A A Spector

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Elastic properties of the composite outer hair cell wall
    A A Spector
    Department of Biomedical Engineering, The Johns Hopkins University University, Baltimore, MD 21205, USA
    Ann Biomed Eng 26:157-65. 1998
  2. ncbi request reprint Mechanosensitive channels in the lateral wall can enhance the cochlear outer hair cell frequency response
    Alexander A Spector
    Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Traylor 411, Baltimore, MD 21205, USA
    Ann Biomed Eng 33:991-1002. 2005
  3. ncbi request reprint Effectiveness, active energy produced by molecular motors, and nonlinear capacitance of the cochlear outer hair cell
    Alexander A Spector
    Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Traylor 411, Baltimore, Maryland 21205, USA
    J Biomech Eng 127:391-9. 2005
  4. ncbi request reprint Effect of outer hair cell piezoelectricity on high-frequency receptor potentials
    Alexander A Spector
    Department of Biomedical Engineering and Center for Computational Medicine and Biology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Acoust Soc Am 113:453-61. 2003
  5. pmc Simulation of motor-driven cochlear outer hair cell electromotility
    A A Spector
    Department of Biomedical Engineering, Center for Computational Medicine and Biology and Center for Hearing Sciences, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Biophys J 81:11-24. 2001
  6. ncbi request reprint Mechanical and electromotile characteristics of auditory outer hair cells
    A A Spector
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
    Med Biol Eng Comput 37:247-51. 1999
  7. ncbi request reprint On the mechanoelectrical coupling in the cochlear outer hair cell
    A A Spector
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Acoust Soc Am 107:1435-41. 2000
  8. ncbi request reprint Nonlinear electroelastic model for the composite outer hair cell wall
    A A Spector
    Department of Biomedical Engineering and Center for Computational Medicine and Biology, Johns Hopkins University, Baltimore, MD 21205, USA
    ORL J Otorhinolaryngol Relat Spec 61:287-93. 1999
  9. ncbi request reprint Modeling 3-D deformation of outer hair cells and their production of the active force in the cochlea
    A A Spector
    Department of Biomedical Engineering and Center for Computational Medicine and Biology, Johns Hopkins University, 720 Rutland Ave, Baltimore, MD 21205, USA
    Biomech Model Mechanobiol 1:123-35. 2002
  10. ncbi request reprint Modes and balance of energy in the piezoelectric cochlear outer hair cell wall
    Alexander A Spector
    Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Ave, Baltimore, MD 21205, USA
    J Biomech Eng 126:17-25. 2004

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Elastic properties of the composite outer hair cell wall
    A A Spector
    Department of Biomedical Engineering, The Johns Hopkins University University, Baltimore, MD 21205, USA
    Ann Biomed Eng 26:157-65. 1998
    ..These solutions provide necessary information for the future determination of the OHC elastic properties...
  2. ncbi request reprint Mechanosensitive channels in the lateral wall can enhance the cochlear outer hair cell frequency response
    Alexander A Spector
    Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Traylor 411, Baltimore, MD 21205, USA
    Ann Biomed Eng 33:991-1002. 2005
    ..The effect of the channels is especially significant in an intermediate range of sound frequencies, and the channel-related gain is up to 3-4 times between 3 and 15 kHz...
  3. ncbi request reprint Effectiveness, active energy produced by molecular motors, and nonlinear capacitance of the cochlear outer hair cell
    Alexander A Spector
    Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Traylor 411, Baltimore, Maryland 21205, USA
    J Biomech Eng 127:391-9. 2005
    ..We analyze the cell and motor's effectiveness within a broad range of cellular parameters and estimate it to be within a range of 12%-30%...
  4. ncbi request reprint Effect of outer hair cell piezoelectricity on high-frequency receptor potentials
    Alexander A Spector
    Department of Biomedical Engineering and Center for Computational Medicine and Biology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Acoust Soc Am 113:453-61. 2003
    ..4 mV throughout the whole frequency range. In long cells, we have found that the effect of the piezoelectric properties is much weaker. These results are consistent with major features of the cochlear amplifier...
  5. pmc Simulation of motor-driven cochlear outer hair cell electromotility
    A A Spector
    Department of Biomedical Engineering, Center for Computational Medicine and Biology and Center for Hearing Sciences, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Biophys J 81:11-24. 2001
    ..The motor density has a strong effect on the electromotile strain. Such effect on the active force is significantly lower because of the interplay between the active and passive properties of the cell wall...
  6. ncbi request reprint Mechanical and electromotile characteristics of auditory outer hair cells
    A A Spector
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
    Med Biol Eng Comput 37:247-51. 1999
    ..The obtained estimates provide important information for the modelling of organ-level cochlear mechanics...
  7. ncbi request reprint On the mechanoelectrical coupling in the cochlear outer hair cell
    A A Spector
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Acoust Soc Am 107:1435-41. 2000
    ..The current and the charge transfer caused by the cell stretch under the voltage-clamp conditions is analyzed, and shows good agreement of predictions with experimental data...
  8. ncbi request reprint Nonlinear electroelastic model for the composite outer hair cell wall
    A A Spector
    Department of Biomedical Engineering and Center for Computational Medicine and Biology, Johns Hopkins University, Baltimore, MD 21205, USA
    ORL J Otorhinolaryngol Relat Spec 61:287-93. 1999
    ..As a result, active strains, active forces, and mechanical energy stored in each of the two layers are presented as functions of the wall (membrane) potential...
