Debasish Sinha

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc βA3/A1-Crystallin controls anoikis-mediated cell death in astrocytes by modulating PI3K/AKT/mTOR and ERK survival pathways through the PKD/Bit1-signaling axis
    B Ma
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cell Death Dis 2:e217. 2011
  2. pmc βA3/A1-crystallin is required for proper astrocyte template formation and vascular remodeling in the retina
    Debasish Sinha
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD, 21231, USA
    Transgenic Res 21:1033-42. 2012
  3. ncbi request reprint betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development
    Debasish Sinha
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Bunting Blaustein Cancer Research Building II, 1550 Orleans St, Room 146, Baltimore, MD 21231, USA
    Mol Cell Neurosci 37:85-95. 2008
  4. ncbi request reprint A spontaneous mutation affects programmed cell death during development of the rat eye
    Debasish Sinha
    Department of Ophthalmology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    Exp Eye Res 80:323-35. 2005
  5. ncbi request reprint A potential role for beta- and gamma-crystallins in the vascular remodeling of the eye
    Cheng Zhang
    Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Dev Dyn 234:36-47. 2005
  6. pmc Impaired endolysosomal function disrupts Notch signalling in optic nerve astrocytes
    Mallika Valapala
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Nat Commun 4:1629. 2013
  7. ncbi request reprint The effect of nerve growth factor on corneal sensitivity after laser in situ keratomileusis
    Myung Jin Joo
    Wilmer Eye Institute, The Johns Hopkins Hospital, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Arch Ophthalmol 122:1338-41. 2004
  8. pmc A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye
    Cheng Zhang
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA
    Eur J Cell Biol 90:440-8. 2011
  9. pmc Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat
    J Samuel Zigler
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Cell Sci 124:523-31. 2011
  10. doi request reprint VEGF 165 b in the developing vasculatures of the fetal human eye
    Takayuki Baba
    Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Dev Dyn 241:595-607. 2012

