L J Sokoll

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Short-term stability of the molecular forms of prostate-specific antigen and effect on percent complexed prostate-specific antigen and percent free prostate-specific antigen
    Lori J Sokoll
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore Maryland 21287, USA
    Urology 60:24-30. 2002
  2. ncbi request reprint Measurement of parathyroid hormone and application of parathyroid hormone in intraoperative monitoring
    Lori J Sokoll
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Clin Lab Med 24:199-216. 2004
  3. ncbi request reprint Complexed prostate-specific antigen as a staging tool for prostate cancer: a prospective study in 420 men
    Lori J Sokoll
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 60:18-23. 2002
  4. pmc [-2]proenzyme prostate specific antigen for prostate cancer detection: a national cancer institute early detection research network validation study
    Lori J Sokoll
    Departments of Pathology and Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 180:539-43; discussion 543. 2008
  5. ncbi request reprint Intraoperative parathyroid hormone analysis: A study of 200 consecutive cases
    L J Sokoll
    Departments of Pathology and Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Chem 46:1662-8. 2000
  6. ncbi request reprint Multicenter analytical performance evaluation of the Elecsys proBNP assay
    Lori J Sokoll
    Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Chem Lab Med 42:965-72. 2004
  7. pmc A prospective, multicenter, National Cancer Institute Early Detection Research Network study of [-2]proPSA: improving prostate cancer detection and correlating with cancer aggressiveness
    Lori J Sokoll
    Department of Pathology, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Meyer B 125, Baltimore, MD 21287, USA
    Cancer Epidemiol Biomarkers Prev 19:1193-200. 2010
  8. ncbi request reprint Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients
    Y Wang
    Department of Pathology, Johns Hopkins Medical Institutions, 600 N. Wolfe Street/Meyer B-121, Baltimore, MD 21287, USA
    Cancer Lett 167:99-104. 2001
  9. ncbi request reprint Evaluation of pregnancy-associated plasma protein A as a prognostic indicator in acute coronary syndrome patients
    Omar F Laterza
    Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe St Meyer B125, Baltimore, MA 21287, USA
    Clin Chim Acta 348:163-9. 2004
  10. ncbi request reprint Evaluation of the clinical performance of equimolar- and skewed-response total prostate-specific antigen assays versus complexed and free PSA assays and their ratios in discriminating between benign prostatic hyperplasia and prostate cancer
    Frank H Wians
    Department of Pathology, The University of Texas Southwestern Medical Center, 193 Dallas, TX, USA
    Clin Chim Acta 326:81-95. 2002

Detail Information

Publications64

  1. ncbi request reprint Short-term stability of the molecular forms of prostate-specific antigen and effect on percent complexed prostate-specific antigen and percent free prostate-specific antigen
    Lori J Sokoll
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore Maryland 21287, USA
    Urology 60:24-30. 2002
    ..Thus, specimen handling should be considered when interpreting PSA results. It is recommended that specimens not analyzed the same day (within 8 hours of collection) be stored frozen at -20 degrees C...
  2. ncbi request reprint Measurement of parathyroid hormone and application of parathyroid hormone in intraoperative monitoring
    Lori J Sokoll
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Clin Lab Med 24:199-216. 2004
    ..The clinical laboratory will continue to play a vital role in providing testing and support for this important mediator of mineral metabolism...
  3. ncbi request reprint Complexed prostate-specific antigen as a staging tool for prostate cancer: a prospective study in 420 men
    Lori J Sokoll
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 60:18-23. 2002
    ..985). In summary, cPSA was equivalent to total PSA in predicting organ-confined disease. Present and future models and nomograms using PSA as an indicator of pathological stage could consider use of cPSA...
  4. pmc [-2]proenzyme prostate specific antigen for prostate cancer detection: a national cancer institute early detection research network validation study
    Lori J Sokoll
    Departments of Pathology and Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 180:539-43; discussion 543. 2008
    ..This study evaluated the [-2]proenzyme prostate specific antigen serum marker using a blinded reference specimen set from 3 National Cancer Institute Early Detection Research Network centers from men with an indication for prostate biopsy...
  5. ncbi request reprint Intraoperative parathyroid hormone analysis: A study of 200 consecutive cases
    L J Sokoll
    Departments of Pathology and Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Chem 46:1662-8. 2000
    ..The purpose of this study was to evaluate the analytical performance of a rapid PTH assay and its clinical performance in a series of 200 patients...
