Robert Siliciano

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay
    Gregory M Laird
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    PLoS Pathog 9:e1003398. 2013
  2. pmc Antiretroviral dynamics determines HIV evolution and predicts therapy outcome
    Daniel I S Rosenbloom
    Department of Mathematics, Harvard University, Cambridge, Massachusetts, USA
    Nat Med 18:1378-85. 2012
  3. pmc Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation
    Sifei Xing
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Antimicrob Chemother 67:398-403. 2012
  4. pmc HIV latency
    Robert F Siliciano
    Department of Medicine, Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA
    Cold Spring Harb Perspect Med 1:a007096. 2011
  5. pmc Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy
    Maria Salgado
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Retrovirology 8:97. 2011
  6. pmc Viral suppression of multiple escape mutants by de novo CD8(+) T cell responses in a human immunodeficiency virus-1 infected elite suppressor
    Karen A O'Connell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Retrovirology 8:63. 2011
  7. pmc Evolution of the HIV-1 nef gene in HLA-B*57 positive elite suppressors
    Maria Salgado
    Department of Medicine, Johns Hopkins University School of Medicine, 733 N, Broadway, Baltimore, MD 21205, USA
    Retrovirology 7:94. 2010
  8. pmc Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART
    Ahmad R Sedaghat
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore Maryland 21205, USA
    BMC Infect Dis 8:2. 2008
  9. ncbi request reprint Stability of the latent reservoir for HIV-1 in patients receiving valproic acid
    Janet D Siliciano
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
    J Infect Dis 195:833-6. 2007
  10. doi request reprint Biomarkers of HIV replication
    Janet D Siliciano
    Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA
    Curr Opin HIV AIDS 5:491-7. 2010

Research Grants

  1. Latent Viral Reservoirs in HIV 1 Infection
    Robert F Siliciano; Fiscal Year: 2010
  2. Latent Viral Reservoirs in HIV 1 Infection
    Robert Siliciano; Fiscal Year: 2004
  3. SIGNIFICANCE OF LOW LEVEL VIREMIA IN PATIENTS ON HAART
    Robert Siliciano; Fiscal Year: 2005
  4. Latent Viral Reservoirs in HIV 1 Infection
    Robert Siliciano; Fiscal Year: 2005
  5. SIGNIFICANCE OF LOW LEVEL VIREMIA IN PATIENTS ON HAART
    Robert Siliciano; Fiscal Year: 2006
  6. Latent Viral Reservoirs in HIV 1 Infection
    Robert Siliciano; Fiscal Year: 2006
  7. Latent Viral Reservoirs in HIV 1 Infection
    Robert Siliciano; Fiscal Year: 2007
  8. Latent Viral Reservoirs in HIV 1 Infection
    Robert Siliciano; Fiscal Year: 2009
  9. Intermolecular cooperativity in the action of antiviral agents
    Robert Siliciano; Fiscal Year: 2009
  10. Intermolecular cooperativity in the action of antiviral agents
    Robert F Siliciano; Fiscal Year: 2010

Collaborators

  • Jun O Liu
  • Alison L Hill
  • Joseph Cofrancesco
  • Joel E Gallant
  • Janet D Siliciano
  • Joseph B Margolick
  • S Alireza Rabi
  • Sifei Xing
  • Joel N Blankson
  • Karen A O'Connell
  • Maria Salgado
  • Hao Zhang
  • Neeta S Shroff
  • Liang Shan
  • Gregory M Laird
  • Daniel I S Rosenbloom
  • Shridhar Bhat
  • Moira A McMahon
  • Hung Chih Yang
  • Justin R Bailey
  • Jun Lai
  • Ahmad R Sedaghat
  • Evelyn E Eisele
  • Stanley Chioma
  • Martin A Nowak
  • Joseph A Lopez
  • Jordyn L Manucci
  • Robert W Hegarty
  • Lin Shen
  • Hector C Bravo
  • Thomas C Quinn
  • Mark A Marzinke
  • William Clarke
  • Amina A Chaudhry
  • Autumn R Breaud
  • Rafael A Irizarry
  • Robert W Buckheit
  • Teresa L Parsons
  • Cynthia K Bullen
  • David M Margolis
  • Stuart C Ray
  • Timothy P Brennan
  • Claus O Wilke
  • Stephen J Gange
  • Marc Callender
  • Richard D Moore
  • Eleanor Pitt

