Zhaoli Sun

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Hepatic allograft-derived Kupffer cells regulate T cell response in rats
    Zhaoli Sun
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Liver Transpl 9:489-97. 2003
  2. ncbi request reprint Amelioration of oxidative mitochondrial DNA damage and deletion after renal ischemic injury by the KATP channel opener diazoxide
    Zhaoli Sun
    Department of Surgery, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 749, Baltimore, MD 21205, USA
    Am J Physiol Renal Physiol 294:F491-8. 2008
  3. doi request reprint Recruitment of host progenitor cells in rat liver transplants
    Zhaoli Sun
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hepatology 49:587-97. 2009
  4. ncbi request reprint In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats
    Zhaoli Sun
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 125:202-15. 2003
  5. ncbi request reprint Reactive oxygen species are essential mediators in antigen presentation by Kupffer cells
    Kosei Maemura
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Immunol Cell Biol 83:336-43. 2005
  6. ncbi request reprint Lipopolysaccharides induced increases in Fas ligand expression by Kupffer cells via mechanisms dependent on reactive oxygen species
    Keiichiro Uchikura
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Gastrointest Liver Physiol 287:G620-6. 2004
  7. ncbi request reprint Over-expression of AIF-1 in liver allografts and peripheral blood correlates with acute rejection after transplantation in rats
    Yuichi Nagakawa
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Transplant 4:1949-57. 2004
  8. ncbi request reprint Oxidative mitochondrial DNA damage and deletion in hepatocytes of rejecting liver allografts in rats: role of TNF-alpha
    Yuichi Nagakawa
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hepatology 42:208-15. 2005
  9. ncbi request reprint In vitro and ex vivo delivery of short hairpin RNAs for control of hepatitis C viral transcript expression
    Bonnie E Lonze
    Division of Transplant Surgery, Department of Surgery, The John Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Arch Surg 147:384-7. 2012
  10. doi request reprint Stem cell mobilization is life saving in an animal model of acute liver failure
    Anthony L Mark
    Department of Surgery, Walter Reed Army Hospital, Bethesda, MD, USA
    Ann Surg 252:591-6. 2010

