Research Topics
| J B SegalSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic reviewJodi B Segal
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
JAMA 301:2472-85. 2009..Testing for genetic risks for venous thromboembolism (VTE) is common, but the safety and utility of such testing need review...
Preliminary competencies for comparative effectiveness researchJodi B Segal
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Clin Transl Sci 5:476-9. 2012..Although CER is particularly broad concept, we anticipate that these preliminary, relatively generic competencies will be used in tailoring curricula to individual learners from a variety of programmatic perspectives...- Chapter 3: choosing the important outcomes for a systematic review of a medical testJodi B Segal
Johns Hopkins University School of Medicine, 1830 E Monument St, Baltimore, MD 21287, USA
J Gen Intern Med 27:S20-7. 2012..This decision depends on the needs of the stakeholder(s), who should be assisted in prioritizing the outcomes for inclusion... - Risk of venous thromboembolism after total hip and knee replacement in older adults with comorbidity and co-occurring comorbidities in the Nationwide Inpatient Sample (2003-2006)Alok Kapoor
Hospital Medicine Unit, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
BMC Geriatr 10:63. 2010..Identifying a high risk cohort such as older adults with comorbidities and co-occurring comorbidities who might benefit most from high potency prophylaxis would improve how we currently perform preoperative assessment... 
Accuracy of identification of patients with immune thrombocytopenic purpura through administrative records: a data validation studyJodi B Segal
Johns Hopkins University School of Medicine, Department of Medicine, Baltimore, Maryland 21205, USA
Am J Hematol 75:12-7. 2004..ICD-9-CM code 287.3 in administrative billing data is likely to be sufficiently sensitive and specific, particularly when inpatient data are used, for the estimation of the prevalence of ITP...- Management of venous thromboembolism: a systematic review for a practice guidelineJodi B Segal
Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Ann Intern Med 146:211-22. 2007..New treatments are available for treatment of venous thromboembolism... - Concentrations of B vitamins and homocysteine in children with sickle cell anemiaJodi B Segal
Department of Medicine and Pediatrics, The Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University School of Medicine and Medical Institutions, Baltimore, MD 21205, USA
South Med J 97:149-55. 2004..We aimed to test whether children with sickle cell anemia have elevated concentrations of serum homocysteine with diminished levels of folate or B vitamins from accelerated blood cell turnover... - Preoperative acute normovolemic hemodilution: a meta-analysisJodi B Segal
Department of Medicine, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Transfusion 44:632-44. 2004..The aim of this study was to quantify the efficacy and safety of preoperative ANH with a systematic review and meta-analysis... - Prevalence of immune thrombocytopenia: analyses of administrative dataJ B Segal
Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Thromb Haemost 4:2377-83. 2006..The prevalence of immune thrombocytopenic purpura (ITP) in the USA is unknown. The paucity of data makes clinical trial design and resource allocation challenging... - Platelet counts differ by sex, ethnicity, and age in the United StatesJodi B Segal
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Ann Epidemiol 16:123-30. 2006..The aim of the study is to show that differences in platelet counts by ethnicity, sex, and age are not explained by environmental factors... - Outpatient therapy with low molecular weight heparin for the treatment of venous thromboembolism: a review of efficacy, safety, and costsJodi B Segal
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Med 115:298-308. 2003..To summarize the evidence comparing the efficacy, safety, and costs of outpatient and inpatient treatment of venous thromboembolism... - Review of the evidence on diagnosis of deep venous thrombosis and pulmonary embolismJodi B Segal
Johns Hopkins University School of Medicine, Department of Medicine, Baltimore, MD, USA
Ann Fam Med 5:63-73. 2007..This review summarizes the evidence regarding the efficacy of techniques for diagnosis of deep venous thrombosis (DVT) and pulmonary embolism... - Using propensity scores subclassification to estimate effects of longitudinal treatments: an example using a new diabetes medicationJodi B Segal
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Med Care 45:S149-57. 2007..When using observational data to compare the effectiveness of medications, it is essential to account parsimoniously for patients' longitudinal characteristics that lead to changes in treatments over time... - Testing strategies for diagnosing lupus anticoagulant: decision analysisJodi B Segal