Detail Information

Publications13

  1. pmc Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay
    Gregory M Laird
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    PLoS Pathog 9:e1003398. 2013
    ..The reductions in both labor and cost make this assay suitable for quantifying the frequency of latently infected cells in clinical trials of HIV-1 eradication strategies...
  2. pmc Antiretroviral dynamics determines HIV evolution and predicts therapy outcome
    Daniel I S Rosenbloom
    Department of Mathematics, Harvard University, Cambridge, Massachusetts, USA
    Nat Med 18:1378-85. 2012
    ..Our approach represents a first step for simulating clinical trials of untested anti-HIV regimens and may help in the selection of new drug regimens for investigation...
  3. pmc Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation
    Sifei Xing
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Antimicrob Chemother 67:398-403. 2012
    ..Eradication strategies involve reactivation of this latent reservoir; however, agents that reactivate latent HIV-1 through non-specific T cell activation are toxic...
  4. pmc HIV latency
    Robert F Siliciano
    Department of Medicine, Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA
    Cold Spring Harb Perspect Med 1:a007096. 2011
    ..Several approaches are under exploration for reactivating latent virus with the hope that this will allow elimination of the latent reservoir...
  5. pmc Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy
    Maria Salgado
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Retrovirology 8:97. 2011
    ....
  6. pmc Viral suppression of multiple escape mutants by de novo CD8(+) T cell responses in a human immunodeficiency virus-1 infected elite suppressor
    Karen A O'Connell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Retrovirology 8:63. 2011
    ..These responses, in combination with low viral fitness of each variant, may contribute to sustained elite control in this ES...
  7. pmc Evolution of the HIV-1 nef gene in HLA-B*57 positive elite suppressors
    Maria Salgado
    Department of Medicine, Johns Hopkins University School of Medicine, 733 N, Broadway, Baltimore, MD 21205, USA
    Retrovirology 7:94. 2010
    ..The results provide further evidence of ongoing viral replication in ES and suggest that the nef and gag genes in these patients respond similarly to selective pressure from the host...
  8. pmc Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART
    Ahmad R Sedaghat
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore Maryland 21205, USA
    BMC Infect Dis 8:2. 2008
    ..However, the mechanism underlying the long half-life of the latent reservoir is unknown. The most likely potential mechanisms are low-level viral replication and the intrinsic stability of latently infected cells...
  9. ncbi request reprint Stability of the latent reservoir for HIV-1 in patients receiving valproic acid
    Janet D Siliciano
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
    J Infect Dis 195:833-6. 2007
    ..We conclude that the clinical use of VA has no ancillary effect on the decay of the latent reservoir...
  10. doi request reprint Biomarkers of HIV replication
    Janet D Siliciano
    Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA
    Curr Opin HIV AIDS 5:491-7. 2010
    ....
  11. pmc Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation
    Sifei Xing
    Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    J Virol 85:6060-4. 2011
    ..The extent to which disulfiram reactivates latent HIV-1 in patient cells is unclear, but the drug alone or in combination may be useful in future eradication strategies...
  12. pmc Influence of host gene transcription level and orientation on HIV-1 latency in a primary-cell model
    Liang Shan
    Department of Medicine, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    J Virol 85:5384-93. 2011
    ..Our findings suggest that disrupting the negative control of HIV-1 transcription by upstream host promoters could facilitate the reactivation of latent HIV-1 in some resting CD4(+) T cells...
  13. pmc Consistent inhibition of HIV-1 replication in CD4+ T cells by acyclovir without detection of human herpesviruses
    Moira A McMahon
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 85:4618-22. 2011
    ..The data support acyclovir as an inhibitor of HIV-1 replication in herpesvirus-negative cells...

