Research Topics
Species | R VaradhanSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Higher levels and blunted diurnal variation of cortisol in frail older womenRavi Varadhan
Division of Geriatric Medicine and Gerontology, School of Medicine, John Hopkins University, Baltimore, MD, USA
J Gerontol A Biol Sci Med Sci 63:190-5. 2008..We evaluated whether higher levels and blunted diurnal variation of salivary cortisol are cross-sectionally associated with frailty burden...
Evaluating health outcomes in the presence of competing risks: a review of statistical methods and clinical applicationsRavi Varadhan
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Med Care 48:S96-105. 2010..Although statistical methods exist for quantifying the probability of benefit from an intervention while accounting for competing events, these methods have not been widely adopted by clinical researchers...
Frailty and impaired cardiac autonomic control: new insights from principal components aggregation of traditional heart rate variability indicesRavi Varadhan
The Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 64:682-7. 2009..We propose a new measure of heart rate variability (HRV) to capture the impairment in cardiac autonomic control associated with frailty...- Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailtyR Varadhan
The Center on Aging and Health, Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, United States
Mech Ageing Dev 129:666-70. 2008.... - Physiological complexity underlying heart rate dynamics and frailty status in community-dwelling older womenPaulo H M Chaves
Departments of cMedicine and dEpidemiology, Division of Geriatrics Medicine and Gerontology, Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Am Geriatr Soc 56:1698-703. 2008..For supporting validity, relationships between frailty and traditional linear indices of heart rate variability (HRV) were also assessed... - Association between reduced heart rate variability and cognitive impairment in older disabled women in the community: Women's Health and Aging Study IDae Hyun Kim
Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
J Am Geriatr Soc 54:1751-7. 2006..To examine the independent association between heart rate variability (HRV), a marker of cardiac autonomic function, and cognitive impairment... - Frailty status and altered dynamics of circulating energy metabolism hormones after oral glucose in older womenR R Kalyani
Division of Endocrinology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Nutr Health Aging 16:679-86. 2012..Frailty status is associated with altered glucose-insulin dynamics. Here, we sought to investigate whether alteration in the dynamics of other circulating energy metabolism hormones after oral glucose is associated with frailty status... - Relationship of a dominant advanced glycation end product, serum carboxymethyl-lysine, and abnormal glucose metabolism in adults: the Baltimore Longitudinal Study of AgingR D Semba
Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
J Nutr Health Aging 14:507-13. 2010..We investigated the relationship between a dominant serum AGE, N-carboxymethyl-lysine (CML), and glucose metabolism... - The use of angiotensin-converting enzyme inhibitors and diuretics is associated with a reduced incidence of impairment on cognition in elderly womenS Yasar
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Clin Pharmacol Ther 84:119-26. 2008..Therefore, the use of ACE-Is or diuretics was associated with reduced incidence of impairment of both global and domain-specific cognition in elderly women, and may help delay progression to dementia... - Oxidative stress is associated with greater mortality in older women living in the communityRichard D Semba
Department of Ophthalmology, National Institute on Aging, Baltimore, Maryland, USA
J Am Geriatr Soc 55:1421-5. 2007..To determine whether oxidative stress, as implied by oxidative damage to proteins, is associated with greater mortality in older women living in the community... - Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling womenRichard D Semba
Johns Hopkins University School of Medicine, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
Aging Clin Exp Res 21:182-90. 2009..To characterize the relationship between advanced glycation end products (AGEs) and circulating receptors for AGEs (RAGE) with cardiovascular disease mortality... - Low serum carotenoids and development of severe walking disability among older women living in the community: the women's health and aging study IRichard D Semba
The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Age Ageing 36:62-7. 2007..to determine whether low serum carotenoid levels, an indicator of low intake of fruits and vegetables, are associated with the progression of disability in older women... - Oxidative protein damage is associated with poor grip strength among older women living in the communityCaitlin Howard
Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Appl Physiol 103:17-20. 2007..043). These results suggest oxidative protein damage is independently associated with low grip strength among older women living in the community. Increased oxidative stress may be contributing to loss of muscle strength in older adults... - Relationships of cardiac, pulmonary, and muscle reserves and frailty to exercise capacity in older womenCarlos O Weiss
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 65:287-94. 2010..We assessed whether the relationship of three main physiological systems-cardiac, pulmonary, and musculoskeletal-to EC is independent or interactive and whether their effect on EC varies with respect to frailty status... - Low serum selenium concentrations are associated with poor grip strength among older women living in the communityJustine Beck
Johns Hopkins Medical Institutions, Baltimore, MD, USA
Biofactors 29:37-44. 2007..04). This study supports the idea that selenium is important to muscle strength in older women... - Oxidative protein damage is associated with elevated serum interleukin-6 levels among older moderately to severely disabled women living in the communityMargaret Dayhoff-Brannigan
John Hopkins Medical Institutes, Baltimore, MD, USA
J Gerontol A Biol Sci Med Sci 63:179-83. 2008..Elevated interleukin (IL)-6 is associated with adverse outcomes. Our objective was to determine whether serum protein carbonyls, an indicator of oxidative protein damage and oxidative stress, were associated with IL-6... - Oxidative stress and severe walking disability among older womenRichard D Semba
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Med 120:1084-9. 2007..Serum protein carbonyls are markers of oxidative damage to proteins and are caused by oxidative stress... - Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling womenJustine Beck
Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Nutrition 24:964-8. 2008.... - Low serum carotenoids are associated with a decline in walking speed in older womenN Alipanah
Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Nutr Health Aging 13:170-5. 2009..The aim was to determine whether total serum carotenoid concentrations, a marker for fruit and vegetable intake, and serum selenium are related to changes in walking speed in older women... - Initial manifestations of frailty criteria and the development of frailty phenotype in the Women's Health and Aging Study IIQian Li Xue
Department of Medicine, School of Medicine, Johns Hopkins University, 2024 E Monument Street, Suite 2 700, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 63:984-90. 2008..This study aims to characterize natural history by which commonly used frailty criteria manifest and to assess whether the rate of progression to frailty depends on initial manifestations... - Low micronutrient levels as a predictor of incident disability in older womenBenedetta Bartali
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853 6301, USA
Arch Intern Med 166:2335-40. 2006..The role of nutritional status in the disablement process is still unclear. The objective of this study was to assess whether low concentrations of nutrients predict the development and course of disability... - Relationships between brachial-ankle pulse wave velocity and conventional atherosclerotic risk factors in community-dwelling peopleYoshinori Fujiwara
Community Health Research Group, Tokyo Metropolitan Institute of Gerontology, Japan
Prev Med 39:1135-42. 2004..A simple instrument has been developed to measure brachial-ankle pulse wave velocity (baPWV). The aim of the present study was to use this instrument to study the relationship between baPWV and conventional atherosclerotic risk factors... - Risk-treatment paradox in use of statinsCarlos O Weiss
JAMA 292:169; author reply 169. 2004