Gregg Semenza

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Involvement of hypoxia-inducible factor 1 in human cancer
    Gregg L Semenza
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Intern Med 41:79-83. 2002
  2. pmc Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells
    Weibo Luo
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, USA
    Oncotarget 2:551-6. 2011
  3. pmc HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
    H Zhang
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Oncogene 31:1757-70. 2012
  4. doi request reprint Hypoxia-inducible factor 1 and cardiovascular disease
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry and McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 email
    Annu Rev Physiol 76:39-56. 2014
  5. doi request reprint Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry and McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 email
    Annu Rev Pathol 9:47-71. 2014
  6. doi request reprint Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis
    G L Semenza
    Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Oncogene 32:4057-63. 2013
  7. pmc Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
    Daniele M Gilkes
    Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cancer Res 11:456-66. 2013
  8. pmc Molecular mechanisms mediating metastasis of hypoxic breast cancer cells
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Mol Med 18:534-43. 2012
  9. pmc The role of hypoxia-inducible factors in oxygen sensing by the carotid body
    Gregg L Semenza
    Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Adv Exp Med Biol 758:1-5. 2012
  10. pmc Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Pharmacol Sci 33:207-14. 2012

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Involvement of hypoxia-inducible factor 1 in human cancer
    Gregg L Semenza
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Intern Med 41:79-83. 2002
    ..Fourth, in addition to intratumoral hypoxia, genetic alterations in tumor suppressor genes and oncogenes induce HIF-1 activity...
  2. pmc Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells
    Weibo Luo
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, USA
    Oncotarget 2:551-6. 2011
    ..The recent discovery of novel physical and functional interactions between PKM2 and HIF-1 in cancer cells has provided insight into molecular mechanisms underlying the Warburg effect...
  3. pmc HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
    H Zhang
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Oncogene 31:1757-70. 2012
    ..ANGPTL4 is a secreted factor that inhibits EC-EC interaction, whereas L1CAM increases the adherence of BrCa cells to ECs. Interference with HIF, ANGPTL4 or L1CAM expression inhibits vascular metastasis of BrCa cells to the lungs...
  4. doi request reprint Hypoxia-inducible factor 1 and cardiovascular disease
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry and McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 email
    Annu Rev Physiol 76:39-56. 2014
    ..Analysis of animal models suggests that by activation of these homeostatic mechanisms, HIF-1 plays a critical protective role in the pathophysiology of ischemic heart disease and pressure-overload heart failure. ..
  5. doi request reprint Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry and McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 email
    Annu Rev Pathol 9:47-71. 2014
    ..In contrast, HIFs contribute to the pathogenesis of pulmonary arterial hypertension, systemic hypertension associated with sleep apnea, ocular neovascularization, hereditary erythrocytosis, and cancer. ..
  6. doi request reprint Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis
    G L Semenza
    Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Oncogene 32:4057-63. 2013
    ..In addition, lysyl oxidase (LOX) and LOX-like proteins, which are secreted by hypoxic breast cancer cells, remodel extracellular matrix in the lungs, which leads to BMDC recruitment and metastatic niche formation...
  7. pmc Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
    Daniele M Gilkes
    Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cancer Res 11:456-66. 2013
    ..We show that PLOD2 is critical for fibrillar collagen formation by breast cancer cells, increases tumor stiffness, and is required for metastasis to lymph nodes and lungs...
  8. pmc Molecular mechanisms mediating metastasis of hypoxic breast cancer cells
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Mol Med 18:534-43. 2012
    ..Digoxin, a drug that inhibits HIF-1 activity, blocks primary tumor growth, vascularization, invasion, and metastasis in ex vivo and in vivo assays...
  9. pmc The role of hypoxia-inducible factors in oxygen sensing by the carotid body
    Gregg L Semenza
    Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Adv Exp Med Biol 758:1-5. 2012
    ..Thus, IH disrupts the balance between HIF-1-dependent pro-oxidant and HIF-2-dependent anti-oxidant activities, and this loss of redox homeostasis underlies the pathogenesis of autonomic morbidities associated with IH...
  10. pmc Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Pharmacol Sci 33:207-14. 2012
    ....
  11. pmc Hypoxia-inducible factors in physiology and medicine
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 148:399-408. 2012
    ....