Research Grants32

  1. Latent Viral Reservoirs in HIV 1 Infection
    Robert F Siliciano; Fiscal Year: 2010
    ..Curing HIV infection will require new ways to eliminate this latent reservoir. The studies proposed here are designed to find new drugs that can eliminate this latent reservoir. ..
  2. Latent Viral Reservoirs in HIV 1 Infection
    Robert Siliciano; Fiscal Year: 2004
    ..Together, these studies should help to elucidate how HIV-1 latency operates in vivo. ..
  3. SIGNIFICANCE OF LOW LEVEL VIREMIA IN PATIENTS ON HAART
    Robert Siliciano; Fiscal Year: 2005
    ....
  4. Latent Viral Reservoirs in HIV 1 Infection
    Robert Siliciano; Fiscal Year: 2005
    ..Together, these studies should help to elucidate how HIV-1 latency operates in vivo. ..
  5. SIGNIFICANCE OF LOW LEVEL VIREMIA IN PATIENTS ON HAART
    Robert Siliciano; Fiscal Year: 2006
    ....
  6. Latent Viral Reservoirs in HIV 1 Infection
    Robert Siliciano; Fiscal Year: 2006
    ..Together, these studies should help to elucidate how HIV-1 latency operates in vivo. ..
  7. Latent Viral Reservoirs in HIV 1 Infection
    Robert Siliciano; Fiscal Year: 2007
    ..Together, these studies should help to elucidate how HIV-1 latency operates in vivo. ..
  8. Latent Viral Reservoirs in HIV 1 Infection
    Robert Siliciano; Fiscal Year: 2009
    ..Curing HIV infection will require new ways to eliminate this latent reservoir. The studies proposed here are designed to find new drugs that can eliminate this latent reservoir. ..
  9. Intermolecular cooperativity in the action of antiviral agents
    Robert Siliciano; Fiscal Year: 2009
    ..The method incorporates a previously unappreciated factor that contributes enormously to the ability of drugs and vaccines to inhibit HIV. The goal is to facilitate the design of drugs and vaccines that maximally inhibit HIV. ..
  10. Intermolecular cooperativity in the action of antiviral agents
    Robert F Siliciano; Fiscal Year: 2010
    ..The method incorporates a previously unappreciated factor that contributes enormously to the ability of drugs and vaccines to inhibit HIV. The goal is to facilitate the design of drugs and vaccines that maximally inhibit HIV. ..
  11. SIGNIFICANCE OF LOW LEVEL VIREMIA IN PATIENTS ON HAART
    Robert Siliciano; Fiscal Year: 2004
    ....
  12. SIGNIFICANCE OF LOW LEVEL VIREMIA IN PATIENTS ON HAART
    Robert Siliciano; Fiscal Year: 2003
    ....
  13. CYTOLYTIC T CELL RESPONSE IN AIDS VACCINE RECIPENTS
    Robert Siliciano; Fiscal Year: 1999
    ..nonresponders. Antigen processing and presentation will then be studied using cells from non-responders. Finally the ability of HIV-1 specific CTL to lyse newly or chronically infected resting CD4 T cells will be examined. ..
  14. LATENT VIRAL RESERVOIRS IN HIV1 INFECTION
    Robert Siliciano; Fiscal Year: 1999
    ..Finally, the investigators will develop an experimental system for identifying stimuli that could be used to mobilize the latent reservoir for elimination. ..
  15. CYTOLYTIC T CELL RESPONSES IN AIDS VACCINE RECIPIENTS
    Robert Siliciano; Fiscal Year: 1992
    ....
  16. CYTOLYTIC T CELL RESPONSES IN AIDS VACCINE RECIPIENTS
    Robert Siliciano; Fiscal Year: 1993
    ....
  17. CYTOLYTIC T CELL RESPONSE IN AIDS VACCINE RECIPENTS
    Robert Siliciano; Fiscal Year: 2000
    ..nonresponders. Antigen processing and presentation will then be studied using cells from non-responders. Finally the ability of HIV-1 specific CTL to lyse newly or chronically infected resting CD4 T cells will be examined. ..
  18. LATENT VIRAL RESERVOIRS IN HIV1 INFECTION
    Robert Siliciano; Fiscal Year: 2000
    ..Finally, the investigators will develop an experimental system for identifying stimuli that could be used to mobilize the latent reservoir for elimination. ..
  19. CYTOLYTIC T CELL RESPONSE IN AIDS VACCINE RECIPENTS
    Robert Siliciano; Fiscal Year: 2001
    ..nonresponders. Antigen processing and presentation will then be studied using cells from non-responders. Finally the ability of HIV-1 specific CTL to lyse newly or chronically infected resting CD4 T cells will be examined. ..
  20. LATENT VIRAL RESERVOIRS IN HIV1 INFECTION
    Robert Siliciano; Fiscal Year: 2001
    ..Finally, the investigators will develop an experimental system for identifying stimuli that could be used to mobilize the latent reservoir for elimination. ..
  21. SIGNIFICANCE OF LOW LEVEL VIREMIA IN PATIENTS ON HAART
    Robert Siliciano; Fiscal Year: 2002
    ....
  22. LATENT VIRAL RESERVOIRS IN HIV1 INFECTION
    Robert Siliciano; Fiscal Year: 2002
    ..Finally, the investigators will develop an experimental system for identifying stimuli that could be used to mobilize the latent reservoir for elimination. ..
  23. Latent Viral Reservoirs in HIV 1 Infection
    Robert Siliciano; Fiscal Year: 2009
    ..Curing HIV infection will require new ways to eliminate this latent reservoir. The studies proposed here are designed to find new drugs that can eliminate this latent reservoir. ..