Richard Semba

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint The discovery of the vitamins
    Richard D Semba
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Vitam Nutr Res 82:310-5. 2012
  2. ncbi request reprint Consumption of micronutrient-fortified milk and noodles is associated with lower risk of stunting in preschool-aged children in Indonesia
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Food Nutr Bull 32:347-53. 2011
  3. pmc Serum 25-hydroxyvitamin D and pulmonary function in older disabled community-dwelling women
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Gerontol A Biol Sci Med Sci 67:683-9. 2012
  4. ncbi request reprint Serum carotenoids and pulmonary function in older community-dwelling women
    R D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Nutr Health Aging 16:291-6. 2012
  5. pmc Relationship of serum fibroblast growth factor 21 with abnormal glucose metabolism and insulin resistance: the Baltimore Longitudinal Study of Aging
    Richard D Semba
    Department of Opthalmology, Johns Hopkins School of Medicine, Smith Building, 400 North Broadway, M015, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 97:1375-82. 2012
  6. pmc Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study
    Richard D Semba
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Smith Building, M015, 400 N Broadway, Baltimore, MD 21287, USA
    Eur J Appl Physiol 112:1215-20. 2012
  7. pmc Dietary intake associated with serum versus urinary carboxymethyl-lysine, a major advanced glycation end product, in adults: the Energetics Study
    R D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Eur J Clin Nutr 66:3-9. 2012
  8. pmc Micronutrient malnutrition and wasting in adults with pulmonary tuberculosis with and without HIV co-infection in Malawi
    Monique van Lettow
    Johns Hopkins University School of Medicine, Baltimore, USA
    BMC Infect Dis 4:61. 2004
  9. ncbi request reprint Low serum micronutrient concentrations predict frailty among older women living in the community
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 61:594-9. 2006
  10. pmc Serum antioxidants and inflammation predict red cell distribution width in older women: the Women's Health and Aging Study I
    Richard D Semba
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
    Clin Nutr 29:600-4. 2010

Detail Information

Publications127 found, 100 shown here

  1. doi request reprint The discovery of the vitamins
    Richard D Semba
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Vitam Nutr Res 82:310-5. 2012
    ..Our understanding of the vitamins continues to evolve from the initial period of discovery...
  2. ncbi request reprint Consumption of micronutrient-fortified milk and noodles is associated with lower risk of stunting in preschool-aged children in Indonesia
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Food Nutr Bull 32:347-53. 2011
    ..Micronutrient deficiencies contribute to stunting, and micronutrient-fortified foods are a potential strategy to reduce child stunting...
  3. pmc Serum 25-hydroxyvitamin D and pulmonary function in older disabled community-dwelling women
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Gerontol A Biol Sci Med Sci 67:683-9. 2012
    ..Our objective was to examine the relationship between serum 25-hydroxyvitamin D (25[OH]D), serum parathyroid hormone, and pulmonary function in older women...
  4. ncbi request reprint Serum carotenoids and pulmonary function in older community-dwelling women
    R D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Nutr Health Aging 16:291-6. 2012
    ..Serum carotenoids are considered the most reliable indicator of fruit and vegetable intake...
  5. pmc Relationship of serum fibroblast growth factor 21 with abnormal glucose metabolism and insulin resistance: the Baltimore Longitudinal Study of Aging
    Richard D Semba
    Department of Opthalmology, Johns Hopkins School of Medicine, Smith Building, 400 North Broadway, M015, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 97:1375-82. 2012
    ..The relationship of fibroblast growth factor 21 (FGF21) with glucose metabolism and insulin resistance has not been well characterized in community-dwelling adults...
  6. pmc Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study
    Richard D Semba
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Smith Building, M015, 400 N Broadway, Baltimore, MD 21287, USA
    Eur J Appl Physiol 112:1215-20. 2012
    ..20, standard error = 0.35, P = 0.0009) in adults with plasma klotho <681 pg/mL. These results suggest that older adults with lower plasma klotho have poor skeletal muscle strength...
  7. pmc Dietary intake associated with serum versus urinary carboxymethyl-lysine, a major advanced glycation end product, in adults: the Energetics Study
    R D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Eur J Clin Nutr 66:3-9. 2012
    ..The objective was to describe dietary intake, the dominant source of exposure to AGEs, with carboxymethyl-lysine (CML), a major AGE, in serum and urine, respectively...
  8. pmc Micronutrient malnutrition and wasting in adults with pulmonary tuberculosis with and without HIV co-infection in Malawi
    Monique van Lettow
    Johns Hopkins University School of Medicine, Baltimore, USA
    BMC Infect Dis 4:61. 2004
    ..We hypothesized that micronutrient malnutrition is associated with wasting and higher plasma human immunodeficiency virus (HIV) load in adults with pulmonary tuberculosis...
  9. ncbi request reprint Low serum micronutrient concentrations predict frailty among older women living in the community
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 61:594-9. 2006
    ..Micronutrient deficiencies are common among older adults. We hypothesized that low serum micronutrient concentrations were predictive of frailty among older disabled women living in the community...