Johns Hopkins University School of Medicine, Department of Medicine, Baltimore, Maryland, USA
Am J Hematol 70:195-205. 2002..On the basis of these cost and utility results, clinicians' strategies for detecting LA may need modification. These strategies would then optimally be tested in clinical trials... - Autologous blood transfusion in the United States: clinical and nonclinical determinants of useJ B Segal
Department of Medicine, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Transfusion 41:1539-47. 2001..The use of autologous blood is not well quantified. This study aimed at identifying the frequency and determinants of use of autologous transfusion in the United States... - Prompt reduction in use of medications for comorbid conditions after bariatric surgeryJodi B Segal
Johns Hopkins University School of Medicine, 1830 E Monument St Room 8047, Baltimore, MD 21287, USA
Obes Surg 19:1646-56. 2009..We explored this by assessing the change in use of medications to treat diabetes mellitus, hypertension, and hyperlipidemia in the year following surgery... - Diffusion into use of exenatide for glucose control in diabetes mellitus: a retrospective cohort study of a new therapyJodi B Segal
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Clin Ther 29:1784-94. 2007..Exenatide was approved by the US Food and Drug Administration (FDA) in April 2005 as adjunctive therapy to metformin or a sulfonylurea for the treatment of type 2 diabetes mellitus (DM)... - Prevention of thromboembolism in atrial fibrillation. A meta-analysis of trials of anticoagulants and antiplatelet drugsJ B Segal
Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Gen Intern Med 15:56-67. 2000..This review summarizes the evidence regarding the efficacy of these medications... - Limitations of D-dimer testing in unselected inpatients with suspected venous thromboembolismDaniel J Brotman
Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA
Am J Med 114:276-82. 2003..To determine the utility and limitations of D-dimer testing for the evaluation of venous thromboembolism in hospitalized patients... - Coagulation markers predicting cardiac transplant rejectionJ B Segal
Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Transplantation 72:233-7. 2001..The elevation of PF 1.2 suggests that there is systemic generation of thrombin generation. These markers may be useful for noninvasively monitoring patients for organ rejection or for after response to treatment... - Treatment of venous thromboembolism with low-molecular-weight heparin: a synthesis of the evidence published in systematic literature reviewsJ A Krishnan
Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, USA
Respir Med 98:376-86. 2004..To evaluate the methodology and cumulative evidence presented in systematic reviews of clinical trials comparing low-molecular-weight heparin (LMWH) with unfractionated heparin (UFH) for the treatment of venous thromboembolism... - Impact of bariatric surgery on hypertensive disorders in pregnancy: retrospective analysis of insurance claims dataWendy L Bennett
Department of Medicine, Division of General Internal Medicine, The Johns Hopkins University School of Medicine, 2024 E Monument Street, Room 2 611, Baltimore, MD 21205, USA
BMJ 340:c1662. 2010..To determine whether women who had a delivery after bariatric surgery have lower rates of hypertensive disorders in pregnancy compared with women who had a delivery before bariatric surgery... - Thrombotic thrombocytopenic purpura at the Johns Hopkins Hospital from 1992 to 2008: clinical outcomes and risk factors for relapseHuichun Zhan
Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Ross Research 1032, 720 Rutland Avenue, Baltimore, MD 21205, USA
Transfusion 50:868-74. 2010..We aimed to describe the clinical spectrum of TTP, to determine the valid endpoint for plasma exchange cessation, and to explore the risk factors for disease relapse... - Induction of fetal hemoglobin synthesis in children with sickle cell anemia on low-dose oral sodium phenylbutyrate therapyLinda M S Resar
Department of Pediatrics, Johns Hopkins University School of Medicine, Ross Research Building, Room 1125, 720 Rutland Avenue, Baltimore, MD 21205, USA
J Pediatr Hematol Oncol 24:737-41. 2002..We conclude that lower dose SPB is effective in inducing HbF synthesis in some children with HbSS. Further trials are warranted to determine the optimal treatment regimen... - Analytic validity of genetic tests to identify factor V Leiden and prothrombin G20210AAshkan Emadi
Department of Internal Medicine, Johns Hopkins University, Baltimore, MD, USA
Am J Hematol 85:264-70. 2010..There is high-grade evidence that most, but not all, clinical laboratories test for FVL and prothrombin G20210A accurately... - Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention populationNauder Faraday
