H S Singer

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Antineuronal antibodies in OCD: comparisons in children with OCD-only, OCD+chronic tics and OCD+PANDAS
    Colin Gause
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
    J Neuroimmunol 214:118-24. 2009
  2. ncbi request reprint The treatment of tics
    H S Singer
    Departments of Neurology and Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Harvey 811, Baltimore, MD 21287 8811, USA
    Curr Neurol Neurosci Rep 1:195-202. 2001
  3. ncbi request reprint Sequence variants in SLITRK1 are associated with Tourette's syndrome
    Jesse F Abelson
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 310:317-20. 2005
  4. ncbi request reprint Antibrain antibodies in children with autism and their unaffected siblings
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Jefferson Street Building 124, 600 N Wolfe Street, Baltimore, MD 21287 1000, USA
    J Neuroimmunol 178:149-55. 2006
  5. ncbi request reprint Glutamatergic modulatory therapy for Tourette syndrome
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Med Hypotheses 74:862-7. 2010
  6. ncbi request reprint PANDAS: a commentary
    Harvey S Singer
    Departments of Neurology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 1000, USA
    J Psychosom Res 55:31-9. 2003
  7. doi request reprint Motor stereotypies
    Harvey S Singer
    Departments of Neurology and Pediatrics, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
    Semin Pediatr Neurol 16:77-81. 2009
  8. ncbi request reprint Neurobiology of Tourette's syndrome: concepts of neuroanatomic localization and neurochemical abnormalities
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Brain Dev 25:S70-84. 2003
  9. doi request reprint Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: A pregnant dam mouse model
    Harvey S Singer
    Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
    J Neuroimmunol 211:39-48. 2009
  10. ncbi request reprint Anti-basal ganglia antibodies in PANDAS
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mov Disord 19:406-15. 2004

Research Grants

  1. Pharmacogenetics in Tourette Syndrom
    Harvey Singer; Fiscal Year: 2004
  2. NEUROLOGICAL SCIENCES ACADEMIC DEVELOPMENT AWARD
    Harvey Singer; Fiscal Year: 2007

Detail Information

Publications59

  1. doi request reprint Antineuronal antibodies in OCD: comparisons in children with OCD-only, OCD+chronic tics and OCD+PANDAS
    Colin Gause
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
    J Neuroimmunol 214:118-24. 2009
    ..ASO titers were similar in all groups and did not correlate with immunoassays. It remains controversial whether childhood OCD is associated with autoimmune mechanisms...
  2. ncbi request reprint The treatment of tics
    H S Singer
    Departments of Neurology and Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Harvey 811, Baltimore, MD 21287 8811, USA
    Curr Neurol Neurosci Rep 1:195-202. 2001
    ..This manuscript reviews each of these approaches with emphasis on more recent pharmacologic trials...
  3. ncbi request reprint Sequence variants in SLITRK1 are associated with Tourette's syndrome
    Jesse F Abelson
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 310:317-20. 2005
    ..Wild-type SLITRK1, but not the frameshift mutant, enhanced dendritic growth in primary neuronal cultures. Collectively, these findings support the association of rare SLITRK1 sequence variants with TS...
  4. ncbi request reprint Antibrain antibodies in children with autism and their unaffected siblings
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Jefferson Street Building 124, 600 N Wolfe Street, Baltimore, MD 21287 1000, USA
    J Neuroimmunol 178:149-55. 2006
    ..01). Results suggest that children with autistic disorder and their siblings exhibit differences compared to controls in autoimmune reactivity to specific epitopes located in distinct brain regions...
  5. ncbi request reprint Glutamatergic modulatory therapy for Tourette syndrome
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Med Hypotheses 74:862-7. 2010
    ..If validated, modulation of the glutamate system could provide a valuable new pharmacological approach in the treatment of tics associated with Tourette syndrome...
  6. ncbi request reprint PANDAS: a commentary
    Harvey S Singer
    Departments of Neurology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 1000, USA
    J Psychosom Res 55:31-9. 2003
    ..This commentary reviews clinical and laboratory issues pertinent to the diagnosis of this entity. We conclude that PANDAS is an intriguing hypothesis that requires further confirmation...
