Charles Steenbergen

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Nuclear miRNA regulates the mitochondrial genome in the heart
    Samarjit Das
    Department of Pathology, Cardiovascular Division, Johns Hopkins University, Baltimore, MD 21205
    Circ Res 110:1596-603. 2012
  2. pmc Cardioprotection and altered mitochondrial adenine nucleotide transport
    Charles Steenbergen
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA
    Basic Res Cardiol 104:149-56. 2009
  3. pmc Creatine kinase overexpression improves ATP kinetics and contractile function in postischemic myocardium
    Ashwin Akki
    Cardiology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287 6568, USA
    Am J Physiol Heart Circ Physiol 303:H844-52. 2012
  4. pmc Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation
    Samarjit Das
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA
    Circ Res 103:983-91. 2008
  5. ncbi request reprint Ablation of PLB exacerbates ischemic injury to a lesser extent in female than male mice: protective role of NO
    Heather R Cross
    Department of Pathology, Duke University Medical Center, Durham 27710, USA
    Am J Physiol Heart Circ Physiol 284:H683-90. 2003
  6. pmc Integration and regression of implanted engineered human vascular networks during deep wound healing
    Donny Hanjaya-Putra
    Department of Chemical and Biomolecular Engineering, Johns Hopkins Physical Sciences Oncology Center and Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland, USA
    Stem Cells Transl Med 2:297-306. 2013
  7. pmc Effect of p38 MAP kinases on contractility and ischemic injury in intact heart
    H R Cross
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Acta Physiol Hung 96:307-23. 2009
  8. ncbi request reprint Ca(2+) loading and adrenergic stimulation reveal male/female differences in susceptibility to ischemia-reperfusion injury
    Heather R Cross
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Heart Circ Physiol 283:H481-9. 2002
  9. pmc MR proton spectroscopy for myocardial lipid deposition quantification: a quantitative comparison between 1.5T and 3T
    Bharath Ambale Venkatesh
    Department of Radiology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Magn Reson Imaging 36:1222-30. 2012
  10. ncbi request reprint Overexpression of A(3) adenosine receptors decreases heart rate, preserves energetics, and protects ischemic hearts
    Heather R Cross
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Heart Circ Physiol 283:H1562-8. 2002

Research Grants

  1. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 2009
  2. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 2007
  3. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 2006
  4. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 2002
  5. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 1993
  6. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 2010

