Dhananjay Vaidya

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Sex-specific association of age with carotid artery distensibility: multi-ethnic study of atherosclerosis
    Dhananjay Vaidya
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Womens Health (Larchmt) 21:516-20. 2012
  2. ncbi request reprint Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1
    Nauder Faraday
    Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 115:2490-6. 2007
  3. pmc Sex hormone levels and subclinical atherosclerosis in postmenopausal women: the Multi-Ethnic Study of Atherosclerosis
    Pamela Ouyang
    Johns Hopkins University, Baltimore, MD 21224, USA
    Atherosclerosis 204:255-61. 2009
  4. pmc The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women
    Rita Rastogi Kalyani
    Departments of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 94:4127-35. 2009
  5. ncbi request reprint The association of brachial artery diameter with noncalcified coronary plaque burden in apparently healthy individuals
    Dhananjay Vaidya
    Departments of aMedicine bRadiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Coron Artery Dis 24:657-62. 2013
  6. pmc A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability
    J Enrique Herrera-Galeano
    Departments of Medicine and Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Arterioscler Thromb Vasc Biol 28:1484-90. 2008
  7. doi request reprint Ethnic-specific determinants of exercise capacity in a healthy high-risk population
    Rochelle V Brown
    Division of General Internal Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Med Sci Sports Exerc 44:1150-6. 2012
  8. pmc Platelet inhibition by aspirin 81 and 325 mg/day in men versus women without clinically apparent cardiovascular disease
    Rehan Qayyum
    Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 101:1359-63. 2008
  9. pmc Native platelet aggregation and response to aspirin in persons with the metabolic syndrome and its components
    Dhananjay Vaidya
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Metab Syndr Relat Disord 7:289-96. 2009
  10. ncbi request reprint Racial differences of lipoprotein subclass distributions in postmenopausal women
    Amit N Vora
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ethn Dis 18:176-80. 2008

