John J Strouse

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Hydroxyurea for sickle cell disease: a systematic review for efficacy and toxicity in children
    John J Strouse
    Department of Pediatrics, Johns Hopkins University School of Medicine, Division of Pediatric Hematology, 720 Rutland Ave, Ross 1125, Baltimore, MD 21205, USA
    Pediatrics 122:1332-42. 2008
  2. pmc A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease
    Ted Wun
    University of California, Davis Cancer Center, 4501 X St, Ste, 3016, Sacramento, CA, 95817, USA
    J Hematol Oncol 6:17. 2013
  3. pmc Hydroxyurea for the treatment of sickle cell disease: efficacy, barriers, toxicity, and management in children
    John J Strouse
    Division of Pediatric Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatr Blood Cancer 59:365-71. 2012
  4. ncbi request reprint Significant responses to platinum-based chemotherapy in renal medullary carcinoma
    John J Strouse
    Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA
    Pediatr Blood Cancer 44:407-11. 2005
  5. pmc The epidemiology, evaluation and treatment of stroke in adults with sickle cell disease
    John J Strouse
    Division of Pediatric Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Expert Rev Hematol 4:597-606. 2011
  6. pmc The excess burden of stroke in hospitalized adults with sickle cell disease
    John J Strouse
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Hematol 84:548-52. 2009
  7. pmc Corticosteroids and increased risk of readmission after acute chest syndrome in children with sickle cell disease
    John J Strouse
    Division of Pediatric Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatr Blood Cancer 50:1006-12. 2008
  8. ncbi request reprint Primary hemorrhagic stroke in children with sickle cell disease is associated with recent transfusion and use of corticosteroids
    John J Strouse
    Division of Pediatric Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pediatrics 118:1916-24. 2006
  9. pmc Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA)
    John J Strouse
    Division of Pediatric Hematology, Department of Pediatrics, the Neurocirculatory Physiology Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Blood 108:379-81. 2006
  10. ncbi request reprint Pediatric melanoma: risk factor and survival analysis of the surveillance, epidemiology and end results database
    John J Strouse
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Clin Oncol 23:4735-41. 2005