Division of Cardiac Surgical Intensive Care, Department of Anesthesiology Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Am J Cardiol 98:774-9. 2006..quot;.. - Venous thromboembolism occurs infrequently in meningioma patients receiving combined modality prophylaxisDavid E Gerber
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cancer 109:300-5. 2007..Therefore, we conducted a retrospective review of postoperative meningioma patients receiving contemporary VTE prophylaxis and diagnostic methods to define the current incidence of and risk factors for symptomatic VTE in this population... - Evaluating health outcomes in the presence of competing risks: a review of statistical methods and clinical applicationsRavi Varadhan
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Med Care 48:S96-105. 2010..Although statistical methods exist for quantifying the probability of benefit from an intervention while accounting for competing events, these methods have not been widely adopted by clinical researchers... - Hospitalization rates and costs of care of patients with sickle-cell anemia in the state of Maryland in the era of hydroxyureaSophie Lanzkron
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Hematol 81:927-32. 2006..Hospital utilization among adults with SCA has increased significantly. There are likely many factors that have played a role in this increase. One factor that appears to be involved is the underutilization of HU... - Duration of vitamin K antagonist therapy for venous thromboembolism: a systematic review of the literatureMichael B Streiff
Department of Medicine, Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Hematol 81:684-91. 2006..The aim of this study was to evaluate the evidence on the optimal duration of vitamin K antagonist (VKA) therapy for venous thromboembolism (VTE)... - High prevalence and correlates of low bone mineral density in young adults with sickle cell diseaseRedonda G Miller
Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, MD 21287, USA
Am J Hematol 81:236-41. 2006..02), and low serum zinc concentrations (P < 0.01). The prevalence of osteopenia and osteoporosis in young adults with SCD is extremely high. Further research is needed to address fracture risk and therapeutic interventions... - Reduced incidence of gestational diabetes with bariatric surgeryAnne E Burke
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Am Coll Surg 211:169-75. 2010..Our objective was to determine the association of bariatric surgery with the incidence of GDM and related complications... - Medication utilization and annual health care costs in patients with type 2 diabetes mellitus before and after bariatric surgeryMartin A Makary
Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Arch Surg 145:726-31. 2010..To examine the relationship of bariatric surgery with the use of diabetes medications and with total health care costs in patients with type 2 diabetes mellitus... - Hydroxyurea for sickle cell disease: a systematic review for efficacy and toxicity in childrenJohn J Strouse
Department of Pediatrics, Johns Hopkins University School of Medicine, Division of Pediatric Hematology, 720 Rutland Ave, Ross 1125, Baltimore, MD 21205, USA
Pediatrics 122:1332-42. 2008..Hydroxyurea is the only approved medication for the treatment of sickle cell disease in adults; there are no approved drugs for children... - Effect of anti-platelet factor-4/heparin antibody induction on early saphenous vein graft occlusion after coronary artery bypass surgeryT J Gluckman
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
J Thromb Haemost 7:1457-64. 2009..Recent evidence suggests that anti-PF4/heparin antibodies may be prothrombogenic even in the absence of thrombocytopenia and clinically-recognized HIT... - Systematic review: Hydroxyurea for the treatment of adults with sickle cell diseaseSophie Lanzkron
School of Medicine, Johns Hopkins University, 1830 East Monument Street, Suite 7300, Baltimore, MD 21205, USA
Ann Intern Med 148:939-55. 2008..Hydroxyurea is the only approved drug for treatment of sickle cell disease... - Usefulness of clinical prediction rules for the diagnosis of venous thromboembolism: a systematic reviewLeonardo J Tamariz
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Med 117:676-84. 2004..To summarize the evidence on the predictive value of clinical prediction rules for the diagnosis of venous thromboembolism... - Efficacy of agents for pharmacologic conversion of atrial fibrillation and subsequent maintenance of sinus rhythm: a meta-analysis of clinical trialsM R Miller
Division of Pediatric Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Fam Pract 49:1033-46. 2000..Physicians have little evidentiary guidance for pharmacologic agent selection for atrial fibrillation (AF)... - A systematic review of barriers and interventions to improve appropriate use of therapies for sickle cell diseaseCarlton Haywood