Collaborators

Detail Information

Publications39

  1. pmc Sex-specific association of age with carotid artery distensibility: multi-ethnic study of atherosclerosis
    Dhananjay Vaidya
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Womens Health (Larchmt) 21:516-20. 2012
    ..We examined whether the association of carotid artery DC with age differed by sex in the Multi-Ethnic Study of Atherosclerosis (MESA)...
  2. ncbi request reprint Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1
    Nauder Faraday
    Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 115:2490-6. 2007
    ..Genetic variation is a proposed but unproved mechanism for insufficient ASA responsiveness...
  3. pmc Sex hormone levels and subclinical atherosclerosis in postmenopausal women: the Multi-Ethnic Study of Atherosclerosis
    Pamela Ouyang
    Johns Hopkins University, Baltimore, MD 21224, USA
    Atherosclerosis 204:255-61. 2009
    ..In contrast, SHBG and testosterone were associated with extent of coronary calcium but in the opposite direction compared to carotid intimal-medial thickness. These differences warrant further evaluation...
  4. pmc The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women
    Rita Rastogi Kalyani
    Departments of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 94:4127-35. 2009
    ..Previous studies have not explored possible factors explaining these relationships...
  5. ncbi request reprint The association of brachial artery diameter with noncalcified coronary plaque burden in apparently healthy individuals
    Dhananjay Vaidya
    Departments of aMedicine bRadiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Coron Artery Dis 24:657-62. 2013
    ..We thus examined the association of brachial artery diameter (BAD), an artery that does not suffer clinical atherosclerosis, with the presence and the extent of coronary CP and NCP...
  6. pmc A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability
    J Enrique Herrera-Galeano
    Departments of Medicine and Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Arterioscler Thromb Vasc Biol 28:1484-90. 2008
    ..We looked for novel genetic variants in PEAR1 and studied their association with agonist-induced native platelet aggregation and with the inhibitory effect of aspirin on platelets...
  7. doi request reprint Ethnic-specific determinants of exercise capacity in a healthy high-risk population
    Rochelle V Brown
    Division of General Internal Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Med Sci Sports Exerc 44:1150-6. 2012
    ..We thus examined exercise capacity and its biopsychosocial correlates in a healthy population of AA and EA at increased risk of CVD...
  8. pmc Platelet inhibition by aspirin 81 and 325 mg/day in men versus women without clinically apparent cardiovascular disease
    Rehan Qayyum
    Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 101:1359-63. 2008
    ..In conclusion, women continue to have greater residual platelet activity after high-dose aspirin compared with men treated with a lower dose of aspirin...
  9. pmc Native platelet aggregation and response to aspirin in persons with the metabolic syndrome and its components
    Dhananjay Vaidya
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Metab Syndr Relat Disord 7:289-96. 2009
    ..We determined the extent to which persons with increased risk for CAD with and without the metabolic syndrome accrued antiplatelet benefits from aspirin therapy...
  10. ncbi request reprint Racial differences of lipoprotein subclass distributions in postmenopausal women
    Amit N Vora
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ethn Dis 18:176-80. 2008
    ..We assessed racial differences in lipoprotein particle size, a marker of atherosclerosis risk, among women with coronary disease...
  11. pmc Severity of inducible myocardial ischemia predicts incident acute coronary syndromes in asymptomatic individuals with a family history of premature coronary artery disease
    Brian G Kral
    Division of Cardiology, Department of Medicine, The Johns Hopkins GeneSTAR Research Program, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Nucl Cardiol 19:28-36. 2012
    ....
  12. pmc Relation of subclinical coronary artery atherosclerosis to cerebral white matter disease in healthy subjects from families with early-onset coronary artery disease
    Brian G Kral
    Division of Cardiology, Department of Medicine, Johns Hopkins GeneSTAR Research Program, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Cardiol 112:747-52. 2013
    ..In conclusion, these findings support the premise of possible shared causal pathways in 2 vascular beds in families at increased risk for early-onset vascular disease...
  13. pmc Effect of positive well-being on incidence of symptomatic coronary artery disease
    Lisa R Yanek
    GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland Electronic address
    Am J Cardiol 112:1120-5. 2013
    ....
  14. pmc The association of endogenous sex hormones with lipoprotein subfraction profile in the Multi-Ethnic Study of Atherosclerosis
    Dhananjay Vaidya
    Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Metabolism 57:782-90. 2008
    ..These findings highlight the potential to improve the lipoprotein profile with sex hormones, but emphasize the intricacies of the interactions...
  15. pmc Leukocyte count is associated with increased platelet reactivity and diminished response to aspirin in healthy individuals with a family history of coronary artery disease
    Nauder Faraday
    Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Thromb Res 124:311-7. 2009
    ..Leukocytes may promote platelet reactivity and thrombus formation, providing a basis for increased risk, but a relation between leukocyte count and platelet function has not been studied...
  16. pmc The robustness of generalized estimating equations for association tests in extended family data
    Bhoom Suktitipat
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21205, USA
    Hum Hered 74:17-26. 2012
    ....
  17. pmc Ageing, menopause, and ischaemic heart disease mortality in England, Wales, and the United States: modelling study of national mortality data
    Dhananjay Vaidya
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    BMJ 343:d5170. 2011
    ..To use changes in heart disease mortality rates with age to investigate the plausibility of attributing women's lower heart disease mortality than men to the protective effects of premenopausal sex hormones...
  18. ncbi request reprint Defining the metabolic syndrome construct: Multi-Ethnic Study of Atherosclerosis (MESA) cross-sectional analysis
    Dhananjay Vaidya
    Johns Hopkins University, Baltimore, Maryland, Baltimore, MD 21287, USA
    Diabetes Care 30:2086-90. 2007
    ..We operationalized the "syndrome" concept and tested whether the metabolic syndrome was compatible with these operational constructs...
  19. pmc Incidence of coronary artery disease in siblings of patients with premature coronary artery disease: 10 years of follow-up
    Dhananjay Vaidya
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Cardiol 100:1410-5. 2007
    ..In conclusion, in families with a history of premature CAD, the excess risk observed cannot be attributed to traditional risk factors, suggesting a major role for as yet undetermined genetic and other susceptibility factors...
  20. ncbi request reprint Fasting plasma glucose predicts survival and angiographic progression in high-risk postmenopausal women with coronary artery disease
    Dhananjay Vaidya
    Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Womens Health (Larchmt) 16:228-34. 2007
    ..We studied the association of baseline fasting plasma glucose (FPG) levels with survival and coronary artery disease (CAD) progression among postmenopausal women without unstable angina...