Research Grants

Detail Information

Publications31

  1. doi request reprint Hydroxyurea for sickle cell disease: a systematic review for efficacy and toxicity in children
    John J Strouse
    Department of Pediatrics, Johns Hopkins University School of Medicine, Division of Pediatric Hematology, 720 Rutland Ave, Ross 1125, Baltimore, MD 21205, USA
    Pediatrics 122:1332-42. 2008
    ..Hydroxyurea is the only approved medication for the treatment of sickle cell disease in adults; there are no approved drugs for children...
  2. pmc A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease
    Ted Wun
    University of California, Davis Cancer Center, 4501 X St, Ste, 3016, Sacramento, CA, 95817, USA
    J Hematol Oncol 6:17. 2013
    ..To evaluate the safety of prasugrel, a thienopyridine antiplatelet agent, in adult patients with SCD, we conducted a double-blind, randomized, placebo-controlled study...
  3. pmc Hydroxyurea for the treatment of sickle cell disease: efficacy, barriers, toxicity, and management in children
    John J Strouse
    Division of Pediatric Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatr Blood Cancer 59:365-71. 2012
    ..However, there are substantial gaps in our knowledge to be addressed by on-going and planned studies in children...
  4. ncbi request reprint Significant responses to platinum-based chemotherapy in renal medullary carcinoma
    John J Strouse
    Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA
    Pediatr Blood Cancer 44:407-11. 2005
    ..We describe two adolescents with metastatic disease who had significant responses to cisplatin or carboplatin in combination with gemcitabine and paclitaxel...
  5. pmc The epidemiology, evaluation and treatment of stroke in adults with sickle cell disease
    John J Strouse
    Division of Pediatric Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Expert Rev Hematol 4:597-606. 2011
    ....
  6. pmc The excess burden of stroke in hospitalized adults with sickle cell disease
    John J Strouse
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Hematol 84:548-52. 2009
    ..Stroke in SCD is associated with several known adult risk factors for ischemic and hemorrhagic stroke. Studies for the primary and secondary prevention of stroke in adults with SCD are urgently needed...
  7. pmc Corticosteroids and increased risk of readmission after acute chest syndrome in children with sickle cell disease
    John J Strouse
    Division of Pediatric Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatr Blood Cancer 50:1006-12. 2008
    ..We performed a retrospective cohort study to evaluate risk factors for readmission and prolonged hospitalization after different treatments for ACS...
  8. ncbi request reprint Primary hemorrhagic stroke in children with sickle cell disease is associated with recent transfusion and use of corticosteroids
    John J Strouse
    Division of Pediatric Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pediatrics 118:1916-24. 2006
    ..We performed a retrospective case-control study to evaluate risk and prognostic factors for primary hemorrhagic stroke among children with sickle cell disease...
  9. pmc Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA)
    John J Strouse
    Division of Pediatric Hematology, Department of Pediatrics, the Neurocirculatory Physiology Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Blood 108:379-81. 2006
    ..005). CASL MRI may identify children with neurocognitive impairment, before damage is evident by structural MRI or TCD...
  10. ncbi request reprint Pediatric melanoma: risk factor and survival analysis of the surveillance, epidemiology and end results database
    John J Strouse
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Clin Oncol 23:4735-41. 2005
    ..To evaluate risk factors for the development of and factors influencing survival in pediatric melanoma...
  11. pmc Severe pandemic H1N1 and seasonal influenza in children and young adults with sickle cell disease
    John J Strouse
    Division of Pediatric Hematology, Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA
    Blood 116:3431-4. 2010
    ..04) were associated with ACS, and older age (OR 1.1 per year, P = .02) and prior ACS (OR 3.3 per episode in last year, P < .006) with intensive care. Influenza, especially H1N1, causes critical illness in SCD and should be prevented...
  12. ncbi request reprint A systematic review of barriers and interventions to improve appropriate use of therapies for sickle cell disease
    Carlton Haywood
    Johns Hopkins Berman Institute of Bioethics, Johns Hopkins University School of Medicine, Division of Hematology, 2024 E Monument St, Rm 2 521, Baltimore, MD 21287, USA
    J Natl Med Assoc 101:1022-33. 2009
    ....
  13. doi request reprint Urgency of emergency department visits by children with sickle cell disease: a comparison of 3 chronic conditions
    David G Bundy
    Department of Pediatrics, Division of Quality and Safety, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Acad Pediatr 11:333-41. 2011
    ..This study examined ED use by children with SCD by comparing the urgency of ED visits among children with SCD, asthma, and diabetes mellitus...
  14. pmc Unsuspected rickettsioses among patients with acute febrile illness, Sri Lanka, 2007
    Megan E Reller
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Emerg Infect Dis 18:825-9. 2012
    ..Additionally, 342 (38.7%) had exposure to spotted fever and/or typhus group rickettsioses and 121 (13.7%) scrub typhus. Increased awareness of rickettsioses and better tests are needed...
  15. pmc Unsuspected dengue and acute febrile illness in rural and semi-urban southern Sri Lanka
    Megan E Reller
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Emerg Infect Dis 18:256-63. 2012
    ..Only 14% of patients had clinically suspected dengue; however, 54% had serologically confirmed acute or past DENV infection. DENV is a major and largely unrecognized cause of fever in southern Sri Lanka, especially in young adults...
  16. pmc Systematic review: Hydroxyurea for the treatment of adults with sickle cell disease
    Sophie Lanzkron
    School of Medicine, Johns Hopkins University, 1830 East Monument Street, Suite 7300, Baltimore, MD 21205, USA
    Ann Intern Med 148:939-55. 2008
    ..Hydroxyurea is the only approved drug for treatment of sickle cell disease...
  17. pmc Incidental findings on brain magnetic resonance imaging of children with sickle cell disease
    Lori C Jordan
    Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Pediatrics 126:53-61. 2010
