Research Topics
| Mark S SulkowskiSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Current management of hepatitis C virus infection in patients with HIV co-infectionMark S Sulkowski
Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
J Infect Dis 207:S26-32. 2013..As such, these HCV PI-based regimens have emerged as the standard for the treatment of HCV genotype 1 infection in carefully selected HIV-infected patients...
Anemia during treatment with peginterferon Alfa-2b/ribavirin and boceprevir: Analysis from the serine protease inhibitor therapy 2 (SPRINT-2) trialMark S Sulkowski
Johns Hopkins University School of Medicine, Baltimore, MD 21287 0003, USA
Hepatology 57:974-84. 2013..Prospective studies are needed to confirm this observation...
HCV therapy in HIV-infected patientsMark S Sulkowski
Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Liver Int 33:63-7. 2013....
Hepatitis C virus-human immunodeficiency virus coinfectionMark S Sulkowski
Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Liver Int 32:129-34. 2012..Accordingly, these agents may be recommended for HCV treatment in carefully selected HIV-infected persons...
Hepatic profile analyses of tipranavir in Phase II and III clinical trialsJaromir Mikl
SUNY at Albany, School of Public Health, Rensselaer NY, USA
BMC Infect Dis 9:203. 2009....
Rapid fibrosis progression among HIV/hepatitis C virus-co-infected adultsMark S Sulkowski
Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
AIDS 21:2209-16. 2007....
Management of hepatic complications in HIV-infected personsMark S Sulkowski
Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
J Infect Dis 197:S279-93. 2008..Despite the complexity and potential for antiretroviral-associated hepatotoxicity, ART usually is safe for patients with viral hepatitis coinfection, and, in some cases, treatment for HIV infection may be beneficial for the liver...
Hepatitis C virus treatment-related anemia is associated with higher sustained virologic response rateMark S Sulkowski
Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0003, USA
Gastroenterology 139:1602-11, 1611.e1. 2010..We investigated the relationships among treatment outcomes, anemia, and their management with RBV dose reduction and/or erythropoiesis-stimulating agents (ESAs)...
Viral hepatitis and HIV coinfectionMark S Sulkowski
Johns Hopkins University School of Medicine, 600 North Wolfe Street, 1830 Building, Room 448, Baltimore, MD 21287, USA
J Hepatol 48:353-67. 2008..Current approaches to management of HIV-infected persons coinfected with HBV or HCV are discussed in this review...
Management of adverse effects of Peg-IFN and ribavirin therapy for hepatitis CMark S Sulkowski
Viral Hepatitis Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Nat Rev Gastroenterol Hepatol 8:212-23. 2011....
Incidence and risk factors for steatosis progression in adults coinfected with HIV and hepatitis C virusTinsay A Woreta
The Johns Hopkins Hospital University School of Medicine, Baltimore, Maryland 21287, USA
Gastroenterology 140:809-17. 2011..We prospectively examined the natural history of steatosis in patients coinfected with HIV and HCV who attended an urban HIV clinic...
Relationship of liver disease stage and antiviral therapy with liver-related events and death in adults coinfected with HIV/HCVBerkeley N Limketkai
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
JAMA 308:370-8. 2012..Human immunodeficiency virus (HIV) accelerates hepatitis C virus (HCV) disease progression; however, the effect of liver disease stage and antiviral therapy on the risk of clinical outcomes is incompletely understood...
Kupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitutionAshwin Balagopal
Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
AIDS 23:2397-404. 2009..Although hepatic macrophages (Kupffer cells) clear most microbial translocation products and can be infected by HIV, their fate in HIV progression has not been carefully investigated...
Hepatotoxicity associated with protease inhibitor-based antiretroviral regimens with or without concurrent ritonavirMark S Sulkowski
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
AIDS 18:2277-84. 2004....
The effect of HAART and HCV infection on the development of hyperglycemia among HIV-infected personsShruti H Mehta
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland 21287, USA
J Acquir Immune Defic Syndr 33:577-84. 2003..CONCLUSION: In this urban HIV cohort, the risk of hyperglycemia was increased in HCV-coinfected patients and those prescribed a PI...
Hepatic steatosis and antiretroviral drug use among adults coinfected with HIV and hepatitis C virusMark S Sulkowski
Division of Infectious Diseases Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
AIDS 19:585-92. 2005....
The effect of antiretroviral therapy on liver disease among adults with HIV and hepatitis C coinfectionShruti H Mehta
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD 21205-0003, USA
Hepatology 41:123-31. 2005..Recognition of bridging fibrosis and cirrhosis in some but not most patients underscores the importance of identifying and treating liver disease in HIV/HCV coinfected persons...
