Research Topics
| M TorbensonSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP productionJean-Francois H Geschwind
Division of Cardiovascular and Interventional Radiology, The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185, USA
Cancer Res 62:3909-13. 2002....- Review of the clinicopathologic features of fibrolamellar carcinomaMichael Torbenson
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Adv Anat Pathol 14:217-23. 2007..Although their morphologic appearance on routine stains is well defined, their etiology is still unknown and much of their molecular biology remains poorly described and awaits future investigation... - De novo hepatocellular carcinoma in a liver allograft associated with recurrent hepatitis BM Torbenson
Department of Pathology, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 1503 East Jefferson, Baltimore, MD 21231, USA
Transplant Proc 37:2205-6. 2005..We describe the clinical and pathological features of a case of de novo hepatocellular carcinoma arising in a cirrhotic allograft 9 years following transplantation for chronic hepatitis B... - Glycogenic hepatopathy: an underrecognized hepatic complication of diabetes mellitusMichael Torbenson
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Am J Surg Pathol 30:508-13. 2006..We conclude that glycogenic hepatopathy can cause hepatomegaly and significant transaminase elevations in individuals with type I diabetes mellitus. The pathology is distinct from steatohepatitis... - Bile duct dysplasia in the setting of chronic hepatitis C and alcohol cirrhosisMichael Torbenson
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Am J Surg Pathol 31:1410-3. 2007..Alcohol also seems to be a risk factor. The dysplastic changes are multifocal, involve septal sized bile ducts, and are typically papillary... - A quantitative profile of the patent medicine industry in Baltimore from 1863 to 1930Michael Torbenson
Department of Pathology, Room B314, 1503 E Jefferson, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Pharm Hist 49:15-27. 2007..The temporal correlation of this decline with the passage of the Food and Drugs Act of 1906 argues strongly that this legislation was an important contributor to the decline of the industry... 
Iron in the liver: a review for surgical pathologistsMichael Torbenson
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore 21231, MD
Adv Anat Pathol 18:306-17. 2011..In this review, the current literature is discussed with a focus on aspects that are most relevant to the practice of surgical pathology...- Bile ducts and ductules are positive for CD56 (N-CAM) in most cases of extrahepatic biliary atresiaMichael Torbenson
Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
Am J Surg Pathol 27:1454-7. 2003.... - Neonatal giant cell hepatitis: histological and etiological findingsMichael Torbenson
Departments of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Am J Surg Pathol 34:1498-503. 2010..In this study, we examined 2 separate tertiary care center cohorts of individuals with NGCH to better understand the potential etiologies and their histological correlates... - Hepatocellular carcinomas show abnormal expression of fibronectin proteinMichael Torbenson
Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA
Mod Pathol 15:826-30. 2002..Fibronectin shows abnormal cytoplasmic and/or membranous staining in the majority of HCCs. The implications of fibronectin overexpression are uncertain but may reflect a critical step in tumor genesis... - Hepatitis B viral DNA is methylated in liver tissuesP Vivekanandan
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
J Viral Hepat 15:103-7. 2008..In conclusion, HBV-DNA can be methylated in human tissues and methylation may play an important role in regulation of HBV gene expression... 
Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolutionXiao Hong Wang
Viral Hepatitis Center, Div of Inf Dis, Department of Medicine, Johns Hopkins University School of Medicine, 1503 E Jefferson Street, Suite 114, Baltimore, MD 21231, USA, and Southwest Hospital, Chongqing, People s Republic of China
J Virol 81:6513-22. 2007..Thus, in a small but carefully matched cohort we found evidence for rapid neutral evolution of HCV in persons with rapid progression of hepatic fibrosis, suggesting higher turnover of infected cells...- Occult hepatitis B viral DNA in liver carcinomas from a region with a low prevalence of chronic hepatitis B infectionR Kannangai
Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
J Viral Hepat 11:297-301. 2004..Thus, in this study occult HBV was of genotype A and was found in a low percentage of cases of HCC and was associated with low tissue HBV DNA copy numbers and no detectable evidence for viral replication... - Breath biomarkers and non-alcoholic fatty liver disease: preliminary observationsS F Solga
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Biomarkers 11:174-83. 2006..In particular, breath ethanol can be associated with hepatic steatosis, and breath acetone can be associated with non-alcoholic steatohepatitis... - Rapid fibrosis progression among HIV/hepatitis C virus-co-infected adultsMark S Sulkowski
Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
AIDS 21:2209-16. 2007.... - Hepatic steatosis associated with increased central body fat by dual-energy X-ray absorptiometry and uncontrolled HIV in HIV/hepatitis C co-infected personsTodd T Brown
