Paul L Soto

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc A critical examination of best dose analysis for determining cognitive-enhancing potential of drugs: studies with rhesus monkeys and computer simulations
    Paul L Soto
    Division of Behavioral Biology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 228:611-22. 2013
  2. ncbi request reprint Interactions of cocaine with dopamine D₂-like antagonists in squirrel monkeys
    Paul L Soto
    Division of Behavioral Biology, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Suite 3000, Johns Hopkins Bayview Campus, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 226:393-400. 2013
  3. pmc Citalopram enhances cocaine's subjective effects in rats
    Paul L Soto
    Behavioral Biology Research Center, Johns Hopkins University, Baltimore, Maryland 21224 6823, USA
    Behav Pharmacol 20:759-62. 2009
  4. ncbi request reprint Behavioral economics of food reinforcement and the effects of prefeeding, extinction, and eticlopride in dopamine D2 receptor mutant mice
    Paul L Soto
    Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, Johns Hopkins University, Ross 469, 720 Rutland Ave, Baltimore, MD 21205, USA
    Psychopharmacology (Berl) 215:775-84. 2011
  5. pmc Lack of cocaine-like discriminative-stimulus effects of σ-receptor agonists in rats
    Takato Hiranita
    Psychobiology Section, Medications Discovery Research Branch, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Behav Pharmacol 22:525-30. 2011
  6. pmc Stimulants as specific inducers of dopamine-independent σ agonist self-administration in rats
    Takato Hiranita
    Psychobiology Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland T H, G T, T A K, J L K and Behavioral Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland P L S
    J Pharmacol Exp Ther 347:20-9. 2013
  7. pmc Preclinical efficacy of N-substituted benztropine analogs as antagonists of methamphetamine self-administration in rats
    Takato Hiranita
    Psychobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland T H, S J K, G T, T A K, J L K Division of Behavioral Biology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland P L S
    J Pharmacol Exp Ther 348:174-91. 2014
  8. pmc Self-administration of cocaine induces dopamine-independent self-administration of sigma agonists
    Takato Hiranita
    Psychobiology Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Neuropsychopharmacology 38:605-15. 2013
  9. pmc Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine
    Takato Hiranita
    Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 332:515-24. 2010
  10. pmc Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors
    Takato Hiranita
    Psychobiology Section, Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 339:662-77. 2011

Collaborators

Detail Information

Publications13

  1. pmc A critical examination of best dose analysis for determining cognitive-enhancing potential of drugs: studies with rhesus monkeys and computer simulations
    Paul L Soto
    Division of Behavioral Biology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 228:611-22. 2013
    ..Best dose analysis involves identifying the dose associated with the greatest improvement in performance for each subject and comparing performances associated with these individually determined best doses to control performances...
  2. ncbi request reprint Interactions of cocaine with dopamine D₂-like antagonists in squirrel monkeys
    Paul L Soto
    Division of Behavioral Biology, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Suite 3000, Johns Hopkins Bayview Campus, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 226:393-400. 2013
    ..Studies investigating dopamine D₂ receptor antagonism of cocaine's discriminative stimulus effects have resulted in varied effects possibly due to the use of different antagonists, species, and procedures...
  3. pmc Citalopram enhances cocaine's subjective effects in rats
    Paul L Soto
    Behavioral Biology Research Center, Johns Hopkins University, Baltimore, Maryland 21224 6823, USA
    Behav Pharmacol 20:759-62. 2009
    ....
  4. ncbi request reprint Behavioral economics of food reinforcement and the effects of prefeeding, extinction, and eticlopride in dopamine D2 receptor mutant mice
    Paul L Soto
    Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, Johns Hopkins University, Ross 469, 720 Rutland Ave, Baltimore, MD 21205, USA
    Psychopharmacology (Berl) 215:775-84. 2011
    ..Several studies have investigated the reinforcing effects of food in genetically engineered mice lacking dopamine D(2) receptors (DA D(2)Rs); however, behavioral economic analyses quantifying reinforcement have not been conducted...
  5. pmc Lack of cocaine-like discriminative-stimulus effects of σ-receptor agonists in rats
    Takato Hiranita
    Psychobiology Section, Medications Discovery Research Branch, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Behav Pharmacol 22:525-30. 2011
    ..The previously found differences in neurochemical effects of cocaine and σR agonists may contribute to their different subjective effects...
  6. pmc Stimulants as specific inducers of dopamine-independent σ agonist self-administration in rats
    Takato Hiranita
    Psychobiology Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland T H, G T, T A K, J L K and Behavioral Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland P L S
    J Pharmacol Exp Ther 347:20-9. 2013
    ..It is further suggested that induced σ1R reinforcing mechanisms may play an essential role in treatment-resistant stimulant abuse, suggesting new approaches for the development of effective medications for its treatment. ..
  7. pmc Preclinical efficacy of N-substituted benztropine analogs as antagonists of methamphetamine self-administration in rats
    Takato Hiranita
    Psychobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland T H, S J K, G T, T A K, J L K Division of Behavioral Biology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland P L S
    J Pharmacol Exp Ther 348:174-91. 2014
    ....
  8. pmc Self-administration of cocaine induces dopamine-independent self-administration of sigma agonists
    Takato Hiranita
    Psychobiology Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Neuropsychopharmacology 38:605-15. 2013
    ..It is further suggested that induced σ(1)R mechanisms may have an essential role in treatment-resistant stimulant abuse, suggesting new approaches for the development of effective medications for stimulant abuse...
  9. pmc Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine
    Takato Hiranita
    Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 332:515-24. 2010
    ....
  10. pmc Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors
    Takato Hiranita
    Psychobiology Section, Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 339:662-77. 2011
    ..These findings suggest that the unique effects of rimcazole analogs are due to dual actions at the DAT and σRs and that a combined target approach may have utility in development of medical treatments for cocaine abuse...
  11. pmc Long-term exposure to oral methylphenidate or dl-amphetamine mixture in peri-adolescent rhesus monkeys: effects on physiology, behavior, and dopamine system development
    Paul L Soto
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neuropsychopharmacology 37:2566-79. 2012
    ..Thus, methylphenidate and amphetamine at therapeutic blood/plasma levels during peri-adolescence in non-human primates have little effect on physiological or behavioral/cognitive development...
  12. pmc Allosteric modulation of GABA(A) receptor subtypes:effects on visual recognition and visuospatial working memory in rhesus monkeys [corrected]
    Paul L Soto
    Division of Behavioral Biology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neuropsychopharmacology 38:2315-25. 2013
    ....
  13. pmc Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors
    Takato Hiranita
    Psychobiology Section, Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 329:677-86. 2009
    ..These findings further support the low abuse liability of BZT analogs and their potential development as medications for cocaine abuse...