  10. pmc Serum antioxidants and inflammation predict red cell distribution width in older women: the Women's Health and Aging Study I
    Richard D Semba
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
    Clin Nutr 29:600-4. 2010
    ..The aims were to determine whether total serum carotenoids, α-tocopherol, selenium, protein carbonyls, and interleukin-6 (IL-6) are associated with RDW and predict RDW over time...
  11. pmc Relationship of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality in older community-dwelling adults
    R D Semba
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Eur J Clin Nutr 64:203-9. 2010
    ..We hypothesized that low serum 25(OH)D levels predicted mortality in older adults...
  12. pmc Coverage of vitamin A capsule programme in Bangladesh and risk factors associated with non-receipt of vitamin A
    Richard D Semba
    Wilmer Eye Institute Johns Hopkins School of Medicine 550 N Broadway, Suite 700 Baltimore, MD 21205 USA
    J Health Popul Nutr 28:143-8. 2010
    ..Special efforts are required to ensure that the coverage of the national vitamin A programme is increased further so that the most vulnerable children are also better protected against morbidity, mortality, and blindness...
  13. doi request reprint Iron-fortified milk and noodle consumption is associated with lower risk of anemia among children aged 6-59 mo in Indonesia
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Clin Nutr 92:170-6. 2010
    ..Anemia is common among children in developing countries and is associated with decreased cognitive and physical development. Iron-fortified foods may decrease child anemia...
  14. ncbi request reprint Denture use, malnutrition, frailty, and mortality among older women living in the community
    R D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Nutr Health Aging 10:161-7. 2006
    ..The relationships between denture use, malnutrition, frailty, and mortality in older women have not been well characterized...
  15. ncbi request reprint Addressing tuberculosis in the context of malnutrition and HIV coinfection
    Richard D Semba
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Food Nutr Bull 31:S345-64. 2010
    ..The situation is complicated by the HIV/AIDS pandemic, widespread undernutrition, smoking, diabetes, increased mobility, and emergence of multi- and extensively drug-resistant tuberculosis...
  16. ncbi request reprint The impact of anemia on energy and physical functioning in individuals with AIDS
    Richard D Semba
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Arch Intern Med 165:2229-36. 2005
    ..To our knowledge, the relationship between changes in hemoglobin level and energy and physical functioning in the anemic and "normal" ranges of hemoglobin among individuals with AIDS has not been well characterized...
  17. pmc Relationship of the presence of a household improved latrine with diarrhea and under-five child mortality in Indonesia
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD 21287, USA
    Am J Trop Med Hyg 84:443-50. 2011
    ..22, 95% CI = 1.12-1.32, P < 0.0001) in separate multivariable logistic regression models adjusting for covariates. The lack of a household improved latrine is associated with diarrhea and under-five child mortality in Indonesia...
  18. pmc Plasma klotho and mortality risk in older community-dwelling adults
    Richard D Semba
    Baltimore, MD 21287, USA
    J Gerontol A Biol Sci Med Sci 66:794-800. 2011
    ..It is not known whether there is a relationship between plasma levels of secreted klotho protein and longevity in humans...
  19. ncbi request reprint Diarrhea and fever as risk factors for anemia among children under age five living in urban slum areas of Indonesia
    Richard D Semba
    The Johns Hopkins Medical Institutions, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
    Int J Infect Dis 12:62-70. 2008
    ..To characterize diarrhea and fever as risk factors for anemia among children in developing countries...
  20. ncbi request reprint T cell subsets and mortality in older community-dwelling women
    Richard D Semba
    Division of Ocular Immunology, Department of Ophthalmology, Johns Hopkins Medical Institutions, 550 North Broadway, Suite 700, Baltimore, MD 21287, USA
    Exp Gerontol 40:81-7. 2005
    ..When analyses were stratified by frailty status, these data suggest that CD8+CD28- lymphocyte counts were significantly higher among women who were frail compared with pre-frail and non-frail women...
  21. ncbi request reprint Effect of periodic vitamin A supplementation on mortality and morbidity of human immunodeficiency virus-infected children in Uganda: A controlled clinical trial
    Richard D Semba
    Department of Ophthalmology Johns Hopkins School of Medicine, Baltimore, MD, USA
    Nutrition 21:25-31. 2005
    ..We investigated whether vitamin A supplementation would decrease mortality and morbidity rates in children infected with the human immunodeficiency virus (HIV)...
  22. pmc Low serum carotenoids and development of severe walking disability among older women living in the community: the women's health and aging study I
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Age Ageing 36:62-7. 2007
    ..to determine whether low serum carotenoid levels, an indicator of low intake of fruits and vegetables, are associated with the progression of disability in older women...
  23. doi request reprint The role of expanded coverage of the national vitamin A program in preventing morbidity and mortality among preschool children in India
    Richard D Semba
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Nutr 140:208S-12S. 2010
    ..Expanded coverage of the vitamin A program in India will help protect children from morbidity, mortality, and blindness...