  9. ncbi request reprint Modeling 3-D deformation of outer hair cells and their production of the active force in the cochlea
    A A Spector
    Department of Biomedical Engineering and Center for Computational Medicine and Biology, Johns Hopkins University, 720 Rutland Ave, Baltimore, MD 21205, USA
    Biomech Model Mechanobiol 1:123-35. 2002
    ..This is different from the experimental conditions in which the active force is usually measured. We estimate the active force as a function of the relative position of the planes, angle of the cell's inclination, and the cell length...
  10. ncbi request reprint Modes and balance of energy in the piezoelectric cochlear outer hair cell wall
    Alexander A Spector
    Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Ave, Baltimore, MD 21205, USA
    J Biomech Eng 126:17-25. 2004
    ..We use the energy balance to introduce and estimate the effectiveness of the cell's electromotile response...
  11. ncbi request reprint Outer hair cell active force generation in the cochlear environment
    Zhijie Liao
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Acoust Soc Am 122:2215-25. 2007
    ..Our findings can provide a better understanding of the outer hair cell's role in the cochlear amplifier...
  12. ncbi request reprint Electromechanical models of the outer hair cell composite membrane
    A A Spector
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Membr Biol 209:135-52. 2006
    ..Despite considerable progress, many problems still confound modelers. Thus, this article will conclude with a discussion of unanswered questions and highlight directions for future research...
  13. ncbi request reprint Effect of voltage-dependent membrane properties on active force generation in cochlear outer hair cell
    Zhijie Liao
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Acoust Soc Am 118:3737-46. 2005
    ..The obtained results can be important for a better understanding of the OHC active force production and the contribution of cell electromotility to the cochlear amplification, sensitivity, and nonlinearity...
  14. ncbi request reprint Modeling high-frequency electromotility of cochlear outer hair cell in microchamber experiment
    Zhijie Liao
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Acoust Soc Am 117:2147-57. 2005
    ..The distribution of the viscous losses inside the fluids was also estimated. The proposed approach can help in a better understanding of the high-frequency OHC electromotility under experimental and physiological conditions...
  15. ncbi request reprint Characterization of the nuclear deformation caused by changes in endothelial cell shape
    Ronald P Jean
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Biomech Eng 126:552-8. 2004
    ....
  16. pmc High-frequency force generation in the constrained cochlear outer hair cell: a model study
    Zhijie Liao
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Assoc Res Otolaryngol 6:378-89. 2005
    ....
  17. ncbi request reprint Nanostructure, effective properties, and deformation pattern of the cochlear outer hair cell cytoskeleton
    Alexander A Spector
    Department of Biomedical Engineering and Center for Computational Medicine and Biology, Johns Hopkins University, Baltimore, MD 21205, USA
    J Biomech Eng 124:180-7. 2002
    ..We discovered a pattern of highly inhomogeneous deformation of the cytoskeleton where the circumferential strain is primarily determined by the deformation of the intermediate material...
  18. ncbi request reprint Finite-element analysis of the adhesion-cytoskeleton-nucleus mechanotransduction pathway during endothelial cell rounding: axisymmetric model
    Ronald P Jean
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Biomech Eng 127:594-600. 2005
    ..This study of endothelial cell mechanobiology suggests the possibility that mechanotransduction could result, in part, from nuclear deformation, and may be relevant to angiogenesis, wound healing, and endothelial barrier dysfunction...
  19. doi request reprint Modeling the mechanics of tethers pulled from the cochlear outer hair cell membrane
    Kristopher R Schumacher
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
    J Biomech Eng 130:031007. 2008
    ..The model's results provide a better understanding of the mechanics of tethers pulled from cell membranes...
  20. ncbi request reprint Computational analysis of the tether-pulling experiment to probe plasma membrane-cytoskeleton interaction in cells
    Kristopher R Schumacher
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 80:041905. 2009
    ..We also present a validation of our model by using experimental data on CHO and HEK cells. The proposed method can be an effective tool in the analyses of experiments to probe the properties of cellular membranes...
  21. pmc Kinetic and mechanical analysis of live tube morphogenesis
    Alan M Cheshire
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Dev Dyn 237:2874-88. 2008
    ....
  22. ncbi request reprint Voltage-induced bending and electromechanical coupling in lipid bilayers
    Ben Harland
    Department of Mechanical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 81:031907. 2010
    ..We also discuss how electromechanical coupling in membranes may influence transmembrane protein function...
  23. pmc Emergent patterns of growth controlled by multicellular form and mechanics
    Celeste M Nelson
    Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:11594-9. 2005
    ..Thus, tissue form is not only a consequence but also an active regulator of tissue growth...
  24. pmc Effects of chlorpromazine on mechanical properties of the outer hair cell plasma membrane
    David R Murdock
    Department of Bioengineering, Rice University, Houston, Texas 77251 1892, USA
    Biophys J 89:4090-5. 2005
    ..The CPZ-induced changes in tether viscoelastic behavior suggest that alterations in the mechanical properties of the OHC lateral wall could play a role in the modulation of OHC electromotility by CPZ...