A G Shaikh

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint 'Staircase' square-wave jerks in early Parkinson's disease
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, 600 North Wolfe Street, Path 2 210, Baltimore, MD 21287, USA
    Br J Ophthalmol 95:705-9. 2011
  2. pmc Hypothetical membrane mechanisms in essential tremor
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
    J Transl Med 6:68. 2008
  3. doi request reprint Gaze fixation deficits and their implication in ataxia-telangiectasia
    A G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, Maryland, USA
    J Neurol Neurosurg Psychiatry 80:858-64. 2009
  4. ncbi request reprint A new familial disease of saccadic oscillations and limb tremor provides clues to mechanisms of common tremor disorders
    Aasef G Shaikh
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Brain 130:3020-31. 2007
  5. pmc Saccadic burst cell membrane dysfunction is responsible for saccadic oscillations
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neuroophthalmol 28:329-36. 2008
  6. pmc Sustained eye closure slows saccades
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21287, United States
    Vision Res 50:1665-75. 2010
  7. doi request reprint Pseudonystagmus--clinical features and quantitative characteristics
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, 600 North Wolfe Street, Pathology 2 210, Baltimore, MD 21287, USA
    Nat Rev Neurol 6:519-23. 2010
  8. pmc Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Brain 133:923-40. 2010
  9. pmc Irregularity distinguishes limb tremor in cervical dystonia from essential tremor
    A G Shaikh
    Department of Neurology, The Johns Hopkins Hospital, 600 North Wolfe Street, Pathology 2 210, Baltimore, MD 21287, USA
    J Neurol Neurosurg Psychiatry 79:187-9. 2008
  10. ncbi request reprint Neurons compute internal models of the physical laws of motion
    Dora E Angelaki
    Department of Neurobiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Nature 430:560-4. 2004

Detail Information

Publications15

  1. doi request reprint 'Staircase' square-wave jerks in early Parkinson's disease
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, 600 North Wolfe Street, Path 2 210, Baltimore, MD 21287, USA
    Br J Ophthalmol 95:705-9. 2011
    ..Visually guided saccades and gaze-fixation ability were recorded in patients with early Parkinson's disease (PD)...
  2. pmc Hypothetical membrane mechanisms in essential tremor
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
    J Transl Med 6:68. 2008
    ..Such instability is enhanced by increased neural membrane excitability and the circuit begins to oscillate. These oscillations manifest as tremor...
  3. doi request reprint Gaze fixation deficits and their implication in ataxia-telangiectasia
    A G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, Maryland, USA
    J Neurol Neurosurg Psychiatry 80:858-64. 2009
    ..Unstable fixation often leads to difficulty reading and blurred vision. Here we characterise the disturbance of visual fixation in A-T...
  4. ncbi request reprint A new familial disease of saccadic oscillations and limb tremor provides clues to mechanisms of common tremor disorders
    Aasef G Shaikh
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Brain 130:3020-31. 2007
    ....
  5. pmc Saccadic burst cell membrane dysfunction is responsible for saccadic oscillations
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neuroophthalmol 28:329-36. 2008
    ..Our simulations suggest that alterations in membrane properties that lead to an increase in PIR, a reduction in external glycinergic inhibition, or both can cause saccadic oscillations...
  6. pmc Sustained eye closure slows saccades
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21287, United States
    Vision Res 50:1665-75. 2010
    ..These results indicate a role for OPNs in generating the abrupt onset and high velocities of saccades. We hypothesize that the mechanism involved is PIR in pre-motor burst neurons...
  7. doi request reprint Pseudonystagmus--clinical features and quantitative characteristics
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, 600 North Wolfe Street, Pathology 2 210, Baltimore, MD 21287, USA
    Nat Rev Neurol 6:519-23. 2010
    ..This case highlights the fact that in patients with pseudonystagmus, oscillopsia is attributable to the association of head tremor and vestibular hypofunction...
  8. pmc Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Brain 133:923-40. 2010
    ..We conclude that oculopalatal tremor oscillations originate in the hypertrophic inferior olive and are amplified by learning in the cerebellum...
  9. pmc Irregularity distinguishes limb tremor in cervical dystonia from essential tremor
    A G Shaikh
    Department of Neurology, The Johns Hopkins Hospital, 600 North Wolfe Street, Pathology 2 210, Baltimore, MD 21287, USA
    J Neurol Neurosurg Psychiatry 79:187-9. 2008
    ..Whether a common central mechanism underlies the tremor in these conditions is unknown. We addressed this issue by quantifying limb tremor in 19 patients with CD and 35 patients with ET...
  10. ncbi request reprint Neurons compute internal models of the physical laws of motion
    Dora E Angelaki
    Department of Neurobiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Nature 430:560-4. 2004
    ..We show that the firing rates of these populations of neurons reflect the computations necessary to construct an internal model representation of the physical equations of motion...
  11. doi request reprint Think membranes and ion channels
    David S Zee
    Curr Opin Neurol 21:1-2. 2008
  12. ncbi request reprint Sensory vestibular contributions to constructing internal models of self-motion
    Andrea M Green
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8108, St Louis, MO 63110, USA
    J Neural Eng 2:S164-79. 2005
    ....
  13. ncbi request reprint Excitability of auditory brainstem neurons, in vivo, is increased by cyclic-AMP
    Aasef G Shaikh
    Department of Otolaryngology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Hear Res 201:70-80. 2005
    ..Based on these findings, we propose that the second messenger, cAMP, can significantly modulate neural excitability and spontaneous discharge in SOC neurons, principally by shifting the activation of Ih channels...
  14. ncbi request reprint Multiple reference frames for motion in the primate cerebellum
    Aasef G Shaikh
    Department of Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 24:4491-7. 2004
    ..This differential representation of motion-related information implies potential differences in the functional roles of these areas...
  15. ncbi request reprint Hyperpolarization-activated (I(h)) conductances affect brainstem auditory neuron excitability
    Aasef G Shaikh
    Department of Otolaryngology, Wayne State University, 550 E Canfield Avenue, Rm 327, Detroit, MI 48201, USA
    Hear Res 183:126-36. 2003
    ..The variability in the ZD7288 reduction in excitability and its variation with the BF of units could be an indication of regulation and plasticity in neuronal encoding of sounds...