Johns Hopkins School of Medicine, USA
AIDS 24:811-7. 2010..To evaluate the relationship between regional body composition and liver disease (fibrosis or steatosis) in HIV/HCV co-infected individuals... - Obstructive sleep apnea, insulin resistance, and steatohepatitis in severe obesityVsevolod Y Polotsky
Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Am J Respir Crit Care Med 179:228-34. 2009..Obstructive sleep apnea is associated with insulin resistance and liver injury. It is unknown whether apnea contributes to insulin resistance and steatohepatitis in severe obesity... - Role of liver biopsy in management of chronic hepatitis C: a systematic reviewKelly A Gebo
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Hepatology 36:S161-72. 2002.... - Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmissionEdward J Fuchs
Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 5554, USA
J Infect Dis 195:703-10. 2007..To inform the development of rectal microbicide formulation, we evaluated the effects of hyperosmolar gels on the rectal mucosa... - Screening tests for hepatocellular carcinoma in patients with chronic hepatitis C: a systematic reviewKelly A Gebo
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Hepatology 36:S84-92. 2002..In conclusion, screening of patients with chronic hepatitis C with AFP and ultrasound may improve detection of HCC, but studies are needed to determine whether screening improves clinical outcomes... - Beta-catenin immunohistochemistry separates mesenteric fibromatosis from gastrointestinal stromal tumor and sclerosing mesenteritisElizabeth Montgomery
Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Am J Surg Pathol 26:1296-301. 2002..beta-Catenin staining identifies lesions that are, instead, mesenteric fibromatoses... - Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATPYoung H Ko
The Russell H Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
Biochem Biophys Res Commun 324:269-75. 2004..In all 19 treated animals advanced cancers were eradicated without apparent toxicity or recurrence. These findings attest to the feasibility of completely destroying advanced, highly glycolytic cancers... - Treatment of chronic hepatitis C: a systematic reviewGeetanjali Chander
Department of Medicine and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Hepatology 36:S135-44. 2002..Thus, the combination of peginterferon and ribavirin was the most efficacious treatment in patients with HCV genotype 1. Long-term outcomes were improved in patients with hepatitis C who achieved an SVR with treatment... - Chronic intermittent hypoxia and acetaminophen induce synergistic liver injury in miceVladimir Savransky
Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
Exp Physiol 94:228-39. 2009..We conclude that CIH and chronic APAP treatment lead to synergistic liver injury, which may have clinical implications for patients with OSA... - Chronic intermittent hypoxia predisposes to liver injuryVladimir Savransky
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Hepatology 45:1007-13. 2007..CONCLUSION: In the absence of obesity, CIH leads to mild liver injury via oxidative stress and excessive glycogen accumulation in hepatocytes and sensitizes the liver to a second insult, whereas NASH does not develop... - Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liverVladimir Savransky
Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Am J Physiol Gastrointest Liver Physiol 293:G871-7. 2007..We conclude that CIH induces lipid peroxidation and inflammation in the livers of mice on a high-fat, high-cholesterol diet... - EGFR is phosphorylated at Ty845 in hepatocellular carcinomaRajesh Kannangai
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Mod Pathol 19:1456-61. 2006..We conclude that EGFR is phosphorylated at tyrosine 845 in most hepatocellular carcinomas and that EGFR expression by immunohistochemistry does not correlate well with STAT-3, STAT-5, MAPK, or AKT immunostaining... - Intraarterial therapy with a new potent inhibitor of tumor metabolism (3-bromopyruvate): identification of therapeutic dose and method of injection in an animal model of liver cancerMustafa Vali
Division of Vascular and Interventional Radiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
J Vasc Interv Radiol 18:95-101. 2007..The authors performed a stepwise study in rabbits to determine the therapeutic dose and method of delivery of 3-BrPA... - Hepatic giant cells in hepatitis C virus (HCV) mono-infection and HCV/HIV co-infectionS T L Micchelli
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Clin Pathol 61:1058-61. 2008..The clinical and biological significance of syncytial giant cell change of hepatocytes in hepatitis C viral (HCV) infection is poorly understood... - Primary liver carcinoma arising in people younger than 30 yearsWalter M Klein
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Am J Clin Pathol 124:512-8. 2005..HCCs are the most common primary liver carcinoma in children and young adults followed by FLCs. They are morphologically similar to adult HCC, but more likely to be CK7(+)... - The effect of steatosis on echogenicity of colorectal liver metastases on intraoperative ultrasonographyMark G Van Vledder
Department of Surgery, The Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
