Robert Siliciano

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc CD8+ T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutants
    Christopher W Pohlmeyer
    Department of Medicine, Johns Hopkins University School of Medicine, 733 N, Broadway, BRB 880, Baltimore, MD 21205, USA
    Retrovirology 10:152. 2013
  2. pmc HIV latency and integration site placement in five cell-based models
    Scott Sherrill-Mix
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Retrovirology 10:90. 2013
  3. pmc Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay
    Gregory M Laird
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    PLoS Pathog 9:e1003398. 2013
  4. pmc Antiretroviral dynamics determines HIV evolution and predicts therapy outcome
    Daniel I S Rosenbloom
    Department of Mathematics, Harvard University, Cambridge, Massachusetts, USA
    Nat Med 18:1378-85. 2012
  5. pmc Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation
    Sifei Xing
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Antimicrob Chemother 67:398-403. 2012
  6. pmc HIV latency
    Robert F Siliciano
    Department of Medicine, Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA
    Cold Spring Harb Perspect Med 1:a007096. 2011
  7. pmc Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy
    Maria Salgado
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Retrovirology 8:97. 2011
  8. pmc Viral suppression of multiple escape mutants by de novo CD8(+) T cell responses in a human immunodeficiency virus-1 infected elite suppressor
    Karen A O'Connell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Retrovirology 8:63. 2011
  9. pmc Evolution of the HIV-1 nef gene in HLA-B*57 positive elite suppressors
    Maria Salgado
    Department of Medicine, Johns Hopkins University School of Medicine, 733 N, Broadway, Baltimore, MD 21205, USA
    Retrovirology 7:94. 2010
  10. pmc Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART
    Ahmad R Sedaghat
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore Maryland 21205, USA
    BMC Infect Dis 8:2. 2008

Collaborators

  • Jun O Liu
  • Alison L Hill
  • Joseph Cofrancesco
  • Joel E Gallant
  • Janet D Siliciano
  • Joel N Blankson
  • Joseph B Margolick
  • S Alireza Rabi
  • Sifei Xing
  • Liang Shan
  • Karen A O'Connell
  • Maria Salgado
  • Hao Zhang
  • Neeta S Shroff
  • Christopher W Pohlmeyer
  • Gregory M Laird
  • Scott Sherrill-Mix
  • Daniel I S Rosenbloom
  • Robert W Buckheit
  • Shridhar Bhat
  • Hung Chih Yang
  • Moira A McMahon
  • Justin R Bailey
  • Jun Lai
  • Ahmad R Sedaghat
  • Luis M Agosto
  • Karen E Ocwieja
  • Charles C Berry
  • Evelyn E Eisele
  • David Looney
  • Frederic D Bushman
  • Vicente Planelles
  • Marylinda Famiglietti
  • Matthew J Pace
  • Stanley Chioma
  • John Guatelli
  • Alberto Bosque
  • Mary K Lewinski
  • Nirav Malani
  • Una O'Doherty
  • Martin A Nowak
  • Joseph A Lopez
  • Cynthia K Bullen
  • William Clarke
  • Amina A Chaudhry
  • Jordyn L Manucci
  • Robert W Hegarty
  • Lin Shen
  • David M Margolis
  • Autumn R Breaud
  • Teresa L Parsons
  • Thomas C Quinn
  • Hector C Bravo
  • Mark A Marzinke
  • Rafael A Irizarry
  • Stuart C Ray
  • Timothy P Brennan
  • Claus O Wilke
  • Eleanor Pitt
  • Marc Callender
  • Richard D Moore
  • Stephen J Gange