  12. ncbi request reprint Evaluation of HIF-1 inhibitors as anticancer agents
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, 733 North Broadway, Suite 671, Baltimore, MD 21205, USA
    Drug Discov Today 12:853-9. 2007
    ..Determining which combination of drugs to administer to any given patient remains a major obstacle to improving cancer treatment outcomes...
  13. ncbi request reprint Hypoxia-inducible factor 1 (HIF-1) pathway
    Gregg L Semenza
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Suite 671, 733 North Broadway, Baltimore, MD 21205, USA
    Sci STKE 2007:cm8. 2007
    ..A growing number of proteins and small molecules have been identified that regulate HIF-1 activity by modulating the physical or functional interaction of PHD2, VHL, FIH-1, RACK1, or HSP90 with HIF-1alpha...
  14. ncbi request reprint Vasculogenesis, angiogenesis, and arteriogenesis: mechanisms of blood vessel formation and remodeling
    Gregg L Semenza
    Vascular Biology Program, Institute for Cell Engineering Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biochem 102:840-7. 2007
    ....
  15. ncbi request reprint Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1
    Gregg L Semenza
    Vascular Biology Program and Institute for Cell Engineering, Departments of Pediatrics, Medicine, Oncology and Radiation Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Physiol 92:988-91. 2007
    ..Administration of viral vectors encoding constitutively active forms of the HIF-1alpha subunit results in increased tissue perfusion in animal models of ischaemic cardiovascular disease...
  16. ncbi request reprint HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia
    Gregg L Semenza
    Vascular Biology Program, Institute for Cell Engineering, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Antioxid Redox Signal 9:1391-6. 2007
    ....
  17. ncbi request reprint Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
    Gregg L Semenza
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biochem J 405:1-9. 2007
    ....
  18. ncbi request reprint HIF-1 mediates the Warburg effect in clear cell renal carcinoma
    Gregg L Semenza
    Institute for Cell Engineering, Departments of Pediatrics, Medicine, Oncology, and Radiation Oncology, and McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Bioenerg Biomembr 39:231-4. 2007
    ..These findings delineate for the first time the molecular mechanisms underlying the Warburg effect in a human cancer...
  19. ncbi request reprint Hypoxia and cancer
    Gregg L Semenza
    Vascular Biology Program, Institute for Cell Engineering, The John Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Metastasis Rev 26:223-4. 2007
  20. pmc Tumor metabolism: cancer cells give and take lactate
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, Department of Pediatrics, John Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Invest 118:3835-7. 2008
    ..MCT1 expression was detected exclusively in nonhypoxic regions of human cancer biopsy samples, and in combination, these data suggest that MCT1 inhibition holds potential as a novel cancer therapy...
  21. ncbi request reprint Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1
    Gregg L Semenza
    Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Physiol 91:803-6. 2006
    ....
  22. ncbi request reprint Development of novel therapeutic strategies that target HIF-1
    Gregg L Semenza
    Vascular Biology Program of the Johns Hopkins Institute for Cell Engineering, Broadway Research Building, Suite 671, 733 North Broadway, Baltimore, MD 21205, USA
    Expert Opin Ther Targets 10:267-80. 2006
    ..Several novel compounds with anticancer activity have been shown to inhibit HIF-1 and may be useful as components of individualised multidrug therapeutic regimens chosen based on molecular analyses of tumour biopsies...
  23. ncbi request reprint Involvement of hypoxia-inducible factor 1 in pulmonary pathophysiology
    Gregg L Semenza
    The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Chest 128:592S-594S. 2005
    ..These studies implicate HIF-1 in pathophysiologic alterations of both smooth muscle and endothelial cell biology in patients with pulmonary hypertension...
  24. pmc New insights into nNOS regulation of vascular homeostasis
    Gregg L Semenza
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Invest 115:2976-8. 2005
    ....
  25. ncbi request reprint Hypoxia and human disease-and the Journal of Molecular Medicine
    G L Semenza
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Suite 671, 733 North Broadway, Baltimore, MD, 21205, USA
    J Mol Med (Berl) 85:1293-4. 2007
  26. pmc Mitochondrial autophagy: life and breath of the cell
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, Department of Pediatrics, McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Autophagy 4:534-6. 2008
    ..These studies indicate that mitochondrial autophagy represents an adaptive metabolic response to hypoxia that is necessary to maintain redox homeostasis and cell survival...
