Victor Velculescu

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Defining the blueprint of the cancer genome
    Victor E Velculescu
    Ludwig Center for Cancer Genetics and Therapeutics, The Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Carcinogenesis 29:1087-91. 2008
  2. ncbi request reprint The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
    Chuan Hsiang Huang
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 318:1744-8. 2007
  3. pmc Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma
    Mark Sausen
    Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Nat Genet 45:12-7. 2013
  4. pmc Sodium ion channel mutations in glioblastoma patients correlate with shorter survival
    Avadhut D Joshi
    Department of Neurosurgery, Johns Hopkins University Medical School, Baltimore, MD 21231, USA
    Mol Cancer 10:17. 2011
  5. pmc Patient-oriented gene set analysis for cancer mutation data
    Simina M Boca
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 N, Wolfe Street, Baltimore, MD 21205, USA
    Genome Biol 11:R112. 2010
  6. pmc Identification of microbial DNA in human cancer
    Christopher G Duncan
    Preston Robert Tisch Brain Tumor Center, Pediatric Brain Tumor Foundation Institute, Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    BMC Med Genomics 2:22. 2009
  7. pmc Genome-wide linkage scan for colorectal cancer susceptibility genes supports linkage to chromosome 3q
    Simone Picelli
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    BMC Cancer 8:87. 2008
  8. pmc Understanding the enemy
    Victor E Velculescu
    Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA
    Sci Transl Med 3:98ps37. 2011
  9. ncbi request reprint Analysing uncharted transcriptomes with SAGE
    V E Velculescu
    Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, 1650 Orleans St, Baltimore MD 21231, USA
    Trends Genet 16:423-5. 2000
  10. pmc Design and analysis issues in genome-wide somatic mutation studies of cancer
    Giovanni Parmigiani
    Ludwig Center for Cancer Genetics and Therapeutics, and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Genomics 93:17-21. 2009

