Research Topics
| O A SelnesSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Cognitive changes with coronary artery disease: a prospective study of coronary artery bypass graft patients and nonsurgical controlsOla A Selnes
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ann Thorac Surg 75:1377-84; discussion 1384-6. 2003..We compared changes in cognitive performance at 3 and 12 months after CABG with those in a control group of patients with comparable risk factors for coronary artery disease (CAD) who had not undergone surgery...
Cognition 6 years after surgical or medical therapy for coronary artery diseaseOla A Selnes
Department of Neurology, Baltimore, MD 21205 1910, USA
Ann Neurol 63:581-90. 2008..Long-term cognitive decline after CABG has been reported, but without appropriate control subjects, it is not known whether this decline is specific to CABG or related to other factors such as cerebrovascular disease...
Neurocognitive outcomes 3 years after coronary artery bypass graft surgery: a controlled studyOla A Selnes
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ann Thorac Surg 84:1885-96. 2007..Because most studies did not include a control group, a causal link of such decline with the use of cardiopulmonary bypass has not been established...
Self-reported memory symptoms with coronary artery disease: a prospective study of CABG patients and nonsurgical controlsOla A Selnes
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Cogn Behav Neurol 17:148-56. 2004..We compared the incidence of self-reported memory symptoms at 3 and 12 months after CABG with that of a control group of patients with comparable risk factors for coronary artery disease but without surgery...
Cognitive and neurobehavioral dysfunction after cardiac bypass proceduresOla A Selnes
Department of Neurology, Division of Cognitive Neuroscience, Johns Hopkins University School of Medicine, Reed Hall East 2, 1620 McElderry Street, Baltimore, MD 21287, USA
Neurol Clin 24:133-45. 2006....
Etiology of cognitive change after CABG surgery: more than just the pump?Ola A Selnes
Division of Cognitive Neuroscience, Johns Hopkins University School of Medicine, 1620 McElderry Street, Reed Hall East-2, Baltimore, MD 21205-2189, USA
Nat Clin Pract Cardiovasc Med 5:314-5. 2008
Cognitive outcomes three years after coronary artery bypass surgery: a comparison of on-pump coronary artery bypass graft surgery and nonsurgical controlsOla A Selnes
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 1910, USA
Ann Thorac Surg 79:1201-9. 2005....
Neurocognitive complications after coronary artery bypass surgeryOla A Selnes
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Ann Neurol 57:615-21. 2005..Thus, whereas both short- and long-term postoperative cognitive changes have been associated with CABG, only the short-term, transient changes appear to be directly related to the use of cardiopulmonary bypass...
Vascular cognitive impairmentOla A Selnes
Cognitive Neuroscience Division, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 1910, USA
Nat Clin Pract Neurol 2:538-47. 2006..In patients with AD, the contribution of amyloid-beta protein to the degree of cognitive impairment has not been clearly defined...
Neurocognitive aspects of medication adherence in HIV infectionOla A Selnes
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Acquir Immune Defic Syndr 31:S132-5. 2002..Traditional measures of new learning and recall may not be among the best neuropsychologic predictors of adherence. Rather, certain aspects of frontal and executive functioning appear to be more strongly associated with good adherence...
Do management strategies for coronary artery disease influence 6-year cognitive outcomes?Ola A Selnes
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ann Thorac Surg 88:445-454. 2009..Previous uncontrolled studies have suggested that there is late cognitive decline after coronary artery bypass grafting that may be attributable to use of the cardiopulmonary bypass pump...
Determinants of cognitive change after coronary artery bypass surgery: a multifactorial problemO A Selnes
Department of Neurology and Zanvyl Krieger Mind Brain Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ann Thorac Surg 67:1669-76. 1999..Several studies have investigated predictors of cognitive decline after coronary artery bypass grafting (CABG), but there is little consensus as to which specific factors are predictive of poor cognitive outcomes...
