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Species | Aaron A R TobianSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
High-risk human papillomavirus prevalence is associated with HIV infection among heterosexual men in Rakai, UgandaAaron A R Tobian
Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
Sex Transm Infect 89:122-7. 2013..Knowledge of HR-HPV prevalence, risk factors and genotype distribution among heterosexual men is important to establish risk-reduction prevention strategies...- Human papillomavirus incidence and clearance among HIV-positive and HIV-negative men in sub-Saharan AfricaAaron A R Tobian
Department of Pathology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
AIDS 26:1555-65. 2012..Penile and cervical cancer rates are highest in sub-Saharan Africa. However, little is known about the impact of HIV infection on HR-HPV acquisition and clearance among heterosexual men... - A 'snip' in time: what is the best age to circumcise?Brian J Morris
School of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia
BMC Pediatr 12:20. 2012..This is an important issue for many parents, but also pediatricians, other doctors, policy makers, public health authorities, medical bodies, and males themselves... - Male circumcision and herpes simplex virus type 2 infection in female partners: a randomized trial in Rakai, UgandaAaron A R Tobian
Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
J Infect Dis 205:486-90. 2012..17 cases per 100 person-years in the control arm (IRR, 0.85 [95% CI, .44-1.67]; P = .62). Contrary to findings in males, male circumcision did not affect HSV-2 acquisition among female partners... 
Prevention of allergic transfusion reactions to platelets and red blood cells through plasma reductionAaron A R Tobian
Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA
Transfusion 51:1676-83. 2011..This study evaluated whether removing plasma from apheresis platelets (APs) or red blood cells (RBCs) by concentrating or washing transfusion products can decrease the incidence of ATRs...- Male circumcision and anatomic sites of penile high-risk human papillomavirus in Rakai, UgandaAaron A R Tobian
Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
Int J Cancer 129:2970-5. 2011..3% vs. 23.8%, respectively, p = 0.02) and circumcised men (21.5% vs. 15.5%, respectively, p = 0.24). MC reduced HR-HPV prevalence on both the coronal sulcus and shaft... - Time course and etiology of death in patients with severe anemiaAaron A R Tobian
Transfusion Medicine Division, Department of Pathology, The Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
Transfusion 49:1395-9. 2009..Mortality increases as hemoglobin (Hb) levels fall. Among severely anemic patients, the clinical course, cause of death, and whether there are any warning signs before death are unknown... - Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in Rakai, UgandaAaron A R Tobian
Department of Pathology, Johns Hopkins University School of Medicine, Maryland, USA
J Infect Dis 199:945-9. 2009..70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: NCT00425984 and NCT00124878 .)... - Therapeutic plasma exchange reduces ABO titers to permit ABO-incompatible renal transplantationAaron A R Tobian
Transfusion Medicine Division, Department of Pathology, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Transfusion 49:1248-54. 2009..Therapeutic plasma exchange (TPE) is performed to permit ABO-incompatible (ABO-I) kidney transplants, but little is known about how well TPE reduces ABO antibodies or complications related to TPE in this clinical setting... - The critical role of plasmapheresis in ABO-incompatible renal transplantationAaron A R Tobian
Department of Pathology, Transfusion Medicine Division, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Transfusion 48:2453-60. 2008..This article reviews the literature to provide a historical perspective of TPE for ABO-I kidney transplantation and also provides the Johns Hopkins Hospital protocol with a focus on both titers and TPE... - Circumcision of HIV-infected men and transmission of human papillomavirus to female partners: analyses of data from a randomised trial in Rakai, UgandaAaron A R Tobian
Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Lancet Infect Dis 11:604-12. 2011..We assessed whether circumcision of HIV-infected men would reduce the transmission of high-risk HPV to their female partners... - N-terminal pro-brain natriuretic peptide is a useful diagnostic marker for transfusion-associated circulatory overloadAaron A R Tobian
Transfusion Medicine Division and Clinical Chemistry Division, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Transfusion 48:1143-50. 2008..In this study, whether NT-proBNP is a useful diagnostic marker for TACO was evaluated... 