Collaborators

Detail Information

Publications16

  1. pmc βA3/A1-Crystallin controls anoikis-mediated cell death in astrocytes by modulating PI3K/AKT/mTOR and ERK survival pathways through the PKD/Bit1-signaling axis
    B Ma
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cell Death Dis 2:e217. 2011
    ..We propose that βA3/A1-crystallin is a novel regulator of both life and death decisions in ocular astrocytes...
  2. pmc βA3/A1-crystallin is required for proper astrocyte template formation and vascular remodeling in the retina
    Debasish Sinha
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD, 21231, USA
    Transgenic Res 21:1033-42. 2012
    ....
  3. ncbi request reprint betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development
    Debasish Sinha
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Bunting Blaustein Cancer Research Building II, 1550 Orleans St, Room 146, Baltimore, MD 21231, USA
    Mol Cell Neurosci 37:85-95. 2008
    ..Our data implicate betaA3/A1-crystallin as an important regulatory factor mediating vascular patterning and remodeling in the retina...
  4. ncbi request reprint A spontaneous mutation affects programmed cell death during development of the rat eye
    Debasish Sinha
    Department of Ophthalmology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    Exp Eye Res 80:323-35. 2005
    ..The transient layer of Chievitz persists in adult Nuc1 retina, indicative of delayed development. Hence, Nuc1 is a novel mutation that could be an eye-specific regulator of apoptosis...
  5. ncbi request reprint A potential role for beta- and gamma-crystallins in the vascular remodeling of the eye
    Cheng Zhang
    Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Dev Dyn 234:36-47. 2005
    ..Interestingly, in human PFV (persistent fetal vasculature) disease, where the hyaloid vasculature abnormally persists after birth, we show that astrocytes express both VEGF and crystallins...
  6. pmc Impaired endolysosomal function disrupts Notch signalling in optic nerve astrocytes
    Mallika Valapala
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Nat Commun 4:1629. 2013
    ..We postulate that βA3/A1-crystallin is essential for normal endolysosomal acidification, and thereby, normal activation of Notch signalling in astrocytes...
  7. ncbi request reprint The effect of nerve growth factor on corneal sensitivity after laser in situ keratomileusis
    Myung Jin Joo
    Wilmer Eye Institute, The Johns Hopkins Hospital, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Arch Ophthalmol 122:1338-41. 2004
    ..To determine if topically administered nerve growth factor (NGF) plays a role in accelerating the recovery of corneal sensitivity after laser in situ keratomileusis (LASIK)...
  8. pmc A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye
    Cheng Zhang
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA
    Eur J Cell Biol 90:440-8. 2011
    ..This abnormal association of astrocytes with the hyaloid artery may impede the normal macrophage-mediated remodeling and regression of the hyaloid system...
  9. pmc Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat
    J Samuel Zigler
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Cell Sci 124:523-31. 2011
    ..A3/A1-crystallin is a novel lysosomal protein in RPE, essential for degradation of phagocytosed material...
  10. doi request reprint VEGF 165 b in the developing vasculatures of the fetal human eye
    Takayuki Baba
    Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Dev Dyn 241:595-607. 2012
    ..The localization of VEGF(165) b was distinctly different from VEGF(165) both spatially and temporally and it was often associated with nucleus in progenitors...
  11. pmc Expression of βA3/A1-crystallin in the developing and adult rat eye
    Geetha Parthasarathy
    Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 N Broadway, Smith Research Building, M035, Baltimore, MD 21287, USA
    J Mol Histol 42:59-69. 2011
    ....
  12. ncbi request reprint A novel rat model to study the functions of macrophages during normal development and pathophysiology of the eye
    Stacey Hose
    Department of Ophthalmology, School of Medicine, The Johns Hopkins University, 600 North Wolfe Street Jefferson 3 127A, Baltimore, MD 21287, USA
    Immunol Lett 96:299-302. 2005
    ..Inflammation is known to have an enhanced influx of phagocytic cells. Our data suggests that subpopulations of macrophages perform distinct functions in inducing apoptosis and phagocytic activity during normal conditions and in disease...
  13. ncbi request reprint Comparative efficacy of topical gatifloxacin with ciprofloxacin, amikacin, and clarithromycin in the treatment of experimental Mycobacterium chelonae keratitis
    Joon Young Hyon
    Ocular Microbiology and Immunology Laboratory, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 9121, USA
    Arch Ophthalmol 122:1166-9. 2004
    ..To determine the comparative efficacy of topical gatifloxacin with ciprofloxacin, fortified amikacin, and clarithromycin against Mycobacterium chelonae keratitis in an animal model...
  14. ncbi request reprint Neuroprotection of photoreceptors by minocycline in light-induced retinal degeneration
    Cheng Zhang
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9238, USA
    Invest Ophthalmol Vis Sci 45:2753-9. 2004
    ..This study was conducted to evaluate the neuroprotective effect of minocycline and the role of microglia in light-induced retinal degeneration...
  15. doi request reprint Cannabinoid receptors in conjunctival epithelium: identification and functional properties
    María Iribarne
    Facultad de Ciencias Biomedicas, Universidad Austral, Pilar, Buenos Aires, Argentina
    Invest Ophthalmol Vis Sci 49:4535-44. 2008
    ..The endocannabinoid system may be regulating these processes. Therefore, the authors explored the presence and properties of cannabinoid receptors (CB1 and CB2) in conjunctival epithelial cells...
  16. ncbi request reprint Downregulation of class II transactivator (CIITA) expression by synthetic cannabinoid CP55,940
    Celine Gongora
    Institut de Biotechnologie et Pharmacologie, CNRS UMR 5094, Montpellier, Cedex 5, France
    Immunol Lett 91:11-6. 2004
    ..These data suggests that cannabinoids affect MHC class II expression through actions on CIITA at the transcriptional level...

Research Grants7

  1. MODULATION OF CIITA BY CANNABINOIDS IN HUMAN MICROGLIA
    Debasish Sinha; Fiscal Year: 2004
    ..Microglia form the first line of defense during infection in the CNS and are involved in various immune diseases including AIDS. ..
  2. A novel bA3/A1-crystallin gene mutation results in persistent fetal vasculature
    Debasish Sinha; Fiscal Year: 2010
    ..Our data (published and unpublished) indicate that mutant 2A3/A1-crystallin plays a role in PFV. The proposed studies may help elucidate mechanisms underlying PFV that would have potential therapeutic implications. ..
  3. A novel bA3/A1-crystallin gene mutation results in persistent fetal vasculature
    Debasish Sinha; Fiscal Year: 2009
    ..Our data (published and unpublished) indicate that mutant 2A3/A1-crystallin plays a role in PFV. The proposed studies may help elucidate mechanisms underlying PFV that would have potential therapeutic implications. ..
  4. A novel bA3/A1-crystallin gene mutation results in persistent fetal vasculature
    Debasish Sinha; Fiscal Year: 2009
    ..Our data (published and unpublished) indicate that ?A3/A1- crystallin plays a role in PFV. The proposed studies may help elucidate mechanisms that lead to PFV and would have potential therapeutic implications. ..
  5. A CRYSTALLIN MUTATION WITH ABNORMAL ASTROCYTES AND RETINAL VESSELS
    Debasish Sinha; Fiscal Year: 2010
    ..We believe that studies on the Nuc1 rat will provide new insights into the cellular and molecular mechanisms that regulate vascular development including the molecular interactions among neurons, astrocytes and endothelial cells. ..