Yuan Xiang Tao

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
  2. pmc Inward currents induced by ischemia in rat spinal cord dorsal horn neurons
    Meng Chen
    Department of Oral and Maxillofacial Surgery, McKnight Brain Institute and College of Dentistry, University of Florida, Gainesville, Florida 32610, USA
    Mol Pain 3:10. 2007
  3. pmc Role of spinal cord glutamate transporter during normal sensory transmission and pathological pain states
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, Baltimore, Maryland 21205, USA
    Mol Pain 1:30. 2005
  4. ncbi Neuronal PDZ domains: a promising new molecular target for inhaled anesthetics?
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Interv 4:215-21. 2004
  5. ncbi Are synaptic MAGUK proteins involved in chronic pain?
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Pharmacol Sci 25:397-400. 2004
  6. pmc Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, Maryland 21205, USA
    Mol Pain 3:29. 2007
  7. ncbi Evidence of neuronal excitatory amino acid carrier 1 expression in rat dorsal root ganglion neurons and their central terminals
    F Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Neuroscience 123:1045-51. 2004
  8. ncbi Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 23:6703-12. 2003
  9. pmc Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain
    Fidelis E Atianjoh
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pain 151:226-34. 2010
  10. pmc Distinct expression of synaptic NR2A and NR2B in the central nervous system and impaired morphine tolerance and physical dependence in mice deficient in postsynaptic density-93 protein
    Wen Jinn Liaw
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Pain 4:45. 2008

