Aaron A R Tobian

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Male circumcision: a globally relevant but under-utilized method for the prevention of HIV and other sexually transmitted infections
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287 email
    Annu Rev Med 65:293-306. 2014
  2. pmc Reactivation of herpes simplex virus type 2 after initiation of antiretroviral therapy
    Aaron A R Tobian
    Department of Pathology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    J Infect Dis 208:839-46. 2013
  3. pmc Human papillomavirus clearance among males is associated with HIV acquisition and increased dendritic cell density in the foreskin
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University, Carnegie 437, 600 N Wolfe St, Baltimore, MD 21287, USA
    J Infect Dis 207:1713-22. 2013
  4. pmc High-risk human papillomavirus prevalence is associated with HIV infection among heterosexual men in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Sex Transm Infect 89:122-7. 2013
  5. pmc Human papillomavirus incidence and clearance among HIV-positive and HIV-negative men in sub-Saharan Africa
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    AIDS 26:1555-65. 2012
  6. pmc A 'snip' in time: what is the best age to circumcise?
    Brian J Morris
    School of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia
    BMC Pediatr 12:20. 2012
  7. pmc Male circumcision and herpes simplex virus type 2 infection in female partners: a randomized trial in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    J Infect Dis 205:486-90. 2012
  8. doi request reprint Time course and etiology of death in patients with severe anemia
    Aaron A R Tobian
    Transfusion Medicine Division, Department of Pathology, The Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Transfusion 49:1395-9. 2009
  9. pmc Male circumcision and anatomic sites of penile high-risk human papillomavirus in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    Int J Cancer 129:2970-5. 2011
  10. pmc Circumcision of HIV-infected men and transmission of human papillomavirus to female partners: analyses of data from a randomised trial in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Lancet Infect Dis 11:604-12. 2011

Collaborators

Detail Information

Publications52

  1. doi request reprint Male circumcision: a globally relevant but under-utilized method for the prevention of HIV and other sexually transmitted infections
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287 email
    Annu Rev Med 65:293-306. 2014
    ..Although MC is a globally valuable tool to prevent HIV and other sexually transmitted infections, it is underutilized. Further research is needed to address barriers to MC uptake. ..
  2. pmc Reactivation of herpes simplex virus type 2 after initiation of antiretroviral therapy
    Aaron A R Tobian
    Department of Pathology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    J Infect Dis 208:839-46. 2013
    ..The association between initiation of antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection and possible herpes simplex virus type 2 (HSV-2) shedding and genital ulcer disease (GUD) has not been evaluated...
  3. pmc Human papillomavirus clearance among males is associated with HIV acquisition and increased dendritic cell density in the foreskin
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University, Carnegie 437, 600 N Wolfe St, Baltimore, MD 21287, USA
    J Infect Dis 207:1713-22. 2013
    ..The association between human papillomavirus (HPV) infection and the risk of human immunodeficiency virus (HIV) seroconversion is unclear, and the genital cellular immunology has not been evaluated...
  4. pmc High-risk human papillomavirus prevalence is associated with HIV infection among heterosexual men in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Sex Transm Infect 89:122-7. 2013
    ..Knowledge of HR-HPV prevalence, risk factors and genotype distribution among heterosexual men is important to establish risk-reduction prevention strategies...
  5. pmc Human papillomavirus incidence and clearance among HIV-positive and HIV-negative men in sub-Saharan Africa
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    AIDS 26:1555-65. 2012
    ..Penile and cervical cancer rates are highest in sub-Saharan Africa. However, little is known about the impact of HIV infection on HR-HPV acquisition and clearance among heterosexual men...
  6. pmc A 'snip' in time: what is the best age to circumcise?
    Brian J Morris
    School of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia
    BMC Pediatr 12:20. 2012
    ..This is an important issue for many parents, but also pediatricians, other doctors, policy makers, public health authorities, medical bodies, and males themselves...