  24. pmc Carotenoids as protection against sarcopenia in older adults
    Richard D Semba
    Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Arch Biochem Biophys 458:141-5. 2007
    ....
  25. ncbi request reprint Micronutrient supplements and mortality of HIV-infected adults with pulmonary TB: a controlled clinical trial
    R D Semba
    Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Int J Tuberc Lung Dis 11:854-9. 2007
    ..Zomba and Blantyre, Malawi, Africa...
  26. pmc Types of anemia and mortality among older disabled women living in the community: the Women's Health and Aging Study I
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Aging Clin Exp Res 19:259-64. 2007
    ..To classify the different types of anemia among moderately to severely disabled women living in the community and examine the relationship between types of anemia and mortality...
  27. pmc Low serum selenium is associated with anemia among older adults in the United States
    R D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Eur J Clin Nutr 63:93-9. 2009
    ..We hypothesized that low serum selenium was associated with anemia in humans...
  28. pmc Oxidative stress and severe walking disability among older women
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Med 120:1084-9. 2007
    ..Serum protein carbonyls are markers of oxidative damage to proteins and are caused by oxidative stress...
  29. ncbi request reprint Child malnutrition and mortality among families not utilizing adequately iodized salt in Indonesia
    Richard D Semba
    Johns Hopkins School of Medicine, Baltimore, MD, USA
    Am J Clin Nutr 87:438-44. 2008
    ..Salt iodization is the main strategy for reducing iodine deficiency disorders worldwide. Characteristics of families not using iodized salt need to be known to expand coverage...
  30. doi request reprint Effect of parental formal education on risk of child stunting in Indonesia and Bangladesh: a cross-sectional study
    Richard D Semba
    Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Lancet 371:322-8. 2008
    ..Child stunting is associated with poor child development and increased mortality. Our aim was to determine the effect of length of maternal and paternal education on stunting in children under the age of 5 years...
  31. doi request reprint Coverage of the national vitamin A supplementation program in Ethiopia
    Richard D Semba
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Trop Pediatr 54:141-4. 2008
    ..Expanded coverage of the national vitamin A capsule program may help protect children from nutritional blindness and to help reach Millennium goals for reducing under-five child mortality in Ethiopia...
  32. pmc Paternal smoking and increased risk of infant and under-5 child mortality in Indonesia
    Richard D Semba
    Johns Hopkins School of Medicine, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
    Am J Public Health 98:1824-6. 2008
    ..37; urban, OR = 1.14; 95% CI = 1.05, 1.23). Paternal smoking diverts money from basic necessities to cigarettes and adversely affects child health; tobacco control should therefore be considered among strategies to improve child survival...
  33. pmc Carboxymethyl-lysine, an advanced glycation end product, and decline of renal function in older community-dwelling adults
    Richard D Semba
    Johns Hopkins University School of Medicine, 550N Broadway, Suite 700, Baltimore, MD 21205, USA
    Eur J Nutr 48:38-44. 2009
    ..AGEs have been associated with impaired renal function in diabetes and in uremia. The relationship between AGEs and renal function in community-dwelling adults has not been well characterized...
  34. pmc Elevated serum advanced glycation end products and their circulating receptors are associated with anaemia in older community-dwelling women
    Richard D Semba
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Age Ageing 38:283-9. 2009
    ..to determine whether serum carboxymethyl-lysine, a dominant advanced glycation end product (AGE), and circulating total receptor for AGEs (sRAGE) and endogenous secretory receptor for AGEs (esRAGE) are associated with anaemia...
  35. pmc Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling women
    Richard D Semba
    Johns Hopkins University School of Medicine, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
    Aging Clin Exp Res 21:182-90. 2009
    ..To characterize the relationship between advanced glycation end products (AGEs) and circulating receptors for AGEs (RAGE) with cardiovascular disease mortality...
  36. ncbi request reprint Paternal smoking is associated with increased risk of child malnutrition among poor urban families in Indonesia
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Public Health Nutr 10:7-15. 2007
    ..We sought to characterise the relationship between paternal smoking, child malnutrition and food expenditures...
  37. doi request reprint Low intake of vitamin A-rich foods among children, aged 12-35 months, in India: association with malnutrition, anemia, and missed child survival interventions
    Richard D Semba
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nutrition 26:958-62. 2010
    ..To determine whether children in India who have a low intake of vitamin A-rich foods are at higher risk of malnutrition, anemia, and not receiving child health interventions...
  38. ncbi request reprint Adherence and retention of female injection drug users in a phase III clinical trial in inner city Baltimore
    Richard D Semba
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Drug Alcohol Abuse 33:71-80. 2007
    ..Women lost to follow-up were younger, more often white, not on methadone, and injecting drugs daily. Fair-moderate adherence to visits and treatment occurs among female IDUs in a clinical trial...
