Research Topics
Species | DHANANJAY MADHUKAR VAIDYASummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Association of baseline sex hormone levels with baseline and longitudinal changes in waist-to-hip ratio: Multi-Ethnic Study of AtherosclerosisD Vaidya
Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Int J Obes (Lond) 36:1578-84. 2012..We analyzed the associations of baseline serum levels of testosterone (T), estradiol (E2), sex-hormone-binding globulin (SHBG) and dehydroepiandrosterone (DHEA) with WHR in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort...- The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African AmericansRasika A Mathias
Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
BMC Genet 12:50. 2011.... - Incidence of coronary artery disease in siblings of patients with premature coronary artery disease: 10 years of follow-upDhananjay Vaidya
Johns Hopkins Medical Institutions, Baltimore, MD, USA
Am J Cardiol 100:1410-5. 2007..In conclusion, in families with a history of premature CAD, the excess risk observed cannot be attributed to traditional risk factors, suggesting a major role for as yet undetermined genetic and other susceptibility factors... 
Defining the metabolic syndrome construct: Multi-Ethnic Study of Atherosclerosis (MESA) cross-sectional analysisDhananjay Vaidya
Johns Hopkins University, Baltimore, Maryland, Baltimore, MD 21287, USA
Diabetes Care 30:2086-90. 2007..We operationalized the "syndrome" concept and tested whether the metabolic syndrome was compatible with these operational constructs...- Fasting plasma glucose predicts survival and angiographic progression in high-risk postmenopausal women with coronary artery diseaseDhananjay Vaidya
Johns Hopkins University, Baltimore, Maryland 21287, USA
J Womens Health (Larchmt) 16:228-34. 2007..We studied the association of baseline fasting plasma glucose (FPG) levels with survival and coronary artery disease (CAD) progression among postmenopausal women without unstable angina... - Native platelet aggregation and response to aspirin in persons with the metabolic syndrome and its componentsDhananjay Vaidya
Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Metab Syndr Relat Disord 7:289-96. 2009..We determined the extent to which persons with increased risk for CAD with and without the metabolic syndrome accrued antiplatelet benefits from aspirin therapy... - Independent metabolic syndrome variants predict new-onset coronary artery diseaseDhananjay Vaidya
Department of Medicine, Division of General Internal Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Diabetes Care 33:1376-8. 2010.... 
The association of endogenous sex hormones with lipoprotein subfraction profile in the Multi-Ethnic Study of AtherosclerosisDhananjay Vaidya
Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Metabolism 57:782-90. 2008..These findings highlight the potential to improve the lipoprotein profile with sex hormones, but emphasize the intricacies of the interactions...- Ageing, menopause, and ischaemic heart disease mortality in England, Wales, and the United States: modelling study of national mortality dataDhananjay Vaidya
Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
BMJ 343:d5170. 2011..To use changes in heart disease mortality rates with age to investigate the plausibility of attributing women's lower heart disease mortality than men to the protective effects of premenopausal sex hormones... - Association of endothelial and oxidative stress with metabolic syndrome and subclinical atherosclerosis: multi-ethnic study of atherosclerosisD Vaidya
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Eur J Clin Nutr 65:818-25. 2011..We examined whether the association of MetS with subclinical atherosclerosis is explained by biomarkers of endothelial damage and oxidative stress... - The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal womenRita Rastogi Kalyani
Departments of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 94:4127-35. 2009..Previous studies have not explored possible factors explaining these relationships... - A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregabilityJ Enrique Herrera-Galeano
Departments of Medicine and Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Arterioscler Thromb Vasc Biol 28:1484-90. 2008..We looked for novel genetic variants in PEAR1 and studied their association with agonist-induced native platelet aggregation and with the inhibitory effect of aspirin on platelets... - Racial differences of lipoprotein subclass distributions in postmenopausal womenAmit N Vora
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ethn Dis 18:176-80. 2008..We assessed racial differences in lipoprotein particle size, a marker of atherosclerosis risk, among women with coronary disease... - Skin tissue cholesterol assay correlates with presence of coronary calciumDhananjay Vaidya
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
Atherosclerosis 181:167-73. 2005..CONCLUSIONS: SkTC was associated with the presence of CAC independently of serum lipids/lipoproteins in Caucasians but not African-Americans. SkTC may provide a useful indicator of subclinical atherosclerosis in Caucasians... - Sex hormone levels and subclinical atherosclerosis in postmenopausal women: the Multi-Ethnic Study of AtherosclerosisPamela Ouyang
Johns Hopkins University, Baltimore, MD 21224, USA
Atherosclerosis 204:255-61. 2009..In contrast, SHBG and testosterone were associated with extent of coronary calcium but in the opposite direction compared to carotid intimal-medial thickness. These differences warrant further evaluation... - Leukocyte count is associated with increased platelet reactivity and diminished response to aspirin in healthy individuals with a family history of coronary artery diseaseNauder Faraday
Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Thromb Res 124:311-7. 2009..Leukocytes may promote platelet reactivity and thrombus formation, providing a basis for increased risk, but a relation between leukocyte count and platelet function has not been studied... - Intensive meditation for refractory pain and symptomsMadhav Goyal
