DHANANJAY MADHUKAR VAIDYA

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Association of baseline sex hormone levels with baseline and longitudinal changes in waist-to-hip ratio: Multi-Ethnic Study of Atherosclerosis
    D Vaidya
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int J Obes (Lond) 36:1578-84. 2012
  2. pmc The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
    BMC Genet 12:50. 2011
  3. pmc Incidence of coronary artery disease in siblings of patients with premature coronary artery disease: 10 years of follow-up
    Dhananjay Vaidya
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Cardiol 100:1410-5. 2007
  4. ncbi request reprint Defining the metabolic syndrome construct: Multi-Ethnic Study of Atherosclerosis (MESA) cross-sectional analysis
    Dhananjay Vaidya
    Johns Hopkins University, Baltimore, Maryland, Baltimore, MD 21287, USA
    Diabetes Care 30:2086-90. 2007
  5. ncbi request reprint Fasting plasma glucose predicts survival and angiographic progression in high-risk postmenopausal women with coronary artery disease
    Dhananjay Vaidya
    Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Womens Health (Larchmt) 16:228-34. 2007
  6. pmc Native platelet aggregation and response to aspirin in persons with the metabolic syndrome and its components
    Dhananjay Vaidya
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Metab Syndr Relat Disord 7:289-96. 2009
  7. pmc Independent metabolic syndrome variants predict new-onset coronary artery disease
    Dhananjay Vaidya
    Department of Medicine, Division of General Internal Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Diabetes Care 33:1376-8. 2010
  8. doi request reprint The association of endogenous sex hormones with lipoprotein subfraction profile in the Multi-Ethnic Study of Atherosclerosis
    Dhananjay Vaidya
    Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Metabolism 57:782-90. 2008
  9. pmc Ageing, menopause, and ischaemic heart disease mortality in England, Wales, and the United States: modelling study of national mortality data
    Dhananjay Vaidya
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    BMJ 343:d5170. 2011
  10. pmc Association of endothelial and oxidative stress with metabolic syndrome and subclinical atherosclerosis: multi-ethnic study of atherosclerosis
    D Vaidya
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Eur J Clin Nutr 65:818-25. 2011

