David J Sullivan

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. Poti K, Balaban A, Pal P, Kobayashi T, Goldberg D, Sinnis P, et al. In vivo compartmental kinetics of Plasmodium falciparum histidine-rich protein II in the blood of humans and in BALB/c mice infected with a transgenic Plasmodium berghei parasite expressing histidine-rich protein II. Malar J. 2019;18:78 pubmed publisher
    ..The results thus confirm that the extended duration of RDT positivity after parasite clearance is likely due to pitted, once-infected RBCs that remain positive for PfHRP2. ..
  2. Sullivan D. Quinolines block every step of malaria heme crystal growth. Proc Natl Acad Sci U S A. 2017;114:7483-7485 pubmed publisher
  3. Shannon K, Ahmed S, Rahman H, Prue C, Khyang J, Ram M, et al. Hemoglobin E and Glucose-6-Phosphate Dehydrogenase Deficiency and Plasmodium falciparum Malaria in the Chittagong Hill Districts of Bangladesh. Am J Trop Med Hyg. 2015;93:281-6 pubmed publisher
    ..HbEE, but not HbAE status was associated with increased passive case detection of malaria. ..
  4. Okoth W, Dukes E, Sullivan D. Superior Pyronaridine Single-Dose Pharmacodynamics Compared to Artesunate, Chloroquine, and Amodiaquine in a Murine Malaria Luciferase Model. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..Single-oral-dose pyronaridine was much more potent in vivo than artesunate, chloroquine, and amodiaquine during the initial decline in parasites and cure. ..
  5. Ferrer P, VEGA RODRIGUEZ J, Tripathi A, Jacobs Lorena M, Sullivan D. Antimalarial iron chelator FBS0701 blocks transmission by Plasmodium falciparum gametocyte activation inhibition. Antimicrob Agents Chemother. 2015;59:1418-26 pubmed publisher
    ..These results show the importance of gametocyte iron metabolism as a potential target for new transmission-blocking strategies. ..
  6. Ferrer P, Castillo Neyra R, Roy C, Sullivan D. Dynamic control of hepatic Plasmodium numbers by hepcidin despite elevated liver iron during iron supplementation. Microbes Infect. 2016;18:48-56 pubmed publisher
    ..In summary during iron supplementation the lower hepatic malaria numbers are regulated more by hepcidin than the absolute level of non-heme hepatic iron. ..
  7. Sullivan D. A Single Human Cerebral Malaria Histopathologic Study Can Be Worth a Thousand Experiments. MBio. 2015;6:e01818-15 pubmed publisher
    ..The study also addresses the important association of severe malaria and HIV prevalence. ..
  8. Moonah S, Sanders N, Persichetti J, Sullivan D. Erythrocyte lysis and Xenopus laevis oocyte rupture by recombinant Plasmodium falciparum hemolysin III. Eukaryot Cell. 2014;13:1337-45 pubmed publisher
    ..After merozoite egress from infected erythrocytes, remnant P. falciparum hemolysin III released from digestive vacuoles could potentially contribute to lysis of uninfected erythrocytes to contribute to severe life-threatening anemia. ..
  9. Laban N, Kobayashi T, Hamapumbu H, Sullivan D, Mharakurwa S, Thuma P, et al. Comparison of a PfHRP2-based rapid diagnostic test and PCR for malaria in a low prevalence setting in rural southern Zambia: implications for elimination. Malar J. 2015;14:25 pubmed publisher
    ..More sensitive and specific diagnostic tests will likely be necessary to identify parasite reservoirs and achieve malaria elimination. ..

More Information

Publications16

  1. Niu H, Cui P, Shi W, Zhang S, Feng J, Wang Y, et al. Identification of Anti-Persister Activity against Uropathogenic Escherichia coli from a Clinical Drug Library. Antibiotics (Basel). 2015;4:179-87 pubmed publisher
    ..coli persisters in 3 days in vitro while the current UTI antibiotics failed to do so. Our findings may have implications for the development of a more effective treatment for UTIs. ..
  2. Niu H, Cui P, Yee R, Shi W, Zhang S, Feng J, et al. A Clinical Drug Library Screen Identifies Tosufloxacin as Being Highly Active against Staphylococcus aureus Persisters. Antibiotics (Basel). 2015;4:329-36 pubmed publisher
    ..Further studies are needed to evaluate tosufloxacin in animal models and to explain its unique activity against bacterial persisters. Our findings may have implications for improved treatment of persistent bacterial infections. ..
  3. Feng J, Weitner M, Shi W, Zhang S, Sullivan D, Zhang Y. Identification of Additional Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug Library. Antibiotics (Basel). 2015;4:397-410 pubmed publisher
    ..These studies may have implications for developing more effective treatments of Lyme disease. ..
  4. Shannon K, Khan W, Sack D, Alam M, Ahmed S, Prue C, et al. Subclinical Plasmodium falciparum infections act as year-round reservoir for malaria in the hypoendemic Chittagong Hill districts of Bangladesh. Int J Infect Dis. 2016;49:161-9 pubmed publisher
  5. Walker L, Sullivan D. Impact of Extended Duration of Artesunate Treatment on Parasitological Outcome in a Cytocidal Murine Malaria Model. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..In summary, cytocidal activity of the artemisinin compounds, such as artesunate, can be improved solely by altering the dosing duration. ..
  6. Pisciotta J, Scholl P, Shuman J, Shualev V, Sullivan D. Quantitative characterization of hemozoin in Plasmodium berghei and vivax. Int J Parasitol Drugs Drug Resist. 2017;7:110-119 pubmed publisher
    ..These results suggest CR P. berghei forms significant hemozoin which accumulates in liver and spleen tissues and that the P. vivax chloroquine resistance mechanism differs from P. berghei. ..
  7. Niu H, Yee R, Cui P, Tian L, Zhang S, Shi W, et al. Identification of Agents Active against Methicillin-Resistant Staphylococcus aureus USA300 from a Clinical Compound Library. Pathogens. 2017;6: pubmed publisher
    ..We ranked these new drug candidates according to their MICs against the MRSA strain USA300. Our findings may have implications for more effective treatment of MRSA infections. ..