Division of General Internal Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
J Altern Complement Med 16:627-31. 2010..The objective of this study was to assess patient interest in intensive meditation training for chronic symptoms... - Platelet inhibition by aspirin 81 and 325 mg/day in men versus women without clinically apparent cardiovascular diseaseRehan Qayyum
Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Cardiol 101:1359-63. 2008..In conclusion, women continue to have greater residual platelet activity after high-dose aspirin compared with men treated with a lower dose of aspirin... - Sex hormones, sex hormone binding globulin, and abdominal aortic calcification in women and men in the multi-ethnic study of atherosclerosis (MESA)Erin D Michos
Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD 21287, United States
Atherosclerosis 200:432-8. 2008..Conflicting findings exist regarding the associations of sex hormones with subclinical atherosclerosis... - Impact of a community-based multiple risk factor intervention on cardiovascular risk in black families with a history of premature coronary diseaseDiane M Becker
Division of General Internal Medicine, Johns Hopkins Medical Institutions, 1830 E Monument St, Room 8028, Baltimore, MD 21287, USA
Circulation 111:1298-304. 2005..We tested a community-based multiple risk factor intervention (community-based care [CBC]) and compared it with "enhanced" primary care (EPC) to reduce CHD risk in high-risk black families... - Long-term hormone replacement therapy does not cause increased platelet activationMarlene S Williams
Department of Medicine, Johns Hopkins Medical Institute, Baltimore, MD, USA
Am Heart J 150:434-8. 2005..It is postulated that estrogen may result in increased platelet aggregation... - Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1Nauder Faraday
Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Circulation 115:2490-6. 2007..Genetic variation is a proposed but unproved mechanism for insufficient ASA responsiveness... - Endogenous sex hormones and glucose tolerance status in postmenopausal womenSherita Hill Golden
Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Clin Endocrinol Metab 92:1289-95. 2007..Most studies have not examined these associations in a large group of postmenopausal women... - Platelet functional implications of glycoprotein Ibalpha polymorphisms in African AmericansMarlene S Williams
Department of Medicine, Johns Hopkins Medical Institute, Baltimore, Maryland, USA
Am J Hematol 82:15-22. 2007..We found no significant differences in PFA-100 testing. We conclude from our study that these polymorphisms do not lead to altered platelet function in African Americans... - Sex differences in platelet reactivity and response to low-dose aspirin therapyDiane M Becker
Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
JAMA 295:1420-7. 2006..Failure of aspirin to suppress platelet aggregation in women is one hypothesized mechanism... - Evaluation of platelet function in aspirin treated patients with CADMarlene S Williams
Department of Medicine, Johns Hopkins Medical Institute, Baltimore, MD, USA
J Thromb Thrombolysis 21:241-7. 2006..To obtain a better understanding of platelet function in coronary artery disease in the setting of aspirin therapy, we performed platelet functional testing in patients with ACS and compared results to patients without CAD... - Glucose levels in the normal range predict incident diabetes in families with premature coronary heart diseaseStasia S Reynolds
Divisions of General Internal Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Diabetes Res Clin Pract 74:267-73. 2006..867. CONCLUSION: Higher FPG levels within the designated "normal" range in high risk families are a potent independent risk factor for type 2 diabetes and may serve as a sentinel to trigger primary preventive interventions... - Abnormal PFA-100 closure time is associated with increased platelet aggregation in patients presenting with chest painAndrew D Atiemo
Department of Medicine, Johns Hopkins Medical Institute, Baltimore, MD, USA
J Thromb Thrombolysis 25:173-8. 2008.... - Hormone therapy and antioxidant vitamins do not improve endothelial vasodilator function in postmenopausal women with established coronary artery disease: a substudy of the Women's Angiographic Vitamin and Estrogen (WAVE) trialMark Kelemen
University of Maryland Medical Center, 419 West Redwood Street, Suite 550, Baltimore, Maryland 21201, USA
Atherosclerosis 179:193-200. 2005.... - Sex differences in left ventricular function in older persons with mild hypertensionJimmy G Lim
Division of Cardiology, Department of Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins University, Baltimore, MD, USA
Am Heart J 150:934-40. 2005..Our findings are consistent with the increased risk older women have of developing heart failure because of hypertension... - Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studiesThemistocles L Assimes
Department of Medicine, Stanford University School of Medicine, Stanford, California 94304 1334, USA
J Am Coll Cardiol 56:1552-63. 2010..We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD)... - Does prevalence of the metabolic syndrome in women with coronary artery disease differ by the ATP III and IDF criteria?Todd M Brown
Health Services Research Training Program, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Womens Health (Larchmt) 17:841-7. 2008..Whether the IDF definition identifies a greater prevalence of the metabolic syndrome than the ATP III definition in women with coronary artery disease (CAD) is unknown...
Research Grants
- Genetic Determinants of Premature Vascular Dysfunction in FamiliesDHANANJAY MADHUKAR VAIDYA; Fiscal Year: 2010..Our results will help us understand what genes and mechanisms lead to premature artery diseases. ..