Research Grants

  1. Genetic Determinants of Premature Vascular Dysfunction in Families
    DHANANJAY MADHUKAR VAIDYA; Fiscal Year: 2010

Detail Information

Publications32

  1. pmc Association of baseline sex hormone levels with baseline and longitudinal changes in waist-to-hip ratio: Multi-Ethnic Study of Atherosclerosis
    D Vaidya
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int J Obes (Lond) 36:1578-84. 2012
    ..We analyzed the associations of baseline serum levels of testosterone (T), estradiol (E2), sex-hormone-binding globulin (SHBG) and dehydroepiandrosterone (DHEA) with WHR in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort...
  2. pmc The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
    BMC Genet 12:50. 2011
    ....
  3. pmc Incidence of coronary artery disease in siblings of patients with premature coronary artery disease: 10 years of follow-up
    Dhananjay Vaidya
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Cardiol 100:1410-5. 2007
    ..In conclusion, in families with a history of premature CAD, the excess risk observed cannot be attributed to traditional risk factors, suggesting a major role for as yet undetermined genetic and other susceptibility factors...
  4. ncbi request reprint Defining the metabolic syndrome construct: Multi-Ethnic Study of Atherosclerosis (MESA) cross-sectional analysis
    Dhananjay Vaidya
    Johns Hopkins University, Baltimore, Maryland, Baltimore, MD 21287, USA
    Diabetes Care 30:2086-90. 2007
    ..We operationalized the "syndrome" concept and tested whether the metabolic syndrome was compatible with these operational constructs...
  5. ncbi request reprint Fasting plasma glucose predicts survival and angiographic progression in high-risk postmenopausal women with coronary artery disease
    Dhananjay Vaidya
    Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Womens Health (Larchmt) 16:228-34. 2007
    ..We studied the association of baseline fasting plasma glucose (FPG) levels with survival and coronary artery disease (CAD) progression among postmenopausal women without unstable angina...
  6. pmc Native platelet aggregation and response to aspirin in persons with the metabolic syndrome and its components
    Dhananjay Vaidya
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Metab Syndr Relat Disord 7:289-96. 2009
    ..We determined the extent to which persons with increased risk for CAD with and without the metabolic syndrome accrued antiplatelet benefits from aspirin therapy...
  7. pmc Independent metabolic syndrome variants predict new-onset coronary artery disease
    Dhananjay Vaidya
    Department of Medicine, Division of General Internal Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Diabetes Care 33:1376-8. 2010
    ....
  8. doi request reprint The association of endogenous sex hormones with lipoprotein subfraction profile in the Multi-Ethnic Study of Atherosclerosis
    Dhananjay Vaidya
    Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Metabolism 57:782-90. 2008
    ..These findings highlight the potential to improve the lipoprotein profile with sex hormones, but emphasize the intricacies of the interactions...
  9. pmc Ageing, menopause, and ischaemic heart disease mortality in England, Wales, and the United States: modelling study of national mortality data
    Dhananjay Vaidya
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    BMJ 343:d5170. 2011
    ..To use changes in heart disease mortality rates with age to investigate the plausibility of attributing women's lower heart disease mortality than men to the protective effects of premenopausal sex hormones...
  10. pmc Association of endothelial and oxidative stress with metabolic syndrome and subclinical atherosclerosis: multi-ethnic study of atherosclerosis
    D Vaidya
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Eur J Clin Nutr 65:818-25. 2011
    ..We examined whether the association of MetS with subclinical atherosclerosis is explained by biomarkers of endothelial damage and oxidative stress...
  11. pmc The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women
    Rita Rastogi Kalyani
    Departments of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 94:4127-35. 2009
    ..Previous studies have not explored possible factors explaining these relationships...
  12. pmc A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability
    J Enrique Herrera-Galeano
    Departments of Medicine and Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Arterioscler Thromb Vasc Biol 28:1484-90. 2008
    ..We looked for novel genetic variants in PEAR1 and studied their association with agonist-induced native platelet aggregation and with the inhibitory effect of aspirin on platelets...
  13. ncbi request reprint Racial differences of lipoprotein subclass distributions in postmenopausal women
    Amit N Vora
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ethn Dis 18:176-80. 2008
    ..We assessed racial differences in lipoprotein particle size, a marker of atherosclerosis risk, among women with coronary disease...
  14. ncbi request reprint Skin tissue cholesterol assay correlates with presence of coronary calcium
    Dhananjay Vaidya
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
    Atherosclerosis 181:167-73. 2005
    ..We tested whether skin tissue cholesterol (SkTC) is associated with subclinical atherosclerosis, assessed using carotid intima-medial thickness (IMT) and coronary artery calcification (CAC)...
  15. pmc Sex hormone levels and subclinical atherosclerosis in postmenopausal women: the Multi-Ethnic Study of Atherosclerosis
    Pamela Ouyang
    Johns Hopkins University, Baltimore, MD 21224, USA
    Atherosclerosis 204:255-61. 2009
    ..In contrast, SHBG and testosterone were associated with extent of coronary calcium but in the opposite direction compared to carotid intimal-medial thickness. These differences warrant further evaluation...
  16. pmc Leukocyte count is associated with increased platelet reactivity and diminished response to aspirin in healthy individuals with a family history of coronary artery disease
    Nauder Faraday
    Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Thromb Res 124:311-7. 2009
    ..Leukocytes may promote platelet reactivity and thrombus formation, providing a basis for increased risk, but a relation between leukocyte count and platelet function has not been studied...
