Genomes and Genes
Affiliation: Johns Hopkins Bloomberg School of Public Health
- Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrationsRobert B Scharpf
550 N, Broadway, Suite 1101, Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
BMC Genet 15:81. 2014..Whether copy number polymorphisms (CNPs) contribute to uric acid levels is unknown...
- Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rateAdrienne Tin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Hum Genet 58:461-6. 2013..However, careful attention must be paid to the correlation of systematic errors and inconsistent associations when different biomarkers or methods are used to measure the quantitative trait. ..
- Genome-wide significant locus of beta-trace protein, a novel kidney function biomarker, identified in European and African AmericansAdrienne Tin
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Nephrol Dial Transplant 28:1497-504. 2013..Beta-trace protein (BTP), measured in serum or plasma, has potential as a novel biomarker for kidney function. Little is known about the genes influencing BTP levels...
- Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulinAdrienne Tin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Hum Genet 132:619-27. 2013..The identification of the two novel loci for B2M extends our understanding of its metabolism and informs its use as a kidney filtration biomarker...
- Association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants identified by UMOD gene region sequencingAnna Kottgen
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
PLoS ONE 7:e38311. 2012..To identify novel rare variants as well as common variants that may account for this GWAS signal, the exons and 4 kb upstream region of UMOD were sequenced...
- Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function alleleAdrienne Tin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
Hum Mol Genet 20:4056-68. 2011..Our data support the importance of multi-ethnic GWAS in the identification of novel risk loci as well as functional variants...