M Torbenson

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production
    Jean Francois H Geschwind
    Division of Cardiovascular and Interventional Radiology, The Russell H Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    Cancer Res 62:3909-13. 2002
  2. ncbi request reprint Review of the clinicopathologic features of fibrolamellar carcinoma
    Michael Torbenson
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Adv Anat Pathol 14:217-23. 2007
  3. ncbi request reprint De novo hepatocellular carcinoma in a liver allograft associated with recurrent hepatitis B
    M Torbenson
    Department of Pathology, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 1503 East Jefferson, Baltimore, MD 21231, USA
    Transplant Proc 37:2205-6. 2005
  4. ncbi request reprint Glycogenic hepatopathy: an underrecognized hepatic complication of diabetes mellitus
    Michael Torbenson
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Surg Pathol 30:508-13. 2006
  5. ncbi request reprint Bile duct dysplasia in the setting of chronic hepatitis C and alcohol cirrhosis
    Michael Torbenson
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Surg Pathol 31:1410-3. 2007
  6. ncbi request reprint A quantitative profile of the patent medicine industry in Baltimore from 1863 to 1930
    Michael Torbenson
    Department of Pathology, Room B314, 1503 E Jefferson, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Pharm Hist 49:15-27. 2007
  7. doi request reprint Iron in the liver: a review for surgical pathologists
    Michael Torbenson
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore 21231, MD
    Adv Anat Pathol 18:306-17. 2011
  8. ncbi request reprint Bile ducts and ductules are positive for CD56 (N-CAM) in most cases of extrahepatic biliary atresia
    Michael Torbenson
    Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    Am J Surg Pathol 27:1454-7. 2003
  9. doi request reprint Neonatal giant cell hepatitis: histological and etiological findings
    Michael Torbenson
    Departments of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Surg Pathol 34:1498-503. 2010
  10. ncbi request reprint Hepatocellular carcinomas show abnormal expression of fibronectin protein
    Michael Torbenson
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    Mod Pathol 15:826-30. 2002