  39. doi request reprint Purchase of drinking water is associated with increased child morbidity and mortality among urban slum-dwelling families in Indonesia
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
    Int J Hyg Environ Health 212:387-97. 2009
    ..Greater efforts must be made to ensure access to safe drinking water, a basic human right and target of the Millennium Development Goals, in urban slums...
  40. ncbi request reprint Effect of micronutrients and iron supplementation on hemoglobin, iron status, and plasma hepatitis C and HIV RNA levels in female injection drug users: a controlled clinical trial
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 45:298-303. 2007
    ..Iron deficiency is common among female injection drug users, but it is unclear whether iron supplementation can reduce anemia and improve iron status without increasing plasma hepatitis C virus (HCV) or HIV RNA levels...
  41. pmc Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling women
    Richard D Semba
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, MD 21287, USA
    Nutr Res 29:525-30. 2009
    ..4 nmol/L) of 25(OH)D in a multivariate Cox proportional hazards model adjusting for demographics, season, and conventional risk factors. Older community-dwelling women with low 25(OH)D levels are at an increased risk of death...
  42. pmc Relationship of an advanced glycation end product, plasma carboxymethyl-lysine, with slow walking speed in older adults: the InCHIANTI study
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Eur J Appl Physiol 108:191-5. 2010
    ..R. 1.87, 95% C.I. 1.15-3.04, P = 0.01) adjusting for the same covariates. In older community-dwelling adults, elevated plasma CML is independently associated with slow walking speed...
  43. ncbi request reprint Malnutrition and infectious disease morbidity among children missed by the childhood immunization program in Indonesia
    Richard D Semba
    Hopkins School of Medicine, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
    Southeast Asian J Trop Med Public Health 38:120-9. 2007
    ..3, 13.4, and 19.2% (both p < 0.0001). Expanded programmatic coverage is needed to reach children who are missed by childhood immunizations in rural Indonesia, as missed children are at higher risk of morbidity and mortality...
  44. pmc Advanced glycation end products and their circulating receptors and level of kidney function in older community-dwelling women
    Richard D Semba
    Johns Hopkins Medical Institutions, 550 N Broadway, Baltimore, MD 21205, USA
    Am J Kidney Dis 53:51-8. 2009
    ..Advanced glycation end products (AGEs) and the receptor for AGE (RAGE) are implicated in the pathogenesis of kidney disease; however, their relation with level of kidney function has not been well characterized...
  45. pmc Fat mass is inversely associated with serum carboxymethyl-lysine, an advanced glycation end product, in adults
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Nutr 141:1726-30. 2011
    ..These findings suggest that serum CML concentration is strongly affected by body fat, possibly because CML is preferentially deposited in fat tissue or because adipocytes affect the metabolism of AGE...
  46. ncbi request reprint Assessment of vitamin A status of preschool children in Indonesia using plasma retinol-binding protein
    R D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Trop Pediatr 48:84-7. 2002
    ..Measurement of plasma RBP by radial immunodiffusion is simple and inexpensive, and this test can be used as a simple surrogate measure for vitamin A concentrations in large field studies...
  47. ncbi request reprint The anemia of vitamin A deficiency: epidemiology and pathogenesis
    R D Semba
    Department of Ophthalmology Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Eur J Clin Nutr 56:271-81. 2002
    ..To gain insight into vitamin A deficiency as a cause of anemia...
  48. pmc Serum carboxymethyl-lysine, an advanced glycation end product, is associated with increased aortic pulse wave velocity in adults
    Richard D Semba
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Hypertens 22:74-9. 2009
    ..Our aim was to determine whether elevated serum advanced glycation end products are associated with increased arterial stiffness in relatively healthy, community-dwelling adults...
  49. ncbi request reprint Risk factors and cumulative incidence of anaemia among HIV-infected injection drug users
    Richard D Semba
    Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Int J STD AIDS 13:119-23. 2002
    ..92; 95% CI: 0.88, 0.95) and marijuana use (OR 0.75; 95% CI: 0.61, 0.92) were associated with a lower risk of anaemia. The cumulative incidence of anaemia is high among IDUs, and women are at highest risk of anaemia...
  50. ncbi request reprint High prevalence of iron deficiency and anemia among female injection drug users with and without HIV infection
    Richard D Semba
    Department of Ophthalmology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    J Acquir Immune Defic Syndr 29:142-4. 2002
    ..Anemia is associated with increased progression of disease and higher mortality during HIV infection...
  51. ncbi request reprint Prevalence and cumulative incidence of and risk factors for anemia in a multicenter cohort study of human immunodeficiency virus-infected and -uninfected women
    Richard D Semba
    Department of Ophthalmology, Schools of Medicine and Hygiene and of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Clin Infect Dis 34:260-6. 2002
    ..94), history of fever (OR, 1.42; 95% CI, 1.13-1.80), and zidovudine use (OR, 1.14; 95% CI, 1.01-1.30). Anemia was common and associated with an increased risk of death (hazards ratio, 1.64; 95% CI, 1.21-2.23) among HIV-positive women...
