Hiromi Sesaki

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc UGO1 encodes an outer membrane protein required for mitochondrial fusion
    H Sesaki
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 152:1123-34. 2001
  2. pmc Regulation of ammonia homeostasis by the ammonium transporter AmtA in Dictyostelium discoideum
    Ryuji Yoshino
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan 305 8572
    Eukaryot Cell 6:2419-28. 2007
  3. pmc Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria
    Yasushi Tamura
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 185:1029-45. 2009
  4. pmc The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice
    Junko Wakabayashi
    Department of Cell Biology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Cell Biol 186:805-16. 2009
  5. pmc Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage
    Yusuke Kageyama
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 197:535-51. 2012
  6. pmc Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane
    Hiromi Sesaki
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Biol Cell 14:2342-56. 2003
  7. ncbi request reprint Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion
    Hiromi Sesaki
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 308:276-83. 2003
  8. pmc Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p
    Hiromi Sesaki
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 173:651-8. 2006
  9. pmc Phosphatidylethanolamine biosynthesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins UPS1P and UPS2P
    Yasushi Tamura
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 287:43961-71. 2012
  10. pmc Role for two conserved intermembrane space proteins, Ups1p and Ups2p, [corrected] in intra-mitochondrial phospholipid trafficking
    Yasushi Tamura
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 287:15205-18. 2012

