Robert W Veltri

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Nuclear roundness variance predicts prostate cancer progression, metastasis, and death: A prospective evaluation with up to 25 years of follow-up after radical prostatectomy
    Robert W Veltri
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Prostate 70:1333-9. 2010
  2. doi request reprint Nuclear morphometry, epigenetic changes, and clinical relevance in prostate cancer
    Robert W Veltri
    The Brady Urological Research Institute, Park 213, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD, 21287, USA
    Adv Exp Med Biol 773:77-99. 2014
  3. pmc Nuclear morphometry, nucleomics and prostate cancer progression
    Robert W Veltri
    Fisher Biomarker and Biorepository Laboratory, The Brady Urological Research Institute, Baltimore, MD 21287, USA
    Asian J Androl 14:375-84. 2012
  4. doi request reprint Prediction of prostate-specific antigen recurrence in men with long-term follow-up postprostatectomy using quantitative nuclear morphometry
    Robert W Veltri
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cancer Epidemiol Biomarkers Prev 17:102-10. 2008
  5. ncbi request reprint Nucleic acid-based marker approaches to urologic cancers
    Robert W Veltri
    Department of Urology, The Brady Urologic Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287 2101, USA
    Urol Oncol 24:510-27. 2006
  6. ncbi request reprint Ability to predict metastasis based on pathology findings and alterations in nuclear structure of normal-appearing and cancer peripheral zone epithelium in the prostate
    Robert W Veltri
    The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Clin Cancer Res 10:3465-73. 2004
  7. pmc Long-term assessment of prostate cancer progression free survival: evaluation of pathological parameters, nuclear shape and molecular biomarkers of pathogenesis
    Robert W Veltri
    James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Prostate 68:1806-15. 2008
  8. ncbi request reprint Stromal-epithelial measurements of prostate cancer in native Japanese and Japanese-American men
    R W Veltri
    James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Prostate Cancer Prostatic Dis 7:232-7. 2004
  9. ncbi request reprint Impact of age on total and complexed prostate-specific antigen cutoffs in a contemporary referral series of men with prostate cancer
    Robert W Veltri
    Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 60:47-52. 2002
  10. ncbi request reprint Comparison of logistic regression and neural net modeling for prediction of prostate cancer pathologic stage
    Robert W Veltri
    Johns Hopkins Hospital, Department of Urology, 600 North Wolfe St, Baltimore, MD 21287, USA
    Clin Chem 48:1828-34. 2002

Collaborators

Detail Information

Publications43

  1. doi request reprint Nuclear roundness variance predicts prostate cancer progression, metastasis, and death: A prospective evaluation with up to 25 years of follow-up after radical prostatectomy
    Robert W Veltri
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Prostate 70:1333-9. 2010
    ..Therefore, we evaluated the prognostic value of nuclear roundness variance (NRV) for prostate cancer (PCa) progression, metastasis and PCa-specific death free survivals in a cohort of 116 men after radical prostatectomy (RP)...
  2. doi request reprint Nuclear morphometry, epigenetic changes, and clinical relevance in prostate cancer
    Robert W Veltri
    The Brady Urological Research Institute, Park 213, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD, 21287, USA
    Adv Exp Med Biol 773:77-99. 2014
    ..Finally, we address how we can best utilize this knowledge to improve the efficacy of personalized treatment of cancer. ..
  3. pmc Nuclear morphometry, nucleomics and prostate cancer progression
    Robert W Veltri
    Fisher Biomarker and Biorepository Laboratory, The Brady Urological Research Institute, Baltimore, MD 21287, USA
    Asian J Androl 14:375-84. 2012
    ..These series of cellular and tissue-related malignancy-associated events can be quantified to assess disease progression and management...
  4. doi request reprint Prediction of prostate-specific antigen recurrence in men with long-term follow-up postprostatectomy using quantitative nuclear morphometry
    Robert W Veltri
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cancer Epidemiol Biomarkers Prev 17:102-10. 2008
    ....
  5. ncbi request reprint Nucleic acid-based marker approaches to urologic cancers
    Robert W Veltri
    Department of Urology, The Brady Urologic Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287 2101, USA
    Urol Oncol 24:510-27. 2006
    ..We review only nucleic acid-based molecular biomarkers in urologic oncology that can assist the clinician in establishing the diagnosis of disease, or that can predict the behavior of the disease or the patient's survival...
  6. ncbi request reprint Ability to predict metastasis based on pathology findings and alterations in nuclear structure of normal-appearing and cancer peripheral zone epithelium in the prostate
    Robert W Veltri
    The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Clin Cancer Res 10:3465-73. 2004
    ..The nuclear structure information was combined with routine pathological findings to predict metastatic PCa progression and/or death...