  52. ncbi request reprint Integration of vitamin A supplementation with the Expanded Programme on Immunization: lack of impact on morbidity or infant growth
    R D Semba
    Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Acta Paediatr 90:1107-11. 2001
    ..Vitamin A supplementation had no apparent impact upon linear or ponderal growth or infectious disease morbidity in the first 15 mo of age when integrated with the Expanded Programme on Immunization...
  53. ncbi request reprint Vitamin A and immunity to viral, bacterial and protozoan infections
    R D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Nutr Soc 58:719-27. 1999
    ..Immune responses vary considerably during different infections, and the available data suggest that the modulation of immune function by vitamin A may also vary widely, depending on the type of infection and immune responses involved...
  54. ncbi request reprint Highly active antiretroviral therapy associated with improved anemia among HIV-infected women
    R D Semba
    Department of Ophthalmology, Department of Epidemiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    AIDS Patient Care STDS 15:473-80. 2001
    ..01), whereas there was no significant change in the prevalence of anemia among those on non-HAART ART or those who had no reported treatment. HAART is associated with a large reduction in anemia among HIV-infected women...
  55. pmc Does accumulation of advanced glycation end products contribute to the aging phenotype?
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Smith Building, M015, 400 North Broadway, Baltimore, MD 21287, USA
    J Gerontol A Biol Sci Med Sci 65:963-75. 2010
    ....
  56. ncbi request reprint Impact of vitamin A supplementation on anaemia and plasma erythropoietin concentrations in pregnant women: a controlled clinical trial
    R D Semba
    Department of Ophthalmology, and Center for Human Nutrition, The Johns Hopkins University Schools of Medicine and Hygiene and Public Health, Baltimore, Maryland, USA
    Eur J Haematol 66:389-95. 2001
    ..Although studies suggest that vitamin A or its metabolites influence the synthesis of erythropoietin in vitro and in animal models, it is unclear whether vitamin A supplementation increases plasma erythropoietin concentrations in humans...
  57. ncbi request reprint Hyporetinolemia and acute phase proteins in children with and without xerophthalmia
    R D Semba
    Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Am J Clin Nutr 72:146-53. 2000
    ..The relations among hyporetinolemia, acute phase proteins, and vitamin A status in children are unclear...
  58. pmc Oxidative stress is associated with greater mortality in older women living in the community
    Richard D Semba
    Department of Ophthalmology, National Institute on Aging, Baltimore, Maryland, USA
    J Am Geriatr Soc 55:1421-5. 2007
    ..To determine whether oxidative stress, as implied by oxidative damage to proteins, is associated with greater mortality in older women living in the community...
  59. ncbi request reprint Improvement of anemia among HIV-infected injection drug users receiving highly active antiretroviral therapy
    R D Semba
    Department of Ophthalmology, Schools of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Acquir Immune Defic Syndr 26:315-9. 2001
    ..HAART was associated with an improvement in anemia, and potential mechanisms that may be involved include a reduction in opportunistic infections and the anemia of chronic disease and an improvement in nutritional status...
  60. ncbi request reprint Paternal smoking is associated with greater food insecurity among poor families in rural Indonesia
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Asia Pac J Clin Nutr 20:618-23. 2011
    ..Among poor families in rural Indonesia, households with a father who smokes are at greater risk of household food insecurity...
  61. pmc Mastitis and immunological factors in breast milk of lactating women in Malawi
    R D Semba
    Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Clin Diagn Lab Immunol 6:671-4. 1999
    ..0001); and RANTES, 82 versus 3 ng/liter (P < 0.0001). Elevated sodium concentrations in breast milk are associated with an increase in levels of some immunological and inflammatory factors in breast milk...
  62. ncbi request reprint Assessment of iron status using plasma transferrin receptor in pregnant women with and without human immunodeficiency virus infection in Malawi
    R D Semba
    Departments of Ophthalmology and Epidemiology, Johns Hopkins University Schools of Medicine and Hygiene and Public Health, Baltimore, Maryland, USA
    Eur J Clin Nutr 54:872-7. 2000
    ..Although anemia is highly prevalent during pregnancy and is common during human immunodeficiency virus (HIV) infection, anemia and iron status have not been well characterized in HIV-infected pregnant women...
  63. ncbi request reprint Risk factors for xerophthalmia among mothers and their children and for mother-child pairs with xerophthalmia in Cambodia
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins School of Medicine, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
    Arch Ophthalmol 122:517-23. 2004
    ..To characterize the risk of xerophthalmia among nonpregnant women and their children and the risk factors for households in which both mother and child have xerophthalmia...
  64. pmc Plasma klotho and cardiovascular disease in adults
    Richard D Semba
    Department of Ophthalmology, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    J Am Geriatr Soc 59:1596-601. 2011
    ..To determine whether plasma klotho, a recently discovered hormone that has been implicated in atherosclerosis, is related to prevalent cardiovascular disease (CVD) in adults...