  6. ncbi request reprint Multicenter analytical performance evaluation of the Elecsys proBNP assay
    Lori J Sokoll
    Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Chem Lab Med 42:965-72. 2004
    ..In summary, the Elecsys proBNP assay exhibits good technical performance and is suitable for use in routine clinical laboratories to aid in the diagnosis of congestive heart failure...
  7. pmc A prospective, multicenter, National Cancer Institute Early Detection Research Network study of [-2]proPSA: improving prostate cancer detection and correlating with cancer aggressiveness
    Lori J Sokoll
    Department of Pathology, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Meyer B 125, Baltimore, MD 21287, USA
    Cancer Epidemiol Biomarkers Prev 19:1193-200. 2010
    ..The study objective was to characterize the clinical utility of serum [-2]proPSA for prostate cancer detection and assess its association with aggressive disease...
  8. ncbi request reprint Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients
    Y Wang
    Department of Pathology, Johns Hopkins Medical Institutions, 600 N. Wolfe Street/Meyer B-121, Baltimore, MD 21287, USA
    Cancer Lett 167:99-104. 2001
    ..39+/-0.35 units/l) compared with healthy subjects (0.27+/-0.02 units/l, P<0.05). Taken together, our data suggest that FAS expression may be a useful tumor marker for breast cancer and play a role in assessing cancer virulence...
  9. ncbi request reprint Evaluation of pregnancy-associated plasma protein A as a prognostic indicator in acute coronary syndrome patients
    Omar F Laterza
    Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe St Meyer B125, Baltimore, MA 21287, USA
    Clin Chim Acta 348:163-9. 2004
    ..Our goal was to determine the ability of circulating concentrations of PAPP-A to predict adverse events in patients presenting to the Emergency Department (ED) with symptoms of ACS...
  10. ncbi request reprint Evaluation of the clinical performance of equimolar- and skewed-response total prostate-specific antigen assays versus complexed and free PSA assays and their ratios in discriminating between benign prostatic hyperplasia and prostate cancer
    Frank H Wians
    Department of Pathology, The University of Texas Southwestern Medical Center, 193 Dallas, TX, USA
    Clin Chim Acta 326:81-95. 2002
    ..The advantages of EMR over SKR tPSA assays are controversial...
  11. ncbi request reprint Serum acid phosphatase level and biochemical recurrence following radical prostatectomy for men with clinically localized prostate cancer
    M Han
    Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 57:707-11. 2001
    ..Proportional hazards modeling using preoperative variables demonstrated that the serum ACP level is an independent predictor of tumor recurrence following RRP...
  12. pmc One hundred consecutive minimally invasive parathyroid explorations
    R Udelsman
    Departments of Surgery and Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Surg 232:331-9. 2000
    ..To review the outcomes of 100 consecutive minimally invasive parathyroid explorations...
  13. ncbi request reprint Unusually high concentrations of cTnI and cTnT in a patient with catastrophic antiphospholipid antibody syndrome
    Omar F Laterza
    Department of Pathology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Meyer B125, Baltimore, MD 21287, USA
    Clin Chim Acta 337:173-6. 2003
    ..The degree of their elevation, in the context of the chronic autoimmune condition of the patient, elicited a thorough investigation for the presence of interfering antibodies...
  14. ncbi request reprint Proenzyme psa for the early detection of prostate cancer in the 2.5-4.0 ng/ml total psa range: preliminary analysis
    Lori J Sokoll
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Urology 61:274-6. 2003
    ..5 to 4.0 ng/mL total PSA range. pPSA, the precursor form of PSA that contains a 7 amino acid leader peptide, and truncated forms such as [-2]pPSA and [-4]pPSA can be measured in serum by research immunoassay...
  15. ncbi request reprint Serum leptin and pathological findings at the time of radical prostatectomy
    Stephen J Freedland
    James Buchanan Brady Urological Institute and the Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 173:773-6. 2005
    ..Obese men have higher serum leptin, a hormone produced by adipocytes, which has also been shown to be an in vitro prostate cancer growth factor. We examined whether serum leptin correlates with advanced pathological findings at RP...
  16. ncbi request reprint Prostate-specific antigen (PSA) protein does not affect growth of prostate cancer cells in vitro or prostate cancer xenografts in vivo
    Samuel R Denmeade
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Prostate 56:45-53. 2003
    ..Recent data also suggest that the PSA protein itself, independent of enzymatic activity, may also function as an endothelial cell-specific inhibitor of angiogenesis...
