D L Thomas
Affiliation: Johns Hopkins University
- Seroreactivity to hepatitis E virus in areas where the disease is not endemicD L Thomas
Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
J Clin Microbiol 35:1244-7. 1997..Until the basis for HEV seroreactivity in such areas is elucidated, anti-HEV results should be interpreted with caution...
- Racial differences in HLA class II associations with hepatitis C virus outcomesC L Thio
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21231 1001, USA
J Infect Dis 184:16-21. 2001..36; 95% CI, 1.23-4.52) and its DQB1*0201 haplotype. These results support a role for class II alleles in the immune response to HCV and underscore the importance of studying genetic associations in an ethnically diverse cohort...
- Dynamics of SEN virus infection among injection drug usersL E Wilson
Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD 21231 1001, USA
J Infect Dis 184:1315-9. 2001..Among Baltimore IDUs, SENV-D and SENV-H infections are common and dynamic, including both viral clearance and reinfection. The clinical significance of SENV infection in this setting remains unknown...
- An analysis of tumor necrosis factor alpha gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infectionC L Thio
Department of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
Genes Immun 5:294-300. 2004..Further study of this polymorphism and haplotype is needed to understand these associations and the role of TNF-alpha in determining outcomes of HCV infection...
- Human immunodeficiency virus seroconversion and evolution of the hepatitis C virus quasispeciesQ Mao
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Virol 75:3259-67. 2001..These results are consistent with the hypothesis that HIV infection alters the HCV quasispecies, but the number of subjects and observation time may be too low to characterize the full effect...
- Hypervariable region 1 sequence stability during hepatitis C virus replication in chimpanzeesS C Ray
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Virol 74:3058-66. 2000..These findings demonstrate that nonsynonymous mutations indicate selection pressure rather than being an incidental result of HCV replication...
- Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infectionM S Sulkowski
Department of Medicine, Johns Hopkins University Schools of Medicine, Baltimore, MD 21287, USA
JAMA 283:74-80. 2000..Use of antiretroviral drugs, including protease inhibitors, for treatment of human immunodeficiency virus (HIV) infection has been anecdotally associated with hepatotoxicity, particularly in persons coinfected with hepatitis C or B virus...
- Liver enzyme values in injection drug users with chronic hepatitis CS H Mehta
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA
Dig Liver Dis 37:674-80. 2005..Liver enzymes fluctuate in chronic hepatitis C virus infection. However, the range that can be attributed to the course of hepatitis C virus (versus an intercurrent cause of hepatitis) is unknown...
- Isoniazid preventive therapy, hepatitis C virus infection, and hepatotoxicity among injection drug users infected with Mycobacterium tuberculosisP Sadaphal
Department of Epidemiology, The Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21231-1001, USA
Clin Infect Dis 33:1687-91. 2001..The risk of transaminase value elevation and drug discontinuation for HCV-infected persons receiving isoniazid was within the range reported for populations with lower HCV prevalence...
- MICA and recovery from hepatitis C virus and hepatitis B virus infectionsP S Karacki
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Genes Immun 5:261-6. 2004....
- Admixture analysis of spontaneous hepatitis C virus clearance in individuals of African descentG L Wojcik
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Genes Immun 15:241-6. 2014..Additionally, signals of selection in this area suggest positive selection due to some ancestral pathogen or environmental pressure in African, but not in European populations...
- Hip bone geometry in HIV/HCV-co-infected men and healthy controlsV Walker Harris
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Osteoporos Int 23:1779-87. 2012..We compared hip strength between HIV/HCV-co-infected men and healthy men and found that HIV/HCV-co-infected men had decreased hip strength due to lower lean body mass...
- Multicenter evaluation of hepatitis C RNA levels among female injection drug usersD L Thomas
Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
J Infect Dis 183:973-6. 2001..However, <6% of person-to-person variance was explained by the factors evaluated. Additional research is needed to ascertain what determines the level of HCV RNA in blood...
- Anti-inflammatory cytokines, pro-fibrogenic chemokines and persistence of acute HCV infectionW O Osburn
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Viral Hepat 20:404-13. 2013....
- Hepatitis C virus infection as an opportunistic disease in persons infected with human immunodeficiency virusM S Sulkowski
Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Clin Infect Dis 30:S77-84. 2000..Strategies to prevent primary HCV infection and to modify the progression of HCV-related liver disease are urgently needed for HIV-HCV-coinfected individuals...
- Class II HLA alleles and hepatitis B virus persistence in African AmericansC L Thio
Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Infect Dis 179:1004-6. 1999..These results underscore the importance of the class II-mediated immune response in recovery from HBV infection...
- Occult hepatitis B viral DNA in liver carcinomas from a region with a low prevalence of chronic hepatitis B infectionR Kannangai
Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
J Viral Hepat 11:297-301. 2004..Thus, in this study occult HBV was of genotype A and was found in a low percentage of cases of HCC and was associated with low tissue HBV DNA copy numbers and no detectable evidence for viral replication...
- Hepatitis C. Epidemiologic quandariesD L Thomas
Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Clin Liver Dis 5:955-68. 2001..In addition, large, prospective studies are necessary to characterize the frequency [table: see text] of transmission between sexual partners and the potential role of cesarian section in reducing HCV transmission to infants...