G L Semenza

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    G L Semenza
    Center for Medical Genetics, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    J Biol Chem 271:32529-37. 1996
  2. ncbi request reprint V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression
    B H Jiang
    Center for Medical Genetics, Department of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Cancer Res 57:5328-35. 1997
  3. ncbi request reprint Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
    L E Kotch
    Institute of Genetic MedicineDepartment of PediatricsDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287 3914, USA
    Dev Biol 209:254-67. 1999
  4. pmc HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    E Laughner
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-3914, USA
    Mol Cell Biol 21:3995-4004. 2001
  5. ncbi request reprint Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity
    F Agani
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Mol Pharmacol 54:749-54. 1998
  6. ncbi request reprint Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension
    B H Jiang
    Center for Medical Genetics, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    J Biol Chem 272:19253-60. 1997
  7. pmc Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    J A Forsythe
    Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
    Mol Cell Biol 16:4604-13. 1996
  8. pmc Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
    C H Sutter
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Proc Natl Acad Sci U S A 97:4748-53. 2000
  9. pmc Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
    N V Iyer
    Center for Medical Genetics, Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914 USA
    Genes Dev 12:149-62. 1998
  10. ncbi request reprint Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics
    H Zhong
    The Johns Hopkins Oncology Center, Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Res 60:1541-5. 2000

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    G L Semenza
    Center for Medical Genetics, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    J Biol Chem 271:32529-37. 1996
    ..These results provide further evidence that the coordinate transcriptional activation of genes encoding glycolytic enzymes which occurs in hypoxic cells is mediated by HIF-1...
  2. ncbi request reprint V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression
    B H Jiang
    Center for Medical Genetics, Department of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Cancer Res 57:5328-35. 1997
    ..These studies link an oncogene to the induction of HIF-1 expression, thus providing a mechanism for hypoxic adaptation by tumor cells...
  3. ncbi request reprint Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
    L E Kotch
    Institute of Genetic MedicineDepartment of PediatricsDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287 3914, USA
    Dev Biol 209:254-67. 1999
    ..Rather than being associated with VEGF deficiency, the vascular defects in Hif1a-/- embryos were spatially correlated with cell death, the onset of which preceded vascular regression...
  4. pmc HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    E Laughner
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-3914, USA
    Mol Cell Biol 21:3995-4004. 2001
    ..These data provide a molecular basis for VEGF induction and tumor angiogenesis by heregulin-HER2 signaling and establish a novel mechanism for the regulation of HIF-1alpha expression...
  5. ncbi request reprint Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity
    F Agani
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Mol Pharmacol 54:749-54. 1998
    ....
  6. ncbi request reprint Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension
    B H Jiang
    Center for Medical Genetics, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    J Biol Chem 272:19253-60. 1997
    ..These results indicate that increased transcriptional activity mediated by HIF-1 in hypoxic cells results from both increased HIF-1alpha protein levels and increased activity of HIF-1alpha transactivation domains...
  7. pmc Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    J A Forsythe
    Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
    Mol Cell Biol 16:4604-13. 1996
    ..VEGF mRNA was not induced by hypoxia in mutant cells that do not express the HIF-1beta (ARNT) subunit. These findings implicate HIF-1 in the activation of VEGF transcription in hypoxic cells...
  8. pmc Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
    C H Sutter
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Proc Natl Acad Sci U S A 97:4748-53. 2000
    ..We demonstrate that hypoxia results in decreased ubiquitination of HIF-1alpha and that missense mutations increase HIF-1alpha expression under nonhypoxic conditions by blocking ubiquitination...
  9. pmc Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
    N V Iyer
    Center for Medical Genetics, Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914 USA
    Genes Dev 12:149-62. 1998
    ..5 and E9.5, coincident with the onset of developmental defects and cell death in Hif1a-/- embryos. These results demonstrate that HIF-1alpha is a master regulator of cellular and developmental O2 homeostasis...
  10. ncbi request reprint Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics
    H Zhong
    The Johns Hopkins Oncology Center, Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Res 60:1541-5. 2000
    ..These data indicate that pharmacological agents that target PI3K, AKT, or FRAP in tumor cells inhibit HIF-1alpha expression and that such inhibition may contribute to therapeutic efficacy...
  11. ncbi request reprint Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
    B H Jiang
    Center for Medical Genetics, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    J Biol Chem 271:17771-8. 1996
    ..Overexpression of a HIF-1alpha construct with deletions of the basic domain and carboxy terminus blocked reporter gene activation by endogenous HIF-1 in hypoxic cells...
  12. pmc General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 90:4304-8. 1993
    ..These results provide evidence that HIF-1 and its recognition sequence are common components of a general mammalian cellular response to hypoxia...