Hepatitis C and progression of HIV diseaseMark S Sulkowski
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument St, Room 448, Baltimore, MD 21287 0003, USA
JAMA 288:199-206. 2002..Conflicting reports exist regarding the effect of hepatitis C virus (HCV) on the progression of human immunodeficiency virus (HIV) disease...
Controlled HIV viral replication, not liver disease severity associated with low bone mineral density in HIV/HCV co-infectionDiala El-Maouche
Johns Hopkins School of Medicine, Baltimore, MD, USA
J Hepatol 55:770-6. 2011..To evaluate the prevalence and risk factors for low bone mineral density (BMD) in persons co-infected with HIV and Hepatitis C...
Stability of liver fibrosis among HCV-infected injection drug usersShruti H Mehta
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Antivir Ther 17:813-21. 2012....
Hepatitis C virus infection in HIV-infected patientsMark S Sulkowski
Division of Infectious Diseases, Johns Hopkins Medical Institutions, 1830 East Monument Street, Room 319, Baltimore, MD 21287, USA
Curr HIV/AIDS Rep 1:128-35. 2004..This review focuses on the epidemiology, natural history, and management of HCV in the HIV-infected patient...
Detection of liver disease in injection drug usersDavid L Thomas
Department of Medicine, Johns Hopkins School of Medicine, 1503 East Jefferson Street, Baltimore, MD 21231, USA
J Addict Dis 27:19-24. 2008....
Treatment algorithm for the management of hepatitis C in HIV-coinfected personsMark S Sulkowski
Johns Hopkins Medical Institutions, 1830 East Monument Street, Room 319, Baltimore, MD 21287 0003, USA
J Hepatol 44:S49-55. 2006..Although, the available data has led to consensus among experts regarding the need to medically manage HCV disease in HIV-infected persons, uncertainty remains regarding the best treatment algorithm for coinfected patients...
Needlestick transmission of hepatitis CMark S Sulkowski
Johns Hopkins School of Medicine, 424 N Bond St, Baltimore, MD 21231, USA
JAMA 287:2406-13. 2002..These data underscore the importance of identifying persons with acute HCV infection and promptly referring them to experienced clinicians who can provide updated counseling and treatment...
Daily versus thrice-weekly interferon alfa-2b plus ribavirin for the treatment of chronic hepatitis C in HIV-infected persons: a multicenter randomized controlled trialMark S Sulkowski
Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Acquir Immune Defic Syndr 35:464-72. 2004..In conclusion, SVR was achieved in 19% of HIV/HCV coinfected subjects treated with daily IFN plus RBV, but the effectiveness of therapy was substantially diminished by relatively high rates of treatment-related toxicity...
Anemia in the treatment of hepatitis C virus infectionMark S Sulkowski
Center for Viral Hepatitis, Johns Hopkins University, Baltimore, Maryland 21205, USA
Clin Infect Dis 37:S315-22. 2003..Higher RBV doses and adherence to HCV therapy have been associated with higher sustained virologic response (SVR) rates. Maintenance of RBV dose with epoetin alfa may improve adherence, thereby affecting SVR...
Vitamin D deficiency and its relation to bone mineral density and liver fibrosis in HIV-HCV coinfectionDiala El-Maouche
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
Antivir Ther 18:237-42. 2013..Fractures and cirrhosis are major causes of morbidity and mortality among HIV-HCV-coinfected individuals. It is not known whether vitamin D deficiency is associated with these outcomes...
Provisional guidance on the use of hepatitis C virus protease inhibitors for treatment of hepatitis C in HIV-infected personsDavid L Thomas
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Clin Infect Dis 54:979-83. 2012..Pending results of ongoing investigations, this article represents provisional guidance on the use of HCV PIs in HIV-infected persons...
Treatment of chronic hepatitis C: a systematic reviewGeetanjali Chander
Department of Medicine and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Hepatology 36:S135-44. 2002..Thus, the combination of peginterferon and ribavirin was the most efficacious treatment in patients with HCV genotype 1. Long-term outcomes were improved in patients with hepatitis C who achieved an SVR with treatment...
Hepatitis C in the HIV-infected patientMark S Sulkowski
Viral Hepatitis Section, Division of Infectious Diseases, Johns Hopkins School of Medicine, Suite 102, 424 North Bond Street, Baltimore, MD 21231, USA
Clin Liver Dis 7:179-94. 2003..Future efforts should include prospective studies that demonstrate the natural history and optimal management of HIV/HCV-coinfected patients, including the feasibility of liver transplantation...
