Cornelia L Trimble

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Effectiveness of screening for cervical cancer in an inpatient hospital setting
    Cornelia L Trimble
    Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Obstet Gynecol 103:310-6. 2004
  2. pmc Human papillomavirus 16-associated cervical intraepithelial neoplasia in humans excludes CD8 T cells from dysplastic epithelium
    Cornelia L Trimble
    Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Immunol 185:7107-14. 2010
  3. pmc Naturally occurring systemic immune responses to HPV antigens do not predict regression of CIN2/3
    Cornelia L Trimble
    Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cancer Immunol Immunother 59:799-803. 2010
  4. pmc Development of therapeutic HPV vaccines
    Cornelia L Trimble
    Johns Hopkins University Hospital, Baltimore, MD, USA
    Lancet Oncol 10:975-80. 2009
  5. pmc A phase I trial of a human papillomavirus DNA vaccine for HPV16+ cervical intraepithelial neoplasia 2/3
    Cornelia L Trimble
    Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Clin Cancer Res 15:361-7. 2009
  6. ncbi request reprint Prospects for therapeutic HPV vaccines
    Cornelia L Trimble
    Department of Gynecology and Obstetrics, The Johns Hopkins Hospital, 600 North Wolfe St, Phipps 255, Baltimore, MD 21287, USA
    Gynecol Oncol 99:S249-50. 2005
  7. pmc Spontaneous regression of high-grade cervical dysplasia: effects of human papillomavirus type and HLA phenotype
    Cornelia L Trimble
    Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Clin Cancer Res 11:4717-23. 2005
  8. pmc New technologies for cervical cancer screening
    Alaina J Brown
    Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Best Pract Res Clin Obstet Gynaecol 26:233-42. 2012
  9. doi request reprint Disparities in human papillomavirus vaccine completion among vaccine initiators
    Betty Chou
    Departments of Gynecology and Obstetrics, Oncology, and Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Obstet Gynecol 118:14-20. 2011
  10. ncbi request reprint The PapSpin: a reasonable alternative to other, more expensive liquid-based Papanicolaou tests
    Dorothy L Rosenthal
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 6940, USA
    Cancer 108:137-43. 2006

Research Grants

  1. A Phase I/II Trial of a Therapeutic HPV Vaccine
    Cornelia Trimble; Fiscal Year: 2004
  2. THERAPEUTIC VACCINES FOR HPV DISEASES
    Cornelia Trimble; Fiscal Year: 2005
  3. Therapeutic DNA-MVA prime boost vaccination for HPV disease
    Cornelia Trimble; Fiscal Year: 2007
  4. Mechanisms of mucosal immune evasion in high grade cervical dysplasia
    Cornelia L Trimble; Fiscal Year: 2010

