L A Shimoda

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. request reprint
    Shimoda L, Sylvester J, Sham J. Mobilization of intracellular Ca(2+) by endothelin-1 in rat intrapulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2000;278:L157-64 pubmed
    ..These results suggest that ET-1 initiates depolarization in PASMCs, leading to Ca(2+) influx through voltage-gated Ca(2+) channels and Ca(2+) release from ryanodine- and inositol 1,4,5-trisphosphate-sensitive stores...
  2. request reprint
    Shimoda L, Sylvester J, Booth G, Shimoda T, Meeker S, Undem B, et al. Inhibition of voltage-gated K(+) currents by endothelin-1 in human pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol. 2001;281:L1115-22 pubmed
    ..Our results are consistent with data we reported previously in the rat, suggesting similar mechanisms may be operative in both species...
  3. request reprint
    Shimoda L, Fallon M, Pisarcik S, Wang J, Semenza G. HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol. 2006;291:L941-9 pubmed
    ....
  4. request reprint
    Shimoda L, Luke T, Sylvester J, Shih H, Jain A, Swenson E. Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1002-12 pubmed
    ..These results suggest that AZ attenuates HPV by selectively inhibiting hypoxia-induced Ca2+ responses via a mechanism independent of CA inhibition, changes in pH(i), or membrane potential. ..

Detail Information

Publications4

  1. request reprint
    Shimoda L, Sylvester J, Sham J. Mobilization of intracellular Ca(2+) by endothelin-1 in rat intrapulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2000;278:L157-64 pubmed
    ..These results suggest that ET-1 initiates depolarization in PASMCs, leading to Ca(2+) influx through voltage-gated Ca(2+) channels and Ca(2+) release from ryanodine- and inositol 1,4,5-trisphosphate-sensitive stores...
  2. request reprint
    Shimoda L, Sylvester J, Booth G, Shimoda T, Meeker S, Undem B, et al. Inhibition of voltage-gated K(+) currents by endothelin-1 in human pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol. 2001;281:L1115-22 pubmed
    ..Our results are consistent with data we reported previously in the rat, suggesting similar mechanisms may be operative in both species...
  3. request reprint
    Shimoda L, Fallon M, Pisarcik S, Wang J, Semenza G. HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol. 2006;291:L941-9 pubmed
    ....
  4. request reprint
    Shimoda L, Luke T, Sylvester J, Shih H, Jain A, Swenson E. Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1002-12 pubmed
    ..These results suggest that AZ attenuates HPV by selectively inhibiting hypoxia-induced Ca2+ responses via a mechanism independent of CA inhibition, changes in pH(i), or membrane potential. ..