Detail Information

Publications15

  1. pmc CD8+ T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutants
    Christopher W Pohlmeyer
    Department of Medicine, Johns Hopkins University School of Medicine, 733 N, Broadway, BRB 880, Baltimore, MD 21205, USA
    Retrovirology 10:152. 2013
    ..Surprisingly, viruses amplified from the plasma of ES have been shown to contain multiple escape mutations, and it is not clear how immunologic control is maintained in the face of virologic escape...
  2. pmc HIV latency and integration site placement in five cell-based models
    Scott Sherrill-Mix
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Retrovirology 10:90. 2013
    ....
  3. pmc Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay
    Gregory M Laird
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    PLoS Pathog 9:e1003398. 2013
    ..The reductions in both labor and cost make this assay suitable for quantifying the frequency of latently infected cells in clinical trials of HIV-1 eradication strategies...
  4. pmc Antiretroviral dynamics determines HIV evolution and predicts therapy outcome
    Daniel I S Rosenbloom
    Department of Mathematics, Harvard University, Cambridge, Massachusetts, USA
    Nat Med 18:1378-85. 2012
    ..Our approach represents a first step for simulating clinical trials of untested anti-HIV regimens and may help in the selection of new drug regimens for investigation...
  5. pmc Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation
    Sifei Xing
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Antimicrob Chemother 67:398-403. 2012
    ..Eradication strategies involve reactivation of this latent reservoir; however, agents that reactivate latent HIV-1 through non-specific T cell activation are toxic...
  6. pmc HIV latency
    Robert F Siliciano
    Department of Medicine, Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA
    Cold Spring Harb Perspect Med 1:a007096. 2011
    ..Several approaches are under exploration for reactivating latent virus with the hope that this will allow elimination of the latent reservoir...
  7. pmc Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy
    Maria Salgado
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Retrovirology 8:97. 2011
    ....
  8. pmc Viral suppression of multiple escape mutants by de novo CD8(+) T cell responses in a human immunodeficiency virus-1 infected elite suppressor
    Karen A O'Connell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Retrovirology 8:63. 2011
    ..These responses, in combination with low viral fitness of each variant, may contribute to sustained elite control in this ES...
  9. pmc Evolution of the HIV-1 nef gene in HLA-B*57 positive elite suppressors
    Maria Salgado
    Department of Medicine, Johns Hopkins University School of Medicine, 733 N, Broadway, Baltimore, MD 21205, USA
    Retrovirology 7:94. 2010
    ..The results provide further evidence of ongoing viral replication in ES and suggest that the nef and gag genes in these patients respond similarly to selective pressure from the host...
  10. pmc Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART
    Ahmad R Sedaghat
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore Maryland 21205, USA
    BMC Infect Dis 8:2. 2008
    ..However, the mechanism underlying the long half-life of the latent reservoir is unknown. The most likely potential mechanisms are low-level viral replication and the intrinsic stability of latently infected cells...
  11. ncbi request reprint Biomarkers of HIV replication
    Janet D Siliciano
    Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA
    Curr Opin HIV AIDS 5:491-7. 2010
    ....
  12. ncbi request reprint Stability of the latent reservoir for HIV-1 in patients receiving valproic acid
    Janet D Siliciano
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
    J Infect Dis 195:833-6. 2007
    ..We conclude that the clinical use of VA has no ancillary effect on the decay of the latent reservoir...
  13. pmc Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation
    Sifei Xing
    Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    J Virol 85:6060-4. 2011
    ..The extent to which disulfiram reactivates latent HIV-1 in patient cells is unclear, but the drug alone or in combination may be useful in future eradication strategies...
  14. pmc Influence of host gene transcription level and orientation on HIV-1 latency in a primary-cell model
    Liang Shan
    Department of Medicine, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    J Virol 85:5384-93. 2011
    ..Our findings suggest that disrupting the negative control of HIV-1 transcription by upstream host promoters could facilitate the reactivation of latent HIV-1 in some resting CD4(+) T cells...
  15. pmc Consistent inhibition of HIV-1 replication in CD4+ T cells by acyclovir without detection of human herpesviruses
    Moira A McMahon
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 85:4618-22. 2011
    ..The data support acyclovir as an inhibitor of HIV-1 replication in herpesvirus-negative cells...