  7. doi request reprint Motor stereotypies
    Harvey S Singer
    Departments of Neurology and Pediatrics, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
    Semin Pediatr Neurol 16:77-81. 2009
    ..Although some view these movements as behaviors produced to alter a state of arousal, there is increasing evidence to support a neurobiological mechanism. Behavioral and pharmacological therapies have been used with varying effect...
  8. ncbi request reprint Neurobiology of Tourette's syndrome: concepts of neuroanatomic localization and neurochemical abnormalities
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Brain Dev 25:S70-84. 2003
    ..This review provides information essential for understanding current and future proposals pertaining to the neurobiology of this intriguing disorder...
  9. doi request reprint Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: A pregnant dam mouse model
    Harvey S Singer
    Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
    J Neuroimmunol 211:39-48. 2009
    ..These studies demonstrate that the transplacental passage of IgG from MCAD is capable of inducing long-term behavioral consequences...
  10. ncbi request reprint Anti-basal ganglia antibodies in PANDAS
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mov Disord 19:406-15. 2004
    ..Further immunoblot analyses using a caudate supernatant fraction are required to completely exclude the possibility of minor antibody repertoire differences in PANDAS subjects, especially in those who primarily have tics...
  11. pmc The need for caution in considering the diagnostic utility of antibasal ganglia antibodies in movement disorders
    H S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Jefferson Street Building 124, 600 N Wolfe Street, Baltimore, MD, USA
    Arch Dis Child 89:595-7. 2004
  12. doi request reprint Serial immune markers do not correlate with clinical exacerbations in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections
    Harvey S Singer
    Division of Pediatric Neurology, Johns Hopkins Hospital, Rubenstein Child Health Building, Suite 2158, 200 N Wolfe St, Baltimore, MD 21287, USA
    Pediatrics 121:1198-205. 2008
    ....
  13. ncbi request reprint Tourette's syndrome: from behaviour to biology
    Harvey S Singer
    Department of Neurology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lancet Neurol 4:149-59. 2005
    ..Traditional neuroleptics are the standard treatment for TS, but there is increasing interest in non-neuroleptic drugs, behavioural therapies, and surgical approaches...
  14. ncbi request reprint Antibodies against fetal brain in sera of mothers with autistic children
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States
    J Neuroimmunol 194:165-72. 2008
    ..Data support a possible complex association between genetic/metabolic/environmental factors and the placental transfer of maternal antibodies in autism...
  15. ncbi request reprint Microinfusion of antineuronal antibodies into rodent striatum: failure to differentiate between elevated and low titers
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Jefferson Street Building 124, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Neuroimmunol 163:8-14. 2005
    ..This report emphasizes that any conclusions about antibody-mediated movement disorders that are based upon results from the rodent infusion model must be considered with caution...
  16. ncbi request reprint Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurology 65:1701-7. 2005
    ..Confirmatory evidence has, in part, been based on controversial findings of autoantibodies in the sera of children with these disorders...
  17. ncbi request reprint Anti-basal ganglia antibody abnormalities in Sydenham chorea
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Jefferson Street Building 124, 600 North Wolfe Street, Baltimore, MD 21287 1000, USA
    J Neuroimmunol 136:154-61. 2003
    ..In contrast to WB with discriminant analysis, ELISA measurements did not significantly differentiate between the SC group and controls...
  18. doi request reprint Tourette syndrome and other tic disorders
    Harvey S Singer
    Departments of Neurology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore 21287, USA
    Handb Clin Neurol 100:641-57. 2011
    ..Evidence supports an abnormality of synaptic neurotransmission, likely involving the dopaminergic system...
  19. doi request reprint Educating child neurologists about movement disorders
    Harvey S Singer
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Semin Pediatr Neurol 18:98-103. 2011
    ..Specific suggestions and recommendations are provided for further discussion...
  20. doi request reprint Stereotypic movement disorders
    Harvey S Singer
    Departments of Neurology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore 21287, USA
    Handb Clin Neurol 100:631-9. 2011
    ..There is increasing evidence to support a neurobiological mechanism. Response to behavioral and pharmacological therapies is variable...
  21. ncbi request reprint Treatment of tics and tourette syndrome
    Harvey S Singer
    Departments of Neurology and Pediatrics, Johns Hopkins Hospital, The David M Rubenstein Child Health Building, Suite 2158, 200 North Wolfe Street, Baltimore, MD, 21287, USA
    Curr Treat Options Neurol 12:539-61. 2010
    ..Stimulant medication is effective in treating ADHD in children with tics; studies reducing concerns about its use are discussed...