Collaborators

Detail Information

Publications40

  1. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
    ..The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29-31, 2007)...
  2. pmc Inward currents induced by ischemia in rat spinal cord dorsal horn neurons
    Meng Chen
    Department of Oral and Maxillofacial Surgery, McKnight Brain Institute and College of Dentistry, University of Florida, Gainesville, Florida 32610, USA
    Mol Pain 3:10. 2007
    ..Our results suggest that ischemia caused reversal operation of glutamate transporters, leading to the release of glutamate via glutamate transporters and the subsequent activation of glutamate receptors in the spinal dorsal horn neurons...
  3. pmc Role of spinal cord glutamate transporter during normal sensory transmission and pathological pain states
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, Baltimore, Maryland 21205, USA
    Mol Pain 1:30. 2005
    ....
  4. ncbi Neuronal PDZ domains: a promising new molecular target for inhaled anesthetics?
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Interv 4:215-21. 2004
    ..These inhibitory effects are immediate, potent, reversible, and occur at a hydrophobic peptidebinding groove on the surface of the PDZ domain. Thus, the PDZ domain might be a new molecular target for inhalational anesthetics...
  5. ncbi Are synaptic MAGUK proteins involved in chronic pain?
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Pharmacol Sci 25:397-400. 2004
    ..Recent studies of the role of a family of synaptic membrane-associated guanylate kinase proteins in chronic pain provide new insights into central mechanisms of chronic pain that could result in new biochemical targets for its treatment...
  6. pmc Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, Maryland 21205, USA
    Mol Pain 3:29. 2007
    ..Our findings suggest that nNOS, especially in the dorsal root ganglion, may participate in the development and/or maintenance of mechanical hypersensitivity after nerve injury...
  7. ncbi Evidence of neuronal excitatory amino acid carrier 1 expression in rat dorsal root ganglion neurons and their central terminals
    F Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Neuroscience 123:1045-51. 2004
    ..Our findings suggest that EAAC1 might play an important role in transmission and modulation of nociceptive information via the regulation of pre-synaptically released glutamate...
  8. ncbi Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 23:6703-12. 2003
    ..PSD-93 appears to be important for NMDAR synaptic targeting and function and to be a potential biochemical target for the treatment of persistent pain...
  9. pmc Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain
    Fidelis E Atianjoh
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pain 151:226-34. 2010
    ....
  10. pmc Distinct expression of synaptic NR2A and NR2B in the central nervous system and impaired morphine tolerance and physical dependence in mice deficient in postsynaptic density-93 protein
    Wen Jinn Liaw
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Pain 4:45. 2008
    ..The selective effect of PSD-93 deletion on synaptic NMDAR expression in these two major pain-related regions might provide the better strategies for the prevention and treatment of opioid tolerance and physical dependence...
  11. ncbi Targeted disruption of PSD-93 gene reduces platelet-activating factor-induced neurotoxicity in cultured cortical neurons
    Yun Xu
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Neurol 189:16-24. 2004
    ....
  12. ncbi Synaptic PDZ domain-mediated protein interactions are disrupted by inhalational anesthetics
    Ming Fang
    Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 278:36669-75. 2003
    ..These findings reveal the PDZ domain as a new molecular target for inhalational anesthetics...
  13. ncbi Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain
    Ya Chun Chu
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pain 119:113-23. 2005
    ..Our findings suggest that spinal cord nNOS might play a critical role in central mechanisms of the development and/or maintenance of chronic inflammatory pain...
  14. ncbi Effect of knock down of spinal cord PSD-93/chapsin-110 on persistent pain induced by complete Freund's adjuvant and peripheral nerve injury
    Bosheng Zhang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, MD 21205, USA
    Pain 106:187-96. 2003
    ..This suggests that spinal cord PSD-93/chapsin-110 might be involved in the central mechanism of chronic pain. Our work might provide a new target for the therapy of chronic pain...
  15. pmc Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1
    Wei Wang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Pain 7:11. 2011
    ..PICK1 appears to be required for peripheral nerve injury-induced neuropathic pain development and to be a potential biochemical target for treating this disorder...
  16. pmc Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain
    Jang Su Park
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Pain 4:67. 2008
    ..These findings suggest that spinal AMPARs might participate in the central spinal mechanism of persistent inflammatory pain...
  17. pmc A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons
    Xiuli Zhao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 16:1024-31. 2013
    ..These findings suggest endogenous Kcna2 antisense RNA as a therapeutic target for the treatment of neuropathic pain. ..
  18. ncbi Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord
    Wen Jinn Liaw
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, MD 21205, USA
    Pain 115:60-70. 2005
    ..Our results suggest that glutamate uptake through spinal glutamate transporters is critical for maintaining normal sensory transmission under physiologic conditions...
  19. pmc mTOR and its downstream pathway are activated in the dorsal root ganglion and spinal cord after peripheral inflammation, but not after nerve injury
    Lingli Liang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 1721 East Madison Street, 370 Ross, Baltimore, MD 21205, USA
    Brain Res 1513:17-25. 2013
    ..Our results strongly suggest that mTOR and its downstream pathway contribute to the development of chronic inflammatory pain...
  20. ncbi Role of micro-opioid receptors in formalin-induced pain behavior in mice
    Cheng Shui Zhao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Exp Neurol 184:839-45. 2003
    ..These results suggest an important modulatory role of endogenous micro-opioid receptor mechanisms in tonic pain states...
  21. pmc Increased expression of sodium channel subunit Nav1.1 in the injured dorsal root ganglion after peripheral nerve injury
    Wei Wang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Anat Rec (Hoboken) 294:1406-11. 2011
    ..1-positive cells in the ipsilateral L5 DRG were also significantly increased. Our results suggest that an early increase in DRG Nav1.1 expression after peripheral nerve injury might be involved in the induction of neuropathic pain...
  22. pmc Absence of μ opioid receptor mRNA expression in astrocytes and microglia of rat spinal cord
    Sheng Chin Kao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Neuroreport 23:378-84. 2012