Neuropsychological outcomes after coronary artery bypass graftingOla A Selnes
Cognitive Neuroscience Division, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2189, USA
J Int Neuropsychol Soc 16:221-6. 2010..Late cognitive changes do occur, but comparison with patients undergoing off-pump surgery or those being treated medically suggests that these changes are not specific to CABG or more specifically to the use of cardiopulmonary bypass...
Patient Tan revisited: a case of atypical global aphasia?O A Selnes
Department of Neurology, Division of Cognitive Neurology, Johns Hopkins University School of Medicine, USA
J Hist Neurosci 9:233-7. 2000..Contemporary evidence in support of a robust relationship between stereotypical utterances and Global aphasia suggests that patient Tan may have suffered from a Global rather than Broca's aphasia...
Cognitive changes 5 years after coronary artery bypass grafting: is there evidence of late decline?O A Selnes
Division of Cognitive Neurology, Department of Neurology, Meyer 222, The Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
Arch Neurol 58:598-604. 2001..To determine the long-term (preoperative to 5 years postoperative) and late (1-5 years postoperative) changes in cognitive test performance in patients after coronary artery bypass grafting...
Subjective memory symptoms in surgical and nonsurgical coronary artery patients: 6-year follow-upGuy M McKhann
Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA
Ann Thorac Surg 87:27-34. 2009....
CSF antiretroviral drug penetrance and the treatment of HIV-associated psychomotor slowingN Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurology 57:542-4. 2001..Multiple and single CSF-penetrating HAART may be equivalent for treating HIV-associated psychomotor slowing...
Is there cognitive decline 1 year after CABG? Comparison with surgical and nonsurgical controlsG M McKhann
Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Neurology 65:991-9. 2005..Because most studies have not included comparable control groups, it remains unclear whether postoperative cognitive changes are specific to cardiopulmonary bypass, general aspects of surgery, or vascular pathologies of the aging brain...
Response to systemic HIV viral load suppression correlates with psychomotor speed performanceN Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurology 61:567-9. 2003..Changes in plasma HIV viral load in HIV-positive individuals with cognitive slowing correlate with performance on tests of psychomotor speed...
HIV-associated neurologic disease incidence changes:: Multicenter AIDS Cohort Study, 1990-1998N Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurology 56:257-60. 2001..The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing...
Memory loss in persons with HIV/AIDS: assessment and strategies for copingOla A Selnes
Division of Cognitive Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
AIDS Read 15:289-92, 294. 2005..Because of the widespread use of thiamine food supplementation, alcohol is now a less common cause of severe memory impairment. HAART remains the treatment of choice for HIV-related dementia...
Incidental white matter hyperintensities on magnetic resonance imaging in HIV-1 infection. Multicenter AIDS Cohort StudyJ C McArthur
Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21205
J Acquir Immune Defic Syndr 3:252-9. 1990..Our studies imply that focal white matter hyperintensities identified on MR are not specific for HIV-1 infection and are probably incidental and of no clinical significance...
Hypoperfusion of Wernicke's area predicts severity of semantic deficit in acute strokeA E Hillis
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Neurol 50:561-6. 2001..These results add further evidence for the crucial role of Wernicke's area (Brodmann's area 22) in word comprehension and indicate that the magnitude of delay on PWI may be a gross indicator of tissue dysfunction...
Delirium after coronary artery bypass graft surgery and late mortalityRebecca F Gottesman
Department of Neurology, Johns Hopkins University, 600 N Wolfe Street, Baltimore, MD 21287, USA
Ann Neurol 67:338-44. 2010..The primary goal of this study was to determine whether patients with delirium after coronary artery bypass graft (CABG) surgery have higher long-term out-of-hospital mortality when compared with CABG patients without delirium...
Neuropsychological test profile differences between young and old human immunodeficiency virus-positive individualsNed Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Neurovirol 13:203-9. 2007..These differences could be a result of advanced age itself or age-associated comorbidities such as coexisting cerebrovascular or neurodegenerative disease...