Johns Hopkins Berman Institute of Bioethics, Johns Hopkins University School of Medicine, Division of Hematology, 2024 E Monument St, Rm 2 521, Baltimore, MD 21287, USA
J Natl Med Assoc 101:1022-33. 2009.... - The epidemiology of immune thrombocytopenic purpuraPatrick F Fogarty
Division of Hematology Oncology, Department of Medicine, University of California San Francisco, San Francisco, California 94143 1270, USA
Curr Opin Hematol 14:515-9. 2007..This review updates the American Society of Hematology and British guidelines on immune thrombocytopenic purpura incidence, prevalence, and natural history, with recent observations from the peer-reviewed medical literature... - Venous thromboembolism in patients with HIV/AIDS: a case-control studyAima A Ahonkhai
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Acquir Immune Defic Syndr 48:310-4. 2008..We investigated the prevalence of established risk factors for VTE in this population and explored novel risk factors... - Heparin-induced antibodies and cardiovascular risk in patients on dialysisLars M Asmis
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Thromb Haemost 100:498-504. 2008..In dialysis patients these antibodies were not an independent risk factor for cardiovascular events and mortality. Our data do not suggest that dialysis patients should be monitored for HIA antibodies in the absence of thrombocytopenia... - Cardiac troponin T and C-reactive protein as markers of acute cardiac allograft rejectionJ J Chance
Department of Pathology, Johns Hopkins Hospital, 600 N. Wolfe Street/Meyer B-125, Baltimore, MD 21287-7065, USA
Clin Chim Acta 312:31-9. 2001..When combined with a normal serum creatinine, a troponin T > or =0.1 ng/ml prior to endomyocardial biopsy correlated with graft rejection in almost all cases, making biopsy unnecessary... - Validating billing data for RBC transfusions: a brief reportJ B Segal
Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institution, Baltimore, MD, USA
Transfusion 41:530-3. 2001..035) than billed patients. CONCLUSIONS: The billing for RBC transfusion in one large institution is reassuringly valid. The specificity is excellent, and the sensitivity is higher than that seen in other studies of coding validity... - Usefulness of decreased levels of D-dimer in predicting progressive accelerated graft arteriosclerosisThomas A Hennebry
Division of Cardiology, Department of Medicine, Baltimore, Maryland 21287, USA
Am J Cardiol 89:884-7. 2002 - Incidence of antiplatelet factor 4/heparin antibody induction in patients undergoing percutaneous coronary revascularizationTyler J Gluckman
Department of Medicine Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
Am J Cardiol 95:744-7. 2005..Correlations were then made across antibody induction, heparin exposure, and clinical outcome at 6 months... - Accuracy of CT in the diagnosis of pulmonary embolism: a systematic literature reviewJohn Eng
Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 N Wolfe St, Central Radiology Viewing Area, Rm. 117, Baltimore, MD 21287, USA
AJR Am J Roentgenol 183:1819-27. 2004..Accuracy studies of recent generations of MDCT scanners are not yet available despite the current dissemination of this technology... - Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based reviewJodi B Segal
Department of Medicine, Johns Hopkins University School of Medicine, 1830 E. Monument Street, Baltimore, MD 21205, USA
Transfusion 45:1413-25. 2005..Randomized controlled trials should be performed to provide stronger evidence for clinical decision making regarding preprocedure transfusion... - Management of venous thromboembolism: a clinical practice guideline from the American College of Physicians and the American Academy of Family PhysiciansVincenza Snow
American College of Physicians, Philadelphia, Pennsylvania 19106, USA
Ann Intern Med 146:204-10. 2007..The target patient population is patients receiving a diagnosis of pulmonary embolism or lower-extremity deep venous thrombosis... - Management of atrial fibrillation: review of the evidence for the role of pharmacologic therapy, electrical cardioversion, and echocardiographyRobert L McNamara
Cardiovascular Section, Yale University School of Medicine, New Haven, Connecticut 06520 8017, USA
Ann Intern Med 139:1018-33. 2003.... - The incidence of and risk factors for venous thromboembolism (VTE) and bleeding among 1514 patients undergoing hematopoietic stem cell transplantation: implications for VTE preventionDavid E Gerber
Division of Hematology Oncology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
Blood 112:504-10. 2008..2; 95% CI, 1.4-3.6). In HSCT patients, VTE is primarily catheter-related and 3-fold less common than clinically significant bleeding. These findings warrant consideration when selecting VTE prophylaxis in HSCT patients...
Research Grants
- Immune Thrombocytopenia and Low-Level Mercury ExposureJodi Segal; Fiscal Year: 2006..Segal with the necessary support for successful completion ..