  27. doi request reprint O2 sensing: only skin deep?
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering Departments of Pediatrics, Medicine, Oncology, and Radiation Oncology, Baltimore, MD 21205, USA
    Cell 133:206-8. 2008
    ....
  28. pmc Hypoxia. Cross talk between oxygen sensing and the cell cycle machinery
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Cell Physiol 301:C550-2. 2011
    ..Thus HIF and MCM proteins act in a mutually antagonistic manner, providing a novel molecular mechanism for homeostatic regulation of cell proliferation based on the relative levels of these proteins...
  29. ncbi request reprint Oxygen homeostasis
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MA 21205, USA
    Wiley Interdiscip Rev Syst Biol Med 2:336-61. 2010
    ..Recent studies have elucidated complex mechanisms by which HIF-1 activity is regulated and by which HIF-1 regulates gene expression, with profound consequences for prenatal development, postnatal physiology, and disease pathogenesis...
  30. pmc Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biochim Biophys Acta 1813:1263-8. 2011
    ..HIF-1-dependent regulation of mitochondrial metabolism may also contribute to the protective effects of ischemic preconditioning. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection...
  31. pmc Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    G L Semenza
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Oncogene 29:625-34. 2010
    ....
  32. pmc HIF-1: upstream and downstream of cancer metabolism
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Suite 671, 733 North Broadway, Baltimore, MD 21205, United States
    Curr Opin Genet Dev 20:51-6. 2010
    ..Many metabolic abnormalities in cancer cells increase HIF-1 activity. As a result, a feed-forward mechanism can be activated that drives HIF-1 activation and may promote tumor progression...
  33. ncbi request reprint Regulation of vascularization by hypoxia-inducible factor 1
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering McKusick Nathans Institute of Genetic Medicine, Baltimore, Maryland 21205, USA
    Ann N Y Acad Sci 1177:2-8. 2009
    ....
  34. pmc Vascular responses to hypoxia and ischemia
    Gregg L Semenza
    Institute for Cell Engineering, Departments of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arterioscler Thromb Vasc Biol 30:648-52. 2010
    ..Impairment of HIF-1-dependent responses to hypoxia is a major factor contributing to the impaired vascular responses to ischemia that are associated with aging and diabetes...
  35. ncbi request reprint HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery
    G L Semenza
    The Johns Hopkins University Schoolof Medicine, Baltimore, MD 21205, USA
    Curr Pharm Des 15:3839-43. 2009
    ....
  36. ncbi request reprint Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Blood 114:2015-9. 2009
    ..Intense efforts are under way to identify small molecule hydroxylase inhibitors that can be administered chronically to selectively induce erythropoiesis without undesirable side effects...
  37. doi request reprint Regulation of oxygen homeostasis by hypoxia-inducible factor 1
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, McKusick Nathans Institute of Genetic Medicine, Baltimore, Maryland, USA
    Physiology (Bethesda) 24:97-106. 2009
    ..HIF-1 also mediates maladaptive responses to chronic continuous and intermittent hypoxia, which underlie the development of pulmonary and systemic hypertension, respectively...
  38. ncbi request reprint Regulation of cancer cell metabolism by hypoxia-inducible factor 1
    Gregg L Semenza
    Institute for Cell Engineering, Department of Pediatrics, McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, United States
    Semin Cancer Biol 19:12-6. 2009
    ..Targeting HIF-1 or metabolic enzymes encoded by HIF-1 target genes may represent a novel therapeutic approach to cancer...
  39. ncbi request reprint Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 14:7969-70. 2008
    ..In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis...
  40. ncbi request reprint Hypoxia-inducible factor 1 and cancer pathogenesis
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    IUBMB Life 60:591-7. 2008
    ..Proof of principle studies in mouse models suggests that inhibition of HIF-1 activity may have therapeutic effects, especially in combination with other anticancer drugs...
  41. ncbi request reprint Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1
    Gregg L Semenza
    Program in Vascular Cell Engineering, Johns Hopkins University School of Medicine, 733 N Broadway, Suite 671, Baltimore, MD 21205, USA
    Proc Am Thorac Soc 2:68-70. 2005
    ..HIF-1 plays critical roles both during development and in response to physiologic and pathophysiologic stimuli in the adult. Here, the involvement of HIF-1 in lung pathophysiology will be discussed...