  17. ncbi request reprint Assessment of BNP and NT-proBNP in emergency department patients presenting with suspected acute coronary syndromes
    Scott J Cameron
    Clinical Chemistry Division, Department of Pathology, Johns Hopkins Medical Institutions, Meyer B 121, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Clin Biochem 39:11-8. 2006
    ..The relationship between BNP and NT-proBNP among physiologically and clinically relevant demographic subgroups has never been clarified in the context of the emergency department (ED)...
  18. ncbi request reprint Association between serum adiponectin, and pathological stage and grade in men undergoing radical prostatectomy
    Stephen J Freedland
    The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    J Urol 174:1266-70. 2005
    ..Obesity has been associated with advanced stage and a higher risk of biochemical progression following radical prostatectomy (RP) in several series. We examined whether serum adiponectin is associated with advanced disease stage at RP...
  19. ncbi request reprint Evaluation of proprostate specific antigen for early detection of prostate cancer in men with a total prostate specific antigen range of 4.0 to 10.0 ng/ml
    Masood A Khan
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Urol 170:723-6. 2003
    ..There is increasing evidence that proPSA is associated preferentially with prostate cancer. The objective of this study was to determine whether proPSA can influence the detection of early prostate cancer...
  20. pmc Cytokine profiling of prostatic fluid from cancerous prostate glands identifies cytokines associated with extent of tumor and inflammation
    Kazutoshi Fujita
    The Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA
    Prostate 68:872-82. 2008
    ..In order to better understand the relationship between cytokines and prostate cancer, we profiled cytokines in prostatic fluids obtained from cancerous prostate glands and correlated them to both cancer status and inflammatory grade...
  21. ncbi request reprint Dissociation between androgen responsiveness for malignant growth vs. expression of prostate specific differentiation markers PSA, hK2, and PSMA in human prostate cancer models
    Samuel R Denmeade
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Prostate 54:249-57. 2003
    ..regulation of expression of prostate differentiation specific markers PSA, hK2, and PSMA...
  22. ncbi request reprint A multi-marker approach for the prediction of adverse events in patients with acute coronary syndromes
    Scott J Cameron
    Department of Pathology, Clinical Chemistry Division, Johns Hopkins Medical Institutions, 600 N Wolfe Street, Baltimore, MD 21287, United States
    Clin Chim Acta 376:168-73. 2007
    ..We evaluated the prognostic performance of each of these markers, individually, and in combination in patients presenting to the emergency department (ED) with ACS symptoms...
  23. ncbi request reprint Complexed prostate-specific antigen for the diagnosis of biochemical recurrence after radical prostatectomy
    J Kellogg Parsons
    James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institution, Baltimore, MD, USA
    BJU Int 99:758-61. 2007
    ..To determine the validity of using complexed prostate-specific antigen (cPSA) levels for diagnosing biochemical recurrence after radical prostatectomy (RP)...
  24. ncbi request reprint Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer
    Zhen Zhang
    Department of Pathology, Biomarker Discovery Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 64:5882-90. 2004
    ..These biomarkers demonstrated the potential to improve the detection of early stage ovarian cancer...
  25. pmc Glycoproteomics for prostate cancer detection: changes in serum PSA glycosylation patterns
    Danni L Meany
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Proteome Res 8:613-9. 2009
    ..71) appeared to perform better than percent free PSA (AUC = 0.54) in its diagnostic gray zone between 10 and 20% in a subset of 21 subjects. A separate study of 16 additional subjects showed similar findings...
  26. ncbi request reprint Comparison of predictive accuracy for pathologically organ confined clinical stage T1c prostate cancer using human glandular kallikrein 2 and prostate specific antigen combined with clinical stage and Gleason grade
    Alexander Haese
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 173:752-6. 2005
    ..Now we evaluated the usefulness of hK2, as measured by 2 entirely different immunoassay designs, to enhance the discrimination of pathologically organ from nonorgan confined clinical stage T1c PCa...
  27. ncbi request reprint N-terminal pro-brain natriuretic peptide is a useful diagnostic marker for transfusion-associated circulatory overload
    Aaron A R Tobian
    Transfusion Medicine Division and Clinical Chemistry Division, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Transfusion 48:1143-50. 2008
    ..In this study, whether NT-proBNP is a useful diagnostic marker for TACO was evaluated...
