L A Shimoda
Affiliation: Johns Hopkins University
- Shimoda L, Sylvester J, Sham J. Mobilization of intracellular Ca(2+) by endothelin-1 in rat intrapulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2000;278:L157-64 pubmed..These results suggest that ET-1 initiates depolarization in PASMCs, leading to Ca(2+) influx through voltage-gated Ca(2+) channels and Ca(2+) release from ryanodine- and inositol 1,4,5-trisphosphate-sensitive stores...
- Shimoda L, Sylvester J, Booth G, Shimoda T, Meeker S, Undem B, et al. Inhibition of voltage-gated K(+) currents by endothelin-1 in human pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol. 2001;281:L1115-22 pubmed..Our results are consistent with data we reported previously in the rat, suggesting similar mechanisms may be operative in both species...
- Shimoda L, Fallon M, Pisarcik S, Wang J, Semenza G. HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol. 2006;291:L941-9 pubmed....
- Shimoda L, Luke T, Sylvester J, Shih H, Jain A, Swenson E. Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1002-12 pubmed..These results suggest that AZ attenuates HPV by selectively inhibiting hypoxia-induced Ca2+ responses via a mechanism independent of CA inhibition, changes in pH(i), or membrane potential. ..