L A Shimoda
Affiliation: Johns Hopkins University
Shimoda L, Laurie S. Vascular remodeling in pulmonary hypertension. J Mol Med (Berl). 2013;91:297-309 pubmed publisher
Shimoda L, Sylvester J, Sham J. Mobilization of intracellular Ca(2+) by endothelin-1 in rat intrapulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2000;278:L157-64 pubmed
..These results suggest that ET-1 initiates depolarization in PASMCs, leading to Ca(2+) influx through voltage-gated Ca(2+) channels and Ca(2+) release from ryanodine- and inositol 1,4,5-trisphosphate-sensitive stores...
Shimoda L, Sylvester J, Booth G, Shimoda T, Meeker S, Undem B, et al
. Inhibition of voltage-gated K(+) currents by endothelin-1 in human pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol. 2001;281:L1115-22 pubmed
..Our results are consistent with data we reported previously in the rat, suggesting similar mechanisms may be operative in both species...
Shimoda L, Fallon M, Pisarcik S, Wang J, Semenza G. HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol. 2006;291:L941-9 pubmed
Shimoda L, Luke T, Sylvester J, Shih H, Jain A, Swenson E. Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1002-12 pubmed
..These results suggest that AZ attenuates HPV by selectively inhibiting hypoxia-induced Ca2+ responses via a mechanism independent of CA inhibition, changes in pH(i), or membrane potential. ..