    ..Our findings indicate that MOR expression is absent from spinal cord astrocytes and microglia, suggesting that these cell types are indirectly activated by MOR agonists under chronic opioid tolerance conditions...
  23. pmc Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvant
    Myron Yaster
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Anesthesiology 114:412-23. 2011
    ..However, their ultrastructural localization is unknown. Moreover, whether and how they participate in inflammatory pain has not been carefully studied...
  24. pmc Dynamic temporal and spatial regulation of mu opioid receptor expression in primary afferent neurons following spinal nerve injury
    Chun yi Lee
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
    Eur J Pain 15:669-75. 2011
    ..These temporal and anatomically specific changes in mOR expression following nerve injury are likely to have functional consequences on pain-associated behaviors and opioid analgesia...
  25. pmc Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn
    Ji Tain Xu
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Brain Res 1336:46-57. 2010
    ..Our findings support the view that mTOR and its downstream effectors do not play a key role in acute pain...
  26. pmc Spinal cord NMDA receptor-mediated activation of mammalian target of rapamycin is required for the development and maintenance of bone cancer-induced pain hypersensitivities in rats
    Ming Hung Shih
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Pain 13:338-49. 2012
    ..These findings suggest that PCC-induced dorsal horn activation of the mTOR pathway participates in NMDA receptor-triggered dorsal central sensitization under cancer pain conditions...
  27. pmc Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons
    Longchang Fan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Pain 10:8. 2014
    ..2 antisense RNA, in addition to the increase in Kv1.2 protein expression, in the injured DRG. Our findings suggest that Kv1.2 may be a novel potential target for preventing and/or treating neuropathic pain. ..
  28. ncbi Lumbar sympathectomy attenuates cold allodynia but not mechanical allodynia and hyperalgesia in rats with spared nerve injury
    Chengshui Zhao
    Department of Anesthesiology and Critical Care Medicine, Baltimore, Maryland, USA
    J Pain 8:931-7. 2007
    ..However, the sympathetic nervous system may be involved, in part, in the mechanisms of cold allodynia in the SNI model...
  29. pmc Protein kinase B/Akt is required for complete Freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons
    Lingli Liang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Pain 14:638-47. 2013
    ..Our findings suggest that the Akt pathway participates in inflammation-induced upregulation of Nav1.7 and Nav1.8 expression in DRG neurons. This participation might contribute to the maintenance of chronic inflammatory pain...
  30. pmc AMPA receptor trafficking in inflammation-induced dorsal horn central sensitization
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neurosci Bull 28:111-20. 2012
    ..Understanding these mechanisms may allow the development of novel therapeutic strategies for treating persistent pain...
  31. pmc Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, 720 Rutland Avenue, Ross 350, Baltimore, MD 21205, USA
    Pain 138:318-29. 2008
    ..Therefore, peripherally acting MOR agonists may represent a promising therapeutic approach for alleviating neuropathic pain...
  32. pmc Are voltage-gated sodium channels on the dorsal root ganglion involved in the development of neuropathic pain?
    Wei Wang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Pain 7:16. 2011
    ..We finally discuss their potential involvement in neuropathic pain...
  33. pmc Persistent inflammation induces GluR2 internalization via NMDA receptor-triggered PKC activation in dorsal horn neurons
    Jang Su Park
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:3206-19. 2009
    ..These results suggest that dorsal horn GluR2 internalization might participate in the maintenance of NMDA receptor/PKC-dependent nociceptive hypersensitivity in persistent inflammatory pain...
  34. pmc Dorsal horn alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking in inflammatory pain
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Anesthesiology 112:1259-65. 2010
    ....
  35. pmc Cloning and characterization of E-dlg, a novel splice variant of mouse homologue of the Drosophila discs large tumor suppressor binds preferentially to SAP102
    Peizhong Mao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    IUBMB Life 60:684-92. 2008
    ..4 in a pull-down assay. E-dlg was highly expressed in embryonic and some adult mouse tissues, such as brain, kidney, and ovary. Furthermore, in situ hybridization showed that E-dlg was mostly expressed in olfactory bulb and cerebellum...
  36. pmc Proteome of synaptosome-associated proteins in spinal cord dorsal horn after peripheral nerve injury
    Om V Singh
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proteomics 9:1241-53. 2009
    ..These changes might participate in the central mechanism that underlies the maintenance of neuropathic pain...
  37. pmc Peripheral nerve injury up-regulates expression of interactor protein for cytohesin exchange factor 1 (IPCEF1) mRNA in rat dorsal root ganglion
    Xiaowei Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 367 Ross, 720 Rutland Ave, Baltimore, MD 21205, USA
    Naunyn Schmiedebergs Arch Pharmacol 380:459-63. 2009
    ....
  38. ncbi Mechanical pain hypersensitivity after incisional surgery is enhanced in rats subjected to neonatal peripheral inflammation: effects of N-methyl-D-aspartate receptor antagonists
    Ya Chun Chu
    Department of Anesthesiology, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taiwan, Republic of China
    Anesthesiology 106:1204-12. 2007
    ..The current study examined the characteristics of postoperative incisional pain behaviors in adult rats that were subjected to neonatal peripheral inflammation...
  39. ncbi Involvement of the NMDA receptor/nitric oxide signal pathway in platelet-activating factor-induced neurotoxicity
    Yun Xu
    Department of Neurology, The Affiliated Drum Tower Hospital of Nanjing University School of Medicine, Nanjing University, Nanjing 210000, PR China
    Neuroreport 15:263-6. 2004
    ..Our findings suggest that the NMDA receptor/NO signaling pathway might contribute to the pathological mechanism of cell death triggered via PAF receptor activation...
  40. ncbi Proteomic analysis of spinal protein expression in rats exposed to repeated intrathecal morphine injection
    Hao Ai Shui
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan
    Proteomics 7:796-803. 2007
    ..It is very likely that these identified proteins may serve as potential molecular targets for prevention of the development of morphine tolerance and physical dependence...

Research Grants2

  1. PKC-Dependent Spinal GluR2 Internalization Triggered by NMDARs in Chronic Pain
    Yuan Xiang Tao; Fiscal Year: 2007
    ..The proposed studies will provide new insights into the mechanisms of both AMPA receptor and NMDA receptor actions on chronic pain and open a door for the development of new analgesics in treatment or prevention of chronic pain. ..