  42. ncbi request reprint Life with oxygen
    Gregg L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Broadway Research Building, Suite 671, 733 North Broadway, Baltimore, MD 21205, USA
    Science 318:62-4. 2007
    ..Pharmacologic agents that activate or inhibit the hypoxia signal transduction pathway may be useful therapies for ischemic and neoplastic disorders, respectively, which are the major causes of mortality in industrialized societies...
  43. ncbi request reprint Intratumoral hypoxia, radiation resistance, and HIF-1
    Gregg L Semenza
    Program in Vascular Cell Engineering, The Johns Hopkins University School of Medicine, 733 North Broadway, Suite 671, Baltimore, MD 21205, USA
    Cancer Cell 5:405-6. 2004
    ..In this issue of Cancer Cell, now provide evidence that radiation induces HIF-1-mediated expression of VEGF and bFGF in tumor cells, which promotes endothelial cell survival...
  44. ncbi request reprint Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology
    G L Semenza
    Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Johns Hopkins Hospital, CMSC 1004, 600 North Wolfe Street, Baltimore, MD 21287 3914, USA
    Trends Mol Med 7:345-50. 2001
    ..Modulation of HIF-1 activity by genetic or pharmacological means could provide a novel therapeutic approach to these common causes of mortality...
  45. ncbi request reprint HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus
    G L Semenza
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cell 107:1-3. 2001
    ..A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation...
  46. pmc Oxygen-regulated transcription factors and their role in pulmonary disease
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Respir Res 1:159-62. 2000
    ..Angiotensin II induces HIF-1 expression and hypertrophy of pulmonary arterial smooth muscle cells. HIF-1 might therefore have multiple roles in the pathogenesis of pulmonary vascular remodeling...
  47. ncbi request reprint Targeting HIF-1 for cancer therapy
    Gregg L Semenza
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Nat Rev Cancer 3:721-32. 2003
    ..In preclinical studies, inhibition of HIF-1 activity has marked effects on tumour growth. Efforts are underway to identify inhibitors of HIF-1 and to test their efficacy as anticancer therapeutics...
  48. ncbi request reprint HIF-1 and tumor progression: pathophysiology and therapeutics
    Gregg L Semenza
    Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, CMSC 1004, Baltimore, MD 21287 3914, USA
    Trends Mol Med 8:S62-7. 2002
    ..Increased HIF-1 activity promotes tumor progression, and inhibition of HIF-1 could represent a novel approach to cancer therapy...
  49. pmc Physiology meets biophysics: visualizing the interaction of hypoxia-inducible factor 1 alpha with p300 and CBP
    Gregg L Semenza
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Proc Natl Acad Sci U S A 99:11570-2. 2002
  50. ncbi request reprint Signal transduction to hypoxia-inducible factor 1
    Gregg Semenza
    Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, CMSC 1004, Baltimore, MD 21287 3914, USA
    Biochem Pharmacol 64:993-8. 2002
    ....
  51. ncbi request reprint Angiogenesis in ischemic and neoplastic disorders
    Gregg L Semenza
    McKusick Nathans Institute of Genetic Medicine and the Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Annu Rev Med 54:17-28. 2003
    ..Novel therapeutic approaches that involve stimulating angiogenesis in ischemic tissue and inhibiting angiogenesis in neoplastic tissue are currently being evaluated in clinical trials...
  52. ncbi request reprint Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease
    G L Semenza
    Institute of Genetic Medicine and Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Pediatr Res 49:614-7. 2001
    ..HIF-1 may also mediate the protective response to cerebral ischemia known as late-phase preconditioning...
  53. ncbi request reprint Hydroxylation of HIF-1: oxygen sensing at the molecular level
    Gregg L Semenza
    Program in Vascular Cell Engineering, Departments of Pediatrics, Medicine, Oncology, and Radiation Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Physiology (Bethesda) 19:176-82. 2004
    ..The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in PO2 are transduced to effect changes in gene expression...
  54. ncbi request reprint HIF-1: using two hands to flip the angiogenic switch
    G L Semenza
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer Metastasis Rev 19:59-65. 2000
    ....
  55. ncbi request reprint Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1
    G L Semenza
    Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Ann N Y Acad Sci 874:262-8. 1999
    ....