  22. ncbi request reprint Baclofen treatment in Tourette syndrome: a double-blind, placebo-controlled, crossover trial
    H S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurology 56:599-604. 2001
    ..To investigate the effectiveness of baclofen for the treatment of tics in children with Tourette syndrome (TS)...
  23. ncbi request reprint Striatal antibodies in children with Tourette's syndrome: multivariate discriminant analysis of IgG repertoires
    J T Wendlandt
    Department of Neurology, Johns Hopkins University School of Medicine, Harvey 811, 600 N. Wolfe Street, Baltimore, MD 21287-8811, USA
    J Neuroimmunol 119:106-13. 2001
    ....
  24. ncbi request reprint Oculomotor abnormalities in boys with tourette syndrome with and without ADHD
    S H Mostofsky
    Kennedy Krieger Institute and the Department of Neurology at the Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    J Am Acad Child Adolesc Psychiatry 40:1464-72. 2001
    ..To assess saccadic eye movements in boys with Tourette syndrome (TS) with and without attention-deficit hyperactivity disorder (ADHD), comparing performance with that of an age-matched group of male controls...
  25. doi request reprint Serum autoantibodies measured by immunofluorescence confirm a failure to differentiate PANDAS and Tourette syndrome from controls
    Christina M Morris
    Department of Neurology, Pathology 235, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neurol Sci 276:45-8. 2009
    ..These results confirm an inability to distinguish patient populations by antibody measurements and raise further concerns about the presence of an autoimmune mechanism in PANDAS and TS...
  26. ncbi request reprint Striatal microinfusion of Tourette syndrome and PANDAS sera: failure to induce behavioral changes
    Christopher R Loiselle
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mov Disord 19:390-6. 2004
    ..Our findings are in contrast to previous reports, and suggest the need for further investigations to determine the validity of the model and of autoimmune-mediated hypotheses for pediatric movement disorders...
  27. ncbi request reprint Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis
    Dustin Y Yoon
    Department of Neurology, Johns Hopkins University School of Medicine, Harriett Lane Outpatient Building, 200 N Wolfe Street, Suite 2158, Baltimore, MD 21205, USA
    J Neurol Sci 255:50-6. 2007
    ..D1 and alpha-2A receptor density were increased in a few frontal regions. These results support the hypothesis of a dopaminergic dysfunction in the frontal lobe and a likely role in the pathophysiology of TS...
  28. ncbi request reprint Executive function in fluency and recall measures among children with Tourette syndrome or ADHD
    E M Mahone
    Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    J Int Neuropsychol Soc 7:102-11. 2001
    ....
  29. ncbi request reprint A double blind randomized placebo control trial of levetiracetam in Tourette syndrome
    Constance L Smith-Hicks
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Mov Disord 22:1764-70. 2007
    ..There was no significant difference between treatments and no evidence of sequence or cross-over effects. In conclusion, Levetiracetam is not more beneficial than placebo in suppressing tics in children with TS...
  30. pmc Latent class analysis of gilles de la tourette syndrome using comorbidities: clinical and genetic implications
    Marco A Grados
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Biol Psychiatry 64:219-25. 2008
    ..This study used latent class analyses (LCA) to identify GTS subphenotypes and assess characteristics and heritability of the classes...
  31. pmc Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PET
    Dean F Wong
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA
    Neuropsychopharmacology 33:1239-51. 2008
    ..The finding of decreased SERT BP, and the possible elevation in 5-HT2AR in individuals with TS who had increased DA rel, suggest a condition of increased phasic DA rel modulated by low 5-HT in concomitant OCD...
  32. doi request reprint Double-blind, crossover study of clonidine and levetiracetam in Tourette syndrome
    Erika F Hedderick
    Department of Neurology, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD 21231, USA
    Pediatr Neurol 40:420-5. 2009
    ..Treatment with clonidine, but not levetiracetam, resulted in a small reduction in Total Tic Score, with an effect size of 0.57...
  33. ncbi request reprint Tic disorders: neural circuits, neurochemistry, and neuroimmunology
    Kendra Harris
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Child Neurol 21:678-89. 2006
    ..We review the neural circuits and neurochemistry of Tourette syndrome and evaluate the evidence for and against a role for autoimmunity in the expression of tics...