  7. pmc Male circumcision and herpes simplex virus type 2 infection in female partners: a randomized trial in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    J Infect Dis 205:486-90. 2012
    ..17 cases per 100 person-years in the control arm (IRR, 0.85 [95% CI, .44-1.67]; P = .62). Contrary to findings in males, male circumcision did not affect HSV-2 acquisition among female partners...
  8. doi request reprint Time course and etiology of death in patients with severe anemia
    Aaron A R Tobian
    Transfusion Medicine Division, Department of Pathology, The Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Transfusion 49:1395-9. 2009
    ..Mortality increases as hemoglobin (Hb) levels fall. Among severely anemic patients, the clinical course, cause of death, and whether there are any warning signs before death are unknown...
  9. pmc Male circumcision and anatomic sites of penile high-risk human papillomavirus in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    Int J Cancer 129:2970-5. 2011
    ..3% vs. 23.8%, respectively, p = 0.02) and circumcised men (21.5% vs. 15.5%, respectively, p = 0.24). MC reduced HR-HPV prevalence on both the coronal sulcus and shaft...
  10. pmc Circumcision of HIV-infected men and transmission of human papillomavirus to female partners: analyses of data from a randomised trial in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Lancet Infect Dis 11:604-12. 2011
    ..We assessed whether circumcision of HIV-infected men would reduce the transmission of high-risk HPV to their female partners...
  11. doi request reprint Male foreskin and oncogenic human papillomavirus infection in men and their female partners
    Aaron A R Tobian
    Department of Population, Family and Reproductive Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21287, USA
    Future Microbiol 6:739-45. 2011
    ..Additional studies that utilize the foreskin mucosa obtained at the time of male circumcision are needed to assess the mucosal microenvironment in HIV and HR-HPV coinfections to develop additional preventive and therapeutic approaches...
  12. ncbi request reprint Transfusion premedications: a growing practice not based on evidence
    Aaron A R Tobian
    Department of Pathology, Transfusion Medicine Division, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Transfusion 47:1089-96. 2007
  13. ncbi request reprint Prevention of allergic transfusion reactions to platelets and red blood cells through plasma reduction
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA
    Transfusion 51:1676-83. 2011
    ..This study evaluated whether removing plasma from apheresis platelets (APs) or red blood cells (RBCs) by concentrating or washing transfusion products can decrease the incidence of ATRs...
  14. ncbi request reprint N-terminal pro-brain natriuretic peptide is a useful diagnostic marker for transfusion-associated circulatory overload
    Aaron A R Tobian
    Transfusion Medicine Division and Clinical Chemistry Division, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Transfusion 48:1143-50. 2008
    ..In this study, whether NT-proBNP is a useful diagnostic marker for TACO was evaluated...
  15. pmc Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University School of Medicine, Maryland, USA
    J Infect Dis 199:945-9. 2009
    ..70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: NCT00425984 and NCT00124878 .)...
  16. ncbi request reprint Therapeutic plasma exchange reduces ABO titers to permit ABO-incompatible renal transplantation
    Aaron A R Tobian
    Transfusion Medicine Division, Department of Pathology, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Transfusion 49:1248-54. 2009
    ..Therapeutic plasma exchange (TPE) is performed to permit ABO-incompatible (ABO-I) kidney transplants, but little is known about how well TPE reduces ABO antibodies or complications related to TPE in this clinical setting...
  17. ncbi request reprint The critical role of plasmapheresis in ABO-incompatible renal transplantation
    Aaron A R Tobian
    Department of Pathology, Transfusion Medicine Division, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Transfusion 48:2453-60. 2008
    ..This article reviews the literature to provide a historical perspective of TPE for ABO-I kidney transplantation and also provides the Johns Hopkins Hospital protocol with a focus on both titers and TPE...
  18. pmc Male circumcision for the prevention of HSV-2 and HPV infections and syphilis
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    N Engl J Med 360:1298-309. 2009
    ..We assessed the efficacy of male circumcision for the prevention of herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) infections and syphilis in HIV-negative adolescent boys and men...