Collaborators

Detail Information

Publications34

  1. pmc Nuclear miRNA regulates the mitochondrial genome in the heart
    Samarjit Das
    Department of Pathology, Cardiovascular Division, Johns Hopkins University, Baltimore, MD 21205
    Circ Res 110:1596-603. 2012
    ..MicroRNAs (miRNAs) are usually 19 to 25 nt long, noncoding RNAs, involved in posttranscriptional gene regulation by binding to the 3'-untranslated regions of target mRNA, which impact on diverse cellular processes...
  2. pmc Cardioprotection and altered mitochondrial adenine nucleotide transport
    Charles Steenbergen
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA
    Basic Res Cardiol 104:149-56. 2009
    ..Two interventions that similarly inhibit mitochondrial adenine nucleotide transport are Bcl-2 overexpression and GSK inhibition. A possible final common mechanism shared by both of these interventions is discussed...
  3. pmc Creatine kinase overexpression improves ATP kinetics and contractile function in postischemic myocardium
    Ashwin Akki
    Cardiology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287 6568, USA
    Am J Physiol Heart Circ Physiol 303:H844-52. 2012
    ....
  4. pmc Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation
    Samarjit Das
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA
    Circ Res 103:983-91. 2008
    ..Both proteomics and adenine nucleotide transport data suggest that GSK regulates VDAC and that VDAC may be an important regulatory site in ischemia/reperfusion injury...
  5. ncbi request reprint Ablation of PLB exacerbates ischemic injury to a lesser extent in female than male mice: protective role of NO
    Heather R Cross
    Department of Pathology, Duke University Medical Center, Durham 27710, USA
    Am J Physiol Heart Circ Physiol 284:H683-90. 2003
    ..Protection in females was decreased by a NOS inhibitor and mimicked in males by an NO donor, implying that protection was NOS mediated...
  6. pmc Integration and regression of implanted engineered human vascular networks during deep wound healing
    Donny Hanjaya-Putra
    Department of Chemical and Biomolecular Engineering, Johns Hopkins Physical Sciences Oncology Center and Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland, USA
    Stem Cells Transl Med 2:297-306. 2013
    ..Overall, this study offers useful insights for the development of vascularization strategies for wound healing and ischemic conditions, for tissue-engineered constructs, and for tissue regeneration...
  7. pmc Effect of p38 MAP kinases on contractility and ischemic injury in intact heart
    H R Cross
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Acta Physiol Hung 96:307-23. 2009
    ..In summary, attenuated p38 activity led to increased myocardial contractility; specific isoforms of p38 and their sub-cellular localization may have different roles in modulating ischemic injury...
  8. ncbi request reprint Ca(2+) loading and adrenergic stimulation reveal male/female differences in susceptibility to ischemia-reperfusion injury
    Heather R Cross
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Heart Circ Physiol 283:H481-9. 2002
    ..Females were therefore protected from the detrimental effects of adrenergic stimulation and Ca(2+) loading via a NOS-mediated mechanism...
  9. pmc MR proton spectroscopy for myocardial lipid deposition quantification: a quantitative comparison between 1.5T and 3T
    Bharath Ambale Venkatesh
    Department of Radiology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Magn Reson Imaging 36:1222-30. 2012
    ..To evaluate 3T magnetic resonance spectroscopy (MRS)-derived myocardial fat-signal fractions in comparison with those from 1.5T MRS...
  10. ncbi request reprint Overexpression of A(3) adenosine receptors decreases heart rate, preserves energetics, and protects ischemic hearts
    Heather R Cross
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Heart Circ Physiol 283:H1562-8. 2002
    ..Therefore, A(3)AR overexpression results in cardioprotection via a specific A(3)AR effect, possibly involving preservation of ATP during ischemia...
  11. pmc Characterization of potential S-nitrosylation sites in the myocardium
    Mark J Kohr
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21257, USA
    Am J Physiol Heart Circ Physiol 300:H1327-35. 2011
    ....
  12. doi request reprint Skeletal muscle ATP kinetics are impaired in frail mice
    Ashwin Akki
    Cardiology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Age (Dordr) 36:21-30. 2014
    ..These observations do not prove, but are consistent with the premise, that energetic abnormalities may contribute metabolically to SM weakness in this geriatric syndrome. ..
  13. ncbi request reprint The role of beta-adrenergic receptor signaling in cardioprotection
    Haiyan Tong
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    FASEB J 19:983-5. 2005
    ..These data show an important role for beta2-AR in cardioprotection and support the novel hypothesis that preconditioning involves switching of beta2-AR coupling from Gs to Gi...
  14. pmc Creatine kinase-overexpression improves myocardial energetics, contractile dysfunction and survival in murine doxorubicin cardiotoxicity
    Ashish Gupta
    Department of Medicine, Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Department of Radiology, Division of Magnetic Resonance Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e74675. 2013
    ....
  15. pmc Mitochondrial adenine nucleotide transport and cardioprotection
    Samarjit Das
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    J Mol Cell Cardiol 52:448-53. 2012
    ..This article is part of a Special Issue entitled "Local Signaling in Myocytes"...
  16. pmc Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved
    Ashish Gupta
    Department of Medicine, Cardiology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Invest 122:291-302. 2012
    ..In addition, these data identify CK as a promising therapeutic target for preventing and treating HF and possibly diseases involving energy-dependent dysfunction in other organs with temporally varying energy demands...
  17. ncbi request reprint Expression of activated PKC epsilon (PKC epsilon) protects the ischemic heart, without attenuating ischemic H(+) production
    Heather R Cross
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Mol Cell Cardiol 34:361-7. 2002
    ..Protection occurred in the PKC epsilon hearts without attenuation of ischemic H(+) production, implying that, at least in this ischemic model, reduced acidification during ischemia is not necessary for cardioprotection...
  18. pmc A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy
    Dipankar Pramanik
    The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Oncotarget 3:640-50. 2012