  28. ncbi request reprint Predicting prostate cancer biochemical recurrence using a panel of serum proteomic biomarkers
    C Nicole Rosenzweig
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 181:1407-14. 2009
    ..We hypothesized that biomarkers are present in preoperative serum, which may be used to predict the probability of biochemical recurrence following radical prostatectomy...
  29. ncbi request reprint Clinical evaluation of the Elecsys total prostate-specific antigen assay on the Elecsys 1010 and 2010 systems
    Alexander Haese
    The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Clin Chem 48:944-7. 2002
  30. ncbi request reprint Quantification of fragments of human serum inter-alpha-trypsin inhibitor heavy chain 4 by a surface-enhanced laser desorption/ionization-based immunoassay
    Jin Song
    Center for Biomarker Discovery, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Clin Chem 52:1045-53. 2006
    ....
  31. ncbi request reprint Standardization of two immunoassays for human glandular kallikrein 2
    Alexander Haese
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21287, USA
    Clin Chem 49:601-10. 2003
    ..We compared two hK2 assays and five different recombinant hK2 variants (rhK2) and suggest a common calibrator as an important step and putative reference substance in hK2 assay standardization...
  32. ncbi request reprint Proteomic approaches to tumor marker discovery
    Alex J Rai
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Arch Pathol Lab Med 126:1518-26. 2002
    ..High-throughput proteomic profiling and bioinformatics tools allow for the rapid screening of a large number of potential biomarkers in serum, plasma, or other body fluids...
  33. ncbi request reprint Initial analyses of colon cancer-specific antigen (CCSA)-3 and CCSA-4 as colorectal cancer-associated serum markers
    Eddy S Leman
    The Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Res 67:5600-5. 2007
    ..ROC curves for CCSA-3 and CCSA-4 reveal an area under the curve of 0.94 (95% CI, 0.90-0.98%). In these initial analyses, CCSA-3 and CCSA-4 show promise as potential serum markers for detection of colorectal cancer and advanced adenomas...
  34. ncbi request reprint Assessment of plasma DNA levels, allelic imbalance, and CA 125 as diagnostic tests for cancer
    Hsueh Wei Chang
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Natl Cancer Inst 94:1697-703. 2002
    ..AI can be detected in genomic tumor DNA released into the blood after necrosis or apoptosis. We evaluated plasma DNA concentration, allelic status in plasma DNA, and serum CA 125 level as screening tests for ovarian and other cancers...
  35. ncbi request reprint Bone to total alkaline phosphatase ratios improve sensitivity and specificity of bone alkaline phosphatase immunoassays
    L J Sokoll
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Biochem 30:625-9. 1997
    ..Evaluate the ability of two bone alkaline phosphatase (ALPB) immunoassays (Ostase, Hybritech Inc and Alkphase-B, Metra Biosystems) to clinically differentiate between osseous and non-osseous ALP sources...
  36. doi request reprint Evaluation of colon cancer-specific antigen 2 as a potential serum marker for colorectal cancer
    Eddy S Leman
    The Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Clin Cancer Res 14:1349-54. 2008
    ..CCSA-2 is a distinct novel colon cancer marker identified using focused proteomics...
  37. ncbi request reprint A new model ELISA, based on two monoclonal antibodies, for quantification of fatty acid synthase
    Young Y Wang
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Immunoassay Immunochem 23:279-92. 2002
    ..In summary, this monoclonal-monoclonal FAS-ELISA is sensitive, accurate, and precise in quantification of fatty acid synthase and has potential as a complementary tool in testing clinical samples...
  38. doi request reprint Accuracy of PCA3 measurement in predicting short-term biopsy progression in an active surveillance program
    Jeffrey J Tosoian
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 183:534-8. 2010
    ..We assessed the relationship between PCA3 and prostate biopsy results in men in a surveillance program...
  39. ncbi request reprint Assessing tumors in living animals through measurement of urinary beta-human chorionic gonadotropin
    I M Shih
    The Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Med 6:711-4. 2000
  40. ncbi request reprint Concentration of enzymatically active prostate-specific antigen (PSA) in the extracellular fluid of primary human prostate cancers and human prostate cancer xenograft models
    S R Denmeade
    The Johns Hopkins Oncology Center, Bunting Blaustein Cancer Research Building, Baltimore, Maryland 21231, USA
    Prostate 48:1-6. 2001
    ..Prostate-specific antigen (PSA) targeted prodrugs are under development in our laboratory. Concentrations of total PSA and enzymatically active PSA produced by various human prostate cancer xenograft models have not been well characterized...