  34. ncbi request reprint Increased prefrontal D2 protein in Tourette syndrome: a postmortem analysis of frontal cortex and striatum
    Karen Minzer
    Department of Neurology, Johns Hopkins University School of Medicine, Jefferson Street Building 1 124, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Neurol Sci 219:55-61. 2004
    ..These results suggest the presence of a prefrontal-dopaminergic abnormality in TS and emphasize the need for a more specific focus on the frontal lobe...
  35. ncbi request reprint Elevated intrasynaptic dopamine release in Tourette's syndrome measured by PET
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Psychiatry 159:1329-36. 2002
    ..The objective of this study was to test the hypothesis that presynaptic dopamine release from the striatum is abnormal in adults with Tourette's syndrome...
  36. ncbi request reprint MRI parcellation of the frontal lobe in boys with attention deficit hyperactivity disorder or Tourette syndrome
    Wendy R Kates
    Division of Psychiatric Neuroimaging, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychiatry Res 116:63-81. 2002
    ....
  37. ncbi request reprint Neuropsychiatric effects of guanfacine in children with mild tourette syndrome: a pilot study
    Dana D Cummings
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Neuropharmacol 25:325-32. 2002
    ..At a moderate dose and short-term treatment duration, guanfacine did not provide significant neuropsychiatric benefits in this group of children with mild TS...
  38. ncbi request reprint Methodologic factors affect the measurement of anti-basal ganglia antibodies
    Christopher A Rippel
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ann Clin Lab Sci 35:121-30. 2005
    ..Methodological variables should be taken into consideration when performing and interpreting neuroimmunological assays using sera or isolated IgG...
  39. doi request reprint Childhood serum anti-fetal brain antibodies do not predict autism
    Christina M Morris
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatr Neurol 41:288-90. 2009
    ..Thus, in contrast to mothers, antibody reactivity against human fetal brain as measured in children ages 3-12 years does not appear to be a useful biomarker for autism...
  40. doi request reprint Pediatric movement disorders: an update
    David S Wolf
    Department of Neurology, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 1000, USA
    Curr Opin Neurol 21:491-6. 2008
    ....
  41. ncbi request reprint Antistreptococcal, neuronal, and nuclear antibodies in Tourette syndrome
    Christopher R Loiselle
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Pediatr Neurol 28:119-25. 2003
    ....
  42. ncbi request reprint Maternal antibrain antibodies in autism
    Andrew W Zimmerman
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    Brain Behav Immun 21:351-7. 2007
    ..The identification of specific serum antibodies in mothers of children with autism that recognize prenatally expressed brain antigens suggests that these autoantibodies could cross the placenta and alter fetal brain development...
  43. doi request reprint Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: single-point and longitudinal assessments
    C M Morris-Berry
    Department of Neurology, Johns Hopkins University School of Medicine, 200N Wolfe St Suite 2158, Baltimore, MD 21287, United States
    J Neuroimmunol 264:106-13. 2013
    ..These data do not support hypotheses suggesting an autoimmune hypothesis in either TS or PANDAS. ..
  44. ncbi request reprint Tourette syndrome: clinical characteristics and current management strategies
    E H Kossoff
    Department of Paediatrics, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Paediatr Drugs 3:355-63. 2001
    ..New therapies for all aspects of TS and its comorbid conditions are in active clinical trials...
  45. ncbi request reprint Disproportionate increases of white matter in right frontal lobe in Tourette syndrome
    K A Fredericksen
    aMRI Analysis Laboratory, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Neurology 58:85-9. 2002
    ....
  46. ncbi request reprint Canine GM2 gangliosidosis: morphological and biochemical analysis
    H S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD
    Vet Pathol 26:114-20. 1989
    ....
  47. ncbi request reprint Behavioral therapy for treatment of stereotypic movements in nonautistic children
    Jonathan M Miller
    Division of Pediatric Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Child Neurol 21:119-25. 2006
    ..The combined use of habit reversal and differential reinforcement of other behavior is beneficial in reducing motor stereotypies in nonautistic children...