Arch Surg 145:661-7. 2010..To investigate the association of relative tumor echogenicity and hepatic steatosis in patients undergoing resection of colorectal liver metastases (CRLM)... - Dysregulation of the Hedgehog pathway in human hepatocarcinogenesisJason K Sicklick
Department of Surgery and Division of Surgical Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Carcinogenesis 27:748-57. 2006.... - Distribution of iron oxide-containing Embosphere particles after transcatheter arterial embolization in an animal model of liver cancer: evaluation with MR imaging and implication for therapyKwang Hun Lee
Division of Vascular and Interventional Radiology, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Blalock 545, Baltimore, MD 21287, USA
J Vasc Interv Radiol 19:1490-6. 2008.... - New intra-arterial drug delivery system for the treatment of liver cancer: preclinical assessment in a rabbit model of liver cancerKelvin Hong
Division of Vascular and Interventional Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Clin Cancer Res 12:2563-7. 2006..CONCLUSIONS: Our results support the concept of DEBs as an effective way to deliver drugs to tumor. This new technology may prove to be a useful weapon against liver cancer... - PEG-b-PPA/DNA micelles improve transgene expression in rat liver through intrabiliary infusionXuan Jiang
Department of Materials Science and Engineering, and Whitaker Biomedical Engineering Institute, Johns Hopkins University, Baltimore, MD 21218, USA
J Control Release 122:297-304. 2007..This study demonstrated the potential of PEG-b-PPA/DNA micelles as an efficient carrier for liver-targeted gene delivery... - Selenium supplementation decreases hepatic fibrosis in mice after chronic carbon tetrachloride administrationMing Ding
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
Biol Trace Elem Res 133:83-97. 2010..The principal mechanisms for the decreased fibrosis are a lower number of collagen-producing stellate cells and increased collagen degradation... - Lack of inducible nitric oxide synthase leads to increased hepatic apoptosis and decreased fibrosis in mice after chronic carbon tetrachloride administrationGhazaleh Aram
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
Hepatology 47:2051-8. 2008..CONCLUSION: NO protects against CCl(4)-induced apoptosis. In the absence of iNOS, there is decreased necrosis, increased apoptosis, and reduced liver fibrosis... - Effects of the type of embolization particles on carboplatin concentration in liver tumors after transcatheter arterial chemoembolization in a rabbit model of liver cancerKelvin Hong
Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, 600 North Wolfe Street, Blalock 545, Baltimore, Maryland 21287, USA
J Vasc Interv Radiol 16:1711-7. 2005..Administration of tris-acryl gelatin microspheres may be clinically advantageous during TACE, as it contributed to greater delivery of chemotherapy to tumor in the present study... - Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administrationGhazaleh Aram
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Hepatology 49:911-9. 2009..CONCLUSION: Decreased hepatic fibrosis after chronic CCl(4) administration in mice with NADPH oxidase deficiency occurs in the setting of greater necrosis and inflammation but decreased apoptosis... - Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver diseaseNaga Chalasani
Indiana University School of Medicine, 1050 Wishard Boulevard, Indianapolis, IN 46202, USA
J Hepatol 48:829-34. 2008..The relationship between severity and zonal location of steatosis and the presence of steatohepatitis and various histological features that define NASH has not been formally studied... - Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseDavid E Kleiner
Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
Hepatology 41:1313-21. 2005..NAS of > or =5 correlated with a diagnosis of NASH, and biopsies with scores of less than 3 were diagnosed as "not NASH.".. - Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in miceXiaoling Xu
Genetics of Development and Disease Branch, NIDDK, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 116:1843-52. 2006..These findings elucidate the relationship between SMAD4 and PTEN and extend our understanding of CC formation... - Role for hedgehog signaling in hepatic stellate cell activation and viabilityJason K Sicklick
Division of Gastroenterology and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Lab Invest 85:1368-80. 2005..Our findings reveal a novel mechanism, namely the Hh pathway, that regulates the activation and viability of HSC... - Sirolimus monotherapy versus sirolimus in combination with steroids and/or MMF for immunosuppression after liver transplantationAnurag Maheshwari
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Dig Dis Sci 51:1677-84. 2006..Conversion to sirolimus was associated with an immediate improvement in renal function that was sustained during the follow-up...
Research Grants
- Genetic and epigenetic regulation of Hepatitis B contributes to liver cancerMichael S Torbenson; Fiscal Year: 2010..abstract_text> ..
- Occult Hepatitis BMichael Torbenson; Fiscal Year: 2007..abstract_text> ..
- Genetic and epigenetic regulation of Hepatitis B contributes to liver cancerMichael Torbenson; Fiscal Year: 2009....