  41. ncbi request reprint Human immunodeficiency virus load in breast milk, mastitis, and mother-to-child transmission of human immunodeficiency virus type 1
    R D Semba
    Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    J Infect Dis 180:93-8. 1999
    ..0001). Mastitis and breast milk HIV-1 load may increase the risk of vertical transmission of HIV-1 through breast-feeding...
  42. ncbi request reprint Rapid intraoperative immunoassay of parathyroid hormone and other hormones: a new paradigm for point-of-care testing
    Lori J Sokoll
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Chem 50:1126-35. 2004
    ..These modifications also allowed the assay to be performed in or near the operating suite...
  43. ncbi request reprint A multicenter evaluation of the PCA3 molecular urine test: pre-analytical effects, analytical performance, and diagnostic accuracy
    Lori J Sokoll
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Chim Acta 389:1-6. 2008
    ..Measurement of prostate cancer gene 3 (PCA3) mRNA normalized to prostate-specific antigen (PSA) mRNA in urine has been proposed as a marker for prostate cancer...
  44. ncbi request reprint Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers
    Jens Koopmann
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Clin Cancer Res 10:2386-92. 2004
    ..In this study, we evaluated serum macrophage inhibitory cytokine-1 (MIC-1) as a marker of pancreatic cancer...
  45. ncbi request reprint Comparison of total prostate-specific antigen and derivative levels in a screening population of black, white, and Korean-American men
    Jae Park
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Marburg 409, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Clin Prostate Cancer 2:173-6. 2003
    ..In a contemporary screening population comparing tPSA, percentage of fPSA, and percentage of cPSA levels in 3 races, there were no significant differences identified among the groups...
  46. ncbi request reprint Role of notch-1 and E-cadherin in the differential response to calcium in culturing normal versus malignant prostate cells
    Susan Dalrymple
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and Departments of Urology and Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21231 1000, USA
    Cancer Res 65:9269-79. 2005
    ..These characteristic changes are consistent with prostate cancer cells' ability to metastasize to bone, a site of high-Ca2+ levels...
  47. ncbi request reprint Clinical utility of proPSA and "benign" PSA when percent free PSA is less than 15%
    Masood A Khan
    Department of Urology, James Buchanan Brady Urological Institute and the Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21287 2101, USA
    Urology 64:1160-4. 2004
    ..A low percent free PSA value indicates a greater risk of cancer, but only 30% to 50% of men with percent free PSA levels of less than 15% actually have cancer at biopsy...
  48. ncbi request reprint EPCA-2: a highly specific serum marker for prostate cancer
    Eddy S Leman
    Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Urology 69:714-20. 2007
    ..To describe the initial assessment of early prostate cancer antigen (EPCA)-2 as a serum marker for the detection of prostate cancer and to examine its sensitivity and specificity...
  49. doi request reprint Retroperitoneal masses with associated human chorionic gonadotropin production: Report of two cases
    Amy S Duffield
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Chim Acta 395:166-9. 2008
    ..The production of human chorionic gonadotropin (hCG) can be stimulated by both pregnancy and malignancy...
  50. ncbi request reprint Sexually transmitted infections and prostatic inflammation/cell damage as measured by serum prostate specific antigen concentration
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Urol 175:1937-42. 2006
    ..We indirectly investigated this question by measuring serum PSA, a possible marker of prostatic inflammation and cell damage, in men with documented STIs...
  51. doi request reprint Interference in clinical chemistry assays by the hemoglobin-based oxygen carrier, Hemospan
    Scott J Cameron
    Department of Pathology, Clinical Chemistry Division, Johns Hopkins Medical Institutions, Meyer B 125 600 N Wolfe Street, Baltimore, MD 21287, USA
    Clin Biochem 42:221-4. 2009
    ..To evaluate interference by the hemoglobin-based oxygen carrier Hemospan on clinical laboratory assays...
  52. ncbi request reprint Analytical performance of 4 automated assays for measurement of cystatin C
    Jinong Li
    Division of Clinical Chemistry, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Chem 56:1336-9. 2010
    ....
  53. ncbi request reprint Fatty acid synthase as a tumor marker: its extracellular expression in human breast cancer
    Young Y Wang
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Exp Ther Oncol 4:101-10. 2004
    ..In comparison with CA27.29, no correlation between these two tumor markers was found. Thus, the extracellular FAS may serve as a potential diagnostic and prognostic marker...