  7. pmc Long-term assessment of prostate cancer progression free survival: evaluation of pathological parameters, nuclear shape and molecular biomarkers of pathogenesis
    Robert W Veltri
    James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Prostate 68:1806-15. 2008
    ..Therefore, we evaluated the prognostic value of these parameters in 105 clinically localized PCa tumors with long-term follow-up after radical prostatectomy for progression-free survival (PFS)...
  8. ncbi request reprint Stromal-epithelial measurements of prostate cancer in native Japanese and Japanese-American men
    R W Veltri
    James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Prostate Cancer Prostatic Dis 7:232-7. 2004
    ....
  9. ncbi request reprint Impact of age on total and complexed prostate-specific antigen cutoffs in a contemporary referral series of men with prostate cancer
    Robert W Veltri
    Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 60:47-52. 2002
    ..0 to 20.0 ng/mL. This study demonstrated that to maintain a given sensitivity level for cPSA and tPSA in the age ranges studied, continuous upward adjustment of the cutoffs was required as age increased...
  10. ncbi request reprint Comparison of logistic regression and neural net modeling for prediction of prostate cancer pathologic stage
    Robert W Veltri
    Johns Hopkins Hospital, Department of Urology, 600 North Wolfe St, Baltimore, MD 21287, USA
    Clin Chem 48:1828-34. 2002
    ..This study compares statistical and neural network (NN) approaches to predict PCa stage...
  11. ncbi request reprint Significant variations in nuclear structure occur between and within Gleason grading patterns 3, 4, and 5 determined by digital image analysis
    Robert W Veltri
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Prostate 67:1202-10. 2007
    ..Quantitative Nuclear Morphometry (QNM) profiles were created to evaluate variability in nuclear structure within each of these grades...
  12. pmc DNA Ploidy as surrogate for biopsy gleason score for preoperative organ versus nonorgan-confined prostate cancer prediction
    Sumit Isharwal
    James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 2101, USA
    Urology 73:1092-7. 2009
    ..To evaluate nuclear morphometric alterations and clinicopathologic features for organ- vs nonorgan-confined prostate carcinoma (PCa) prediction...
  13. ncbi request reprint Quantitative alterations in nuclear structure predict prostate carcinoma distant metastasis and death in men with biochemical recurrence after radical prostatectomy
    Masood A Khan
    The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 98:2583-91. 2003
    ....
  14. pmc Using nuclear morphometry to predict the need for treatment among men with low grade, low stage prostate cancer enrolled in a program of expectant management with curative intent
    Danil V Makarov
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Prostate 68:183-9. 2008
    ..We assessed the use of quantitative clinical and pathologic information to predict which patients would eventually require treatment for prostate cancer (CaP) in an expectant management (EM) cohort...
  15. ncbi request reprint Alterations in nuclear structure and expression of proPSA predict differences between native Japanese and Japanese-American prostate cancer
    Robert W Veltri
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 68:898-904. 2006
    ..To differentiate the benign and/or malignant epithelial cells in prostate cancer (PCa) glands of native Japanese (NJ) and Japanese-American (JA) men using biomarkers...
  16. pmc p300 (histone acetyltransferase) biomarker predicts prostate cancer biochemical recurrence and correlates with changes in epithelia nuclear size and shape
    Sumit Isharwal
    James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Prostate 68:1097-104. 2008
    ..Therefore, we evaluated the prognostic value of p300 expression and its correlation with nuclear alterations seen in tumor cells in men with long-term follow-up after radical prostatectomy (RP)...
  17. ncbi request reprint Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial
    Leonard S Marks
    Department of Urology, Geffen School of Medicine, University of California, Los Angeles, USA
    JAMA 296:2351-61. 2006
    ..Prostate safety is a primary concern when aging men receive testosterone replacement therapy (TRT), but little information is available regarding the effects of TRT on prostate tissue in men...
  18. pmc Prognostic value of Her-2/neu and DNA index for progression, metastasis and prostate cancer-specific death in men with long-term follow-up after radical prostatectomy
    Sumit Isharwal
    The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int J Cancer 123:2636-43. 2008
    ..Further, Her-2/neu expression and %DNA index may be used with clinicopathologic parameters for prediction of long-term prognosis in PCa...
  19. ncbi request reprint Prediction of pathological stage in patients with clinical stage T1c prostate cancer: the new challenge
    Robert W Veltri
    Brady Urological Institute of The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    J Urol 168:100-4. 2002
    ..We developed an algorithm for predicting the likelihood of organ confined disease in patients with clinical stage T1c prostate cancer using biopsy pathology, computer assisted image analysis and serum prostate specific antigen (PSA)...