Collaborators

Detail Information

Publications14

  1. pmc Effectiveness of screening for cervical cancer in an inpatient hospital setting
    Cornelia L Trimble
    Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Obstet Gynecol 103:310-6. 2004
    ..To estimate the effectiveness of an inpatient, hospital-based cervical cancer screening program at a single institution...
  2. pmc Human papillomavirus 16-associated cervical intraepithelial neoplasia in humans excludes CD8 T cells from dysplastic epithelium
    Cornelia L Trimble
    Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Immunol 185:7107-14. 2010
    ..These findings suggest that dysregulated expression of vascular adhesion molecules plays a role in immune evasion very early in the course of HPV disease...
  3. pmc Naturally occurring systemic immune responses to HPV antigens do not predict regression of CIN2/3
    Cornelia L Trimble
    Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cancer Immunol Immunother 59:799-803. 2010
    ..This finding suggests that, in the setting of natural infection, immune responses which are involved in elimination of cervical dysplastic epithelium are not represented to any great extent in the systemic circulation...
  4. pmc Development of therapeutic HPV vaccines
    Cornelia L Trimble
    Johns Hopkins University Hospital, Baltimore, MD, USA
    Lancet Oncol 10:975-80. 2009
    ..In this Review, we discuss recent progress in this field and priorities for future clinical investigations...
  5. pmc A phase I trial of a human papillomavirus DNA vaccine for HPV16+ cervical intraepithelial neoplasia 2/3
    Cornelia L Trimble
    Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Clin Cancer Res 15:361-7. 2009
    ..To evaluate the safety and immunogenicity of a therapeutic human papillomavirus (HPV)16 DNA vaccine administered to women with HPV16+cervical intraepithelial neoplasia (CIN)2/3...
  6. ncbi request reprint Prospects for therapeutic HPV vaccines
    Cornelia L Trimble
    Department of Gynecology and Obstetrics, The Johns Hopkins Hospital, 600 North Wolfe St, Phipps 255, Baltimore, MD 21287, USA
    Gynecol Oncol 99:S249-50. 2005
  7. pmc Spontaneous regression of high-grade cervical dysplasia: effects of human papillomavirus type and HLA phenotype
    Cornelia L Trimble
    Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Clin Cancer Res 11:4717-23. 2005
    ..We carried out a prospective observational cohort study evaluating known, quantifiable prognostic variables of clinical behavior in women with high-grade cervical lesions...
  8. pmc New technologies for cervical cancer screening
    Alaina J Brown
    Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Best Pract Res Clin Obstet Gynaecol 26:233-42. 2012
    ..These methods show promise in changing the way that current cervical cancer screening is undertaken in low-and high-resource settings...
  9. doi request reprint Disparities in human papillomavirus vaccine completion among vaccine initiators
    Betty Chou
    Departments of Gynecology and Obstetrics, Oncology, and Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Obstet Gynecol 118:14-20. 2011
    ..To estimate rates of completing the full three-dose prophylactic human papillomavirus (HPV) vaccination regimen in patients who initiated the series and to identify variables associated with not completing vaccination...
  10. ncbi request reprint The PapSpin: a reasonable alternative to other, more expensive liquid-based Papanicolaou tests
    Dorothy L Rosenthal
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 6940, USA
    Cancer 108:137-43. 2006
    ....
  11. doi request reprint Human papillomavirus vaccination should be offered to young males: Counterpoint
    Cornelia L Trimble
    The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer Epidemiol Biomarkers Prev 17:809. 2008
  12. pmc Active and passive cigarette smoking and the risk of cervical neoplasia
    Cornelia L Trimble
    Department of Obstetrics and Gynecology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Obstet Gynecol 105:174-81. 2005
    ..Using a prospective cohort design, we examined personal cigarette smoking and household passive smoke exposure in relation to the risk of cervical neoplasia...
  13. doi request reprint Impact of payer status on treatment of cervical cancer at a tertiary referral center
    Kimberly L Levinson
    Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Gynecol Oncol 122:324-7. 2011
    ..The study aims to determine the impact of payer status on the likelihood of receiving definitive treatment for invasive cervical cancer at a tertiary medical center...
  14. ncbi request reprint Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion
    Yali Zhai
    Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Cancer Res 67:10163-72. 2007
    ..Other genes with differential expression in invasive SCC versus HSIL may contribute to tumor progression or may be useful as markers for cancer diagnosis or progression risk...

Research Grants5

  1. A Phase I/II Trial of a Therapeutic HPV Vaccine
    Cornelia Trimble; Fiscal Year: 2004
    ....
  2. THERAPEUTIC VACCINES FOR HPV DISEASES
    Cornelia Trimble; Fiscal Year: 2005
    ..These facilities will be used to develop Dr. Trimble's ability to design and execute clinical trials evaluating preneoplastic HPV-associated lesions of the female lower genital tract. ..
  3. Therapeutic DNA-MVA prime boost vaccination for HPV disease
    Cornelia Trimble; Fiscal Year: 2007
    ..We have a demonstrated record in clinical trial design and execution in this patient population, which is disproportionately comprised of minority women who do not access the medical care system effectively. ..
  4. Mechanisms of mucosal immune evasion in high grade cervical dysplasia
    Cornelia L Trimble; Fiscal Year: 2010
    ....