  56. ncbi request reprint Expression of hypoxia-inducible factor 1: mechanisms and consequences
    G L Semenza
    The Johns Hopkins School of Medicine, Baltimore, MD 21287 3914, USA
    Biochem Pharmacol 59:47-53. 2000
    ..Pharmacologic manipulation of HIF-1 levels may provide a novel therapeutic approach to diseases that represent the most common causes of mortality in Western society, including cancer, chronic lung disease, and myocardial ischemia...
  57. ncbi request reprint Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Annu Rev Cell Dev Biol 15:551-78. 1999
    ..HIF-1 thus appears to function as a master regulator of O2 homeostasis that plays essential roles in cellular and systemic physiology, development, and pathophysiology...
  58. ncbi request reprint HIF-1: mediator of physiological and pathophysiological responses to hypoxia
    G L Semenza
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    J Appl Physiol (1985) 88:1474-80. 2000
    ..Genetic or pharmacological modulation of HIF-1 activity in vivo may represent a novel therapeutic approach to these disorders...
  59. ncbi request reprint Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
    G L Semenza
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Crit Rev Biochem Mol Biol 35:71-103. 2000
    ....
  60. ncbi request reprint HIF-1 and human disease: one highly involved factor
    G L Semenza
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914 USA
    Genes Dev 14:1983-91. 2000
  61. ncbi request reprint HIF-1 and mechanisms of hypoxia sensing
    G L Semenza
    Johns Hopkins Hospital, CMSC 1004, 600 North Wolfe Street, Baltimore, Maryland 21287 3914, USA
    Curr Opin Cell Biol 13:167-71. 2001
    ..The signal transduction pathway remains enigmatic, but involves generation of reactive oxygen species. Nitric oxide induces HIF-1 alpha under non-hypoxic conditions but inhibits hypoxia-induced HIF-1 alpha expression...
  62. ncbi request reprint Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    Ryo Fukuda
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 277:38205-11. 2002
    ..Involvement of the MAP kinase pathway represents a novel mechanism for the induction of HIF-1 alpha protein expression in human cancer cells...
  63. ncbi request reprint Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1
    Ryo Fukuda
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Cancer Res 63:2330-4. 2003
    ..Thus, the activity of multiple signal transduction pathways is required for the HIF-1-mediated induction of VEGF expression in colon cancer cells exposed to PGE(2)...
  64. ncbi request reprint OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha
    Jin Hyen Baek
    Institute for Cell Engineering, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 17:503-12. 2005
    ..These data indicate that OS-9 is an essential component of a multiprotein complex that regulates HIF-1alpha levels in an O2-dependent manner...
  65. pmc Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling
    Sergio Rey
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Suite 671, 733 N Broadway, Baltimore, MD 21205, USA
    Cardiovasc Res 86:236-42. 2010
    ..This review will focus on the pivotal role of HIF-1 in vascular homeostasis, the involvement of HIF-1 in vascular diseases, and recent advances in targeting HIF-1 for therapy in preclinical models...
  66. pmc Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization
    Ye V Liu
    Vascular Program, Institute for Cell Engineering, Department of Pharmacology and Molecular Sciences, Mass Spectronomy Proteomics Facility, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Biol Chem 282:37064-73. 2007
    ..These results indicate that intracellular calcium levels can regulate HIF-1alpha expression by modulating calcineurin activity and RACK1 dimerization...
  67. pmc Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
    Jung whan Kim
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 27:7381-93. 2007
    ....
  68. ncbi request reprint HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
    Jung whan Kim
    Graduate Program of Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell Metab 3:177-85. 2006
    ..These studies reveal a hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production...
  69. ncbi request reprint Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1
    Balaji Krishnamachary
    McKusick Nathans Institute of Genetic Medicine and Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Cancer Res 63:1138-43. 2003
    ..These results provide a molecular basis for promotion of the invasive cancer phenotype by hypoxia and/or HIF-1 alpha overexpression...
  70. ncbi request reprint O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1
    Gregg L Semenza
    Johns Hopkins University School of Medicine, McKusick Nathans Institute of Genetic Medicine, Program in Vascular Cell Engineering, Institute for Cell Engineering, Baltimore, MD 21205, USA
    J Appl Physiol 96:1173-7; discussion 1170-2. 2004
    ..Thus HIF-1 mediates critical physiological responses to hypoxia, and the elucidation of these homeostatic mechanisms may lead to novel therapies for the most common causes of mortality in the US population...