  19. ncbi request reprint High-risk human papillomavirus viral load and persistence among heterosexual HIV-negative and HIV-positive men
    Mary K Grabowski
    Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA
    Sex Transm Infect 90:337-43. 2014
    ..High-risk human papillomavirus (HR-HPV) viral load is associated with HR-HPV transmission and HR-HPV persistence in women. It is unknown whether HR-HPV viral load is associated with persistence in HIV-negative or HIV-positive men...
  20. pmc Male circumcision decreases acquisition and increases clearance of high-risk human papillomavirus in HIV-negative men: a randomized trial in Rakai, Uganda
    Ronald H Gray
    Department of Population, Family, and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 201:1455-62. 2010
    ..HR-HPV clearance was determined in men with prior genotype-specific HR-HPV infections. Rate ratios (RRs) and 95% confidence intervals (CIs) of HR-HPV acquisition were estimated by Poisson multiple regression...
  21. pmc Frequent detection of HPV before and after initiation of antiretroviral therapy among HIV/HSV-2 co-infected women in Uganda
    Anne F Rositch
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 8:e55383. 2013
    ..Therefore, we examined the frequency of cervical HPV DNA detection among HIV/HSV-2 co-infected women followed monthly for 6 months both before and after initiation of ART in Rakai, Uganda...
  22. pmc Effects of genital ulcer disease and herpes simplex virus type 2 on the efficacy of male circumcision for HIV prevention: Analyses from the Rakai trials
    Ronald H Gray
    Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Med 6:e1000187. 2009
    ..We assessed the role of GUD and HSV-2 in the protection against HIV afforded by MC...
  23. ncbi request reprint Mycobacterium tuberculosis heat shock fusion protein enhances class I MHC cross-processing and -presentation by B lymphocytes
    Aaron A R Tobian
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 174:5209-14. 2005
    ..HSP fusion proteins have potential advantages for use in vaccines to enhance priming of CD8(+) T cell responses...
  24. pmc Effect of circumcision of HIV-negative men on transmission of human papillomavirus to HIV-negative women: a randomised trial in Rakai, Uganda
    Maria J Wawer
    Department of Population, Family, and Reproductive Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    Lancet 377:209-18. 2011
    ..We assessed the efficacy of male circumcision to reduce prevalence and incidence of high-risk HPV in female partners of circumcised men...
  25. pmc Incident HIV and herpes simplex virus type 2 infection among men in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    AIDS 23:1589-94. 2009
    ..Herpes simplex virus type 2 (HSV-2) infection is associated with an increased risk for acquiring HIV, but little is known about the temporal sequence of these infections...
  26. pmc Cost-effectiveness of prospective red blood cell antigen matching to prevent alloimmunization among sickle cell patients
    Seema Kacker
    Department of Pathology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts
    Transfusion 54:86-97. 2014
    ..Prospective antigen matching can prevent alloimmunization, but is costly and may not benefit most patients...
  27. pmc Male circumcision reduces penile high-risk human papillomavirus viral load in a randomised clinical trial in Rakai, Uganda
    Lauren E Wilson
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Sex Transm Infect 89:262-6. 2013
    ..The goal of this study was to examine the effect of circumcision on HPV viral load among HPV-infected men in a randomised trial of male circumcision...
  28. pmc The rates of HIV superinfection and primary HIV incidence in a general population in Rakai, Uganda
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD 21205, USA
    J Infect Dis 206:267-74. 2012
    ..Human immunodeficiency virus (HIV) superinfection has been documented in high-risk individuals; however, the rate of superinfection among HIV-infected individuals within a general population remains unknown...
  29. doi request reprint The cost-effectiveness of platelet additive solution to prevent allergic transfusion reactions
    Seema Kacker
    Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland Department of Pathology, Johns Hopkins University, Baltimore, Maryland Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota
    Transfusion 53:2609-18. 2013
    ..Storage in platelet additive solution (PAS) has been shown to reduce ATRs from apheresis platelets (APs). This study evaluated the cost-effectiveness of using PAS storage as an alternative method to reduce ATRs...