Research Grants

Detail Information

Publications44

  1. ncbi request reprint Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production
    Jean Francois H Geschwind
    Division of Cardiovascular and Interventional Radiology, The Russell H Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    Cancer Res 62:3909-13. 2002
    ....
  2. ncbi request reprint Review of the clinicopathologic features of fibrolamellar carcinoma
    Michael Torbenson
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Adv Anat Pathol 14:217-23. 2007
    ..Although their morphologic appearance on routine stains is well defined, their etiology is still unknown and much of their molecular biology remains poorly described and awaits future investigation...
  3. ncbi request reprint De novo hepatocellular carcinoma in a liver allograft associated with recurrent hepatitis B
    M Torbenson
    Department of Pathology, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 1503 East Jefferson, Baltimore, MD 21231, USA
    Transplant Proc 37:2205-6. 2005
    ..We describe the clinical and pathological features of a case of de novo hepatocellular carcinoma arising in a cirrhotic allograft 9 years following transplantation for chronic hepatitis B...
  4. ncbi request reprint Glycogenic hepatopathy: an underrecognized hepatic complication of diabetes mellitus
    Michael Torbenson
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Surg Pathol 30:508-13. 2006
    ..We conclude that glycogenic hepatopathy can cause hepatomegaly and significant transaminase elevations in individuals with type I diabetes mellitus. The pathology is distinct from steatohepatitis...
  5. ncbi request reprint Bile duct dysplasia in the setting of chronic hepatitis C and alcohol cirrhosis
    Michael Torbenson
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Surg Pathol 31:1410-3. 2007
    ..Alcohol also seems to be a risk factor. The dysplastic changes are multifocal, involve septal sized bile ducts, and are typically papillary...
  6. ncbi request reprint A quantitative profile of the patent medicine industry in Baltimore from 1863 to 1930
    Michael Torbenson
    Department of Pathology, Room B314, 1503 E Jefferson, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Pharm Hist 49:15-27. 2007
    ..The temporal correlation of this decline with the passage of the Food and Drugs Act of 1906 argues strongly that this legislation was an important contributor to the decline of the industry...
  7. doi request reprint Iron in the liver: a review for surgical pathologists
    Michael Torbenson
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore 21231, MD
    Adv Anat Pathol 18:306-17. 2011
    ..In this review, the current literature is discussed with a focus on aspects that are most relevant to the practice of surgical pathology...
  8. ncbi request reprint Bile ducts and ductules are positive for CD56 (N-CAM) in most cases of extrahepatic biliary atresia
    Michael Torbenson
    Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    Am J Surg Pathol 27:1454-7. 2003
    ....
  9. doi request reprint Neonatal giant cell hepatitis: histological and etiological findings
    Michael Torbenson
    Departments of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Surg Pathol 34:1498-503. 2010
    ..In this study, we examined 2 separate tertiary care center cohorts of individuals with NGCH to better understand the potential etiologies and their histological correlates...
  10. ncbi request reprint Hepatocellular carcinomas show abnormal expression of fibronectin protein
    Michael Torbenson
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    Mod Pathol 15:826-30. 2002
    ..Fibronectin shows abnormal cytoplasmic and/or membranous staining in the majority of HCCs. The implications of fibronectin overexpression are uncertain but may reflect a critical step in tumor genesis...
  11. doi request reprint Hepatitis B viral DNA is methylated in liver tissues
    P Vivekanandan
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Viral Hepat 15:103-7. 2008
    ..In conclusion, HBV-DNA can be methylated in human tissues and methylation may play an important role in regulation of HBV gene expression...
  12. pmc Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolution
    Xiao Hong Wang
    Viral Hepatitis Center, Div of Inf Dis, Department of Medicine, Johns Hopkins University School of Medicine, 1503 E Jefferson Street, Suite 114, Baltimore, MD 21231, USA, and Southwest Hospital, Chongqing, People s Republic of China
    J Virol 81:6513-22. 2007
    ..Thus, in a small but carefully matched cohort we found evidence for rapid neutral evolution of HCV in persons with rapid progression of hepatic fibrosis, suggesting higher turnover of infected cells...
  13. ncbi request reprint Occult hepatitis B viral DNA in liver carcinomas from a region with a low prevalence of chronic hepatitis B infection
    R Kannangai
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    J Viral Hepat 11:297-301. 2004
    ..Thus, in this study occult HBV was of genotype A and was found in a low percentage of cases of HCC and was associated with low tissue HBV DNA copy numbers and no detectable evidence for viral replication...
  14. ncbi request reprint Breath biomarkers and non-alcoholic fatty liver disease: preliminary observations
    S F Solga
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Biomarkers 11:174-83. 2006
    ..In particular, breath ethanol can be associated with hepatic steatosis, and breath acetone can be associated with non-alcoholic steatohepatitis...
  15. ncbi request reprint Rapid fibrosis progression among HIV/hepatitis C virus-co-infected adults
    Mark S Sulkowski
