R Varadhan

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc A framework for organizing and selecting quantitative approaches for benefit-harm assessment
    Milo A Puhan
    Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room E6153, Baltimore, MD 21205, USA
    BMC Med Res Methodol 12:173. 2012
  2. pmc Support of personalized medicine through risk-stratified treatment recommendations - an environmental scan of clinical practice guidelines
    Tsung Yu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    BMC Med 11:7. 2013
  3. doi request reprint A framework for the analysis of heterogeneity of treatment effect in patient-centered outcomes research
    Ravi Varadhan
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Clin Epidemiol 66:818-25. 2013
  4. doi request reprint Evaluating health outcomes in the presence of competing risks: a review of statistical methods and clinical applications
    Ravi Varadhan
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Med Care 48:S96-105. 2010
  5. pmc Frailty and impaired cardiac autonomic control: new insights from principal components aggregation of traditional heart rate variability indices
    Ravi Varadhan
    The Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 64:682-7. 2009
  6. pmc Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty
    R Varadhan
    The Center on Aging and Health, Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, United States
    Mech Ageing Dev 129:666-70. 2008
  7. ncbi request reprint Higher levels and blunted diurnal variation of cortisol in frail older women
    Ravi Varadhan
    Division of Geriatric Medicine and Gerontology, School of Medicine, John Hopkins University, Baltimore, MD, USA
    J Gerontol A Biol Sci Med Sci 63:190-5. 2008
  8. pmc Physiological complexity underlying heart rate dynamics and frailty status in community-dwelling older women
    Paulo H M Chaves
    Departments of cMedicine and dEpidemiology, Division of Geriatrics Medicine and Gerontology, Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Am Geriatr Soc 56:1698-703. 2008
  9. pmc Association between reduced heart rate variability and cognitive impairment in older disabled women in the community: Women's Health and Aging Study I
    Dae Hyun Kim
    Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Am Geriatr Soc 54:1751-7. 2006
  10. doi request reprint Frailty status and altered dynamics of circulating energy metabolism hormones after oral glucose in older women
    R R Kalyani
    Division of Endocrinology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Nutr Health Aging 16:679-86. 2012