Early postoperative cognitive dysfunction and blood pressure during coronary artery bypass graft operationRebecca F Gottesman
Department of Neurology, Johns Hopkins University School of Medicine, Phipps 126, 600 N Wolfe St, Baltimore, MD 21287, USA
Arch Neurol 64:1111-4. 2007..To determine the relationship between change in blood pressure during coronary artery bypass graft operations and early cognitive dysfunction...
A programmable prompting device improves adherence to highly active antiretroviral therapy in HIV-infected subjects with memory impairmentAdriana S A Andrade
Division of Infectious Diseases, Department of Medicine, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
Clin Infect Dis 41:875-82. 2005..Virological and immunological responses were not related to DMAS use in memory-impaired subjects.Conclusion. The DMAS prompting device improved adherence for memory-impaired subjects but not for memory-intact subjects...
A randomized trial of the impact of a programmable medication reminder device on quality of life in patients with AIDSAlbert W Wu
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
AIDS Patient Care STDS 20:773-81. 2006..These differences persisted after controlling for demographics, baseline CD4, and adherence. DMAS was associated with improved adherence but decreased QOL...
The International HIV Dementia Scale: a new rapid screening test for HIV dementiaNed C Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
AIDS 19:1367-74. 2005..The objective of this study was to evaluate the sensitivity and specificity of a new screening test for HIV dementia, the International HIV Dementia Scale (IHDS) in cohorts from the US and Uganda...
Attenuated central nervous system infection in advanced HIV/AIDS with combination antiretroviral therapyJustin C McArthur
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 7609, USA
Arch Neurol 61:1687-96. 2004..Before the introduction of combination antiretroviral therapy (CART), neurological disease correlated with cerebrospinal fluid (CSF) levels of human immunodeficiency virus (HIV) RNA...
Association between hypotension, low ejection fraction and cognitive performance in cardiac patientsRebecca F Gottesman
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Behav Neurol 22:63-71. 2010..The purpose of this study was to determine if cardiac ejection fraction (EF) is associated with cognitive performance, and whether this is modified by low blood pressure...
HIV-associated cognitive impairment before and after the advent of combination therapyNed Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Neurovirol 8:136-42. 2002..Even though HAART has reduced the incidence of HIV dementia, HIV-associated cognitive impairment continues to be a major clinical problem among individuals with advanced infection...
Inter-rater reliability of a clinical staging of HIV-associated cognitive impairmentK Marder
Department of Neurology, Sergievsky Center, New York, NY 10032, USA
Neurology 60:1467-73. 2003..To determine the inter-rater reliability of a modification of the Memorial Sloan-Kettering (MSK) Staging for HIV-associated cognitive impairment...
Encephalopathy and stroke after coronary artery bypass grafting: incidence, consequences, and predictionGuy M McKhann
Zanvyl Krieger Mind Brain Institute, The Johns Hopkins University, 338 Krieger Hall, 3400 N Charles St, Baltimore, MD 21218 2685, USA
Arch Neurol 59:1422-8. 2002..In contrast to perioperative stroke, much less attention has been paid to those with evidence of diffuse brain encephalopathy, presenting as delirium, confusion, coma, and seizures in the immediate postoperative period...
The generalizability of neurocognitive test/retest data derived from a nonclinical sample for detecting change among two HIV+ cohortsAndrew J Levine
Department of Neurology, National Neurological AIDS Bank, UCLA David Geffen School of Medicine, Los Angeles, CA, USA
J Clin Exp Neuropsychol 29:669-78. 2007..Thus, the accuracy of the two methods examined for determining clinically significant change among HIV+ cohorts differs depending upon their similarity with the normative sample...
Depressive symptoms, quality of life, and neuropsychological performance in HIV/AIDS: the impact of gender and injection drug useAmy B Wisniewski
Department of Pediatrics, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
J Neurovirol 11:138-43. 2005..Thus, further study and development of treatment protocols targeted at including women and IDU are needed...