    ..We describe the prevalence and range of incidental intracranial abnormalities identified through MRI of the brain in a large group of children screened for a clinical trial...
  18. doi request reprint Ambulatory care connections of Medicaid-insured children with sickle cell disease
    David G Bundy
    Division of Quality and Safety, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Pediatr Blood Cancer 59:888-94. 2012
    ..We examined when children with SCD establish ambulatory care connections, whether these connections are maintained, and how these connections are used before and after hospitalizations...
  19. pmc Leptospirosis as frequent cause of acute febrile illness in southern Sri Lanka
    Megan E Reller
    Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Emerg Infect Dis 17:1678-84. 2011
    ..7% (95% CI 89.2%-93.8%), respectively. For identifying acute leptospirosis, clinical impression is insensitive, and immunoglobulin M results are more insensitive and costly. Rapid, pathogen-based tests for early diagnosis are needed...
  20. pmc Burden of influenza-related hospitalizations among children with sickle cell disease
    David G Bundy
    Johns Hopkins University School of Medicine, 600 N Wolfe St, CMSC 2 121, Baltimore, MD 21287, USA
    Pediatrics 125:234-43. 2010
    ....
  21. doi request reprint Respiratory syncytial virus and seasonal influenza cause similar illnesses in children with sickle cell disease
    Sara Christina Sadreameli
    Division of Pediatric Pulmonology, Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland
    Pediatr Blood Cancer 61:875-8. 2014
    ..We compared RSV to seasonal influenza infections in children with SCD...
  22. pmc Chikungunya as a cause of acute febrile illness in southern Sri Lanka
    Megan E Reller
    Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Hubert Yeargan Center for Global Health, Durham, North Carolina, United States of America
    PLoS ONE 8:e82259. 2013
    ..We sought to identify and characterize acute chikungunya infection (CHIK) in patients presenting with acute undifferentiated febrile illness in unstudied rural and semi-urban southern Sri Lanka in 2007...
  23. pmc Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure
    Michael R Debaun
    Department of Pediatrics, Division of Hematology Oncology, Vanderbilt University, Nashville, TN, USA
    Blood 119:3684-90. 2012
    ..Hemoglobin concentration and systolic blood pressure are risk factors for SCI in children with SCA and may be therapeutic targets for decreasing the risk of SCI. This study is registered at www.clinicaltrials.gov as #NCT00072761...
  24. doi request reprint Design of the silent cerebral infarct transfusion (SIT) trial
    James F Casella
    Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Pediatr Hematol Oncol 27:69-89. 2010
    ..The goal of this trial is to determine whether blood transfusion therapy will reduce further neurological morbidity in children with SCI, and if so, the magnitude of this benefit...
  25. pmc Anticoagulation monitoring during pediatric extracorporeal membrane oxygenation
    Melania M Bembea
    Department of Anesthesiology and Critical Care, Johns Hopkins University, Baltimore, Maryland 21287, USA
    ASAIO J 59:63-8. 2013
    ..Additional studies are warranted to determine optimal ECMO anticoagulation monitoring...
  26. doi request reprint High rates of recurrent biliary tract obstruction in children with sickle cell disease
    Martha O Amoako
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatr Blood Cancer 60:650-2. 2013
    ..We conducted a retrospective cohort study to describe the recurrence of BTD after cholecystectomy and characterize risk factors for recurrent disease...
  27. doi request reprint Comparison of the use and results of sentinel lymph node biopsy in children and young adults with melanoma
    Euphemia Mu
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer 118:2700-7. 2012
    ..Data on sentinel lymph node (SLN) biopsy in children with melanoma are limited. In this study, the authors compared the factors associated with SLN biopsy use and metastases in pediatric and young adult patients with melanoma...
  28. pmc Fast measurement of blood T1 in the human jugular vein at 3 Tesla
    Qin Qin
    The Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 65:1297-304. 2011
    ..Interestingly, however, studies done on sickle cell anemia patients with much lower Hct (23 ± 3%, n = 10) revealed similar venous blood T(1) = 1924 ± 82 msec, indicating other possible physical influences affecting blood T(1)...
  29. doi request reprint Computerized physician order entry improves compliance with a manual exchange transfusion protocol in the pediatric intensive care unit
    Michael C McCrory
    Departments of Anesthesiology and Pediatrics, Pediatric Critical Care, Baptist Hospital, School of Medicine, Wake Forest University, Winston Salem, NC Department of Pediatrics, Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, MD Departments of Pediatrics and Anesthesiology, Cardiovascular Anesthesiology and Critical Care, Texas Children s Hospital Baylor College of Medicine, Houston, TX
    J Pediatr Hematol Oncol 36:143-7. 2014
    ..To evaluate the use of a computerized physician order entry (CPOE) protocol on manual red blood cell (RBC) exchange transfusion in critically ill children with sickle cell disease...
  30. doi request reprint Hospital-associated venous thromboembolism in children: incidence and clinical characteristics
    Clifford M Takemoto
    Division of Pediatric Hematology, Johns Hopkins University, Baltimore, Md Electronic address
    J Pediatr 164:332-8. 2014
    ..To determine incidence and clinical characteristics of hospital-associated venous thromboembolism (VTE) in pediatric patients...
  31. pmc Subtotal splenic embolization is a safe and effective treatment for isolated splenic vascular tumors associated with consumptive coagulopathy
    Eric H Raabe
    Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Pediatr Hematol Oncol 33:383-6. 2011
    ..One child was successfully treated by subtotal embolization of the spleen, whereas the second child required splenectomy after an initial embolization improved--but did not fully control--his consumptive coagulopathy...

Research Grants2

  1. Predictors of Cognitive Deficits in Sickle Cell Disease
    JOHN STROUSE; Fiscal Year: 2007
    ..CBF measurements may provide information needed to reduce SCI, cognitive impairment, and the resulting academic failure that limits the potential of many children with SCD. ..