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    AIDS 21:2209-16. 2007
    ....
  16. pmc Hepatic steatosis associated with increased central body fat by dual-energy X-ray absorptiometry and uncontrolled HIV in HIV/hepatitis C co-infected persons
    Todd T Brown
    Johns Hopkins School of Medicine, USA
    AIDS 24:811-7. 2010
    ..To evaluate the relationship between regional body composition and liver disease (fibrosis or steatosis) in HIV/HCV co-infected individuals...
  17. pmc Obstructive sleep apnea, insulin resistance, and steatohepatitis in severe obesity
    Vsevolod Y Polotsky
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 179:228-34. 2009
    ..Obstructive sleep apnea is associated with insulin resistance and liver injury. It is unknown whether apnea contributes to insulin resistance and steatohepatitis in severe obesity...
  18. ncbi request reprint Role of liver biopsy in management of chronic hepatitis C: a systematic review
    Kelly A Gebo
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hepatology 36:S161-72. 2002
    ....
  19. ncbi request reprint Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission
    Edward J Fuchs
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 5554, USA
    J Infect Dis 195:703-10. 2007
    ..To inform the development of rectal microbicide formulation, we evaluated the effects of hyperosmolar gels on the rectal mucosa...
  20. ncbi request reprint Screening tests for hepatocellular carcinoma in patients with chronic hepatitis C: a systematic review
    Kelly A Gebo
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hepatology 36:S84-92. 2002
    ..In conclusion, screening of patients with chronic hepatitis C with AFP and ultrasound may improve detection of HCC, but studies are needed to determine whether screening improves clinical outcomes...
  21. ncbi request reprint Beta-catenin immunohistochemistry separates mesenteric fibromatosis from gastrointestinal stromal tumor and sclerosing mesenteritis
    Elizabeth Montgomery
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Am J Surg Pathol 26:1296-301. 2002
    ..beta-Catenin staining identifies lesions that are, instead, mesenteric fibromatoses...
  22. ncbi request reprint Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
    Young H Ko
    The Russell H Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Biochem Biophys Res Commun 324:269-75. 2004
    ..In all 19 treated animals advanced cancers were eradicated without apparent toxicity or recurrence. These findings attest to the feasibility of completely destroying advanced, highly glycolytic cancers...
  23. ncbi request reprint Treatment of chronic hepatitis C: a systematic review
    Geetanjali Chander
    Department of Medicine and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hepatology 36:S135-44. 2002
    ..Thus, the combination of peginterferon and ribavirin was the most efficacious treatment in patients with HCV genotype 1. Long-term outcomes were improved in patients with hepatitis C who achieved an SVR with treatment...
  24. pmc Chronic intermittent hypoxia and acetaminophen induce synergistic liver injury in mice
    Vladimir Savransky
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Exp Physiol 94:228-39. 2009
    ..We conclude that CIH and chronic APAP treatment lead to synergistic liver injury, which may have clinical implications for patients with OSA...
  25. ncbi request reprint Chronic intermittent hypoxia predisposes to liver injury
    Vladimir Savransky
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Hepatology 45:1007-13. 2007
    ..CONCLUSION: In the absence of obesity, CIH leads to mild liver injury via oxidative stress and excessive glycogen accumulation in hepatocytes and sensitizes the liver to a second insult, whereas NASH does not develop...
  26. ncbi request reprint Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver
    Vladimir Savransky
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Gastrointest Liver Physiol 293:G871-7. 2007
    ..We conclude that CIH induces lipid peroxidation and inflammation in the livers of mice on a high-fat, high-cholesterol diet...
  27. ncbi request reprint EGFR is phosphorylated at Ty845 in hepatocellular carcinoma
    Rajesh Kannangai
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Mod Pathol 19:1456-61. 2006
    ..We conclude that EGFR is phosphorylated at tyrosine 845 in most hepatocellular carcinomas and that EGFR expression by immunohistochemistry does not correlate well with STAT-3, STAT-5, MAPK, or AKT immunostaining...
  28. ncbi request reprint Intraarterial therapy with a new potent inhibitor of tumor metabolism (3-bromopyruvate): identification of therapeutic dose and method of injection in an animal model of liver cancer
    Mustafa Vali
    Division of Vascular and Interventional Radiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Vasc Interv Radiol 18:95-101. 2007
    ..The authors performed a stepwise study in rabbits to determine the therapeutic dose and method of delivery of 3-BrPA...
  29. doi request reprint Hepatic giant cells in hepatitis C virus (HCV) mono-infection and HCV/HIV co-infection
    S T L Micchelli
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Pathol 61:1058-61. 2008
    ..The clinical and biological significance of syncytial giant cell change of hepatocytes in hepatitis C viral (HCV) infection is poorly understood...
  30. ncbi request reprint Primary liver carcinoma arising in people younger than 30 years
    Walter M Klein
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Clin Pathol 124:512-8. 2005
    ..HCCs are the most common primary liver carcinoma in children and young adults followed by FLCs. They are morphologically similar to adult HCC, but more likely to be CK7(+)...