Collaborators

Detail Information

Publications32

  1. pmc Defining the blueprint of the cancer genome
    Victor E Velculescu
    Ludwig Center for Cancer Genetics and Therapeutics, The Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Carcinogenesis 29:1087-91. 2008
    ....
  2. ncbi request reprint The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
    Chuan Hsiang Huang
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 318:1744-8. 2007
    ..In addition to providing new insights about the structure of PI3Kalpha, these results suggest specific mechanisms for the effect of oncogenic mutations in p110alpha and p85alpha...
  3. pmc Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma
    Mark Sausen
    Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Nat Genet 45:12-7. 2013
    ..These results highlight the dysregulation of chromatin remodeling in pediatric tumorigenesis and provide new approaches for the management of patients with neuroblastoma...
  4. pmc Sodium ion channel mutations in glioblastoma patients correlate with shorter survival
    Avadhut D Joshi
    Department of Neurosurgery, Johns Hopkins University Medical School, Baltimore, MD 21231, USA
    Mol Cancer 10:17. 2011
    ..Cardiac glycosides, known sodium channel inhibitors, were then tested for their ability to inhibit GBM cell proliferation...
  5. pmc Patient-oriented gene set analysis for cancer mutation data
    Simina M Boca
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 N, Wolfe Street, Baltimore, MD 21205, USA
    Genome Biol 11:R112. 2010
    ..In mutation analysis, these patient-oriented methods are more transparent, interpretable, and statistically powerful than traditional gene-oriented methods...
  6. pmc Identification of microbial DNA in human cancer
    Christopher G Duncan
    Preston Robert Tisch Brain Tumor Center, Pediatric Brain Tumor Foundation Institute, Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    BMC Med Genomics 2:22. 2009
    ..CONCLUSION: DK-MICROBE can identify previously unknown infectious agents in human tumors, and is now available for further applications for the identification of pathogen DNA in human cancer and other diseases...
  7. pmc Genome-wide linkage scan for colorectal cancer susceptibility genes supports linkage to chromosome 3q
    Simone Picelli
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    BMC Cancer 8:87. 2008
    ..In an attempt to identify novel colorectal cancer predisposing genes, we have performed a genome-wide linkage analysis in 30 Swedish non-FAP/non-HNPCC families with a strong family history of colorectal cancer...
  8. pmc Understanding the enemy
    Victor E Velculescu
    Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA
    Sci Transl Med 3:98ps37. 2011
    ..This molecular information is the latest in a series of genetic discoveries that aid in cancer diagnosis and may pave the way to targeted therapeutic agents...
  9. ncbi request reprint Analysing uncharted transcriptomes with SAGE
    V E Velculescu
    Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, 1650 Orleans St, Baltimore MD 21231, USA
    Trends Genet 16:423-5. 2000
    ....
  10. pmc Design and analysis issues in genome-wide somatic mutation studies of cancer
    Giovanni Parmigiani
    Ludwig Center for Cancer Genetics and Therapeutics, and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Genomics 93:17-21. 2009
    ....
  11. ncbi request reprint Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers
    Laura D Wood
    The Ludwig Center for Cancer Genetics and Therapeutics, The Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA
    Hum Mutat 27:1060-1. 2006
    ..Our results implicate these tyrosine kinase genes in the pathogenesis of other tumor types and suggest that they may be useful targets for diagnostic and therapeutic intervention in selected patients...
  12. pmc Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells
    Jihye Yun
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 325:1555-9. 2009
    ..Together, these data suggest that glucose deprivation can drive the acquisition of KRAS pathway mutations in human tumors...
  13. pmc Development of personalized tumor biomarkers using massively parallel sequencing
    Rebecca J Leary
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Sci Transl Med 2:20ra14. 2010
    ..This approach provides an exquisitely sensitive and broadly applicable approach for the development of personalized biomarkers to enhance the clinical management of cancer patients...
  14. pmc Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    Shinichi Yachida
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nature 467:1114-7. 2010
    ..These data provide novel insights into the genetic features underlying pancreatic cancer progression and define a broad time window of opportunity for early detection to prevent deaths from metastatic disease...
  15. ncbi request reprint Oncogenic mutations of PIK3CA in human cancers
    Yardena Samuels
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
    Cell Cycle 3:1221-4. 2004
    ..PIK3CA represents one of the most highly mutated oncogenes identified in human cancers and may be a useful diagnostic and therapeutic target...
  16. ncbi request reprint Mutational analysis of the tyrosine phosphatome in colorectal cancers
    Zhenghe Wang
    Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Science 304:1164-6. 2004
    ..These observations suggest that the mutated tyrosine phosphatases are tumor suppressor genes, regulating cellular pathways that may be amenable to therapeutic intervention...
  17. ncbi request reprint High frequency of mutations of the PIK3CA gene in human cancers
    Yardena Samuels
    Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Science 304:554. 2004
  18. ncbi request reprint Identifying tumor origin using a gene expression-based classification map
    Phillip Buckhaults
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 63:4144-9. 2003
    ..This expression map analysis may provide a reliable and practical approach to determine tumor type in cases of metastatic carcinoma of clinically unknown origin...
  19. ncbi request reprint Mutational analysis of the tyrosine kinome in colorectal cancers
    Alberto Bardelli
    The Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Science 300:949. 2003
  20. pmc Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations
    Hannah Carter
    Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Cancer Res 69:6660-7. 2009
    ..Based on a model that assumed the glioblastoma multiforme mutations are a mixture of drivers and passengers, we estimate that 8% of these mutations are drivers, causally contributing to tumorigenesis...
  21. pmc Comparative lesion sequencing provides insights into tumor evolution
    Sian Jones
    The Ludwig Center for Cancer Genetics and Therapeutics, Department of Biostatistics, Howard Hughes Medical Institute, and Sidney Kimmel Cancer Center at The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 105:4283-8. 2008
    ..These results have important implications for understanding human tumor pathogenesis, particularly those associated with metastasis...
  22. pmc An integrated genomic analysis of human glioblastoma multiforme
    D Williams Parsons
    Ludwig Center for Cancer Genetics and Therapeutics, and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 321:1807-12. 2008
    ..These studies demonstrate the value of unbiased genomic analyses in the characterization of human brain cancer and identify a potentially useful genetic alteration for the classification and targeted therapy of GBMs...
  23. ncbi request reprint The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT
    Chetan Bettegowda
    The Howard Hughes Medical Institute, The Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Biotechnol 24:1573-80. 2006
    ..Through this analysis, we found that C. novyi-NT spores contained mRNA and that the spore transcripts were distinct from those in vegetative forms of the bacterium...
  24. pmc A multidimensional analysis of genes mutated in breast and colorectal cancers
    Jimmy Lin
    Ludwig Center for Cancer Genetics and Therapeutics, and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA
    Genome Res 17:1304-18. 2007
    ..These studies provide a multidimensional framework to guide further research and help identify cellular processes critical for malignant progression and therapeutic intervention...
  25. ncbi request reprint Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms
    Kentaro Nakayama
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 5:779-85. 2006
    ....
  26. ncbi request reprint Colorectal cancer: mutations in a signalling pathway
    D Williams Parsons
    The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
    Nature 436:792. 2005
    ..The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention...
  27. pmc Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T
    Xiaodong Zhang
    Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 104:4060-4. 2007
    ..These studies illuminate a mechanism regulating the STAT3 pathway and suggest that this signaling pathway plays an important role in colorectal tumorigenesis...
  28. ncbi request reprint Mutational analysis of gene families in human cancer
    Alberto Bardelli
    The Oncogenomics Center, Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, 10060 Candiolo To, Italy
    Curr Opin Genet Dev 15:5-12. 2005
    ..Such genomic analyses have already demonstrated their utility in basic and clinical cancer research, and are expected to have an important impact on future diagnostic and therapeutic strategies...
  29. pmc Recurrent KRAS codon 146 mutations in human colorectal cancer
    Sarah Edkins
    Cancer Genome Project, Welcome Trust Sanger Institute, Hinxton, UK
    Cancer Biol Ther 5:928-32. 2006
    ....
  30. ncbi request reprint Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia
    Mohamed Bentires-Alj
    Cancer Biology Program, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Cancer Res 64:8816-20. 2004
    ..Our data demonstrate that mutations in PTPN11 occur at low frequency in several human cancers, especially neuroblastoma and AML, and suggest that Shp2 may be a novel target for antineoplastic therapy...

Research Grants5

  1. Large-scale Genetic Analyses of Gene Families in Colorectal Cancer
    Victor Velculescu; Fiscal Year: 2006
    ....
  2. Large-scale Genetic Analyses of Gene Families in Colorectal Cancer
    Victor Velculescu; Fiscal Year: 2007
    ....
  3. Large-scale Genetic Analyses of Gene Families in Colorectal Cancer
    Victor Velculescu; Fiscal Year: 2009
    ..abstract_text> ..
  4. Large-scale Genetic Analyses of Gene Families in Colorectal Cancer
    Victor E Velculescu; Fiscal Year: 2010
    ..abstract_text> ..