P Talalay

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Sulforaphane accelerates acetaldehyde metabolism by inducing aldehyde dehydrogenases: relevance to ethanol intolerance
    Yusuke Ushida
    Corresponding author Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Alcohol Alcohol 48:526-34. 2013
  2. pmc Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation
    Paul Talalay
    Department of Pharmacology and Molecular Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:17500-5. 2007
  3. ncbi request reprint A fascination with enzymes: the journey not the arrival matters
    Paul Talalay
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Biol Chem 280:28829-47. 2005
  4. ncbi request reprint Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis
    Paul Talalay
    Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Adv Enzyme Regul 43:121-34. 2003
  5. ncbi request reprint Chemoprotection against cancer by induction of phase 2 enzymes
    P Talalay
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins Universit, School of Medicine, Baltimore, MD 21205, USA
    Biofactors 12:5-11. 2000
  6. ncbi request reprint Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism
    P Talalay
    Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Nutr 131:3027S-33S. 2001
  7. pmc Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
    M Ramos-Gomez
    Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:3410-5. 2001
  8. ncbi request reprint Crystal structure of human quinone reductase type 2, a metalloflavoprotein
    C E Foster
    Department of Biophysics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biochemistry 38:9881-6. 1999
  9. pmc Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
    A T Dinkova-Kostova
    Department of Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:3404-9. 2001
  10. pmc Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis
    P Talalay
    Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 85:8261-5. 1988