Quantitative methods for tracking cognitive change 3 years after coronary artery bypass surgerySarah J E Barry
Department of Biostatistics, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Ann Thorac Surg 79:1104-9. 2005..Software to implement the methods in the R statistical package is available from the authors at http://www.biostat.jhsph.edu/sbarry/software/ATSrcode.pdf...
Cognitive dysfunction following cardiopulmonary bypass and cerebral protectionOla A Selnes
Division of Cardiac Surgery, Department of Neurology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Ann Thorac Surg 80:780-1. 2005
Stroke and encephalopathy after cardiac surgery: an updateGuy M McKhann
Department of Neurology, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA
Stroke 37:562-71. 2006..As surgical mortality has declined in recent years, attention has focused on the complications of stroke and encephalopathy after cardiac surgery...
Watershed strokes after cardiac surgery: diagnosis, etiology, and outcomeRebecca F Gottesman
Johns Hopkins Medical Institutions, Baltimore, MD, USA
Stroke 37:2306-11. 2006..The mechanism may include an intraoperative drop in blood pressure from a patient's baseline. These findings have implications for future clinical practice and research...
Psychosocial risk factors of HIV morbidity and mortality: findings from the Multicenter AIDS Cohort Study (MACS)Roxanna Farinpour
UCLA Neuropsychiatric Institute, Los Angeles, CA 90095, USA
J Clin Exp Neuropsychol 25:654-70. 2003....
Assessing HIV-associated dementia: modified HIV dementia scale versus the Grooved PegboardHenraya F Davis
Department of Psychology, Johnson C. Smith University, Charlotte, NC, USA
AIDS Read 12:29-31, 38. 2002..However, the M-HDS requires no equipment and is simpler to administer; so it may be more useful for screening by nonneurologists...
Diabetes, insulin resistance, and dementia among HIV-1-infected patientsVictor G Valcour
University of Hawaii, Neuro AIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, HI, USA
J Acquir Immune Defic Syndr 38:31-6. 2005..The objective of this study was to examine the relationship between HIV-associated dementia (HAD) and diabetes among patients with HIV-1 infection...
Should all patients undergoing cardiac surgery have preoperative psychometric testing: a brain stress test?Charles W Hogue
Anesth Analg 104:1012-4. 2007
An evaluation of neurocognitive status and markers of immune activation as predictors of time to death in advanced HIV infectionJeffrey J Sevigny
Department of Neurology and Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Arch Neurol 64:97-102. 2007..Several markers of immune activation have been identified as potential prognostic markers for human immunodeficiency virus (HIV)-associated morbidity and mortality, but the results from studies are conflicting...
Insulin resistance is associated with cognition among HIV-1-infected patients: the Hawaii Aging With HIV cohortVictor G Valcour
Office of Neurology and Aging Research, University of Hawaii, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
J Acquir Immune Defic Syndr 43:405-10. 2006..To determine if insulin resistance (IR) is associated with lower cognitive performance among HIV-1-infected adults and to determine if advanced age magnifies risk...
Defining cognitive change after CABG: decline versus normal variabilityOla A Selnes
Ann Thorac Surg 82:388-90. 2006
Normative data for determining significance of test-retest differences on eight common neuropsychological instrumentsAndrew J Levine
Department of Psychiatry, UCLA School of Medicine, Los Angeles, CA 90024 1759, USA
Clin Neuropsychol 18:373-84. 2004..Limitations are discussed regarding the applicability of the data. Those with a need to factor out the effects of practice, test-retest reliability and other statistical confounds will find the information within this article useful...
Coronary artery bypass grafting baseline cognitive assessment: essential not optionalOla A Selnes
Ann Thorac Surg 83:374-6. 2007
Do off-pump surgical procedures really improve memory?Ola A Selnes
Ann Thorac Surg 79:1462; author reply 1462. 2005
Late cognitive decline after CABG: inevitable or preventable?Ola A Selnes
Neurology 59:660-1. 2002