  13. pmc FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
    P C Mahon
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Genes Dev 15:2675-86. 2001
    ..Involvement of VHL in association with FIH-1 provides a unifying mechanism for the modulation of HIF-1alpha protein stabilization and transcriptional activation in response to changes in cellular O(2) concentration...
  14. ncbi request reprint Oxygen-independent upregulation of vascular endothelial growth factor and vascular barrier dysfunction during ventilated pulmonary ischemia in isolated ferret lungs
    P M Becker
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 22:272-9. 2000
    ..These results implicate VEGF as a potential mediator of increased pulmonary vascular permeability in this model of acute lung injury...
  15. ncbi request reprint Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1
    G L Semenza
    Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Ann N Y Acad Sci 874:262-8. 1999
    ....
  16. ncbi request reprint Oncogenic alterations of metabolism
    C V Dang
    Dept of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Biochem Sci 24:68-72. 1999
    ....
  17. ncbi request reprint The human hypoxia-inducible factor 1alpha gene: HIF1A structure and evolutionary conservation
    N V Iyer
    Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287, USA
    Genomics 52:159-65. 1998
    ..The proximal 300 bp of 5' flanking sequences was 83% identical, including the SP1 sites and transcription initiation sites. These results suggest evolutionary selection for maintenance of HIF1A structure, function, and regulation...
  18. ncbi request reprint Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914
    J Biol Chem 269:23757-63. 1994
    ..These results support the role of HIF-1 as a mediator of adaptive responses to hypoxia that underlie cellular and systemic oxygen homeostasis...
  19. ncbi request reprint Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia
    L A Shimoda
    Division of Pulmonary and Critical Care Medicine and Institute of Genetic Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
    Am J Physiol Lung Cell Mol Physiol 281:L202-8. 2001
    ..Thus partial deficiency of HIF-1alpha is sufficient to impair hypoxia-induced depolarization, reduction of K+ current density, and PASMC hypertrophy...
  20. pmc Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Proc Natl Acad Sci U S A 92:5510-4. 1995
    ....
  21. ncbi request reprint Expression of hypoxia-inducible factor 1: mechanisms and consequences
    G L Semenza
    The Johns Hopkins School of Medicine, Baltimore, MD 21287 3914, USA
    Biochem Pharmacol 59:47-53. 2000
    ..Pharmacologic manipulation of HIF-1 levels may provide a novel therapeutic approach to diseases that represent the most common causes of mortality in Western society, including cancer, chronic lung disease, and myocardial ischemia...
  22. ncbi request reprint Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Annu Rev Cell Dev Biol 15:551-78. 1999
    ..HIF-1 thus appears to function as a master regulator of O2 homeostasis that plays essential roles in cellular and systemic physiology, development, and pathophysiology...
  23. ncbi request reprint HIF-1: using two hands to flip the angiogenic switch
    G L Semenza
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer Metastasis Rev 19:59-65. 2000
    ....
  24. ncbi request reprint Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
    P J Lee
    Division of Pulmonary and Critical Care, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 272:5375-81. 1997
    ..Taken together, these data demonstrate that hypoxia induces HO-1 expression in animal tissues and cell cultures and implicate HIF-1 in this response...
  25. ncbi request reprint HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus
    G L Semenza
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cell 107:1-3. 2001
    ..A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation...
  26. ncbi request reprint Hypoxia-inducible factor 1: master regulator of O2 homeostasis
    G L Semenza
    Institute for Genetic Medicine, CMSC 1004, The Johns Hopkins UniversitySchool of Medicine, 600 N Wolfe St, Baltimore, Maryland 21287 3914, USA
    Curr Opin Genet Dev 8:588-94. 1998
    ..Recent studies have provided insights into the O2-dependent regulation of HIF-1 expression, target genes regulated by HIF-1, and the effects of HIF-1 deficiency on cellular physiology and embryonic development...
  27. ncbi request reprint Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q
    G L Semenza
    Center for Medical Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287, USA
    Genomics 34:437-9. 1996
    ..33...
  28. ncbi request reprint Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    H Zhong
    The Johns Hopkins Oncology Center, Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Res 59:5830-5. 1999
    ..In brain tumors, HIF-1alpha immunohistochemistry demarcated areas of angiogenesis. These results provide the first clinical data indicating that HIF-1alpha may play an important role in human cancer progression...
  29. ncbi request reprint Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
    G L Semenza
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Crit Rev Biochem Mol Biol 35:71-103. 2000
    ....
  30. ncbi request reprint HIF-1: mediator of physiological and pathophysiological responses to hypoxia
    G L Semenza
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    J Appl Physiol (1985) 88:1474-80. 2000
    ..Genetic or pharmacological modulation of HIF-1 activity in vivo may represent a novel therapeutic approach to these disorders...