  48. ncbi request reprint Repetitive arm and hand movements (complex motor stereotypies) in children
    E Mark Mahone
    Department of Neuropsychology, Kennedy Krieger Institute, 1750 E Fairmount Avenue, Baltimore, MD 21231, USA
    J Pediatr 145:391-5. 2004
    ..To characterize clinical features, associated problems, and outcomes for children with complex motor stereotypies who do not have mental retardation or pervasive developmental disorders...
  49. doi request reprint Paroxysmal kinesigenic dyskinesias and pseudohypo-parathyroidism type Ib
    Katherine P Thomas
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Pediatr Neurol 43:61-4. 2010
    ..We recommend that hypoparathyroidism always be considered in patients with kinesigenic paroxysmal dyskinesias, especially insofar as it is a treatable disorder...
  50. ncbi request reprint Microarray analysis in Tourette syndrome postmortem putamen
    John J Hong
    Department of Neurology, Johns Hopkins University School of Medicine, Jefferson Street Building 124, 600 North Wolfe Street, Baltimore, MD 21287 1000, USA
    J Neurol Sci 225:57-64. 2004
    ....
  51. ncbi request reprint Norepinephrine transporter polymorphisms in Tourette syndrome with and without attention deficit hyperactivity disorder: no evidence for significant association
    Christopher A Rippel
    Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Psychiatr Genet 16:179-80. 2006
    ..Further research with additional NET polymorphisms and larger sample sizes are indicated in the pursuit of biomarkers for therapeutic responders...
  52. ncbi request reprint Autoimmunity and pediatric movement disorders
    Harvey S Singer
    Division of Pediatric Neurology, Johns Hopkins Hospital, Baltimore, Maryland, USA
    Adv Neurol 99:166-78. 2006
  53. ncbi request reprint Effects of IQ on executive function measures in children with ADHD
    E Mark Mahone
    Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD 21231, USA
    Child Neuropsychol 8:52-65. 2002
    ..These results suggest that clinical measures of EF may differ among children with ADHD and controls at average IQ levels, but there is poorer discriminatory power for these measures among children with above average IQ...
  54. ncbi request reprint Dopaminergic polymorphisms in Tourette syndrome: association with the DAT gene (SLC6A3)
    Dustin Y Yoon
    Department of Neurology, Johns Hopkins University School of Medicine, Harriet Lane Children s Health Building, Wolfe Street, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 144:605-10. 2007
    ..Since abnormalities of the dopamine transporter have been hypothesized in the pathophysiology of TS, it is possible that this could be a functional allele associated with clinical expression...
  55. doi request reprint Nonautistic motor stereotypies: clinical features and longitudinal follow-up
    Kendra M Harris
    Department of Neurology, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Pediatr Neurol 38:267-72. 2008
    ..Finally, evidence is emerging that the clinical course of children who exhibit head nodding may differ from those whose motor stereotypy predominantly involves the hands and arms...
  56. ncbi request reprint Discussing outcome in Tourette syndrome
    Harvey S Singer
    Arch Pediatr Adolesc Med 160:103-5. 2006
  57. ncbi request reprint [PANDAS--Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection: is it a specific clinical disorder?]
    Harvey S Singer
    Rev Bras Psiquiatr 26:220-1. 2004
  58. ncbi request reprint Tourette syndrome: diagnosis, strategies, therapies, pathogenesis, and future research directions
    Lori L Olson
    College of Medicine, University of Missouri Columbia, Columbia, MO, USA
    J Child Neurol 21:630-41. 2006
  59. ncbi request reprint Restless legs syndrome: association with streptococcal or mycoplasma infection
    Muneaki Matsuo
    Department of Pediatrics, Faculty of Medicine, Saga University, Saga, Japan
    Pediatr Neurol 31:119-21. 2004
    ..One of three patients had persistently elevated enzyme-linked immunosorbent optical density values against human caudate and putamen...

Research Grants3

  1. Pharmacogenetics in Tourette Syndrom
    Harvey Singer; Fiscal Year: 2004
    ..The identification of genetic polymorphisms that are associated with clinical disease or treatment success, has obvious benefits. ..
  2. NEUROLOGICAL SCIENCES ACADEMIC DEVELOPMENT AWARD
    Harvey Singer; Fiscal Year: 2007
    ..For trainees, preference will be given to well-qualified physicians with evidence of intelligence and scholarly pursuits, competence in clinical activities and a commitment to a career in translational neuroscience. ..