  65. ncbi request reprint Measles blindness
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Surv Ophthalmol 49:243-55. 2004
    ..Higher measles immunization coverage to interrupt measles transmission and interventions aimed at improving vitamin A nutriture of children are the main strategies to prevent measles blindness...
  66. ncbi request reprint Carotenoid and vitamin E status are associated with indicators of sarcopenia among older women living in the community
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Aging Clin Exp Res 15:482-7. 2003
    ..The aim was to determine whether dietary carotenoids and alpha-tocopherol are associated with sarcopenia, as indicated by low grip, hip, and knee strength...
  67. ncbi request reprint Risk factors for nightblindness among women of childbearing age in Cambodia
    R D Semba
    Department of Ophthalmology, Johns Hopkins School of Medicine, 550 North Broadway, Suite 700, Baltimore, MD 21205, USA
    Eur J Clin Nutr 57:1627-32. 2003
    ..To characterize risk factors for nightblindness among nonpregnant women of childbearing age, a group recently recognized to be at high risk of vitamin A deficiency in some developing countries...
  68. ncbi request reprint Are lutein and zeaxanthin conditionally essential nutrients for eye health?
    R D Semba
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Med Hypotheses 61:465-72. 2003
    ....
  69. ncbi request reprint Human immunodeficiency virus load in breast milk, mastitis, and mother-to-child transmission of human immunodeficiency virus type 1
    R D Semba
    Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    J Infect Dis 180:93-8. 1999
    ..0001). Mastitis and breast milk HIV-1 load may increase the risk of vertical transmission of HIV-1 through breast-feeding...
  70. ncbi request reprint Iron-deficiency anemia and the cycle of poverty among human immunodeficiency virus-infected women in the inner city
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Infect Dis 37:S105-11. 2003
    ..Although iron supplementation may prevent or treat iron deficiency, the use of iron supplements needs to be approached with caution in women with HIV and HCV infections...
  71. ncbi request reprint Low plasma selenium concentrations, high plasma human immunodeficiency virus load and high interleukin-6 concentrations are risk factors associated with anemia in adults presenting with pulmonary tuberculosis in Zomba district, Malawi
    M Van Lettow
    Johns Hopkins University School of Medicine, Baltimore, USA
    Eur J Clin Nutr 59:526-32. 2005
    ..Although anemia is common among adults with pulmonary tuberculosis and human immunodeficiency virus (HIV) infection in sub-Saharan Africa, the factors contributing to its pathogenesis have not been well characterized...
  72. ncbi request reprint Epidemiology and microbiology of subclinical mastitis among HIV-infected women in Malawi
    V Nussenblatt
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Int J STD AIDS 16:227-32. 2005
    ..02). Subclinical mastitis is prevalent among breastfeeding mothers and further studies are needed to characterize the differences between infectious and non-infectious subclinical mastitis...
  73. pmc Vitamin A levels and human immunodeficiency virus load in injection drug users
    R D Semba
    Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Clin Diagn Lab Immunol 4:93-5. 1997
    ..HIV-infected adult women appear to be at higher risk of developing vitamin A deficiency...
  74. ncbi request reprint Effect of antibiotic treatment of subclinical mastitis on human immunodeficiency virus type 1 RNA in human milk
    V Nussenblatt
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Trop Pediatr 52:311-5. 2006
    ..These findings have important implications regarding how mothers should be counselled on safety of resuming breastfeeding after resolution of subclinical mastitis...
  75. ncbi request reprint Relation of vitamin A and carotenoid status to growth failure and mortality among Ugandan infants with human immunodeficiency virus
    G Melikian
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nutrition 17:567-72. 2001
    ..16, 95% confidence interval: 1.38 to 7.21, P < 0.006). These data suggest that low concentrations of plasma carotenoids are associated with increased risk of death during HIV infection among infants in Uganda...
  76. ncbi request reprint Iron status and indicators of human immunodeficiency virus disease severity among pregnant women in Malawi
    R D Semba
    Department of Ophthalmology, Johns Hopkins University Schools of Medicine and Hygiene and Public Health, Baltimore, MD 21205, USA
    Clin Infect Dis 32:1496-9. 2001
    ..In contrast to previous studies, these data suggest that iron status is not related to markers of HIV disease severity in pregnant women in Africa...
  77. ncbi request reprint Malnutrition and the severity of lung disease in adults with pulmonary tuberculosis in Malawi
    M Van Lettow
    Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Int J Tuberc Lung Dis 8:211-7. 2004
    ..Zomba Central Hospital, Zomba, Malawi...
  78. pmc Low serum carotenoids are associated with a decline in walking speed in older women
    N Alipanah
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Nutr Health Aging 13:170-5. 2009
    ..The aim was to determine whether total serum carotenoid concentrations, a marker for fruit and vegetable intake, and serum selenium are related to changes in walking speed in older women...
  79. doi request reprint Malnutrition and morbidity among children not reached by the national vitamin A capsule programme in urban slum areas of Indonesia
    S G Berger
    Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Public Health 122:371-8. 2008
    ..Although it has been suggested that there are health disparities between children who are reached or not reached by these programmes, little quantitative work has been undertaken to characterize this relationship...