Transfusion premedications: a growing practice not based on evidenceAaron A R Tobian
Department of Pathology, Transfusion Medicine Division, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Transfusion 47:1089-96. 2007- Male foreskin and oncogenic human papillomavirus infection in men and their female partnersAaron A R Tobian
Department of Population, Family and Reproductive Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21287, USA
Future Microbiol 6:739-45. 2011..Additional studies that utilize the foreskin mucosa obtained at the time of male circumcision are needed to assess the mucosal microenvironment in HIV and HR-HPV coinfections to develop additional preventive and therapeutic approaches... - Male circumcision for the prevention of HSV-2 and HPV infections and syphilisAaron A R Tobian
Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
N Engl J Med 360:1298-309. 2009..We assessed the efficacy of male circumcision for the prevention of herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) infections and syphilis in HIV-negative adolescent boys and men... - Male circumcision decreases acquisition and increases clearance of high-risk human papillomavirus in HIV-negative men: a randomized trial in Rakai, UgandaRonald H Gray
Department of Population, Family, and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
J Infect Dis 201:1455-62. 2010..HR-HPV clearance was determined in men with prior genotype-specific HR-HPV infections. Rate ratios (RRs) and 95% confidence intervals (CIs) of HR-HPV acquisition were estimated by Poisson multiple regression... - Effects of genital ulcer disease and herpes simplex virus type 2 on the efficacy of male circumcision for HIV prevention: Analyses from the Rakai trialsRonald H Gray
Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS Med 6:e1000187. 2009..We assessed the role of GUD and HSV-2 in the protection against HIV afforded by MC... - Effect of circumcision of HIV-negative men on transmission of human papillomavirus to HIV-negative women: a randomised trial in Rakai, UgandaMaria J Wawer
Department of Population, Family, and Reproductive Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
Lancet 377:209-18. 2011..We assessed the efficacy of male circumcision to reduce prevalence and incidence of high-risk HPV in female partners of circumcised men... - Incident HIV and herpes simplex virus type 2 infection among men in Rakai, UgandaAaron A R Tobian
Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
AIDS 23:1589-94. 2009..Herpes simplex virus type 2 (HSV-2) infection is associated with an increased risk for acquiring HIV, but little is known about the temporal sequence of these infections... - The rates of HIV superinfection and primary HIV incidence in a general population in Rakai, UgandaAndrew D Redd
Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD 21205, USA
J Infect Dis 206:267-74. 2012..Human immunodeficiency virus (HIV) superinfection has been documented in high-risk individuals; however, the rate of superinfection among HIV-infected individuals within a general population remains unknown... - Foreskin inflammation is associated with HIV and herpes simplex virus type-2 infections in Rakai, UgandaKristine E Johnson
Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, USA
AIDS 23:1807-15. 2009..We assessed foreskin inflammation associated with HIV and herpes simplex virus type 2 (HSV-2) in circumcised men... - ABO antibody titers are not predictive of hemolytic reactions due to plasma-incompatible platelet transfusionsMatthew S Karafin
Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
Transfusion 52:2087-93. 2012.... - Allergic agonists in apheresis platelet products are associated with allergic transfusion reactionsWilliam J Savage
Department of Pathology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Transfusion 52:575-81. 2012..To assess product factors associated with ATRs, we investigated candidate mediators in apheresis platelet (PLT) products associated with ATRs and controls... - Effects of HIV-1 and herpes simplex virus type 2 infection on lymphocyte and dendritic cell density in adult foreskins from Rakai, UgandaKristine E Johnson
Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Infect Dis 203:602-9. 2011..To assess the cellular basis for these associations, we estimated immunologic cellular densities in foreskin tissue... - Improved performance of enzyme-linked immunosorbent assays and the effect of human immunodeficiency virus coinfection on the serologic detection of herpes simplex virus type 2 in Rakai, UgandaJordyn L Gamiel