  54. ncbi request reprint Dysprealbuminemic hyperthyroxinemia in a patient with hyperthyroid graves disease
    Scott J Cameron
    Clinical Chemistry Division, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287 0003, USA
    Clin Chem 51:1065-9. 2005
    ..These findings indicate that hypothyroidism can be masked by coexisting euthyroid dysprealbuminemic hyperthyroxinemia...
  55. ncbi request reprint Increased plasma DNA integrity in cancer patients
    Brant G Wang
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 63:3966-8. 2003
    ..59. Our findings suggest that increased DNA integrity in plasma DNA is associated with cancer, and measurement of DNA integrity may provide a simple and inexpensive measure for cancer detection...
  56. ncbi request reprint Complexed prostate-specific antigen for early detection of prostate cancer in men with serum prostate-specific antigen levels of 2 to 4 nanograms per milliliter
    Wolfgang Horninger
    Department of Urology, University of Innsbruck, Austria
    Urology 60:31-5. 2002
    ..The use of cPSA as a single test was found to enhance detection of prostate cancer over that of testing with tPSA and PSA ratios in men with tPSA values in the range of 2 to 4 ng/mL...
  57. ncbi request reprint Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility
    O John Semmes
    Department of Microbiology and Molecular Cell Biology, Virginia Prostate Center, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Clin Chem 51:102-12. 2005
    ..This report describes the first stage of a National Cancer Institute/Early Detection Research Network-sponsored multiinstitutional evaluation and validation of this approach for detection of prostate cancer...
  58. ncbi request reprint Volume indexes of total, free, and complexed prostate-specific antigen enhance prediction of extraprostatic disease extension in men with nonpalpable prostate cancer
    Yoshio Naya
    Department of Urology, University of Texas M D Anderson Cancer Center, Houston 77030 4095, USA
    Urology 62:1058-62. 2003
    ..To analyze the ability of volume-adjusted total, complexed, and free prostate-specific antigen (PSA) to predict organ-confined cancer at radical prostatectomy in patients with nonpalpable disease...
  59. ncbi request reprint Total, free and complexed PSA and hK2 for early detection of prostate cancer
    Alexander Haese
    University Clinic Eppendorf, Hamburg, Germany
    MLO Med Lab Obs 35:14-6, 20, 22 passim; quiz 30-1. 2003
  60. ncbi request reprint Comparative analysis of complexed prostate specific antigen, free prostate specific antigen and their ratio in detecting prostate cancer
    Koji Okihara
    University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    J Urol 167:2017-23; discussion 2023-4. 2002
    ..We evaluate the diagnostic use of total, free and complexed serum prostate specific antigen (PSA), and their ratios for enhancing the specificity in detecting prostate cancer...
  61. ncbi request reprint Complexed prostate-specific antigen as a staging tool: results based on a multicenter prospective evaluation of complexed prostate-specific antigen in cancer diagnosis
    Samir S Taneja
    Department of Urology, New York University School of Medicice, NY, USA
    Urology 60:10-7. 2002
    ..Therefore, cPSA could be applied as an accurate predictor of ECE independently or in a nomogram along with other predictive variables...
  62. ncbi request reprint Can volume measurement of the prostate enhance the performance of complexed prostate-specific antigen?
    Yoshio Naya
    Department of Urology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Urology 60:36-41. 2002
    ..05). In the 109 men with a total prostate volume of <30 cm(3), at 90% sensitivity the specificity of cPSA and cPSAD was better than that of percent fPSA. In conclusion, volume-based cPSA can modestly enhance the performance of cPSA...
  63. pmc Rapid parathyroid hormone analysis during venous localization
    Robert Udelsman
    Department of Surgery, Yale University School of Medicine, Yale New Haven Hospital, 330 Cedar Street, New Haven, CT 06520 8062, USA
    Ann Surg 237:714-9; discussion 719-21. 2003
    ..To determine the usefulness of the rapid parathyroid hormone (PTH) assay during venous localization for primary hyperparathyroidism (1 degrees HPTH)...
  64. ncbi request reprint Clinical evaluation of the Elecsys CA 15-3 test in breast cancer patients
    Petra Stieber
    Klinikum der Universitat Munchen Grosshadern, Institut fur Klinische Chemie, Munich, Germany
    Clin Lab 49:15-24. 2003
    ..The findings indicate that the Elecsys CA 15-3 assay is very suitable in routine work for detection of recurrences as well as for therapy control in metastatic breast cancer...