Collaborators

Detail Information

Publications49

  1. doi request reprint Sulforaphane accelerates acetaldehyde metabolism by inducing aldehyde dehydrogenases: relevance to ethanol intolerance
    Yusuke Ushida
    Corresponding author Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Alcohol Alcohol 48:526-34. 2013
    ..The aim of these studies is to upregulate ALDH by dietary means, thereby reducing acetaldehyde toxicity...
  2. pmc Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation
    Paul Talalay
    Department of Pharmacology and Molecular Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:17500-5. 2007
    ..7% (range 8.37-78.1%; P = 0.025). This protection against a carcinogen in humans is catalytic and long lasting...
  3. ncbi request reprint A fascination with enzymes: the journey not the arrival matters
    Paul Talalay
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Biol Chem 280:28829-47. 2005
  4. ncbi request reprint Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis
    Paul Talalay
    Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Adv Enzyme Regul 43:121-34. 2003
  5. ncbi request reprint Chemoprotection against cancer by induction of phase 2 enzymes
    P Talalay
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins Universit, School of Medicine, Baltimore, MD 21205, USA
    Biofactors 12:5-11. 2000
    ....
  6. ncbi request reprint Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism
    P Talalay
    Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Nutr 131:3027S-33S. 2001
    ..Thus, in addition to detoxifying electrophiles, these proteins exercise versatile, long-lasting and catalytic antioxidant protection...
  7. pmc Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
    M Ramos-Gomez
    Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:3410-5. 2001
    ..Moreover, the total loss of anticarcinogenic efficacy of oltipraz in the nrf2-disrupted mice highlights the prime importance of elevated phase 2 gene expression in chemoprotection by this and similar enzyme inducers...
  8. ncbi request reprint Crystal structure of human quinone reductase type 2, a metalloflavoprotein
    C E Foster
    Department of Biophysics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biochemistry 38:9881-6. 1999
    ..Two histidine nitrogens, one cysteine thiol, and a main chain carbonyl group are involved in metal coordination. The metal binding site is solvent-accessible, and is separated from the FAD cofactor by a distance of about 13 A...
  9. pmc Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
    A T Dinkova-Kostova
    Department of Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:3404-9. 2001
    ..Surprisingly, these ortho-hydroxyl groups display a propensity for extensive intermolecular hydrogen bond formation, which may raise the reactivity and facilitate addition of mercaptans, thereby raising inducer potencies...
  10. pmc Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis
    P Talalay
    Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 85:8261-5. 1988
    ....
  11. pmc Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)
    Q Zhao
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:1669-74. 1997
    ..In the absence of this binding site in QR2, the enzyme retains the essential catalytic machinery, including affinity for FAD, but cannot bind phosphorylated hydride donors...
  12. ncbi request reprint Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans
    T A Shapiro
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 10:501-8. 2001
    ..These findings will assist in the design of dosing regimens for clinical studies of broccoli sprout efficacy...
  13. pmc Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release
    M Faig
    Departments of Biophysics and Biophysical Chemistry and Pharmacology and Molecular Sciences, Johns Hopkins Medical School, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 97:3177-82. 2000
    ..In the human QR1-duroquinone structure one ring carbon is significantly closer to the flavin N5, suggesting a direct hydride transfer to this atom...
  14. pmc Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage
    Xiangqun Gao
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:10446-51. 2004
    ..Moreover, the finding that dietary inducers provide indirect antioxidant protection suggests novel strategies for preventing chronic degenerative diseases, such as age-related macular degeneration...
  15. pmc Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
    Jed W Fahey
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Proc Natl Acad Sci U S A 99:7610-5. 2002
    ....
  16. ncbi request reprint Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes
    Jed W Fahey
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205 2185, USA
    Carcinogenesis 26:1247-55. 2005
    ....
  17. doi request reprint Direct and indirect antioxidant properties of inducers of cytoprotective proteins
    Albena T Dinkova-Kostova
    Division of Clinical Pharmacology, Department of Medicine, The Johns Hopkins University School ofMedicine, Baltimore, MD, USA
    Mol Nutr Food Res 52:S128-38. 2008
    ....
  18. ncbi request reprint Dietary amelioration of Helicobacter pylori infection: design criteria for a clinical trial
    Jed W Fahey
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, 406 WBSB, Baltimore, MD 21205 2185, USA
    Cancer Epidemiol Biomarkers Prev 13:1610-6. 2004
    ..For the least variable quartile, as few as 12 subjects would be needed; for the most variable quartile, at least 147 subjects would be required in each arm...
  19. ncbi request reprint The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
    J W Fahey
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Phytochemistry 56:5-51. 2001
    ....
  20. pmc Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane
    X Gao
    Lewis B. and Dorothy Cullman Cancer Chemoprotection Center, and Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:15221-6. 2001
    ..It is therefore highly likely that the multifaceted and prolonged antioxidant protection provided by sulforaphane is a general phenomenon that is mediated through induction of the Phase 2 enzyme response...
  21. ncbi request reprint Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast
    Brian S Cornblatt
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Carcinogenesis 28:1485-90. 2007
    ..These findings provide a strong rationale for evaluating the protective effects of a broccoli sprout preparation in clinical trials of women at risk for breast cancer...
  22. pmc Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors
    Zachary R Healy
    Department of Pharmacology and Molecular Sciences, Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Photodermatol Photoimmunol Photomed 25:45-50. 2009
    ..These methods have permitted evaluation of the efficacy of protectors, such as sulforaphane from crucifers, that defend cells through induction of cytoprotective (phase 2) genes...
  23. ncbi request reprint Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers
    W David Holtzclaw
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Adv Enzyme Regul 44:335-67. 2004
  24. ncbi request reprint Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China
    Thomas W Kensler
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Room E7541, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 14:2605-13. 2005
    ..29). Understanding factors influencing glucosinolate hydrolysis and bioavailability will be required for optimal use of broccoli sprouts in human interventions...
  25. ncbi request reprint Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Cancer Lett 240:243-52. 2006
    ..Thus, topical application of sulforaphane-containing broccoli sprout extracts is a promising strategy for protecting against skin tumor formation after exposure to UV radiation...