  31. pmc Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha
    A Y Yu
    Institute of Genetic Medicine, Division of Pulmonary and Critical Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    J Clin Invest 103:691-6. 1999
    ..These results indicate that partial HIF-1alpha deficiency has significant effects on multiple systemic responses to chronic hypoxia...
  32. ncbi request reprint Purification and characterization of hypoxia-inducible factor 1
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914
    J Biol Chem 270:1230-7. 1995
    ..We conclude that in both cobalt chloride-treated HeLa cells and hypoxic Hep3B cells HIF-1 is composed of two different subunits: 120-kDa HIF-1 alpha and 91-94-kDa HIF-1 beta...
  33. ncbi request reprint 'The metabolism of tumours': 70 years later
    G L Semenza
    Institute of Genetic Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Novartis Found Symp 240:251-60; discussion 260-4. 2001
    ..In human breast cancer and brain tumours, HIF-1alpha overexpression is strongly correlated with tumour grade and vascularity...
  34. ncbi request reprint Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
    D Feldser
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Cancer Res 59:3915-8. 1999
    ..These data provide a novel mechanism by which HIF-1alpha overexpression may occur in tumor cells and contribute to an autocrine growth factor loop...
  35. ncbi request reprint Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease
    G L Semenza
    Institute of Genetic Medicine and Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Pediatr Res 49:614-7. 2001
    ..HIF-1 may also mediate the protective response to cerebral ischemia known as late-phase preconditioning...
  36. ncbi request reprint In vivo expression of mRNAs encoding hypoxia-inducible factor 1
    C M Wiener
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Biochem Biophys Res Commun 225:485-8. 1996
    ..The ubiquitous in vivo expression of HIF-1 alpha and HIF-1 beta (ARNT) mRNA is consistent with the proposed role of HIF-1 in coordinating adaptive transcriptional responses to hypoxia...
  37. ncbi request reprint Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology
    G L Semenza
    Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Johns Hopkins Hospital, CMSC 1004, 600 North Wolfe Street, Baltimore, MD 21287 3914, USA
    Trends Mol Med 7:345-50. 2001
    ..Modulation of HIF-1 activity by genetic or pharmacological means could provide a novel therapeutic approach to these common causes of mortality...
  38. ncbi request reprint Hypoxia inhibits G1/S transition through regulation of p27 expression
    L B Gardner
    Department of Medicine, The Johns Hopkins Oncology Center, Baltimore, Maryland 21205, USA
    J Biol Chem 276:7919-26. 2001
    ..This demonstration of the molecular mechanism of hypoxia-induced G1/S regulation provides insight into a fundamental response of mammalian cells to low oxygen tension...
  39. ncbi request reprint DNA binding and transcriptional properties of wild-type and mutant forms of the homeodomain protein Msx2
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Biochem Biophys Res Commun 209:257-62. 1995
    ..These results provide evidence that Msx2 is a transcriptional repressor and suggest that the mutant form of Msx2 may exert its pathophysiologic effects on craniofacial development by a gain-of-function mechanism...
  40. pmc Oxygen-regulated transcription factors and their role in pulmonary disease
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Respir Res 1:159-62. 2000
    ..Angiotensin II induces HIF-1 expression and hypertrophy of pulmonary arterial smooth muscle cells. HIF-1 might therefore have multiple roles in the pathogenesis of pulmonary vascular remodeling...
  41. ncbi request reprint HIF-1 and mechanisms of hypoxia sensing
    G L Semenza
    Johns Hopkins Hospital, CMSC 1004, 600 North Wolfe Street, Baltimore, Maryland 21287 3914, USA
    Curr Opin Cell Biol 13:167-71. 2001
    ..The signal transduction pathway remains enigmatic, but involves generation of reactive oxygen species. Nitric oxide induces HIF-1 alpha under non-hypoxic conditions but inhibits hypoxia-induced HIF-1 alpha expression...
  42. ncbi request reprint Regulation of metabolism by hypoxia-inducible factor 1
    G L Semenza
    Institute for Cell Engineering, Department of Pediatrics, McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cold Spring Harb Symp Quant Biol 76:347-53. 2011
    ..These results provide a mechanism by which PKM2 promotes metabolic reprogramming and suggest that it plays a broader role in cancer progression than has previously been appreciated...
  43. doi request reprint Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis
    G L Semenza
    Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Oncogene 32:4057-63. 2013
    ..In addition, lysyl oxidase (LOX) and LOX-like proteins, which are secreted by hypoxic breast cancer cells, remodel extracellular matrix in the lungs, which leads to BMDC recruitment and metastatic niche formation...