  71. ncbi request reprint Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1
    Brian D Kelly
    Program in Vascular Cell Engineering, Institute for Cell Engineering, Baltimore, MD, USA
    Circ Res 93:1074-81. 2003
    ....
  72. ncbi request reprint HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
    Huafeng Zhang
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Cell 11:407-20. 2007
    ..We demonstrate that transcription of the gene encoding the coactivator PGC-1beta is C-MYC dependent and that loss of PGC-1beta expression is a major factor contributing to reduced respiration in VHL-deficient renal carcinoma cells...
  73. pmc Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
    KangAe Lee
    Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:2353-8. 2009
    ..These results provide a molecular basis for the antiangiogenic effect of anthracycline therapy and have important implications for refining the use of these drugs to treat human cancer more effectively...
  74. ncbi request reprint Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B
    Balaji Krishnamachary
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 66:2725-31. 2006
    ..Thus, HIF-1 contributes to the epithelial-mesenchymal transition in VHL-null RCC by indirect repression of E-cadherin...
  75. ncbi request reprint Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha
    Jin H Baek
    Vascular Program, Institute for Cell Engineering, The Departments of Pediatrics, Medicine, Oncology, and Radiation Oncology
    J Biol Chem 282:33358-66. 2007
    ..However, in contrast to SSAT2, SSAT1 acts by stabilizing the interaction of HIF-1alpha with RACK1. Thus, the paralogs SSAT1 and SSAT2 play complementary roles in promoting O(2)-independent and O(2)-dependent degradation of HIF-1alpha...
  76. pmc Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells
    Lixin Liu
    Section of Surgical Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cell Physiol 217:319-27. 2008
    ..Thus, HIF-1alpha gene therapy corrects the age-dependent impairment of HIF-1alpha expression, angiogenic cytokine expression, and CACs that contribute to the age-dependent impairment of wound healing in db/db mice...
  77. pmc Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
    Anne Le
    Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:2037-42. 2010
    ....
  78. ncbi request reprint HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
    Ryo Fukuda
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 129:111-22. 2007
    ..Thus, mammalian cells respond to hypoxia by altering COX subunit composition, as previously observed in yeast, but by a completely different molecular mechanism...
  79. pmc The expanding universe of hypoxia
    Huafeng Zhang
    Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Mol Med (Berl) 86:739-46. 2008
    ..In this meeting report, we summarize major developments in the field that were presented at the 2008 Keystone Symposium on Cellular, Physiological, and Pathogenic Responses to Hypoxia...
  80. pmc Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
    KangAe Lee
    Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:17910-5. 2009
    ..These results provide proof of principle that small molecules can inhibit dimerization of HIF-1 and have potent inhibitory effects on tumor growth and vascularization...
  81. pmc Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
    Huafeng Zhang
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 283:10892-903. 2008
    ....
  82. ncbi request reprint Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha
    Jin Hyen Baek
    Vascular Biology Program, Institute for Cell Engineering, Department of Pediatrics, and McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 282:23572-80. 2007
    ..Multivalent interactions by SSAT2 provide a mechanism to ensure efficient complex formation, which is necessary for the extremely rapid ubiquitination and degradation of HIF-1alpha that is observed in oxygenated cells...
  83. ncbi request reprint Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
    Dominador J Manalo
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 105:659-69. 2005
    ....
  84. ncbi request reprint PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning
    Zheqing Cai
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circ Res 97:1351-9. 2005
    ..Perfusion of H2(O2) was sufficient to induce Akt activation. Thus, loss of PTEN activity leads to induction of IPC and feedback mechanisms designed to ensure that Akt activation is transient are responsible for decay of IPC...
  85. ncbi request reprint Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease
    Jon R Resar
    Division of Cardiology, The Johns Hopkins University School of Medicine, Blalock 524, 600 North Wolfe St, Baltimore, MD 21287, USA
    Chest 128:787-91. 2005
    ..Hypoxia inducible factor 1 (HIF-1), a transcriptional activator that functions as a master regulator of oxygen homeostasis, is one possible genetic factor that could play an important role in modulating collateral development...
  86. ncbi request reprint Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia
    Marta Bosch-Marce
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 101:1310-8. 2007
    ..These results indicate that HIF-1 activity is necessary and sufficient for the mobilization of angiogenic cells and that HIF-1alpha gene therapy can counteract the pathological effects of aging in a mouse model of limb ischemia...