  80. pmc Markers of B-vitamin deficiency and frailty in older women
    A M Matteini
    Johns Hopkins Institutions, Baltimore, MD, USA
    J Nutr Health Aging 12:303-8. 2008
    ..To evaluate the association between markers of vitamins B12, B6 and folate deficiency and the geriatric syndrome of frailty...
  81. ncbi request reprint Effect of vitamin A supplementation on morbidity due to Plasmodium falciparum in young children in Papua New Guinea: a randomised trial
    A H Shankar
    Department of International Health, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Lancet 354:203-9. 1999
    ..Vitamin A is central to normal immune function, and supplementation has been shown to lower the morbidity of some infectious diseases. We investigated the effect of vitamin A supplementation on malaria morbidity...
  82. ncbi request reprint Serum antioxidants, inflammation, and total mortality in older women
    J Walston
    School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Epidemiol 163:18-26. 2006
    ..54, 95% confidence interval: 1.03, 2.32). These findings suggest that specific antioxidant nutrients may play an important role in suppressing IL-6 levels in disabled older women...
  83. ncbi request reprint Risk factors and cumulative incidence of anaemia among human immunodeficiency virus-infected children in Uganda
    T D Clark
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Trop Paediatr 22:11-7. 2002
    ..Moderate anaemia and weight-for-height Z-score <-2 were associated with mortality. Anaemia is common and associated with increased mortality in HIV-infected children...
  84. ncbi request reprint Iron supplementation during human immunodeficiency virus infection: a double-edged sword?
    T D Clark
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Med Hypotheses 57:476-9. 2001
    ..The available data do not contraindicate the current practice of iron supplementation in developing countries where there is a high prevalence of both HIV infection and iron deficiency...
  85. ncbi request reprint Micronutrients and the pathogenesis of human immunodeficiency virus infection
    R D Semba
    Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Br J Nutr 81:181-9. 1999
    ....
  86. ncbi request reprint Measles infection in HIV-infected African infants
    R T Perry
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Ann N Y Acad Sci 918:377-80. 2000
    ..In the context of the HIV epidemic, further work is needed to determine the risk of measles and its complications in HIV-positive infants and the optimal age of measles immunization...
  87. pmc Anemia and interleukin-10, tumor necrosis factor alpha, and erythropoietin levels among children with acute, uncomplicated Plasmodium falciparum malaria
    V Nussenblatt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Clin Diagn Lab Immunol 8:1164-70. 2001
    ..Further studies are needed to understand the relationships between age-related immune responses to malaria and their role in the pathogenesis of malarial anemia...
  88. ncbi request reprint Long-term outcome in patients registered with tuberculosis in Zomba, Malawi: mortality at 7 years according to initial HIV status and type of TB
    C T Kang'ombe
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Int J Tuberc Lung Dis 8:829-36. 2004
    ..Zomba Central Hospital, Malawi...
  89. doi request reprint Paternal smoking and increased risk of child malnutrition among families in rural Indonesia
    C M Best
    The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Tob Control 17:38-45. 2008
    ..To determine whether paternal smoking is associated with an increased risk of child malnutrition among families in rural Indonesia...
  90. ncbi request reprint Vitamin A as "anti-infective" therapy, 1920-1940
    R D Semba
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Nutr 129:783-91. 1999
    ..Recent controlled clinical trials of vitamin A from the last 15 y follow a tradition of investigation that began largely in the 1920s...
  91. ncbi request reprint Vitamin D deficiency among older women with and without disability
    R D Semba
    Johns Hopkins Medical Institutions, Baltimore, and the Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD, USA
    Am J Clin Nutr 72:1529-34. 2000
    ..Vitamin D deficiency is associated with bone loss and bone fractures, and the identification of vulnerable populations is important to clinical practice and public health...
  92. pmc Relationship of a dominant advanced glycation end product, serum carboxymethyl-lysine, and abnormal glucose metabolism in adults: the Baltimore Longitudinal Study of Aging
    R D Semba
    Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    J Nutr Health Aging 14:507-13. 2010
    ..We investigated the relationship between a dominant serum AGE, N-carboxymethyl-lysine (CML), and glucose metabolism...
  93. pmc Serum carboxymethyl-lysine, a dominant advanced glycation end product, is associated with chronic kidney disease: the Baltimore longitudinal study of aging
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Ren Nutr 20:74-81. 2010
    ..Our objective was to characterize the relationship between AGEs and renal function in community-dwelling adults...
  94. pmc Plasma carboxymethyl-lysine, an advanced glycation end product, and all-cause and cardiovascular disease mortality in older community-dwelling adults
    Richard D Semba
    Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Geriatr Soc 57:1874-80. 2009
    ..To determine whether older adults with high plasma carboxymethyl-lysine (CML), an advanced glycation end product, are at higher risk of all-cause and cardiovascular disease (CVD) mortality...