Racial differences in hepatitis C treatment eligibilityMichael T Melia
Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Hepatology 54:70-8. 2011..Increased access to treatment may be facilitated by less conservative neutrophil requirements and more effective care for chronic diseases, namely, diabetes and renal insufficiency...
Hepatitis C in the HIV-Infected PersonMark S Sulkowski
Division of Infections Diseases, Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 448, Baltimore, MD 21287-0003, USA
Ann Intern Med 138:197-207. 2003..Such efforts will help to eliminate HCV-related liver disease as an emerging threat to HIV-infected persons...
Management of the hematologic complications of hepatitis C therapyMark S Sulkowski
Viral Hepatitis Center, Johns Hopkins University School of Medicine, 600 North Wolfe Street, 1830 Building, Room 448, Baltimore, MD 21287, USA
Clin Liver Dis 9:601-16, vi. 2005..Consensus guidelines are in place for treating chronic hepatitis C virus infection. This article highlights some of the hematologic complications of hepatitis C therapy. Management options are presented...
Hepatotoxicity associated with nevirapine or efavirenz-containing antiretroviral therapy: role of hepatitis C and B infectionsMark S Sulkowski
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD21205, USA
Hepatology 35:182-9. 2002..Severe hepatotoxicity occurs throughout the course of NNRTI therapy and is more common among patients prescribed nevirapine, those coinfected with HCV or HBV, and those coadministered protease inhibitors...
Drug-induced liver injury associated with antiretroviral therapy that includes HIV-1 protease inhibitorsMark S Sulkowski
Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0003, USA
Clin Infect Dis 38:S90-7. 2004..Clearly, further research is needed to define the interaction of PIs and chronic viral hepatitis in the development of DILI...
Protective interleukin-28B genotype affects hepatitis C virus clearance, but does not contribute to HIV-1 control in a cohort of African-American elite controllers/suppressorsMaria Salgado
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
AIDS 25:385-7. 2011..Thus, it appears that this SNP is not associated with the elite control of HIV-1 infection...
A framework for understanding factors that affect access and utilization of treatment for hepatitis C virus infection among HCV-mono-infected and HIV/HCV-co-infected injection drug usersShruti H Mehta
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA
AIDS 19:S179-89. 2005....
Epidemiology and natural history of hepatitis C virus infection in injection drug users: implications for treatmentMark S Sulkowski
Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Clin Infect Dis 40:S263-9. 2005..Solutions to the problem of HCV infection among IDUs must account for these facts...
Perspectives on HIV/hepatitis C virus co-infection, illicit drug use and mental illnessMark S Sulkowski
Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287-0003, USA
AIDS 19:S8-12. 2005
Hepatotoxicity associated with antiretroviral therapy containing HIV-1 protease inhibitorsMark S Sulkowski
Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Semin Liver Dis 23:183-94. 2003..Further research is needed to understand the etiopathogenesis of PI-associated liver injury, particularly among patients with hepatitis B or C infection...
Specific targeted antiviral therapy for hepatitis CMark S Sulkowski
Johns Hopkins University School of Medicine, 600 North Wolfe Street, 1830 Building, Room 448, Baltimore, MD 21287, USA
Curr Gastroenterol Rep 9:5-13. 2007..This review focuses on hepatitis C protease and polymerase inhibitors that have progressed to phase II clinical development, foreshadowing the era of STAT-Cs...
Hepatic steatosis associated with increased central body fat by dual-energy X-ray absorptiometry and uncontrolled HIV in HIV/hepatitis C co-infected personsTodd T Brown
Johns Hopkins School of Medicine, USA
AIDS 24:811-7. 2010..To evaluate the relationship between regional body composition and liver disease (fibrosis or steatosis) in HIV/HCV co-infected individuals...
Antiretroviral therapy using zidovudine, lamivudine, and efavirenz in South Africa: tolerability and clinical eventsChristopher J Hoffmann
Aurum Institute for Health Research, Johannesburg, South Africa
AIDS 22:67-74. 2008..To describe the safety and tolerability of zidovudine, lamivudine, and efavirenz in a low-income setting...
Antiretroviral-associated liver injuryAnthony O Ogedegbe
Division of Infectious Diseases, Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 448, Baltimore, MD 21287, USA
Clin Liver Dis 7:475-99. 2003....
The HIV-coinfected patient: managing viral hepatitisMark S Sulkowski
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Acquir Immune Defic Syndr 45:S36-7. 2007
Treatment of chronic hepatitis B in HIV-infected persons: thinking outside the black boxChloe L Thio
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Clin Infect Dis 41:1035-40. 2005
Therapy insight: Management of hepatitis C in patients coinfected with HIVMark S Sulkowski
Viral Hepatitis Center, Johns Hopkins Medical Institutions, Baltimore, MD 21287 0003, USA
Nat Clin Pract Gastroenterol Hepatol 2:223-31. 2005..This review considers the management of HCV infection in HIV-infected patients...