  87. ncbi request reprint Functional analysis of the role of hypoxia-inducible factor 1 in the pathogenesis of hypoxic pulmonary hypertension
    Larissa A Shimoda
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkinds University School of Medicine, Baltimore, Maryland 21224, USA
    Methods Enzymol 381:121-9. 2004
  88. ncbi request reprint Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury
    Zheqing Cai
    McKusick Nathans Institute of Genetic Medicine, Baltimore, MD, USA
    Circulation 108:79-85. 2003
    ..Hypoxia-inducible factor 1 (HIF-1) mediates adaptive transcriptional responses to hypoxia/ischemia...
  89. ncbi request reprint Analysis of hypoxia-inducible factor 1alpha expression and its effects on invasion and metastasis
    Balaji Krishnamachary
    Vascular Biology Program, Institute for Cell Engineering, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Methods Enzymol 435:347-54. 2007
    ..Here, we describe methods for immunohistochemical detection of HIF-1alpha in tumor biopsy sections and ex vivo assays for analyzing the effects of hypoxia and HIF-1 on cancer cell invasiveness and cell-cell adhesion...
  90. ncbi request reprint Proceedings of the Oxygen Homeostasis/Hypoxia Meeting
    Bennett Kaufman
    TRI Inc, Rockville, Maryland, USA
    Cancer Res 64:3350-6. 2004
  91. pmc Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR
    Guoxiang Yuan
    The Center for Systems Biology, Department of Medicine, University of Chicago, Illinois 60637, USA
    J Cell Physiol 217:674-85. 2008
    ..Rapamycin or cycloheximide, blocked increased HIF-1alpha levels during re-oxygenation indicating that mTOR-dependent protein synthesis is required for the persistent elevation of HIF-1alpha levels during re-oxygenation...
  92. ncbi request reprint Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling
    Kenji Kasuno
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan 563 0053
    J Biol Chem 279:2550-8. 2004
    ..We conclude that the NO donor NOC18 induces HIF-1alpha synthesis under conditions of NO formation during normoxia and that hydroxylation of HIF-1alpha is not regulated by NOC18...
  93. ncbi request reprint The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway
    Satoshi Takabuchi
    Department of Anesthesia, The Tazuke Kofukai Medical Research Institute Kitano Hospital, Osaka, Japan
    Biochem Biophys Res Commun 324:417-23. 2004
    ..SNP inhibits the accumulation of HIF-1alpha, the regulatory subunit of HIF-1, and the transcriptional activation of HIF-1alpha via a mechanism that is not dependent on either NO or soluble guanylate cyclase...
  94. pmc Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer
    Oliver Stoeltzing
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Am J Pathol 163:1001-11. 2003
    ..02). Our results suggest that autocrine activation of the IGF-IR system significantly affects VEGF expression and angiogenesis in human pancreatic cancer. Thus, IGF-IR may be a valid target in the treatment of pancreatic cancer...
  95. ncbi request reprint The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner
    Satoshi Takabuchi
    Department of Anesthesia, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, 2 4 20, Ohgimachi, Kita ku, Osaka 530 8480, Japan
    FEBS Lett 577:434-8. 2004
    ....
  96. ncbi request reprint Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia
    Guoxiang Yuan
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 280:4321-8. 2005
    ..These observations suggest that IH induces HIF-1 transcriptional activity via a novel signaling pathway involving CaM kinase...
  97. ncbi request reprint ROS signaling in systemic and cellular responses to chronic intermittent hypoxia
    Nanduri R Prabhakar
    Center for Systems Biology, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Antioxid Redox Signal 9:1397-403. 2007
    ....
  98. pmc Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
    Ying Jie Peng
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44109, USA
    J Physiol 577:705-16. 2006
    ....
  99. ncbi request reprint Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling
    Kiichi Hirota
    Department of Anesthesia, The Tazuke Kofukai Medical Research Institute Kitano Hospital, 2 4 20, Ohgimachi, Kita ku, Osaka 530 8480, Japan
    J Biol Chem 279:41521-8. 2004
    ..We conclude that muscarinic acetylcholine signals activate HIF-1 by both stabilization and synthesis of HIF-1alpha and by inducing the transcriptional activity of HIF-1alpha...