Detail Information

Publications26

  1. pmc A framework for organizing and selecting quantitative approaches for benefit-harm assessment
    Milo A Puhan
    Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room E6153, Baltimore, MD 21205, USA
    BMC Med Res Methodol 12:173. 2012
    ..Our aim was to review existing quantitative approaches for benefit-harm assessment and to develop an organizing framework that clarifies differences and aids selection of quantitative approaches for a particular benefit-harm assessment...
  2. pmc Support of personalized medicine through risk-stratified treatment recommendations - an environmental scan of clinical practice guidelines
    Tsung Yu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    BMC Med 11:7. 2013
    ..Our aim was to assess if and how CPGs develop risk-stratified treatment recommendations for the prevention or treatment of common chronic diseases...
  3. doi request reprint A framework for the analysis of heterogeneity of treatment effect in patient-centered outcomes research
    Ravi Varadhan
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Clin Epidemiol 66:818-25. 2013
    ..Heterogeneity of treatment effect analysis should be identified as confirmatory, descriptive, exploratory, or predictive analysis. Evidence should be interpreted in a manner consistent with the analytic goal. ..
  4. doi request reprint Evaluating health outcomes in the presence of competing risks: a review of statistical methods and clinical applications
    Ravi Varadhan
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Med Care 48:S96-105. 2010
    ..Although statistical methods exist for quantifying the probability of benefit from an intervention while accounting for competing events, these methods have not been widely adopted by clinical researchers...
  5. pmc Frailty and impaired cardiac autonomic control: new insights from principal components aggregation of traditional heart rate variability indices
    Ravi Varadhan
    The Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 64:682-7. 2009
    ..We propose a new measure of heart rate variability (HRV) to capture the impairment in cardiac autonomic control associated with frailty...
  6. pmc Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty
    R Varadhan
    The Center on Aging and Health, Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, United States
    Mech Ageing Dev 129:666-70. 2008
    ....
  7. ncbi request reprint Higher levels and blunted diurnal variation of cortisol in frail older women
    Ravi Varadhan
    Division of Geriatric Medicine and Gerontology, School of Medicine, John Hopkins University, Baltimore, MD, USA
    J Gerontol A Biol Sci Med Sci 63:190-5. 2008
    ..We evaluated whether higher levels and blunted diurnal variation of salivary cortisol are cross-sectionally associated with frailty burden...
  8. pmc Physiological complexity underlying heart rate dynamics and frailty status in community-dwelling older women
    Paulo H M Chaves
    Departments of cMedicine and dEpidemiology, Division of Geriatrics Medicine and Gerontology, Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Am Geriatr Soc 56:1698-703. 2008
    ..For supporting validity, relationships between frailty and traditional linear indices of heart rate variability (HRV) were also assessed...
  9. pmc Association between reduced heart rate variability and cognitive impairment in older disabled women in the community: Women's Health and Aging Study I
    Dae Hyun Kim
    Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Am Geriatr Soc 54:1751-7. 2006
    ..To examine the independent association between heart rate variability (HRV), a marker of cardiac autonomic function, and cognitive impairment...
  10. doi request reprint Frailty status and altered dynamics of circulating energy metabolism hormones after oral glucose in older women
    R R Kalyani
    Division of Endocrinology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Nutr Health Aging 16:679-86. 2012
    ..Frailty status is associated with altered glucose-insulin dynamics. Here, we sought to investigate whether alteration in the dynamics of other circulating energy metabolism hormones after oral glucose is associated with frailty status...
  11. pmc Relationship of a dominant advanced glycation end product, serum carboxymethyl-lysine, and abnormal glucose metabolism in adults: the Baltimore Longitudinal Study of Aging
    R D Semba
    Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    J Nutr Health Aging 14:507-13. 2010
    ..We investigated the relationship between a dominant serum AGE, N-carboxymethyl-lysine (CML), and glucose metabolism...
  12. doi request reprint The use of angiotensin-converting enzyme inhibitors and diuretics is associated with a reduced incidence of impairment on cognition in elderly women
    S Yasar
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Clin Pharmacol Ther 84:119-26. 2008
    ..Therefore, the use of ACE-Is or diuretics was associated with reduced incidence of impairment of both global and domain-specific cognition in elderly women, and may help delay progression to dementia...
  13. pmc Relationships of cardiac, pulmonary, and muscle reserves and frailty to exercise capacity in older women
    Carlos O Weiss
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 65:287-94. 2010
    ..We assessed whether the relationship of three main physiological systems-cardiac, pulmonary, and musculoskeletal-to EC is independent or interactive and whether their effect on EC varies with respect to frailty status...
  14. pmc Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling women
    Richard D Semba
    Johns Hopkins University School of Medicine, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
    Aging Clin Exp Res 21:182-90. 2009
    ..To characterize the relationship between advanced glycation end products (AGEs) and circulating receptors for AGEs (RAGE) with cardiovascular disease mortality...
  15. pmc Low serum carotenoids and development of severe walking disability among older women living in the community: the women's health and aging study I
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Age Ageing 36:62-7. 2007
    ..to determine whether low serum carotenoid levels, an indicator of low intake of fruits and vegetables, are associated with the progression of disability in older women...
  16. pmc Oxidative protein damage is associated with poor grip strength among older women living in the community
    Caitlin Howard
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Appl Physiol 103:17-20. 2007
    ..043). These results suggest oxidative protein damage is independently associated with low grip strength among older women living in the community. Increased oxidative stress may be contributing to loss of muscle strength in older adults...
  17. pmc Low serum selenium concentrations are associated with poor grip strength among older women living in the community
    Justine Beck
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Biofactors 29:37-44. 2007
    ..04). This study supports the idea that selenium is important to muscle strength in older women...
  18. pmc Oxidative protein damage is associated with elevated serum interleukin-6 levels among older moderately to severely disabled women living in the community
    Margaret Dayhoff-Brannigan
    John Hopkins Medical Institutes, Baltimore, MD, USA
    J Gerontol A Biol Sci Med Sci 63:179-83. 2008
    ..Elevated interleukin (IL)-6 is associated with adverse outcomes. Our objective was to determine whether serum protein carbonyls, an indicator of oxidative protein damage and oxidative stress, were associated with IL-6...
  19. pmc Oxidative stress and severe walking disability among older women
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Med 120:1084-9. 2007
    ..Serum protein carbonyls are markers of oxidative damage to proteins and are caused by oxidative stress...
  20. pmc Oxidative stress is associated with greater mortality in older women living in the community
    Richard D Semba
    Department of Ophthalmology, National Institute on Aging, Baltimore, Maryland, USA
    J Am Geriatr Soc 55:1421-5. 2007
    ..To determine whether oxidative stress, as implied by oxidative damage to proteins, is associated with greater mortality in older women living in the community...
  21. pmc Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women
    Justine Beck
    Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Nutrition 24:964-8. 2008
    ....
  22. pmc Low serum carotenoids are associated with a decline in walking speed in older women
    N Alipanah
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Nutr Health Aging 13:170-5. 2009
    ..The aim was to determine whether total serum carotenoid concentrations, a marker for fruit and vegetable intake, and serum selenium are related to changes in walking speed in older women...
  23. ncbi request reprint Initial manifestations of frailty criteria and the development of frailty phenotype in the Women's Health and Aging Study II
    Qian Li Xue
    Department of Medicine, School of Medicine, Johns Hopkins University, 2024 E Monument Street, Suite 2 700, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 63:984-90. 2008
    ..This study aims to characterize natural history by which commonly used frailty criteria manifest and to assess whether the rate of progression to frailty depends on initial manifestations...
  24. pmc Low micronutrient levels as a predictor of incident disability in older women
    Benedetta Bartali
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853 6301, USA
    Arch Intern Med 166:2335-40. 2006
    ..The role of nutritional status in the disablement process is still unclear. The objective of this study was to assess whether low concentrations of nutrients predict the development and course of disability...
  25. ncbi request reprint Relationships between brachial-ankle pulse wave velocity and conventional atherosclerotic risk factors in community-dwelling people
    Yoshinori Fujiwara
    Community Health Research Group, Tokyo Metropolitan Institute of Gerontology, Japan
    Prev Med 39:1135-42. 2004
    ..A simple instrument has been developed to measure brachial-ankle pulse wave velocity (baPWV). The aim of the present study was to use this instrument to study the relationship between baPWV and conventional atherosclerotic risk factors...
  26. ncbi request reprint Risk-treatment paradox in use of statins
    Carlos O Weiss
    JAMA 292:169; author reply 169. 2004