Research Grants

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Hepatic allograft-derived Kupffer cells regulate T cell response in rats
    Zhaoli Sun
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Liver Transpl 9:489-97. 2003
    ..In conclusion, these data implicate the possible role of KC-mediated regulation of T cell response in the induction of immune tolerance in liver allografts...
  2. ncbi request reprint Amelioration of oxidative mitochondrial DNA damage and deletion after renal ischemic injury by the KATP channel opener diazoxide
    Zhaoli Sun
    Department of Surgery, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 749, Baltimore, MD 21205, USA
    Am J Physiol Renal Physiol 294:F491-8. 2008
    ....
  3. doi request reprint Recruitment of host progenitor cells in rat liver transplants
    Zhaoli Sun
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hepatology 49:587-97. 2009
    ....
  4. ncbi request reprint In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats
    Zhaoli Sun
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 125:202-15. 2003
    ..This is further complicated by the prevalence of steatosis in about 13%-50% of donor livers, which is associated with a high risk of dysfunction and primary nonfunction...
  5. ncbi request reprint Reactive oxygen species are essential mediators in antigen presentation by Kupffer cells
    Kosei Maemura
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Immunol Cell Biol 83:336-43. 2005
    ..Intracellular endogenous ROS generation during antigen processing may therefore provide essential secondary signalling for KC antigen presentation...
  6. ncbi request reprint Lipopolysaccharides induced increases in Fas ligand expression by Kupffer cells via mechanisms dependent on reactive oxygen species
    Keiichiro Uchikura
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Gastrointest Liver Physiol 287:G620-6. 2004
    ..Exogenous administration of H2O2 stimulated KC FasL expression and subsequent Jurkat cell apoptosis. Intracellular endogenous ROS generation may therefore represent an important signal transduction pathway for FasL expression in KC...
  7. ncbi request reprint Over-expression of AIF-1 in liver allografts and peripheral blood correlates with acute rejection after transplantation in rats
    Yuichi Nagakawa
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Transplant 4:1949-57. 2004
    ..These data indicate that high levels of AIF-1 expression reflect aggressive liver allograft rejection and suggest a role for monitoring AIF-1 in peripheral blood leukocytes as a monitor for increased immunosuppression...
  8. ncbi request reprint Oxidative mitochondrial DNA damage and deletion in hepatocytes of rejecting liver allografts in rats: role of TNF-alpha
    Yuichi Nagakawa
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hepatology 42:208-15. 2005
    ..In conclusion, the data presented implicate TNF-alpha as being capable of causing oxidative DNA damage and mtDNA mutation in hepatocytes...
  9. ncbi request reprint In vitro and ex vivo delivery of short hairpin RNAs for control of hepatitis C viral transcript expression
    Bonnie E Lonze
    Division of Transplant Surgery, Department of Surgery, The John Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Arch Surg 147:384-7. 2012
    ....
  10. doi request reprint Stem cell mobilization is life saving in an animal model of acute liver failure
    Anthony L Mark
    Department of Surgery, Walter Reed Army Hospital, Bethesda, MD, USA
    Ann Surg 252:591-6. 2010
    ..The aim of this study was to determine whether pharmacologic mobilization of endogenous hematopoietic stem cells (HSCs) can aid in liver repair and improve survival in an animal model of ALF...
  11. doi request reprint Generation of humanized animal livers using embryoid body-derived stem cell transplant
    Jayme E Locke
    Division of Transplantation, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Ann Surg 248:487-93. 2008
    ..We sought to use human embryoid body-derived stem cells (EBDs) to populate livers in animals for applications in transplant surgery...
  12. pmc Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration after Full-Thickness Excision: The Synergistic Activity of AMD3100 and Tacrolimus
    Qing Lin
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Invest Dermatol 134:2458-68. 2014
    ..Our findings offer a significant therapeutic approach to wound healing and tissue regeneration. ..
  13. ncbi request reprint Hepatic reticuloendothelial system dysfunction after ischemia-reperfusion: role of P-selectin-mediated neutrophil accumulation
    Nobuaki Sakamoto
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Liver Transpl 9:940-8. 2003
    ..These findings support the hypothesis that I-R induces hepatic RES dysfunction, at least in part, through P-selectin-mediated neutrophil accumulation...
  14. pmc Host stem cells repopulate liver allografts: reverse chimerism
    Zhaoli Sun
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Chimerism 2:120-2. 2011
    ....
  15. pmc Interleukin-6 is an important mediator for mitochondrial DNA repair after alcoholic liver injury in mice
    Xiuying Zhang
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hepatology 52:2137-47. 2010
    ..The mitochondrial injury was reflected by decreased membrane potential, reduced levels of ATP, and apoptosis-inducing factor (AIF)-induced apoptosis...
  16. pmc Acute kidney injury leads to inflammation and functional changes in the brain
    Manchang Liu
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Am Soc Nephrol 19:1360-70. 2008
    ..These data demonstrate that severe ischemic AKI induces inflammation and functional changes in the brain. Targeting these pathways could reduce morbidity and mortality in critically ill patients with severe AKI...
  17. ncbi request reprint Biliary obstruction reduces hepatic killing and phagocytic clearance of circulating microorganisms in rats
    Sumito Hoshino
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Gastrointest Surg 7:497-506. 2003
    ..These findings may help to explain the susceptibility of patients with biliary tract obstruction to the morbidity and mortality of septic complications...
  18. ncbi request reprint Impact of donor-specific antibodies in reconstructive transplantation
    Angelo A Leto Barone
    Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation VCA Laboratory, Johns Hopkins University School of Medicine, Ross Research Building 749D, 720 Rutland Avenue, Baltimore, MD, 21205 USA
    Expert Rev Clin Immunol 9:835-44. 2013
    ..In this review, we will define the role of DSA and mechanisms of AMR in reconstructive transplantation and compare them to established measures and treatment concepts in solid organ transplantation. ..
  19. pmc Disappearance of GFP-positive hepatocytes transplanted into the liver of syngeneic wild-type rats pretreated with retrorsine
    Hiromichi Maeda
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Department of Surgery, Kochi Medical School, Nankoku, Kochi, Japan Cancer Treatment Center, Kochi Medical School, Nankoku, Kochi, Japan
    PLoS ONE 9:e95880. 2014
    ..The differing results from various previously reported studies using GFP could be attributed to the immunogenicity of GFP...
  20. pmc Activation of innate immunity (NK/IFN-gamma) in rat allogeneic liver transplantation: contribution to liver injury and suppression of hepatocyte proliferation
    Kezhen Shen
    Department of Hepatobiliary Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    Am J Physiol Gastrointest Liver Physiol 294:G1070-7. 2008
    ..These findings suggest that, compared with syngeneic transplantation, innate immunity (NK/IFN-gamma) is activated after allogeneic transplantation, which likely contributes to liver injury and inhibits hepatocyte proliferation...

Research Grants2

  1. Repopulation of Liver Allografts by Recipients
    Zhaoli Sun; Fiscal Year: 2007
    ..Our studies may provide new insights into the mechanisms which promote tolerance and regeneration after liver transplantation and will provide the basis for the development of novel therapies. [unreadable] [unreadable] [unreadable]..