Needlestick injuries among surgeons in trainingMartin A Makary
Center for Outcomes Research, Department of Surgery, Health Policy and Management, Johns Hopkins University School of Medicine, Quality and Safety Research Group, Baltimore 21231, USA
N Engl J Med 356:2693-9. 2007..Surgeons in training are at high risk for needlestick injuries. The reporting of such injuries is a critical step in initiating early prophylaxis or treatment...
Cost-effectiveness of peginterferon alfa-2a (40kDa) plus ribavirin in patients with HIV and hepatitis C virus co-infectionJohn Hornberger
The SPHERE Institute Acumen, LLC, Burlingame, CA 94010, USA
J Clin Virol 36:283-91. 2006..The cost-effectiveness of treating these patients with peginterferon alfa-2a/ribavirin has yet to be explored from a US societal perspective...
Regression of splenic lymphoma after treatment of hepatitis C virus infectionLeisha A Emens
N Engl J Med 347:2168-70; author reply 2168-70. 2002
Once-weekly epoetin alfa improves anemia and facilitates maintenance of ribavirin dosing in hepatitis C virus-infected patients receiving ribavirin plus interferon alfaDouglas T Dieterich
Mount Sinai School of Medicine, New York, New York 10029-6574, USA
Am J Gastroenterol 98:2491-9. 2003..Further research is warranted to determine the potential impact on outcomes, including quality of life and sustained viral response rate...
Defining the standard of care: randomized controlled trials for the treatment of hepatitis C in the HIV-infected personMark S Sulkowski
Hepatology 39:906-8. 2004
Epoetin alfa maintains ribavirin dose in HCV-infected patients: a prospective, double-blind, randomized controlled studyNezam H Afdhal
Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Gastroenterology 126:1302-11. 2004..This study assessed whether epoetin alfa could maintain RBV dose, improve quality of life (QOL), and increase hemoglobin (Hb) in anemic HCV-infected patients...
Hepatitis C virus in the setting of HIV or hepatitis B virus coinfectionRichard K Sterling
Virginia Commonwealth University Health System Medical College of Virginia, Richmond, Virginia 23298, USA
Semin Liver Dis 24:61-8. 2004....
Epoetin alfa improves quality of life in anemic HCV-infected patients receiving combination therapyPaul J Pockros
Scripps Clinic, La Jolla, CA 92037, USA
Hepatology 40:1450-8. 2004..Hb improvement was an independent predictor of HRQL improvement in these patients. In conclusion, epoetin alfa provided clinically significant HRQL improvement in HCV-infected patients receiving IFN/RBV therapy...
Epoetin alfa once weekly improves anemia in HIV/hepatitis C virus-coinfected patients treated with interferon/ribavirin: a randomized controlled trialMark S Sulkowski
J Acquir Immune Defic Syndr 39:504-6. 2005
Modulation of interferon-specific gene expression by albumin-interferon-alpha in interferon-alpha-experienced patients with chronic hepatitis CVijayan Balan
Mayo Clinic, Phoenix, AZ, USA
Antivir Ther 11:901-8. 2006..05). In conclusion, alb-IFN demonstrated robust induction of ISG that was consistent with the response associated with an IFN-alpha...
Limited effectiveness of antiviral treatment for hepatitis C in an urban HIV clinicShruti H Mehta
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, USA
AIDS 20:2361-9. 2006..New therapies and treatment strategies are an urgent medical need...
A Phase I/II study evaluating escalating doses of recombinant human albumin-interferon-alpha fusion protein in chronic hepatitis C patients who have failed previous interferon-alpha-based therapyVijayan Balan
Mayo Clinic, Phoenix, AZ, USA
Antivir Ther 11:35-45. 2006..These results support further clinical studies of albumin-IFN-alpha for the treatment of patients with chronic hepatitis C...
Presentation and outcome of hepatocellular carcinoma in HIV-infected patients: a U.S.-Canadian multicenter studyNorbert Brau
Bronx Veterans Affairs VA Medical Center, Infectious Disease Section 111F, 130 West Kingsbridge Road, Bronx, NY 10468, USA
J Hepatol 47:527-37. 2007..HIV-infected patients now live longer and often have complications of liver disease, especially with hepatitis B or C virus coinfection. Limited data are available on those with hepatocellular carcinoma (HCC)...