  20. doi request reprint DNA content in the diagnostic biopsy for benign-adjacent and cancer-tissue areas predicts the need for treatment in men with T1c prostate cancer undergoing surveillance in an expectant management programme
    Sumit Isharwal
    The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    BJU Int 105:329-33. 2010
    ..Prognosis (case series)...
  21. doi request reprint ProPSA and diagnostic biopsy tissue DNA content combination improves accuracy to predict need for prostate cancer treatment among men enrolled in an active surveillance program
    Sumit Isharwal
    James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Urology 77:763.e1-6. 2011
    ....
  22. ncbi request reprint Can prostate specific antigen derivatives and pathological parameters predict significant change in expectant management criteria for prostate cancer?
    Masood A Khan
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Urol 170:2274-8. 2003
    ..Therefore, we determined whether biomarkers could be used to determine those in whom disease is likely to progress and thus those who require definitive therapy...
  23. ncbi request reprint Prostate cancer in native Japanese and Japanese-American men: effects of dietary differences on prostatic tissue
    Leonard S Marks
    Department of Urology, University of California, Los Angeles, Geffen School of Medicine, Los Angeles, California, USA
    Urology 64:765-71. 2004
    ..To investigate the relationship between diet and prostate cancer (CaP) among native Japanese (NJ) and second-generation or third-generation Japanese-American (J-A) men--focusing on the effects of animal fat and soy on prostatic tissues...
  24. ncbi request reprint Natural history of disease progression in patients who fail to achieve an undetectable prostate-specific antigen level after undergoing radical prostatectomy
    Craig G Rogers
    The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer 101:2549-56. 2004
    ..The authors assessed the clinical outcome of men with a persistently detectable PSA level after RRP for clinically localized prostate carcinoma...
  25. ncbi request reprint Quantitative biopsy pathology for the prediction of pathologically organ-confined prostate carcinoma: a multiinstitutional validation study
    Alexander Haese
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 97:969-78. 2003
    ..The current study validates the initial models and presents an new, improved tool for clinical decision making...
  26. ncbi request reprint Evaluation of proprostate specific antigen for early detection of prostate cancer in men with a total prostate specific antigen range of 4.0 to 10.0 ng/ml
    Masood A Khan
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Urol 170:723-6. 2003
    ..There is increasing evidence that proPSA is associated preferentially with prostate cancer. The objective of this study was to determine whether proPSA can influence the detection of early prostate cancer...
  27. ncbi request reprint Comparison of total prostate-specific antigen and derivative levels in a screening population of black, white, and Korean-American men
    Jae Park
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Marburg 409, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Clin Prostate Cancer 2:173-6. 2003
    ..In a contemporary screening population comparing tPSA, percentage of fPSA, and percentage of cPSA levels in 3 races, there were no significant differences identified among the groups...
  28. ncbi request reprint Saw palmetto alters nuclear measurements reflecting DNA content in men with symptomatic BPH: evidence for a possible molecular mechanism
    Robert W Veltri
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 60:617-22. 2002
    ..Saw palmetto herbal blend (SPHB) causes contraction of prostate epithelial cells and suppression of tissue dihydrotestosterone levels in men with symptomatic benign prostatic hyperplasia, but a fundamental mechanism remains unknown...
  29. pmc Hypermethylation of genes detected in urine from Ghanaian adults with bladder pathology associated with Schistosoma haematobium infection
    Xiaoli Zhong
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e59089. 2013
    ..Here we evaluated aberrant promoter DNA methylation as a potential biomarker to detect severe bladder damage that is associated with schistosomiasis by analyzing urine specimens...
  30. ncbi request reprint Extended peripheral zone biopsy schemes increase cancer detection rates and minimize variance in prostate specific antigen and age related cancer rates: results of a community multi-practice study
    Joseph C Presti
    Department of Urology, Stanford University School of Medicine, Stanford, CA, USA
    J Urol 169:125-9. 2003
    ..We assessed the impact of age and prostate specific antigen (PSA) on extended systematic biopsy schemes for detecting prostate carcinoma and better characterized these tumors as a function of patient age and PSA...
  31. ncbi request reprint Cost-benefit analysis of total, free/total, and complexed prostate-specific antigen for prostate cancer screening
    Lars Ellison
    Brady Urological Institute, The Johns Hopkins Medical Institution, Baltimore, Maryland 21287, USA
    Urology 60:42-6. 2002
    ..8 ng/mL. The use of cPSA with a threshold of 3.0 ng/mL identifies a similar number of cancers with fewer biopsies than tPSA at 4.0 ng/mL...