  44. pmc HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
    H Zhang
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Oncogene 31:1757-70. 2012
    ..ANGPTL4 is a secreted factor that inhibits EC-EC interaction, whereas L1CAM increases the adherence of BrCa cells to ECs. Interference with HIF, ANGPTL4 or L1CAM expression inhibits vascular metastasis of BrCa cells to the lungs...
  45. ncbi request reprint Perspectives on oxygen sensing
    G L Semenza
    Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cell 98:281-4. 1999
  46. ncbi request reprint Hypoxia and human disease-and the Journal of Molecular Medicine
    G L Semenza
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Suite 671, 733 North Broadway, Baltimore, MD, 21205, USA
    J Mol Med (Berl) 85:1293-4. 2007
  47. ncbi request reprint HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery
    G L Semenza
    The Johns Hopkins University Schoolof Medicine, Baltimore, MD 21205, USA
    Curr Pharm Des 15:3839-43. 2009
    ....
  48. ncbi request reprint Combination of HIF-1α gene transfection and HIF-1-activated bone marrow-derived angiogenic cell infusion improves burn wound healing in aged mice
    J Du
    1 Department of General Surgery, First Hospital Affiliated to Medical School, Xi an Jiaotong University, Xi an, China 2 Hendrix Burn Laboratory, Section of Surgical Sciences, Department of Surgery, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Gene Ther 20:1070-6. 2013
    ..Our findings offer insight into the pathophysiology of burns in the elderly and point to potential targets for developing new therapeutic strategies. ..
  49. pmc A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Mol Cell Biol 12:5447-54. 1992
    ..We have thus defined a functionally tripartite, 50-nt hypoxia-inducible enhancer which binds several nuclear factors, one of which is induced by hypoxia via de novo protein synthesis...
  50. pmc Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    G L Semenza
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Oncogene 29:625-34. 2010
    ....
  51. ncbi request reprint Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
    D M Aebersold
    Department of Radiation Oncology, University of Bern, Switzerland
    Cancer Res 61:2911-6. 2001
    ....
  52. ncbi request reprint Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1)
    A E Greijer
    Department of Pathology, VUMC, Amsterdam, The Netherlands
    J Pathol 206:291-304. 2005
    ..In conclusion, hypoxia causes down- rather than up-regulation of gene expression and HIF-1 seems to play a major role in the regulation of hypoxia-induced genes...
  53. ncbi request reprint Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis
    R M Tuder
    Department of Pathology, Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Colorado, USA
    J Pathol 195:367-74. 2001
    ..Because markers of angiogenesis are expressed in plexiform lesions in SPH, it is proposed that these lesions may form by a process of disordered angiogenesis...
  54. pmc Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
    R Ravi
    Johns Hopkins Oncology Center, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 USA
    Genes Dev 14:34-44. 2000
    ..These results indicate that amplification of normal HIF-1-dependent responses to hypoxia via loss of p53 function contributes to the angiogenic switch during tumorigenesis...
  55. ncbi request reprint Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis
    R Bos
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    J Natl Cancer Inst 93:309-14. 2001
    ..Increased levels of HIF-1 alpha are associated with increased proliferation and increased expression of ER and VEGF. Thus, increased levels of HIF-1 alpha are potentially associated with more aggressive tumors...
  56. ncbi request reprint Rac1 activity is required for the activation of hypoxia-inducible factor 1
    K Hirota
    Department of Anesthesia, Kyoto University Hospital, Kyoto University, Kyoto 606-8507, Japan
    J Biol Chem 276:21166-72. 2001
    ..We report here that the small GTPase Rac1 is activated in response to hypoxia and is required for the induction of HIF-1alpha protein expression and transcriptional activity in hypoxic cells...
  57. ncbi request reprint Oxygen sensing in the body
    S Lahiri
    Department of Physiology, University of Pennsylvania Medical Center, Philadelphia, 19104 6085, USA
    Prog Biophys Mol Biol 91:249-86. 2006
    ..Carotid body contains all kinds of transmitters, and an interplay between them must occur. But very little has come to be known as yet. Glimpses of these interactions are evident in the discussion in the last section (Prabhakar)...
  58. ncbi request reprint Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane
    T Itoh
    Department of Anesthesia, Kyoto University Hospital, Kyoto University, Kyoto 606-8507, Japan
    FEBS Lett 509:225-9. 2001
    ..Halothane reversibly blocks hypoxia-induced HIF-1alpha protein accumulation and transcriptional activity at clinically relevant doses...
  59. ncbi request reprint SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation
    M Tan
    Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 096, USA
    Oncogene 27:1404-11. 2008
    ..Induced SAG then promotes HIF-1alpha ubiquitination and degradation. This feedback loop may serve as a cellular defensive mechanism to reduce potential cytotoxic effects of prolonged HIF-1 activation under hypoxia...