  30. ncbi request reprint Male circumcision and Mycoplasma genitalium infection in female partners: a randomised trial in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Sex Transm Infect 90:150-4. 2014
    ..Previous randomised trial data have demonstrated that male circumcision reduces Mycoplasma genitalium prevalence in men. We assessed whether male circumcision also reduces M genitalium infection in female partners of circumcised men...
  31. pmc Prolonged toll-like receptor signaling by Mycobacterium tuberculosis and its 19-kilodalton lipoprotein inhibits gamma interferon-induced regulation of selected genes in macrophages
    Rish K Pai
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 4943, USA
    Infect Immun 72:6603-14. 2004
    ..tuberculosis inhibits certain macrophage responses to IFN-gamma, particularly those related to MHC-II Ag presentation. This inhibition may promote M. tuberculosis evasion of T-cell responses and persistence of infection in tuberculosis...
  32. pmc Foreskin inflammation is associated with HIV and herpes simplex virus type-2 infections in Rakai, Uganda
    Kristine E Johnson
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, USA
    AIDS 23:1807-15. 2009
    ..We assessed foreskin inflammation associated with HIV and herpes simplex virus type 2 (HSV-2) in circumcised men...
  33. pmc Differential specificity of HIV incidence assays in HIV subtypes A and D-infected individuals from Rakai, Uganda
    Caroline E Mullis
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    AIDS Res Hum Retroviruses 29:1146-50. 2013
    ..The association of misclassification of the BED-CEIA with the avidity assay in subtype D-infected individuals limits the utility of using these assays in combination within this population...
  34. ncbi request reprint Bacterial heat shock proteins enhance class II MHC antigen processing and presentation of chaperoned peptides to CD4+ T cells
    Aaron A R Tobian
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 173:5130-7. 2004
    ..Bacterial HSPs are a potential source of microbial peptide Ags during phagocytic processing of bacteria during infection and could potentially be incorporated in vaccines to enhance presentation of peptides to CD4+ T cells...
  35. pmc Scratching the surface of allergic transfusion reactions
    William J Savage
    Division of Transfusion Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Transfusion 53:1361-71. 2013
    ..Further understanding of the mechanisms of ATRs is necessary so that rationally designed and cost-effective prevention measures can be developed...
  36. pmc ABO antibody titers are not predictive of hemolytic reactions due to plasma-incompatible platelet transfusions
    Matthew S Karafin
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
    Transfusion 52:2087-93. 2012
    ....
  37. pmc Improved performance of enzyme-linked immunosorbent assays and the effect of human immunodeficiency virus coinfection on the serologic detection of herpes simplex virus type 2 in Rakai, Uganda
    Jordyn L Gamiel
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Vaccine Immunol 15:888-90. 2008
    ..Higher-than-standard-index cutoff values gave optimal sensitivity and specificity. Kalon ELISA was the optimal assay when an index value of 1.5 was used (sensitivity, 91.7%; specificity, 92.4%)...
  38. pmc Male circumcision decreases high-risk human papillomavirus viral load in female partners: a randomized trial in Rakai, Uganda
    Mitzie Ann Davis
    Department of Gynecology Oncology, Moores Cancer Center, UCSD, La Jolla, CA, USA
    Int J Cancer 133:1247-52. 2013
    ..83-1.24). Genotypes with high HR-HPV band intensity were more likely to persist (adjHR = 1.27 95% CI 1.07-1.50), irrespective of male partner circumcision status. MC reduces HR-HPV DNA load in newly infected female partners...
  39. pmc Effects of HIV-1 and herpes simplex virus type 2 infection on lymphocyte and dendritic cell density in adult foreskins from Rakai, Uganda
    Kristine E Johnson
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Infect Dis 203:602-9. 2011
    ..To assess the cellular basis for these associations, we estimated immunologic cellular densities in foreskin tissue...
  40. pmc Frequency and implications of HIV superinfection
    Andrew D Redd
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Lancet Infect Dis 13:622-8. 2013
    ..Additional collaborative research could benefit care of patients and inform future vaccine design. ..
  41. pmc Allergic agonists in apheresis platelet products are associated with allergic transfusion reactions
    William J Savage
    Department of Pathology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Transfusion 52:575-81. 2012
    ..To assess product factors associated with ATRs, we investigated candidate mediators in apheresis platelet (PLT) products associated with ATRs and controls...
