Meir Shamay

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc De novo DNA methyltransferase DNMT3b interacts with NEDD8-modified proteins
    Meir Shamay
    Viral Oncology Program, Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    J Biol Chem 285:36377-86. 2010
  2. pmc Phosphorylation of the chromatin binding domain of KSHV LANA
    Crystal Woodard
    High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS Pathog 8:e1002972. 2012
  3. pmc A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening
    Meir Shamay
    Viral Oncology Program, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Virol 86:5179-91. 2012
  4. pmc Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation
    Jianyong Liu
    Johns Hopkins University School of Medicine, Bunting Blaustein Building CRB308, 1650 Orleans Street, Baltimore, MD 21231, USA
    J Virol 81:4722-31. 2007
  5. pmc Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA
    Meir Shamay
    Viral Oncology Program, Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 103:14554-9. 2006
  6. pmc Bortezomib induction of C/EBPβ mediates Epstein-Barr virus lytic activation in Burkitt lymphoma
    Courtney M Shirley
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 117:6297-303. 2011
  7. pmc Human cytomegalovirus inhibition by cardiac glycosides: evidence for involvement of the HERG gene
    Arun Kapoor
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Antimicrob Agents Chemother 56:4891-9. 2012
  8. pmc CpG methylation as a tool to characterize cell-free Kaposi sarcoma herpesvirus DNA
    Meir Shamay
    Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Infect Dis 205:1095-9. 2012

Collaborators

Detail Information

Publications8

  1. pmc De novo DNA methyltransferase DNMT3b interacts with NEDD8-modified proteins
    Meir Shamay
    Viral Oncology Program, Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    J Biol Chem 285:36377-86. 2010
    ..Chromatin immunoprecipitation assays suggest that DNMT3b recruits CUL4A and NEDD8 to chromatin, whereas deletion of Dnmt3b reduces the association of CUL4A and NEDD8 at a repressed promoter in a cancer cell line...
  2. pmc Phosphorylation of the chromatin binding domain of KSHV LANA
    Crystal Woodard
    High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS Pathog 8:e1002972. 2012
    ..The data indicate that RSK phosphorylation affects both LANA accumulation and function...
  3. pmc A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening
    Meir Shamay
    Viral Oncology Program, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Virol 86:5179-91. 2012
    ..However, LANA expression in telomerase immortalized endothelial cells resulted in telomere shortening. In KSHV-infected cells, telomere shortening may be one more mechanism by which LANA contributes to the development of malignancy...
  4. pmc Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation
    Jianyong Liu
    Johns Hopkins University School of Medicine, Bunting Blaustein Building CRB308, 1650 Orleans Street, Baltimore, MD 21231, USA
    J Virol 81:4722-31. 2007
    ..We conclude that LANA inactivates nuclear GSK-3 and modifies the function of proteins that are GSK-3 substrates. In the case of C/EBPs, this translates into LANA-mediated inhibition of differentiation...
  5. pmc Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA
    Meir Shamay
    Viral Oncology Program, Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 103:14554-9. 2006
    ..The data provide an example of promoter-specific epigenetic DNA modification through viral protein recruitment of de novo Dnmt activity...
  6. pmc Bortezomib induction of C/EBPβ mediates Epstein-Barr virus lytic activation in Burkitt lymphoma
    Courtney M Shirley
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 117:6297-303. 2011
    ..The effects of thapsigargin on EBV lytic gene expression are also inhibited by C/EBPβ knock-down. Therefore, C/EBPβ mediates the activation of EBV lytic gene expression associated with bortezomib and another UPR inducer...
  7. pmc Human cytomegalovirus inhibition by cardiac glycosides: evidence for involvement of the HERG gene
    Arun Kapoor
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Antimicrob Agents Chemother 56:4891-9. 2012
    ..These findings suggest that CG may inhibit HCMV by modulating human cellular targets associated with hERG and that these compounds should be studied for their antiviral activities...
  8. pmc CpG methylation as a tool to characterize cell-free Kaposi sarcoma herpesvirus DNA
    Meir Shamay
    Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Infect Dis 205:1095-9. 2012
    ..The difference in the origins of cfDNA in these settings may in part reflect very different proliferative indices in KS and PEL tumor tissue...