  17. pmc Intensive meditation for refractory pain and symptoms
    Madhav Goyal
    Division of General Internal Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    J Altern Complement Med 16:627-31. 2010
    ..The objective of this study was to assess patient interest in intensive meditation training for chronic symptoms...
  18. pmc Platelet inhibition by aspirin 81 and 325 mg/day in men versus women without clinically apparent cardiovascular disease
    Rehan Qayyum
    Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 101:1359-63. 2008
    ..In conclusion, women continue to have greater residual platelet activity after high-dose aspirin compared with men treated with a lower dose of aspirin...
  19. pmc Sex hormones, sex hormone binding globulin, and abdominal aortic calcification in women and men in the multi-ethnic study of atherosclerosis (MESA)
    Erin D Michos
    Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD 21287, United States
    Atherosclerosis 200:432-8. 2008
    ..Conflicting findings exist regarding the associations of sex hormones with subclinical atherosclerosis...
  20. ncbi request reprint Impact of a community-based multiple risk factor intervention on cardiovascular risk in black families with a history of premature coronary disease
    Diane M Becker
    Division of General Internal Medicine, Johns Hopkins Medical Institutions, 1830 E Monument St, Room 8028, Baltimore, MD 21287, USA
    Circulation 111:1298-304. 2005
    ..We tested a community-based multiple risk factor intervention (community-based care [CBC]) and compared it with "enhanced" primary care (EPC) to reduce CHD risk in high-risk black families...
  21. ncbi request reprint Long-term hormone replacement therapy does not cause increased platelet activation
    Marlene S Williams
    Department of Medicine, Johns Hopkins Medical Institute, Baltimore, MD, USA
    Am Heart J 150:434-8. 2005
    ..It is postulated that estrogen may result in increased platelet aggregation...
  22. ncbi request reprint Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1
    Nauder Faraday
    Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 115:2490-6. 2007
    ..Genetic variation is a proposed but unproved mechanism for insufficient ASA responsiveness...
  23. ncbi request reprint Endogenous sex hormones and glucose tolerance status in postmenopausal women
    Sherita Hill Golden
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Clin Endocrinol Metab 92:1289-95. 2007
    ..Most studies have not examined these associations in a large group of postmenopausal women...
  24. ncbi request reprint Platelet functional implications of glycoprotein Ibalpha polymorphisms in African Americans
    Marlene S Williams
    Department of Medicine, Johns Hopkins Medical Institute, Baltimore, Maryland, USA
    Am J Hematol 82:15-22. 2007
    ..We found no significant differences in PFA-100 testing. We conclude from our study that these polymorphisms do not lead to altered platelet function in African Americans...
  25. ncbi request reprint Sex differences in platelet reactivity and response to low-dose aspirin therapy
    Diane M Becker
    Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    JAMA 295:1420-7. 2006
    ..Failure of aspirin to suppress platelet aggregation in women is one hypothesized mechanism...
  26. ncbi request reprint Evaluation of platelet function in aspirin treated patients with CAD
    Marlene S Williams
    Department of Medicine, Johns Hopkins Medical Institute, Baltimore, MD, USA
    J Thromb Thrombolysis 21:241-7. 2006
    ..To obtain a better understanding of platelet function in coronary artery disease in the setting of aspirin therapy, we performed platelet functional testing in patients with ACS and compared results to patients without CAD...
  27. ncbi request reprint Glucose levels in the normal range predict incident diabetes in families with premature coronary heart disease
    Stasia S Reynolds
    Divisions of General Internal Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Diabetes Res Clin Pract 74:267-73. 2006
    ..Little is known about excess risk of incident diabetes conferred by fasting plasma glucose (FPG) within the normal range (<5.6 mmol/l) for high risk families...
  28. ncbi request reprint Abnormal PFA-100 closure time is associated with increased platelet aggregation in patients presenting with chest pain
    Andrew D Atiemo
    Department of Medicine, Johns Hopkins Medical Institute, Baltimore, MD, USA
    J Thromb Thrombolysis 25:173-8. 2008
    ....
  29. ncbi request reprint Hormone therapy and antioxidant vitamins do not improve endothelial vasodilator function in postmenopausal women with established coronary artery disease: a substudy of the Women's Angiographic Vitamin and Estrogen (WAVE) trial
    Mark Kelemen
    University of Maryland Medical Center, 419 West Redwood Street, Suite 550, Baltimore, Maryland 21201, USA
    Atherosclerosis 179:193-200. 2005
    ....
  30. ncbi request reprint Sex differences in left ventricular function in older persons with mild hypertension
    Jimmy G Lim
    Division of Cardiology, Department of Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins University, Baltimore, MD, USA
    Am Heart J 150:934-40. 2005
    ..It is less clear if sex differences are present among older persons with mild hypertension...
  31. pmc Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies
    Themistocles L Assimes
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94304 1334, USA
    J Am Coll Cardiol 56:1552-63. 2010
    ..We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD)...
  32. pmc Does prevalence of the metabolic syndrome in women with coronary artery disease differ by the ATP III and IDF criteria?
    Todd M Brown
    Health Services Research Training Program, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Womens Health (Larchmt) 17:841-7. 2008
    ..Whether the IDF definition identifies a greater prevalence of the metabolic syndrome than the ATP III definition in women with coronary artery disease (CAD) is unknown...

Research Grants2

  1. Genetic Determinants of Premature Vascular Dysfunction in Families
    DHANANJAY MADHUKAR VAIDYA; Fiscal Year: 2010
    ..Our results will help us understand what genes and mechanisms lead to premature artery diseases. ..