  100. ncbi request reprint Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation
    Oliver Stoeltzing
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston 77030 4009, USA
    J Natl Cancer Inst 96:946-56. 2004
    ..Overexpression of HIF-1alpha is associated with tumor angiogenesis and tumor cell proliferation and invasion. We examined the effects of inhibiting HIF-1alpha activity on angiogenesis and human gastric cancer growth in vivo...
  101. ncbi request reprint Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer
    Peter Buchler
    Department of Surgery, UCLA School of Medicine, Los Angeles, California 90095 6904, USA
    Pancreas 26:56-64. 2003
    ..The microenvironment of low oxygen that is present in human pancreatic cancer in vivo may actively influence tumor growth as well as neovascularization...

Research Grants30

  1. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 2001
    ..abstract_text> ..
  2. HYPOXIA INDUCIBLE FACTOR I AND OXYGEN HOMEOSTASIS
    Gregg Semenza; Fiscal Year: 2001
    ..The knowledge gained from the proposed experiments will be relevant to the treatment of many clinical conditions in which hypoxia or ischemia plays an important pathophysiologic role. ..
  3. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 2000
    ..abstract_text> ..
  4. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 1992
    ..EPO gene DNA from affected family members will be amplified by the polymerase chain reaction and analyzed by nucleotide sequence determination to identify potential disease-causing mutations...
  5. HIF-1-Regulated Endothelial Progenitor Cell Recruitment in Burn Wound Healing
    Gregg Semenza; Fiscal Year: 2007
    ....
  6. HYPOXIA INDUCIBLE FACTOR I AND OXYGEN HOMEOSTASIS
    Gregg Semenza; Fiscal Year: 2002
    ..The knowledge gained from the proposed experiments will be relevant to the treatment of many clinical conditions in which hypoxia or ischemia plays an important pathophysiologic role. ..
  7. HIF-1-Regulated Endothelial Progenitor Cell Recruitment in Burn Wound Healing
    Gregg Semenza; Fiscal Year: 2007
    ..abstract_text> ..
  8. Hypoxia-Inducible Factor 1 and Oxygen Homeostasis
    Gregg Semenza; Fiscal Year: 2007
    ....
  9. Hypoxia-Inducible Factor 1 and Oxygen Homeostasis
    Gregg Semenza; Fiscal Year: 2006
    ....
  10. Hypoxia-Inducible Factor 1 and Oxygen Homeostasis
    Gregg Semenza; Fiscal Year: 2009
    ....
  11. Hypoxia-Inducible Factor 1 and Oxygen Homeostasis
    Gregg Semenza; Fiscal Year: 2005
    ....
  12. HYPOXIA INDUCIBLE FACTOR I AND OXYGEN HOMEOSTASIS
    Gregg Semenza; Fiscal Year: 2004
    ..The knowledge gained from the proposed experiments will be relevant to the treatment of many clinical conditions in which hypoxia or ischemia plays an important pathophysiologic role. ..
  13. HYPOXIA INDUCIBLE FACTOR I AND OXYGEN HOMEOSTASIS
    Gregg Semenza; Fiscal Year: 2003
    ..The knowledge gained from the proposed experiments will be relevant to the treatment of many clinical conditions in which hypoxia or ischemia plays an important pathophysiologic role. ..
  14. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 2002
    ..abstract_text> ..
  15. HYPOXIA INDUCIBLE FACTOR 1 AND OXYGEN HOMEOSTASIS
    Gregg Semenza; Fiscal Year: 1999
    ....
  16. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 1999
    ..abstract_text> ..
  17. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 1990
    ..EPO gene DNA from affected family members will be amplified by the polymerase chain reaction and analyzed by nucleotide sequence determination to identify potential disease-causing mutations...
  18. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 1991
    ..EPO gene DNA from affected family members will be amplified by the polymerase chain reaction and analyzed by nucleotide sequence determination to identify potential disease-causing mutations...
  19. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 1993
    ..EPO gene DNA from affected family members will be amplified by the polymerase chain reaction and analyzed by nucleotide sequence determination to identify potential disease-causing mutations...
  20. HYPOXIA INDUCIBLE FACTOR I AND OXYGEN HOMEOSTASIS
    Gregg Semenza; Fiscal Year: 2000
    ..The knowledge gained from the proposed experiments will be relevant to the treatment of many clinical conditions in which hypoxia or ischemia plays an important pathophysiologic role. ..