  21. pmc The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
    BMC Genet 12:50. 2011
    ....
  22. pmc Independent metabolic syndrome variants predict new-onset coronary artery disease
    Dhananjay Vaidya
    Department of Medicine, Division of General Internal Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Diabetes Care 33:1376-8. 2010
    ....
  23. doi request reprint Persistent high on-treatment platelet reactivity in acute coronary syndrome
    Donald R Lynch
    Department of Medicine, Johns Hopkins Medical Institute, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, 301 Building, Division of Cardiology, Baltimore, MD 21224, USA
    J Thromb Thrombolysis 33:267-73. 2012
    ..This study demonstrates persistent high on-treatment platelet reactivity in ACS patients at a three month follow-up, which may place these patients at increased risk of recurrent cardiovascular events...
  24. ncbi request reprint Evaluation of platelet function in aspirin treated patients with CAD
    Marlene S Williams
    Department of Medicine, Johns Hopkins Medical Institute, Baltimore, MD, USA
    J Thromb Thrombolysis 21:241-7. 2006
    ..To obtain a better understanding of platelet function in coronary artery disease in the setting of aspirin therapy, we performed platelet functional testing in patients with ACS and compared results to patients without CAD...
  25. ncbi request reprint Glucose levels in the normal range predict incident diabetes in families with premature coronary heart disease
    Stasia S Reynolds
    Divisions of General Internal Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Diabetes Res Clin Pract 74:267-73. 2006
    ..Little is known about excess risk of incident diabetes conferred by fasting plasma glucose (FPG) within the normal range (<5.6 mmol/l) for high risk families...
  26. ncbi request reprint Platelet functional implications of glycoprotein Ibalpha polymorphisms in African Americans
    Marlene S Williams
    Department of Medicine, Johns Hopkins Medical Institute, Baltimore, Maryland, USA
    Am J Hematol 82:15-22. 2007
    ..We found no significant differences in PFA-100 testing. We conclude from our study that these polymorphisms do not lead to altered platelet function in African Americans...
  27. ncbi request reprint Abnormal PFA-100 closure time is associated with increased platelet aggregation in patients presenting with chest pain
    Andrew D Atiemo
    Department of Medicine, Johns Hopkins Medical Institute, Baltimore, MD, USA
    J Thromb Thrombolysis 25:173-8. 2008
    ....
  28. pmc Silent myocardial ischaemia and long-term coronary artery disease outcomes in apparently healthy people from families with early-onset ischaemic heart disease
    Brian G Kral
    The Johns Hopkins GeneSTAR Research Program, Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, 1830 East Monument Street, Room 8023, Baltimore, MD 21287, USA
    Eur Heart J 32:2766-72. 2011
    ..The extent to which inducible myocardial ischaemia exists and is associated with long-term incident CAD in apparently healthy siblings of early-onset CAD patients is unknown...
  29. pmc Extreme deep white matter hyperintensity volumes are associated with african american race
    Paul A Nyquist
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Cerebrovasc Dis 37:244-50. 2014
    ..Longitudinal studies are required to see if DWMV is predictive of symptomatic subcortical strokes in this population. © 2014 S. Karger AG, Basel. ..
  30. pmc A common variant in the CDKN2B gene on chromosome 9p21 protects against coronary artery disease in Americans of African ancestry
    Brian G Kral
    Department of Medicine, The Johns Hopkins GeneSTAR Research Program, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Hum Genet 56:224-9. 2011
    ..The findings demonstrate a significant protective effect against incident CAD in African American siblings of persons with premature CAD, with replication in a combination of two additional African American cohorts...
  31. pmc Sex-steroid hormones and electrocardiographic QT-interval duration: findings from the third National Health and Nutrition Examination Survey and the Multi-Ethnic Study of Atherosclerosis
    Yiyi Zhang
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Epidemiol 174:403-11. 2011
    ..The findings suggest that testosterone levels may explain differences in QT-interval duration between men and women and could be a contributor to population variability in QT-interval duration among men...
  32. ncbi request reprint Incident stroke is associated with common carotid artery diameter and not common carotid artery intima-media thickness
    Joseph F Polak
    From the Department of Radiology, Tufts University School of Medicine, Boston, MA J F P Department of Neurology, University of Miami, FL R L S Division of Cardiology W S P and Department of Medicine W S P, D V, Johns Hopkins University School of Medicine, Baltimore, MD Department of Neurology, Wake Forest School of Medicine, Winston Salem, NC M K A and Department of Radiology, Saint Elizabeth s Medical Center, Brighton, MA D H O
    Stroke 45:1442-6. 2014
    ..It is associated with common carotid intima-media thickness (IMT) and left ventricular mass and might therefore also have an association with incident stroke...
  33. ncbi request reprint Endogenous sex hormones and glucose tolerance status in postmenopausal women
    Sherita Hill Golden
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Clin Endocrinol Metab 92:1289-95. 2007
    ..Most studies have not examined these associations in a large group of postmenopausal women...
  34. ncbi request reprint Skin tissue cholesterol assay correlates with presence of coronary calcium
    Dhananjay Vaidya
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
    Atherosclerosis 181:167-73. 2005
    ..We tested whether skin tissue cholesterol (SkTC) is associated with subclinical atherosclerosis, assessed using carotid intima-medial thickness (IMT) and coronary artery calcification (CAC)...
  35. ncbi request reprint Sex differences in platelet reactivity and response to low-dose aspirin therapy
    Diane M Becker
    Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    JAMA 295:1420-7. 2006
    ..Failure of aspirin to suppress platelet aggregation in women is one hypothesized mechanism...
  36. pmc Intensive meditation for refractory pain and symptoms
    Madhav Goyal
    Division of General Internal Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    J Altern Complement Med 16:627-31. 2010
    ..The objective of this study was to assess patient interest in intensive meditation training for chronic symptoms...
  37. pmc Nitric oxide metabolite production in the human preimplantation embryo and successful blastocyst formation
    Christopher W Lipari
    Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology and Infertility, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Fertil Steril 91:1316-8. 2009
    ....
  38. ncbi request reprint Sex differences in left ventricular function in older persons with mild hypertension
    Jimmy G Lim
    Division of Cardiology, Department of Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins University, Baltimore, MD, USA
    Am Heart J 150:934-40. 2005
    ..It is less clear if sex differences are present among older persons with mild hypertension...
  39. ncbi request reprint Long-term hormone replacement therapy does not cause increased platelet activation
    Marlene S Williams
    Department of Medicine, Johns Hopkins Medical Institute, Baltimore, MD, USA
    Am Heart J 150:434-8. 2005
    ..It is postulated that estrogen may result in increased platelet aggregation...