  42. pmc Identification of HIV superinfection in seroconcordant couples in Rakai, Uganda, by use of next-generation deep sequencing
    Andrew D Redd
    Johns Hopkins University School of Medicine, Rangos Building, Room 530, 855 N Wolfe St, Baltimore, MD 21205, USA
    J Clin Microbiol 49:2859-67. 2011
    ..Our results indicate that NGS can be used for detection of HIV superinfection within large cohorts, which could assist in determining the incidence and the epidemiologic, virologic, and immunological correlates of this phenomenon...
  43. pmc The impact of apheresis platelet manipulation on corrected count increment
    Matthew Karafin
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Transfusion 52:1221-7. 2012
    ..However, these processes may damage platelets (PLTs). This study evaluated whether concentrating or washing APs decrease the corrected count increment (CCI)...
  44. pmc Male circumcision for the prevention of acquisition and transmission of sexually transmitted infections: the case for neonatal circumcision
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Arch Pediatr Adolesc Med 164:78-84. 2010
    ..This review evaluates the recent data that support revision of the AAP policy to fully reflect the evidence of long-term health benefits of male circumcision...
  45. ncbi request reprint The impact of platelet additive solution apheresis platelets on allergic transfusion reactions and corrected count increment (CME)
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland
    Transfusion 54:1523-9. 2014
    ..We evaluated the impact of InterSol platelet additive solution (PAS) apheresis platelets (APs) on the incidence of ATRs and the posttransfusion platelet (PLT) increment...
  46. doi request reprint The role of viral introductions in sustaining community-based HIV epidemics in rural Uganda: evidence from spatial clustering, phylogenetics, and egocentric transmission models
    Mary K Grabowski
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Med 11:e1001610. 2014
    ....
  47. pmc Costs and effectiveness of neonatal male circumcision
    Seema Kacker
    Department of Pathology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    Arch Pediatr Adolesc Med 166:910-8. 2012
    ..During the past 20 years, MC rates have declined from 79% to 55%, alongside reduced insurance coverage...
  48. pmc Financial implications of male circumcision scale-up for the prevention of HIV and other sexually transmitted infections in a sub-Saharan African community
    Seema Kacker
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Sex Transm Dis 40:559-68. 2013
    ....
  49. pmc Atopic predisposition of recipients in allergic transfusion reactions to apheresis platelets
    William J Savage
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Transfusion 51:2337-42. 2011
    ..The biologic mechanisms of allergic transfusion reactions (ATRs) are largely unknown. We sought to compare the atopic predisposition of platelet (PLT) recipients who experienced an ATR to nonreactive control recipients...
  50. ncbi request reprint Bacterial heat shock proteins promote CD91-dependent class I MHC cross-presentation of chaperoned peptide to CD8+ T cells by cytosolic mechanisms in dendritic cells versus vacuolar mechanisms in macrophages
    Aaron A R Tobian
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 172:5277-86. 2004
    ..Prokaryotic HSPs are a potential source of microbial peptide Ags during phagocytic processing of bacteria during infection and could potentially be incorporated in vaccines to enhance presentation of peptides to CD8(+) T cells...
  51. doi request reprint Red blood cell transfusion: a clinical practice guideline from the AABB*
    Jeffrey L Carson
    MD, Division of General Internal Medicine, UMDNJ Robert Wood Johnson Medical School, 125 Paterson Street, New Brunswick, NJ 08903, USA
    Ann Intern Med 157:49-58. 2012
    ....
  52. ncbi request reprint Alternate class I MHC antigen processing is inhibited by Toll-like receptor signaling pathogen-associated molecular patterns: Mycobacterium tuberculosis 19-kDa lipoprotein, CpG DNA, and lipopolysaccharide
    Aaron A R Tobian
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 171:1413-22. 2003
    ..g., MTB, may immunologically silence macrophages and evade surveillance by both CD4(+) and CD8(+) T cells, promoting chronic infection...