    ..A composite DOX-curcumin nanoparticle that overcomes both MDR-based DOX chemoresistance and DOX-induced cardiotoxicity holds promise for providing lasting and safe anticancer therapy...
  19. pmc Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing
    Guoming Sun
    Department of Chemical and Biomolecular Engineering, Johns Hopkins Physical Sciences Oncology Center, and the Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 108:20976-81. 2011
    ....
  20. pmc Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathy
    Karl H Schuleri
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Eur Heart J 30:2722-32. 2009
    ..Here we tested the hypothesis that autologous MSCs can be safely injected into a chronic myocardial infarct scar, reduce its size, and improve ventricular function...
  21. pmc Simultaneous measurement of protein oxidation and S-nitrosylation during preconditioning and ischemia/reperfusion injury with resin-assisted capture
    Mark J Kohr
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21257, USA
    Circ Res 108:418-26. 2011
    ..Protein S-nitrosylation (SNO) is increased following myocardial IPC, and SNO is thought to provide cardioprotection, in part, by reducing cysteine oxidation during ischemia/reperfusion (IR) injury...
  22. doi request reprint Relationship of delayed enhancement by magnetic resonance to myocardial perfusion by positron emission tomography in hypertrophic cardiomyopathy
    Paco E Bravo
    Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Circ Cardiovasc Imaging 6:210-7. 2013
    ..We investigated the relationship between DE on CMR and myocardial ischemia in hypertrophic cardiomyopathy...
  23. pmc Does the voltage dependent anion channel modulate cardiac ischemia-reperfusion injury?
    Samarjit Das
    Department of Pathology, Johns Hopkins Medical Institute and Systems Biology Center, NHLBI, NIH, Bethesda, MD, USA
    Biochim Biophys Acta 1818:1451-6. 2012
    ..This article is part of a Special Issue entitled: VDAC structure, function, and regulation of mitochondrial metabolism...
  24. pmc Impact of scar, viable myocardium, and epicardial fat on substrate identification of ventricular tachycardia in a case with nonischemic cardiomyopathy
    Takeshi Sasaki
    Medicine Cardiology Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Pacing Clin Electrophysiol 35:e345-8. 2012
    ..This case provides a unique opportunity to explore the reliability of electrical surrogates of scar in nonischemic cardiomyopathy...
  25. pmc Heterogeneous distribution of myocardial steatosis--an ex vivo evaluation
    Chia Ying Liu
    Department of Radiology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Magn Reson Med 68:1-7. 2012
    ..62% ± 1.1% vs. 0.59% ± 0.4%, P = 0.002). In summary, septal fat content is representative of mean fat percentage. Fat content increases with age; fat distribution may be heterogeneous when associated with cardiovascular disease...
  26. pmc Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice
    Kakali Sarkar
    Department of Medicine, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Suite 671, 733 North Broadway, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:18769-74. 2009
    ....
  27. pmc VAMP-1, VAMP-2, and syntaxin-4 regulate ANP release from cardiac myocytes
    Marcella Ferlito
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Mol Cell Cardiol 49:791-800. 2010
    ..Our data suggest that three specific SNAREs regulate cardiac myocyte exocytosis of ANP. Pathways that modify the exocytic machinery may influence natriuresis and blood pressure...
  28. pmc Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling
    Hong Wei
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 109:E841-50. 2012
    ..Although digoxin has been used for decades as an inotropic agent to treat heart failure, it does not improve survival, suggesting that the countertherapeutic effects of digoxin observed in the TAC mouse model may have clinical relevance...
  29. pmc Ischemic preconditioning attenuates mitochondrial localization of PTEN induced by ischemia-reperfusion
    Lingyun Zu
    720 Rutland Ave, Ross 333, Baltimore, MD 21205, USA
    Am J Physiol Heart Circ Physiol 300:H2177-86. 2011
    ....
  30. ncbi request reprint Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure
    Charles Steenbergen
    Department of Pathology, Duke University Medical Center, Durham 27710, USA
    Am J Physiol Heart Circ Physiol 284:H268-76. 2003
    ..This study identifies several pathways that are altered in human heart failure and provides new targets for therapy...
  31. ncbi request reprint The role of p38 mitogen-activated protein kinase in myocardial ischemia/reperfusion injury; relationship to ischemic preconditioning
    Charles Steenbergen
    Department of Pathology, Duke University Medical Center, Box 3712, DUMC, Durham, NC 27710, USA
    Basic Res Cardiol 97:276-85. 2002
    ....
  32. pmc Controlled activation of morphogenesis to generate a functional human microvasculature in a synthetic matrix
    Donny Hanjaya-Putra
    Department of Chemical and Biomolecular Engineering, Johns Hopkins Physical Sciences Oncology Center and Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA
    Blood 118:804-15. 2011
    ....
  33. pmc Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy
    Peter V Johnston
    Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circulation 120:1075-83, 7 p following 1083. 2009
    ..Cardiosphere-derived cells (CDCs) isolated from human endomyocardial biopsies reduce infarct size and improve cardiac function in mice. Safety and efficacy testing in large animals is necessary for clinical translation...
  34. ncbi request reprint Male and female mice overexpressing the beta(2)-adrenergic receptor exhibit differences in ischemia/reperfusion injury: role of nitric oxide
    Heather R Cross
    Department of Pathology, Box 3712, Duke University Medical Center, Durham, NC 27710, USA
    Cardiovasc Res 53:662-71. 2002
    ....

Research Grants18

  1. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 2009
    ....
  2. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 2007
    ....
  3. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 2006
    ..abstract_text> ..
  4. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 2002
    ..In the third specific aim, the applicants plan to determine the importance of SR calcium cycling in ischemia, whether decreased SR calcium cycling plays a major role in PC, and whether 12-LO metabolites and p38 activation are involved. ..
  5. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 1993
    ..4) Can the effects of adenosine treatment during ischemia on (Ca2+)i, stunning, and lethal injury be dissociated? and 5) Is adenosine involved in the preconditioning-induced attenuation of the rise in (Ca2+)i during subsequent ischemia?..
  6. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 2010
    ....