Research Grants

  1. Mitochondrial Fusion and Division
    Hiromi Sesaki; Fiscal Year: 2010

Collaborators

Detail Information

Publications30

  1. pmc UGO1 encodes an outer membrane protein required for mitochondrial fusion
    H Sesaki
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 152:1123-34. 2001
    ..Our results suggest that Ugo1p is a new outer membrane component of the mitochondrial fusion machinery...
  2. pmc Regulation of ammonia homeostasis by the ammonium transporter AmtA in Dictyostelium discoideum
    Ryuji Yoshino
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan 305 8572
    Eukaryot Cell 6:2419-28. 2007
    ..Taken together, our data clearly demonstrate that AmtA regulates ammonia homeostasis and plays important roles in multiple developmental processes in Dictyostelium...
  3. pmc Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria
    Yasushi Tamura
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 185:1029-45. 2009
    ..Furthermore, we observed synthetic growth defects in ups mutants in combination with loss of Pam17p, which controls the integrity of PAM. Our findings provide a novel molecular mechanism for the regulation of cardiolipin metabolism...
  4. pmc The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice
    Junko Wakabayashi
    Department of Cell Biology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Cell Biol 186:805-16. 2009
    ..These findings clearly demonstrate the physiological importance of Drp1-mediated organelle division in mice...
  5. pmc Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage
    Yusuke Kageyama
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 197:535-51. 2012
    ..Our findings suggest that mitochondrial division serves as a quality control mechanism to suppress oxidative damage and thus promote neuronal survival...
  6. pmc Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane
    Hiromi Sesaki
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Biol Cell 14:2342-56. 2003
    ..Our results raise the possibility that Mgm1p regulates fusion of the mitochondrial outer membrane through its interactions with Fzo1p and Ugo1p...
  7. ncbi request reprint Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion
    Hiromi Sesaki
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 308:276-83. 2003
    ..However, the processing of Mgm1p is not strictly required for mitochondrial fusion, indicating that the 100 kDa form is sufficient to promote fusion...
  8. pmc Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p
    Hiromi Sesaki
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 173:651-8. 2006
    ..Moreover, the human homologue of Ups1p, PRELI, can fully replace Ups1p in yeast cells. Together, our findings provide a conserved mechanism for the alternative topogenesis of Mgm1p and control of mitochondrial morphology...
  9. pmc Phosphatidylethanolamine biosynthesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins UPS1P and UPS2P
    Yasushi Tamura
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 287:43961-71. 2012
    ..Restoration of Psd1p levels rescued PE production defects in ups1Δ mitochondria. Our data provide novel mechanistic insight into PE biogenesis in mitochondria...
  10. pmc Role for two conserved intermembrane space proteins, Ups1p and Ups2p, [corrected] in intra-mitochondrial phospholipid trafficking
    Yasushi Tamura
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 287:15205-18. 2012
    ..Our results suggest that Ups proteins and Mdm31p play important roles in phospholipid biosynthesis in mitochondria. Ups proteins may function in phospholipid trafficking between the outer and inner mitochondrial membranes...
  11. ncbi request reprint Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion
    Hiromi Sesaki
    Department of Cell Biology, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    J Biol Chem 279:28298-303. 2004
    ..Our data indicate that distinct regions of Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion...
  12. pmc Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation
    Yasushi Tamura
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    EMBO J 29:2875-87. 2010
    ..These findings provide a novel mechanism in which the formation of functional protein complexes drives mitochondrial protein import...
  13. ncbi request reprint Yeast mitochondrial division and distribution require the cortical num1 protein
    Kara L Cerveny
    Department of Cell Biology, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Dev Cell 12:363-75. 2007
    ..Thus, our studies have revealed an additional role for Dnm1p in mitochondrial transmission through its interaction with Num1p, thereby providing a link between mitochondrial division and inheritance...
  14. pmc Effects of Fcj1-Mos1 and mitochondrial division on aggregation of mitochondrial DNA nucleoids and organelle morphology
    Kie Itoh
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Biol Cell 24:1842-51. 2013
    ..Our findings suggest an unexpected role of Fcj1-Mos1 and organelle division in maintaining the distribution and size of mtDNA nucleoids...
  15. pmc Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape
    H Sesaki
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 147:699-706. 1999
    ..Our results thus suggest that mitochondrial shape is normally controlled by a balance between division and fusion which requires Dnm1p and Fzo1p, respectively...
  16. pmc Mitochondrial dynamics in neurodegeneration
    Kie Itoh
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Trends Cell Biol 23:64-71. 2013
    ..Here, we review the recent findings on mitochondrial dynamics in neurodegeneration...
  17. pmc The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells
    Zhongyan Zhang
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Biol Cell 22:2235-45. 2011
    ..Consequently, mice lacking Opa1 in beta cells develop hyperglycemia. The data suggest that the function of Opa1 in the maintenance of the electron transport chain is physiologically relevant in beta cells...
  18. pmc Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex
    Cory D Dunn
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Biol Cell 19:5387-97. 2008
    ..We speculate that Mgr3p and Mgr1p function in an adaptor complex that targets substrates to the i-AAA protease for degradation...
  19. pmc Mitochondrial division prevents neurodegeneration
    Zhongyan Zhang
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Autophagy 8:1531-3. 2012
    ..These findings suggest that mitochondrial division functions as an important quality control mechanism that suppresses oxidative damage and neurodegeneration in vivo...
  20. pmc Myosin I links PIP3 signaling to remodeling of the actin cytoskeleton in chemotaxis
    Chun Lin Chen
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Sci Signal 5:ra10. 2012
    ..These data suggest a mechanism through which the PIP3 signal is transmitted through myosin I to the actin cytoskeleton...
  21. pmc Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation
    Yu Wang
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Biol Cell 22:2270-81. 2011
    ..Our data indicate that Htt regulates the phosphorylation status of myosin II during chemotaxis and cytokinesis through PP2A...
  22. pmc Mitochondrial division: molecular machinery and physiological functions
    Yusuke Kageyama
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Opin Cell Biol 23:427-34. 2011
    ..We summarize recent progress in understanding how the division machinery assembles onto mitochondria and how mitochondrial division contributes to cellular physiology and human diseases...
  23. pmc Rho GTPases orient directional sensing in chemotaxis
    Yu Wang
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 110:E4723-32. 2013
    ..Our findings reveal a critical role for Rho GTPases in positioning Ras activation and thereby establishing the accuracy of directional sensing. ..
  24. ncbi request reprint Mitochondrial building blocks
    Robert E Jensen
    Department of Cell Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Trends Cell Biol 14:215-8. 2004
    ..Mootha et al. examined mitochondria from mouse brain, heart, kidney and liver cells, finding that a surprising fraction of the proteins are expressed in only a subset of tissues...
  25. ncbi request reprint Yeast mitochondrial dynamics: fusion, division, segregation, and shape
    R E Jensen
    Department of Cell Biology and Anatomy, Biophysics 100, Johns Hopkins University School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA
    Microsc Res Tech 51:573-83. 2000
    ..Below we summarize our current understanding of the molecules known to be required for yeast mitochondrial dynamics...
  26. doi request reprint Cyclin C: an inducer of mitochondrial division hidden in the nucleus
    Yoshihiro Adachi
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 28:112-4. 2014
    ..In this issue of Developmental Cell, Cooper et al. (2014) report that a nuclear protein, cyclin C, is recruited from nuclei to mitochondria upon oxidative stress and promotes mitochondrial division and apoptosis of the cell. ..
  27. pmc Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity
    Zhonghan Yang
    Department of Medicine and the Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Infect Immun 81:1905-14. 2013
    ..Parasitic nematode infection has both preventive and therapeutic effects against the development of obesity and associated features of metabolic dysfunction in mice...
  28. pmc Proteomic identification of phosphatidylinositol (3,4,5) triphosphate-binding proteins in Dictyostelium discoideum
    Pingbo Zhang
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:11829-34. 2010
    ..Thus, this study advances our understanding of the PtdInsP(3)-mediated signaling mechanisms that control directed cell migration in chemotaxis...
  29. ncbi request reprint Ahead of the curve: mitochondrial fusion and phospholipase D
    Robert E Jensen
    Nat Cell Biol 8:1215-7. 2006
  30. ncbi request reprint Regulation of mitochondrial fusion and division
    Kara L Cerveny
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Trends Cell Biol 17:563-9. 2007
    ..In this review, we discuss how mitochondrial dynamics are controlled and how these events are coordinated with cell growth, mitosis, apoptosis and human diseases...

Research Grants2

  1. Mitochondrial Fusion and Division
    Hiromi Sesaki; Fiscal Year: 2010
    ..To gain a better understanding of the pathogenesis of these diseases, we will investigate the molecular mechanisms and physiological functions of mitochondrial fusion and division. ..