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Clin Vaccine Immunol 15:888-90. 2008..Higher-than-standard-index cutoff values gave optimal sensitivity and specificity. Kalon ELISA was the optimal assay when an index value of 1.5 was used (sensitivity, 91.7%; specificity, 92.4%)... - Identification of HIV superinfection in seroconcordant couples in Rakai, Uganda, by use of next-generation deep sequencingAndrew D Redd
Johns Hopkins University School of Medicine, Rangos Building, Room 530, 855 N Wolfe St, Baltimore, MD 21205, USA
J Clin Microbiol 49:2859-67. 2011..Our results indicate that NGS can be used for detection of HIV superinfection within large cohorts, which could assist in determining the incidence and the epidemiologic, virologic, and immunological correlates of this phenomenon... - Frequent detection of HPV before and after initiation of antiretroviral therapy among HIV/HSV-2 co-infected women in UgandaAnne F Rositch
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
PLoS ONE 8:e55383. 2013..Therefore, we examined the frequency of cervical HPV DNA detection among HIV/HSV-2 co-infected women followed monthly for 6 months both before and after initiation of ART in Rakai, Uganda... - The impact of apheresis platelet manipulation on corrected count incrementMatthew Karafin
Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21287, USA
Transfusion 52:1221-7. 2012..However, these processes may damage platelets (PLTs). This study evaluated whether concentrating or washing APs decrease the corrected count increment (CCI)... - Male circumcision for the prevention of acquisition and transmission of sexually transmitted infections: the case for neonatal circumcisionAaron A R Tobian
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Arch Pediatr Adolesc Med 164:78-84. 2010..This review evaluates the recent data that support revision of the AAP policy to fully reflect the evidence of long-term health benefits of male circumcision... - Atopic predisposition of recipients in allergic transfusion reactions to apheresis plateletsWilliam J Savage
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Transfusion 51:2337-42. 2011..The biologic mechanisms of allergic transfusion reactions (ATRs) are largely unknown. We sought to compare the atopic predisposition of platelet (PLT) recipients who experienced an ATR to nonreactive control recipients... - Costs and effectiveness of neonatal male circumcisionSeema Kacker
Department of Pathology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
Arch Pediatr Adolesc Med 166:910-8. 2012..During the past 20 years, MC rates have declined from 79% to 55%, alongside reduced insurance coverage... - Red blood cell transfusion: a clinical practice guideline from the AABB*Jeffrey L Carson
MD, Division of General Internal Medicine, UMDNJ Robert Wood Johnson Medical School, 125 Paterson Street, New Brunswick, NJ 08903, USA
Ann Intern Med 157:49-58. 2012..RECOMMENDATION 4: The AABB suggests that transfusion decisions be influenced by symptoms as well as hemoglobin concentration (Grade: weak recommendation; low-quality evidence)... - Mycobacterium tuberculosis heat shock fusion protein enhances class I MHC cross-processing and -presentation by B lymphocytesAaron A R Tobian
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
J Immunol 174:5209-14. 2005..HSP fusion proteins have potential advantages for use in vaccines to enhance priming of CD8(+) T cell responses... - Bacterial heat shock proteins enhance class II MHC antigen processing and presentation of chaperoned peptides to CD4+ T cellsAaron A R Tobian
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
J Immunol 173:5130-7. 2004..Bacterial HSPs are a potential source of microbial peptide Ags during phagocytic processing of bacteria during infection and could potentially be incorporated in vaccines to enhance presentation of peptides to CD4+ T cells... - Alternate class I MHC antigen processing is inhibited by Toll-like receptor signaling pathogen-associated molecular patterns: Mycobacterium tuberculosis 19-kDa lipoprotein, CpG DNA, and lipopolysaccharideAaron A R Tobian
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
J Immunol 171:1413-22. 2003..g., MTB, may immunologically silence macrophages and evade surveillance by both CD4(+) and CD8(+) T cells, promoting chronic infection...