  32. pmc Valproic acid causes dose- and time-dependent changes in nuclear structure in prostate cancer cells in vitro and in vivo
    Madeleine S Q Kortenhorst
    Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, James Buchanan Brady Urological Institute, School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Mol Cancer Ther 8:802-8. 2009
    ..Therefore, nuclear structural alterations may serve as a biomarker for histone deacetylase inhibitor treatment...
  33. doi request reprint Non-invasive methods to detect schistosome-based bladder cancer: is the association sufficient for epidemiological use?
    Clive Shiff
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Trans R Soc Trop Med Hyg 104:3-5. 2010
    ..We suggest that early diagnosis of pre-cancerous conditions associated with urinary schistosomiasis, if appropriately treated, could save countless lives...
  34. pmc Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
    Rong Hu
    Department of Urology, Oncology, and Pathology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Cancer Res 69:16-22. 2009
    ..In addition, as expression markers for lethal PCa, these novel AR variants may be explored as potential biomarkers and therapeutic targets for advanced PCa...
  35. ncbi request reprint Evaluation of DD23 as a marker for detection of recurrent transitional cell carcinoma of the bladder in patients with a history of bladder cancer
    Scott M Gilbert
    Department of Urology, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, New York, USA
    Urology 61:539-43. 2003
    ..The murine monoclonal antibody DD23 recognizes a 185-kDa tumor-associated antigen that is expressed in human bladder cancer cells in vitro and in vivo but is not detected in normal urothelium...
  36. ncbi request reprint Clinical utility of squamous and transitional nuclear structure alterations induced by Schistosoma haematobium in chronically infected adults with bladder damage verified by ultrasound in Ghana
    Jean Naples
    Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Anal Quant Cytol Histol 31:143-52. 2009
    ..e., alteration in nuclear size/shape, DNA content and chromatin structure-of intact cells obtained from the sediment of urine specimens collected from people living in an area highly endemic for Schistosoma haematobium in Ghana...
  37. ncbi request reprint Acquisition of paclitaxel resistance is associated with a more aggressive and invasive phenotype in prostate cancer
    John J Kim
    Department of Urology, James Buchanan Brady Urological Institute, Baltimore, Maryland 21287, USA
    J Cell Biochem 114:1286-93. 2013
    ....
  38. ncbi request reprint Urinary markers in the detection of bladder cancer: what's new?
    Matthew E Nielsen
    Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 2101, USA
    Curr Opin Urol 16:350-5. 2006
    ..In the context of relative limitations of the current standard of cystoscopy and cytology, there has been burgeoning activity in the development of novel molecular urine-based markers for bladder cancer detection...
  39. ncbi request reprint Proteomic analysis of dunning prostate cancer cell lines with variable metastatic potential using SELDI-TOF
    M B Gretzer
    The Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Prostate 60:325-31. 2004
    ....
  40. ncbi request reprint Immunohistochemical staining of precursor forms of prostate-specific antigen (proPSA) in metastatic prostate cancer
    Anil V Parwani
    Division of Pathology Informatics and Genito Urinary Pathology, Univeristy of Pittsburgh Medical Center Shadyside Hospital, Department of Pathology, Pittsburgh, PA 15232, USA
    Am J Surg Pathol 30:1231-6. 2006
    ..A panel of markers, including proPSA, should be performed when metastatic prostate carcinoma is in the differential diagnosis...
  41. ncbi request reprint Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinoma
    Ai Ying Chuang
    Department of Pathology, Koo Foundation Sun Yat Sen Cancer Center, Taipei, Taiwan
    Am J Surg Pathol 31:1246-55. 2007
    ..1, and pPSA are useful when high-grade prostate cancer is suspected based on the morphology or clinical findings, yet shows negative or equivocal PSA staining. HMWCK and p63 are superior to the novel markers thrombomodulin and S100P...
  42. ncbi request reprint SELDI protein profiling of dunning R-3327 derived cell lines: identification of molecular markers of prostate cancer progression
    Gunjan Malik
    Center for Biomedical Proteomics, Virginia Prostate Center, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Prostate 67:1565-75. 2007
    ..As a parallel effort, we have been pursuing the identification of the protein(s) comprising the individual discriminatory "peaks" and evaluating their utility as potential biomarkers for prostate cancer progression...
  43. ncbi request reprint DD23 Biomarker: a prospective clinical assessment in routine urinary cytology specimens from patients being monitored for TCC
    Ihor S Sawczuk
    Columbia University, Urology Department, 161 Fort Washington Ave, New York, NY 10032, USA
    Urol Oncol 7:185-90. 2002
    ..A prospective clinical study was conducted to assess the ability of the DD23 murine monoclonal antibody to enhance detection of bladder cancer in routine alcohol fixed urine cytology samples...