and in parallel, on multiple levels, triggered by a main stimulus, e.g., hypoxia...
- A biochemical model of matrix metalloproteinase 9 activation and inhibitionPrakash Vempati
Department of Biomedical Engineering, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
J Biol Chem 282:37585-96. 2007..In all, our analysis serves as a summary of existing kinetic data for MMP9 and a foundation for future models utilizing MMP9 or other MMPs under physiologically well defined microenvironments...