  26. ncbi request reprint Enzymatic and nonenzymatic polarizations of alpha,beta-unsaturated ketosteroids and phenolic steroids. Implications for the roles of hydrogen bonding in the catalytic mechanism of delta 5-3-ketosteroid isomerase
    Q Zhao
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Biochemistry 34:426-34. 1995
    ..0 nm, while the corresponding 4-methyl ether, 4-methoxyandrost-4-ene-3,17-dione, which cannot form an internal hydrogen bond, shows a lambda max of 258.5 nm in aqueous solution.(ABSTRACT TRUNCATED AT 250 WORDS)..
  27. pmc Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:4584-9. 2005
    ..91) over 6 orders of magnitude of concentration. Thus, in addition to blocking inflammation and promoting differentiation, these TP exhibit another very important protective property: the induction of the phase 2 response...
  28. pmc Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:11908-13. 2002
    ..These residues are located in the intervening region between BTB and Kelch repeat domains of Keap1 and probably are the direct sensors of inducers of the phase 2 system...
  29. pmc Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers
    Nobunao Wakabayashi
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:2040-5. 2004
    ....
  30. ncbi request reprint Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts
    Albena T Dinkova-Kostova
    Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 16:847-51. 2007
    ..5- and 4.5-fold after application of 150 nmol doses, once or three times (at 24 h-intervals), respectively, thus providing direct evidence for induction of the phase 2 response in humans...
  31. ncbi request reprint Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study
    Theresa A Shapiro
    Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nutr Cancer 55:53-62. 2006
    ..No significant or consistent subjective or objective abnormal events (toxicities) associated with any of the sprout extract ingestions were observed...
  32. pmc The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction
    R Li
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 92:8846-50. 1995
    ....
  33. ncbi request reprint Phenolic Michael reaction acceptors: combined direct and indirect antioxidant defenses against electrophiles and oxidants
    A T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology, and Moleclar Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Med Chem 3:261-8. 2007
    ..e., acting indirectly, but with much more diverse and long-lasting effects...
  34. pmc Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex
    Michelle L Kerns
    Department of Biological Chemistry, 725 North Wolfe Street, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:14460-5. 2007
    ..Nrf2 induction is brought about by treatment with sulforaphane, a natural product. Sulforaphane thus represents an attractive option for the prevention of skin blistering associated with K14 mutations in EBS...
  35. pmc Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Photochem Photobiol Sci 9:597-600. 2010
    ....
  36. doi request reprint A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N Wolfe Street, WBSB Room 406, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 367:859-65. 2008
    ....
  37. ncbi request reprint Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans
    Lingxiang Ye
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Clin Chim Acta 316:43-53. 2002
    ....
  38. pmc Electrophilic tuning of the chemoprotective natural product sulforaphane
    Young Hoon Ahn
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:9590-5. 2010
    ..We further show in living cells that a sulfoxythiocarbamate analog can label Keap1 on several key cysteine residues as well as other cellular proteins offering new insights into the mechanism of chemoprotection...
  39. ncbi request reprint Role of nicotinamide quinone oxidoreductase 1 (NQO1) in protection against toxicity of electrophiles and reactive oxygen intermediates
    Paul Talalay
    Department of Pharmacology and Molecular Science, Lewis B and Dorothy Cullman Cancer Center Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Methods Enzymol 382:355-64. 2004
  40. pmc Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis
    Zachary R Healy
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 102:14010-5. 2005
    ....
  41. pmc Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention
    Zachary R Healy
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 20:1516-23. 2011
    ..A simple rapid method for determining this activity in tissues and body fluids may therefore be valuable for assessing severity of inflammation and efficacy of intervention...
  42. ncbi request reprint Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1)
    Albena T Dinkova-Kostova
    Department of Pharmacology and Molecular Science, Lewis B and Dorothy Cullman Cancer Center Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Methods Enzymol 382:423-48. 2004
  43. ncbi request reprint The "Prochaska" microtiter plate bioassay for inducers of NQO1
    Jed W Fahey
    Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Methods Enzymol 382:243-58. 2004
  44. pmc Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles
    Hua Liu
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:15926-31. 2008
    ..These studies identify suppression of inflammation as a consistent property of inducers of the phase 2 response and strongly suggest that this property is a central aspect of their chemoprotective actions...
  45. pmc Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice
    Albena T Dinkova-Kostova
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    Nutr Res 28:539-43. 2008
    ..Considering the escalating numbers of individuals worldwide who are overweight or obese, our findings provide further impetus for advocating healthier diets and maintenance of constant body weight in adults...
  46. doi request reprint Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols
    René V Bensasson
    Laboratoire de Chimie des Substances Naturelles, MNHN, USM 0502 UMR 5154 CNRS, Case 54, 63 rue Buffon, F 75005 Paris, France
    Chem Res Toxicol 21:805-12. 2008
    ....
  47. ncbi request reprint Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital
    Vincent Zoete
    Laboratoire de Chimie Biophysique, Universite Louis Pasteur, ISIS, CNRS UMR 7006, Strasbourg, France
    Free Radic Biol Med 36:1418-23. 2004
    ....
  48. ncbi request reprint Harnessing the anticancer power of plants
    Paul Talalay
    Laboratory for Molecular Sciences, Johns Hopkins University School of Medicine, USA
    Johns Hopkins Med Lett Health After 50 14:6. 2002
  49. ncbi request reprint Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities
    Karen Liby
    Dartmouth Medical School, Hanover, NH 03755, USA
    Mol Cancer Ther 6:2113-9. 2007
    ..These results suggest that BA is a useful platform for drug development, and the enhanced potency and varied biological activities of CBA-Im make it a promising candidate for further chemoprevention or chemotherapeutic studies...

Research Grants7

  1. Isolation & Evaluation of Anticarcinogenic Glucosinolate
    Paul Talalay; Fiscal Year: 2005
    ..These pharmacokinetic studies will set the stage for the development of safe and effective dietary chemoprotectors for human use. ..
  2. Isolation and Evaluation of Anticarcinogenic Glucosinolates
    Paul Talalay; Fiscal Year: 2009
    ..We will isolate these components in adequate quantities for evaluation in animals and humans, and formulate appropriate recommendations to achieve disease risk reduction in humans. ..
  3. Isolation and Evaluation of Anticarcinogenic Glucosinolates
    Paul Talalay; Fiscal Year: 2010
    ..We will isolate these components in adequate quantities for evaluation in animals and humans, and formulate appropriate recommendations to achieve disease risk reduction in humans. ..