  31. doi request reprint The effect of steatosis on echogenicity of colorectal liver metastases on intraoperative ultrasonography
    Mark G Van Vledder
    Department of Surgery, The Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Arch Surg 145:661-7. 2010
    ..To investigate the association of relative tumor echogenicity and hepatic steatosis in patients undergoing resection of colorectal liver metastases (CRLM)...
  32. ncbi request reprint Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis
    Jason K Sicklick
    Department of Surgery and Division of Surgical Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Carcinogenesis 27:748-57. 2006
    ....
  33. pmc Distribution of iron oxide-containing Embosphere particles after transcatheter arterial embolization in an animal model of liver cancer: evaluation with MR imaging and implication for therapy
    Kwang Hun Lee
    Division of Vascular and Interventional Radiology, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Blalock 545, Baltimore, MD 21287, USA
    J Vasc Interv Radiol 19:1490-6. 2008
    ....
  34. ncbi request reprint New intra-arterial drug delivery system for the treatment of liver cancer: preclinical assessment in a rabbit model of liver cancer
    Kelvin Hong
    Division of Vascular and Interventional Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Cancer Res 12:2563-7. 2006
    ..Exploiting this property, we delivered drug-eluting microspheres/beads (DEB) loaded with doxorubicin, intra-arterially, in an animal model of liver cancer (Vx-2)...
  35. pmc PEG-b-PPA/DNA micelles improve transgene expression in rat liver through intrabiliary infusion
    Xuan Jiang
    Department of Materials Science and Engineering, and Whitaker Biomedical Engineering Institute, Johns Hopkins University, Baltimore, MD 21218, USA
    J Control Release 122:297-304. 2007
    ..This study demonstrated the potential of PEG-b-PPA/DNA micelles as an efficient carrier for liver-targeted gene delivery...
  36. pmc Selenium supplementation decreases hepatic fibrosis in mice after chronic carbon tetrachloride administration
    Ming Ding
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
    Biol Trace Elem Res 133:83-97. 2010
    ..The principal mechanisms for the decreased fibrosis are a lower number of collagen-producing stellate cells and increased collagen degradation...
  37. doi request reprint Lack of inducible nitric oxide synthase leads to increased hepatic apoptosis and decreased fibrosis in mice after chronic carbon tetrachloride administration
    Ghazaleh Aram
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
    Hepatology 47:2051-8. 2008
    ..05). However, MMP-9 and TIMP-1 protein, determined by western blot, were similarly increased after CCl(4) in both groups of mice...
  38. ncbi request reprint Effects of the type of embolization particles on carboplatin concentration in liver tumors after transcatheter arterial chemoembolization in a rabbit model of liver cancer
    Kelvin Hong
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, 600 North Wolfe Street, Blalock 545, Baltimore, Maryland 21287, USA
    J Vasc Interv Radiol 16:1711-7. 2005
    ....
  39. pmc Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration
    Ghazaleh Aram
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Hepatology 49:911-9. 2009
    ..Matrix metalloproteinase-2 (MMP-2) and MMP-9 mRNA increased more in the gp91(phox(-/-) ) than in WT mice after CCl(4.) Tissue inhibitor of metalloproteinase 1 (TIMP-1) and TIMP-2 increased after CCl(4) only in the gp91(phox(-/-) ) mice...
  40. pmc Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease
    Naga Chalasani
    Indiana University School of Medicine, 1050 Wishard Boulevard, Indianapolis, IN 46202, USA
    J Hepatol 48:829-34. 2008
    ..The relationship between severity and zonal location of steatosis and the presence of steatohepatitis and various histological features that define NASH has not been formally studied...
  41. ncbi request reprint Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 41:1313-21. 2005
    ..NAS of > or =5 correlated with a diagnosis of NASH, and biopsies with scores of less than 3 were diagnosed as "not NASH."..
  42. pmc Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice
    Xiaoling Xu
    Genetics of Development and Disease Branch, NIDDK, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:1843-52. 2006
    ..These findings elucidate the relationship between SMAD4 and PTEN and extend our understanding of CC formation...
  43. ncbi request reprint Role for hedgehog signaling in hepatic stellate cell activation and viability
    Jason K Sicklick
    Division of Gastroenterology and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Lab Invest 85:1368-80. 2005
    ..Our findings reveal a novel mechanism, namely the Hh pathway, that regulates the activation and viability of HSC...
  44. ncbi request reprint Sirolimus monotherapy versus sirolimus in combination with steroids and/or MMF for immunosuppression after liver transplantation
    Anurag Maheshwari
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Dig Dis Sci 51:1677-84. 2006
    ..Conversion to sirolimus was associated with an immediate improvement in renal function that was sustained during the follow-up...

Research Grants4

  1. Genetic and epigenetic regulation of Hepatitis B contributes to liver cancer
    Michael S Torbenson; Fiscal Year: 2010
    ..abstract_text> ..
  2. Occult Hepatitis B
    Michael Torbenson; Fiscal Year: 2007
    ..abstract_text> ..
  3. Genetic and epigenetic regulation of Hepatitis B contributes to liver cancer
    Michael Torbenson; Fiscal Year: 2009
    ....