  95. ncbi request reprint The ocular complications of smallpox and smallpox immunization
    Richard D Semba
    Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Arch Ophthalmol 121:715-9. 2003
    ..In contrast, there has been little experience with the use of these therapies for the ocular complications of smallpox...
  96. pmc Endogenous secretory receptor for advanced glycation end products is associated with low serum interleukin-1 receptor antagonist and elevated IL-6 in older community-dwelling adults
    Candace L Crasto
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Smith Building M015, 400 N Broadway, Baltimore, MD 21287, USA
    J Gerontol A Biol Sci Med Sci 66:437-43. 2011
    ..The relationship between AGEs, RAGE, and inflammation has not been well characterized...
  97. ncbi request reprint Iodine in human milk: perspectives for infant health
    R D Semba
    Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Nutr Rev 59:269-78. 2001
    ..Further studies of human milk iodine are needed to ensure that iodine prophylaxis is providing sufficient iodine for mothers and infants worldwide...
  98. pmc Oxidative protein damage is associated with elevated serum interleukin-6 levels among older moderately to severely disabled women living in the community
    Margaret Dayhoff-Brannigan
    John Hopkins Medical Institutes, Baltimore, MD, USA
    J Gerontol A Biol Sci Med Sci 63:179-83. 2008
    ..Elevated interleukin (IL)-6 is associated with adverse outcomes. Our objective was to determine whether serum protein carbonyls, an indicator of oxidative protein damage and oxidative stress, were associated with IL-6...
  99. ncbi request reprint Effect of zinc and vitamin A supplementation on antibody responses to a pneumococcal conjugate vaccine in HIV-positive injection drug users: a randomized trial
    Maria Deloria-Knoll
    National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    Vaccine 24:1670-9. 2006
    ..Geometric mean titer increased 1.3-3.3-fold for all pneumococcal serotypes. PC-7 elicited an immune response in HIV-infected adults but neither vitamin A nor zinc altered the immunogenicity of the evaluated vaccines...
  100. ncbi request reprint The association between obesity and the frailty syndrome in older women: the Women's Health and Aging Studies
    Caroline S Blaum
    University of Michigan, Medical School, Ann Arbor, Michigan 48109, USA
    J Am Geriatr Soc 53:927-34. 2005
    ..To determine whether obesity is associated with the frailty phenotype and, if so, whether comorbid conditions or inflammatory markers explain this association...
  101. ncbi request reprint Interleukin-6 and human immunodeficiency virus load, but not plasma leptin concentration, predict anorexia and wasting in adults with pulmonary tuberculosis in Malawi
    Monique van Lettow
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Endocrinol Metab 90:4771-6. 2005
    ..Wasting is a prominent feature of tuberculosis and may be more severe among individuals with HIV coinfection. It is likely that several biological mechanisms, including the anorexia of infection, are contributing to wasting...

Research Grants44

  1. Oxidative Stress and the Pathogeneisis of Sarcopenia and Disability in Older Wome
    Richard D Semba; Fiscal Year: 2010
    ....
  2. ADJUNCT VITAMIN A THERAPY FOR TUBERCULOSIS AND HIV/AIDS
    Richard Semba; Fiscal Year: 2005
    ....
  3. ADJUNCT VITAMIN A THERAPY FOR TUBERCULOSIS AND HIV/AIDS
    Richard Semba; Fiscal Year: 2002
    ....
  4. VITAMIN A SUPPLEMENTATION FOR HIV INFECTED CHILDREN
    Richard Semba; Fiscal Year: 2002
    ....
  5. Iron Deficiency and Anemia in HIV and HCV-Infected Women
    Richard Semba; Fiscal Year: 2005
    ..S. and elsewhere. ..
  6. Advanced glycation end products and cardiovascular disease
    Richard D Semba; Fiscal Year: 2010
    ....
  7. Hepcidin and the pathogenesis of anemia in older adults.
    Richard D Semba; Fiscal Year: 2010
    ..This study should provide new insight into the epidemiology and biological mechanisms of anemia among older adults and help identify strategies aimed at the prevention and treatment of anemia. ..
  8. Oxidative stress and the pathogenesis of sarcopenia and*
    Richard Semba; Fiscal Year: 2007
    ..abstract_text> ..
  9. Hepcidin and the pathogenesis of anemia in older adults.
    Richard Semba; Fiscal Year: 2007
    ..This study should provide new insight into the epidemiology and biological mechanisms of anemia among older adults and help identify strategies aimed at the prevention and treatment of anemia. ..
  10. MICRONUTRIENTS AND MOTHER TO CHILD TRANSMISSION OF HIV
    Richard Semba; Fiscal Year: 2001
    ..The relationship between mastitis and breastmilk HIV load and the epidemiology and microbiology of mastitis will be examined in a new cohort of HIV-infected lactating women. ..
  11. VITAMIN A SUPPLEMENTATION FOR HIV-INFECTED CHILDREN
    Richard Semba; Fiscal Year: 1999
    ....